Insensitive parenting may accelerate the development of the amygdala–medial prefrontal cortex circuit / Sandra THIJSSEN in Development and Psychopathology, 29-2 (May 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-2 (May 2017) . - p.505-518 Titre : Insensitive parenting may accelerate the development of the amygdala–medial prefrontal cortex circuit Type de document : Texte imprimé et/ou numérique Auteurs : Sandra THIJSSEN, Auteur ; Ryan L. MUETZEL, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur ; Vincent W.V. JADDOE, Auteur ; Henning TIEMEIER, Auteur ; Frank C. VERHULST, Auteur ; Tonya WHITE, Auteur ; Marinus H. VAN IJZENDOORN, Auteur Article en page(s) : p.505-518 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study examined whether the association between age and amygdala–medial prefrontal cortex (mPFC) connectivity in typically developing 6- to 10-year-old children is correlated with parental care. Resting-state functional magnetic resonance imaging scans were acquired from 124 children of the Generation R Study who at 4 years old had been observed interacting with their parents to assess maternal and paternal sensitivity. Amygdala functional connectivity was assessed using a general linear model with the amygdalae time series as explanatory variables. Higher level analyses assessing Sensitivity × Age as well as exploratory Sensitivity × Age × Gender interaction effects were performed restricted to voxels in the mPFC. We found significant Sensitivity × Age interaction effects on amygdala–mPFC connectivity. Age was related to stronger amygdala–mPFC connectivity in children with a lower combined parental sensitivity score (b = 0.11, p = .004, b = 0.06, p = .06, right and left amygdala, respectively), but not in children with a higher parental sensitivity score, (b = –0.07, p = .12, b = –0.06, p = .12, right and left amygdala, respectively). A similar effect was found for maternal sensitivity, with stronger amygdala–mPFC connectivity in children with less sensitive mothers. Exploratory (parental, maternal, paternal) Sensitivity × Age × Gender interaction analyses suggested that this effect was especially pronounced in girls. Amygdala-mPFC resting-state functional connectivity has been shown to increase from age 10.5 years onward, implying that the positive association between age and amygdala–mPFC connectivity in 6- to 10-year-old children of less sensitive parents represents accelerated development of the amygdala–mPFC circuit. En ligne : http://dx.doi.org/10.1017/s0954579417000141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 [article] Insensitive parenting may accelerate the development of the amygdala–medial prefrontal cortex circuit [Texte imprimé et/ou numérique] / Sandra THIJSSEN, Auteur ; Ryan L. MUETZEL, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur ; Vincent W.V. JADDOE, Auteur ; Henning TIEMEIER, Auteur ; Frank C. VERHULST, Auteur ; Tonya WHITE, Auteur ; Marinus H. VAN IJZENDOORN, Auteur . - p.505-518. Langues : Anglais (eng) in Development and Psychopathology > 29-2 (May 2017) . - p.505-518 Index. décimale : PER Périodiques Résumé : This study examined whether the association between age and amygdala–medial prefrontal cortex (mPFC) connectivity in typically developing 6- to 10-year-old children is correlated with parental care. Resting-state functional magnetic resonance imaging scans were acquired from 124 children of the Generation R Study who at 4 years old had been observed interacting with their parents to assess maternal and paternal sensitivity. Amygdala functional connectivity was assessed using a general linear model with the amygdalae time series as explanatory variables. Higher level analyses assessing Sensitivity × Age as well as exploratory Sensitivity × Age × Gender interaction effects were performed restricted to voxels in the mPFC. We found significant Sensitivity × Age interaction effects on amygdala–mPFC connectivity. Age was related to stronger amygdala–mPFC connectivity in children with a lower combined parental sensitivity score (b = 0.11, p = .004, b = 0.06, p = .06, right and left amygdala, respectively), but not in children with a higher parental sensitivity score, (b = –0.07, p = .12, b = –0.06, p = .12, right and left amygdala, respectively). A similar effect was found for maternal sensitivity, with stronger amygdala–mPFC connectivity in children with less sensitive mothers. Exploratory (parental, maternal, paternal) Sensitivity × Age × Gender interaction analyses suggested that this effect was especially pronounced in girls. Amygdala-mPFC resting-state functional connectivity has been shown to increase from age 10.5 years onward, implying that the positive association between age and amygdala–mPFC connectivity in 6- to 10-year-old children of less sensitive parents represents accelerated development of the amygdala–mPFC circuit. En ligne : http://dx.doi.org/10.1017/s0954579417000141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

Pubertal development mediates the association between family environment and brain structure and function in childhood / Sandra THIJSSEN in Development and Psychopathology, 32-2 (May 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-2 (May 2020) . - p.687-702 Titre : Pubertal development mediates the association between family environment and brain structure and function in childhood Type de document : Texte imprimé et/ou numérique Auteurs : Sandra THIJSSEN, Auteur ; Paul F. COLLINS, Auteur ; Monica LUCIANA, Auteur Article en page(s) : p.687-702 Langues : Anglais (eng) Mots-clés : accelerated development  amygdala–medial prefrontal cortex circuit  family environment  psychosocial acceleration theory  pubertal development Index. décimale : PER Périodiques Résumé : Psychosocial acceleration theory suggests that pubertal maturation is accelerated in response to adversity. In addition, suboptimal caregiving accelerates development of the amygdala-medial prefrontal cortex circuit. These findings may be related. Here, we assess whether associations between family environment and measures of the amygdala-medial prefrontal cortex circuit are mediated by pubertal development in more than 2000 9- and 10-year-old children from the Adolescent Brain Cognitive Development Study (http://dx.doi.org/10.15154/1412097). Using structural equation modeling, demographic, child-reported, and parent-reported data on family dynamics were compiled into a higher level family environment latent variable. Magnetic resonance imaging preprocessing and compilations were performed by the Adolescent Brain Cognitive Development Study's data analysis core. Anterior cingulate cortex (ACC) thickness, area, white matter fractional anisotropy, amygdala volume, and cingulo-opercular network-amygdala resting-state functional connectivity were assessed. For ACC cortical thickness and ACC fractional anisotropy, significant indirect effects indicated that a stressful family environment relates to more advanced pubertal stage and more mature brain structure. For cingulo-opercular network-amygdala functional connectivity, results indicated a trend in the expected direction. For ACC area, evidence for quadratic mediation by pubertal stage was found. Sex-stratified analyses suggest stronger results for girls. Despite small effect sizes, structural measures of circuits important for emotional behavior are associated with family environment and show initial evidence of accelerated pubertal development. En ligne : http://dx.doi.org/10.1017/s0954579419000580 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Pubertal development mediates the association between family environment and brain structure and function in childhood [Texte imprimé et/ou numérique] / Sandra THIJSSEN, Auteur ; Paul F. COLLINS, Auteur ; Monica LUCIANA, Auteur . - p.687-702. Langues : Anglais (eng) in Development and Psychopathology > 32-2 (May 2020) . - p.687-702 Mots-clés : accelerated development  amygdala–medial prefrontal cortex circuit  family environment  psychosocial acceleration theory  pubertal development Index. décimale : PER Périodiques Résumé : Psychosocial acceleration theory suggests that pubertal maturation is accelerated in response to adversity. In addition, suboptimal caregiving accelerates development of the amygdala-medial prefrontal cortex circuit. These findings may be related. Here, we assess whether associations between family environment and measures of the amygdala-medial prefrontal cortex circuit are mediated by pubertal development in more than 2000 9- and 10-year-old children from the Adolescent Brain Cognitive Development Study (http://dx.doi.org/10.15154/1412097). Using structural equation modeling, demographic, child-reported, and parent-reported data on family dynamics were compiled into a higher level family environment latent variable. Magnetic resonance imaging preprocessing and compilations were performed by the Adolescent Brain Cognitive Development Study's data analysis core. Anterior cingulate cortex (ACC) thickness, area, white matter fractional anisotropy, amygdala volume, and cingulo-opercular network-amygdala resting-state functional connectivity were assessed. For ACC cortical thickness and ACC fractional anisotropy, significant indirect effects indicated that a stressful family environment relates to more advanced pubertal stage and more mature brain structure. For cingulo-opercular network-amygdala functional connectivity, results indicated a trend in the expected direction. For ACC area, evidence for quadratic mediation by pubertal stage was found. Sex-stratified analyses suggest stronger results for girls. Despite small effect sizes, structural measures of circuits important for emotional behavior are associated with family environment and show initial evidence of accelerated pubertal development. En ligne : http://dx.doi.org/10.1017/s0954579419000580 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

Pubertal development mediates the association between family environment and brain structure and function in childhood – ADDENDUM / Sandra THIJSSEN in Development and Psychopathology, 33-1 (February 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-1 (February 2021) . - p.372-375 Titre : Pubertal development mediates the association between family environment and brain structure and function in childhood – ADDENDUM Type de document : Texte imprimé et/ou numérique Auteurs : Sandra THIJSSEN, Auteur ; Paul F. COLLINS, Auteur ; Monica LUCIANA, Auteur Article en page(s) : p.372-375 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579420000322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 [article] Pubertal development mediates the association between family environment and brain structure and function in childhood – ADDENDUM [Texte imprimé et/ou numérique] / Sandra THIJSSEN, Auteur ; Paul F. COLLINS, Auteur ; Monica LUCIANA, Auteur . - p.372-375. Langues : Anglais (eng) in Development and Psychopathology > 33-1 (February 2021) . - p.372-375 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579420000322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443

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