Elevated levels of tissue plasminogen activator and E-selectin in male children with autism spectrum disorder / ?eref ?IMSEK in Autism Research, 9-12 (December 2016)  

Public ISBD [article]  inAutism Research > 9-12 (December 2016) . - p.1241-1247 Titre : Elevated levels of tissue plasminogen activator and E-selectin in male children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : ?eref ?IMSEK, Auteur ; ?hsan ÇETIN, Auteur ; Abdullah ÇIM, Auteur ; Sava? KAYA, Auteur Article en page(s) : p.1241-1247 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  inflammation  selectin  tissue plasminogen activator  sPECAM-1 Index. décimale : PER Périodiques Résumé : Although the etiopathology of autism spectrum disorder (ASD) is not clear, immune dysfunction has been proposed as a mechanism for the pathophysiology of ASD. The purpose of this study is to examine serum levels of tissue plasminogen activator (t-PA) and some adhesion molecules in children with ASD that have not been investigated previously in detail. The study group included 35 male children aged from 2 to 9 diagnosed with ASD according to DSM-V criteria. Soluble platelet endothelial adhesion molecule-1 (sPECAM-1), P-selectin, E-selectin, and t-PA in the serum were determined with enzyme-linked immunosorbent assay. Autism behavior check list (ABC) is used for the assessment of ASD severity. The levels of t-PA (P?=?0.025) and E-selectin (P?=?0.007) was detected significantly higher in children with ASD than control group. Serum levels of sPECAM-1 showed statistically significant negative correlation with sensory, body and object-use, language, social, and self-help and total scores in the patient group (r?=??0.349, P?=?0.04; r?=??0.411, P?=?0.01; r?=??0.412, P?=?0.01; r?=??0.417, P?=?0.01, and r?=??0.531, P? En ligne : http://dx.doi.org/10.1002/aur.1638 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Elevated levels of tissue plasminogen activator and E-selectin in male children with autism spectrum disorder [Texte imprimé et/ou numérique] / ?eref ?IMSEK, Auteur ; ?hsan ÇETIN, Auteur ; Abdullah ÇIM, Auteur ; Sava? KAYA, Auteur . - p.1241-1247. Langues : Anglais (eng) in Autism Research > 9-12 (December 2016) . - p.1241-1247 Mots-clés : Autism spectrum disorder  inflammation  selectin  tissue plasminogen activator  sPECAM-1 Index. décimale : PER Périodiques Résumé : Although the etiopathology of autism spectrum disorder (ASD) is not clear, immune dysfunction has been proposed as a mechanism for the pathophysiology of ASD. The purpose of this study is to examine serum levels of tissue plasminogen activator (t-PA) and some adhesion molecules in children with ASD that have not been investigated previously in detail. The study group included 35 male children aged from 2 to 9 diagnosed with ASD according to DSM-V criteria. Soluble platelet endothelial adhesion molecule-1 (sPECAM-1), P-selectin, E-selectin, and t-PA in the serum were determined with enzyme-linked immunosorbent assay. Autism behavior check list (ABC) is used for the assessment of ASD severity. The levels of t-PA (P?=?0.025) and E-selectin (P?=?0.007) was detected significantly higher in children with ASD than control group. Serum levels of sPECAM-1 showed statistically significant negative correlation with sensory, body and object-use, language, social, and self-help and total scores in the patient group (r?=??0.349, P?=?0.04; r?=??0.411, P?=?0.01; r?=??0.412, P?=?0.01; r?=??0.417, P?=?0.01, and r?=??0.531, P? En ligne : http://dx.doi.org/10.1002/aur.1638 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

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