[article]
| Titre : |
Subgrouping Autism Based on Symptom Severity Leads to Differences in the Degree of Convergence Between Core Feature Domains |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
A. WHITTEN, Auteur ; K. E. UNRUH, Auteur ; R. L. SHAFER, Auteur ; James W. BODFISH, Auteur |
| Article en page(s) : |
p.1908-1919 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism Autism core features Phenotype |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Existing models of autism spectrum disorder (ASD) disagree as to whether the core features should be conceptualized as convergent (related) or divergent (unrelated), and the few previous studies addressing this question have found conflicting results. We examined standardized parent ratings of symptoms from three domains (social, communication, repetitive behaviors) in large samples of typically developing children, children with ASD, and ASD subgroups. Our results suggest that the most evidence for divergence lies in typically developing children and lower severity ASD cases, while more evidence for convergence is found in a subset of cases with more severe impairment on any core feature. These results highlight the importance of subgrouping ASD given the degree of phenotypic heterogeneity present across the autism spectrum. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-017-3451-3 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=361 |
in Journal of Autism and Developmental Disorders > 48-6 (June 2018) . - p.1908-1919
[article] Subgrouping Autism Based on Symptom Severity Leads to Differences in the Degree of Convergence Between Core Feature Domains [Texte imprimé et/ou numérique] / A. WHITTEN, Auteur ; K. E. UNRUH, Auteur ; R. L. SHAFER, Auteur ; James W. BODFISH, Auteur . - p.1908-1919. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 48-6 (June 2018) . - p.1908-1919
| Mots-clés : |
Autism Autism core features Phenotype |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Existing models of autism spectrum disorder (ASD) disagree as to whether the core features should be conceptualized as convergent (related) or divergent (unrelated), and the few previous studies addressing this question have found conflicting results. We examined standardized parent ratings of symptoms from three domains (social, communication, repetitive behaviors) in large samples of typically developing children, children with ASD, and ASD subgroups. Our results suggest that the most evidence for divergence lies in typically developing children and lower severity ASD cases, while more evidence for convergence is found in a subset of cases with more severe impairment on any core feature. These results highlight the importance of subgrouping ASD given the degree of phenotypic heterogeneity present across the autism spectrum. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-017-3451-3 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=361 |
|
Subgrouping Autism Based on Symptom Severity Leads to Differences in the Degree of Convergence Between Core Feature Domains in Journal of Autism and Developmental Disorders, 48-6 (June 2018)
