[article] 
inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.173-184

Titre :	Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study
Type de document :	Texte imprimé et/ou numérique
Auteurs :	R. RAGHAVAN, Auteur ; M. D. FALLIN, Auteur ; X. HONG, Auteur ; G. WANG, Auteur ; Y. JI, Auteur ; E. A. STUART, Auteur ; D. PAIGE, Auteur ; X. WANG, Auteur
Article en page(s) :	p.173-184
Langues :	Anglais (eng)
Mots-clés :	Adiponectin  Autism  Cytokines  Preterm birth
Index. décimale :	PER Périodiques
Résumé :	Emerging research suggests that adiponectin, a cytokine produced by adipose tissue, may be implicated in ASD. In this prospective birth cohort study (n = 847), we assessed the association between cord, early childhood plasma adiponectin and the risk of developing ASD. ASD was defined based on ICD codes of physician diagnosis. Cord adiponectin levels were inversely associated with ASD risk (aOR 0.50; 95% CI 0.33, 0.77), independent of preterm birth, early childhood adiponectin and other known ASD risk factors. Early childhood adiponectin, assessed prior to ASD diagnosis, was associated with lower risk of ASD, which attenuated after adjusting for cord adiponectin, indicating the relative importance of cord adiponectin in ASD risk. Further research is warranted to confirm our findings and elucidate biological mechanisms.
En ligne :	http://dx.doi.org/10.1007/s10803-018-3688-5
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376

[article] Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study [Texte imprimé et/ou numérique] / R. RAGHAVAN, Auteur ; M. D. FALLIN, Auteur ; X. HONG, Auteur ; G. WANG, Auteur ; Y. JI, Auteur ; E. A. STUART, Auteur ; D. PAIGE, Auteur ; X. WANG, Auteur . - p.173-184.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.173-184

Mots-clés :	Adiponectin  Autism  Cytokines  Preterm birth
Index. décimale :	PER Périodiques
Résumé :	Emerging research suggests that adiponectin, a cytokine produced by adipose tissue, may be implicated in ASD. In this prospective birth cohort study (n = 847), we assessed the association between cord, early childhood plasma adiponectin and the risk of developing ASD. ASD was defined based on ICD codes of physician diagnosis. Cord adiponectin levels were inversely associated with ASD risk (aOR 0.50; 95% CI 0.33, 0.77), independent of preterm birth, early childhood adiponectin and other known ASD risk factors. Early childhood adiponectin, assessed prior to ASD diagnosis, was associated with lower risk of ASD, which attenuated after adjusting for cord adiponectin, indicating the relative importance of cord adiponectin in ASD risk. Further research is warranted to confirm our findings and elucidate biological mechanisms.
En ligne :	http://dx.doi.org/10.1007/s10803-018-3688-5
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376