[article]
| Titre : |
Interactive Effects of Prenatal Antidepressant Exposure and Likely Gene Disrupting Mutations on the Severity of Autism Spectrum Disorder |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
S. ACKERMAN, Auteur ; S. SCHOENBRUN, Auteur ; C. HUDAC, Auteur ; Raphael BERNIER, Auteur |
| Article en page(s) : |
p.3489-3496 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Asd Antidepressants Autism Genetics Ssri |
| Index. décimale : |
PER Périodiques |
| Résumé : |
To examine the interactive effects of two proposed risk factors which may contribute to symptom severity of Autism Spectrum Disorder (ASD): prenatal antidepressant exposure and likely gene-disrupting (LGD) mutations. Participants included 2748 individuals with ASD from the Simons Simplex Collection. We examined the effects of prenatal antidepressant exposure, maternal depression, presence of an LGD mutation and their interaction on ASD severity. We found a significant interactive effect between antidepressant exposure and the presence of an LGD mutation on ASD severity in the ADOS and ADI-R verbal communication domains. We consider a "two-hit" model in which one variable lays the foundation for an initial risk which is compounded by a second variable. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-017-3246-6 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 |
in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3489-3496
[article] Interactive Effects of Prenatal Antidepressant Exposure and Likely Gene Disrupting Mutations on the Severity of Autism Spectrum Disorder [Texte imprimé et/ou numérique] / S. ACKERMAN, Auteur ; S. SCHOENBRUN, Auteur ; C. HUDAC, Auteur ; Raphael BERNIER, Auteur . - p.3489-3496. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3489-3496
| Mots-clés : |
Asd Antidepressants Autism Genetics Ssri |
| Index. décimale : |
PER Périodiques |
| Résumé : |
To examine the interactive effects of two proposed risk factors which may contribute to symptom severity of Autism Spectrum Disorder (ASD): prenatal antidepressant exposure and likely gene-disrupting (LGD) mutations. Participants included 2748 individuals with ASD from the Simons Simplex Collection. We examined the effects of prenatal antidepressant exposure, maternal depression, presence of an LGD mutation and their interaction on ASD severity. We found a significant interactive effect between antidepressant exposure and the presence of an LGD mutation on ASD severity in the ADOS and ADI-R verbal communication domains. We consider a "two-hit" model in which one variable lays the foundation for an initial risk which is compounded by a second variable. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-017-3246-6 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 |
|
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