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Détail de l'auteur
Auteur Caitlin M. HUDAC |
Documents disponibles écrits par cet auteur (3)
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Brain Mechanisms for Processing Direct and Averted Gaze in Individuals with Autism / Naomi PITSKEL in Journal of Autism and Developmental Disorders, 41-12 (December 2011)
[article]
Titre : Brain Mechanisms for Processing Direct and Averted Gaze in Individuals with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Naomi PITSKEL, Auteur ; Danielle Z. BOLLING, Auteur ; Caitlin M. HUDAC, Auteur ; Stephen LANTZ, Auteur ; Nancy J. MINSHEW, Auteur ; Brent C. VANDER WYK, Auteur ; Kevin A. PELPHREY, Auteur Année de publication : 2011 Article en page(s) : p.1686-1693 Langues : Anglais (eng) Mots-clés : Autism Direct gaze Averted gaze Gaze processing Functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Prior studies have indicated brain abnormalities underlying social processing in autism, but no fMRI study has specifically addressed the differential processing of direct and averted gaze, a critical social cue. Fifteen adolescents and adults with autism and 14 typically developing comparison participants viewed dynamic virtual-reality videos depicting a simple but realistic social scenario, in which an approaching male figure maintained either direct or averted gaze. Significant group by condition interactions reflecting differential responses to direct versus averted gaze in people with autism relative to typically developing individuals were identified in the right temporoparietal junction, right anterior insula, left lateral occipital cortex, and left dorsolateral prefrontal cortex. Our results provide initial evidence regarding brain mechanisms underlying the processing of gaze direction during simple social encounters, providing new insight into the social deficits in individuals with autism. En ligne : http://dx.doi.org/10.1007/s10803-011-1197-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148
in Journal of Autism and Developmental Disorders > 41-12 (December 2011) . - p.1686-1693[article] Brain Mechanisms for Processing Direct and Averted Gaze in Individuals with Autism [Texte imprimé et/ou numérique] / Naomi PITSKEL, Auteur ; Danielle Z. BOLLING, Auteur ; Caitlin M. HUDAC, Auteur ; Stephen LANTZ, Auteur ; Nancy J. MINSHEW, Auteur ; Brent C. VANDER WYK, Auteur ; Kevin A. PELPHREY, Auteur . - 2011 . - p.1686-1693.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 41-12 (December 2011) . - p.1686-1693
Mots-clés : Autism Direct gaze Averted gaze Gaze processing Functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Prior studies have indicated brain abnormalities underlying social processing in autism, but no fMRI study has specifically addressed the differential processing of direct and averted gaze, a critical social cue. Fifteen adolescents and adults with autism and 14 typically developing comparison participants viewed dynamic virtual-reality videos depicting a simple but realistic social scenario, in which an approaching male figure maintained either direct or averted gaze. Significant group by condition interactions reflecting differential responses to direct versus averted gaze in people with autism relative to typically developing individuals were identified in the right temporoparietal junction, right anterior insula, left lateral occipital cortex, and left dorsolateral prefrontal cortex. Our results provide initial evidence regarding brain mechanisms underlying the processing of gaze direction during simple social encounters, providing new insight into the social deficits in individuals with autism. En ligne : http://dx.doi.org/10.1007/s10803-011-1197-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148 Characterizing the autism spectrum phenotype in DYRK1A-related syndrome / Evangeline C. KURTZ-NELSON in Autism Research, 16-8 (August 2023)
[article]
Titre : Characterizing the autism spectrum phenotype in DYRK1A-related syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Evangeline C. KURTZ-NELSON, Auteur ; Hannah M. REA, Auteur ; Aiva C. PETRICEKS, Auteur ; Caitlin M. HUDAC, Auteur ; Tianyun WANG, Auteur ; Rachel K. EARL, Auteur ; Raphael A. BERNIER, Auteur ; Evan E. EICHLER, Auteur ; Emily NEUHAUS, Auteur Article en page(s) : p.1488-1500 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Likely gene-disrupting (LGD) variants in DYRK1A are causative of DYRK1A syndrome and associated with autism spectrum disorder (ASD) and intellectual disability (ID). While many individuals with DYRK1A syndrome are diagnosed with ASD, they may present with a unique profile of ASD traits. We present a comprehensive characterization of the ASD profile in children and young adults with LGDs in DYRK1A. Individuals with LGD variants in DYRK1A (n=29) were compared to children who had ASD with no known genetic cause, either with low nonverbal IQ (n=14) or average or above nonverbal IQ (n=41). ASD was assessed using the ADOS-2, ADI-R, SRS-2, SCQ, and RBS-R. Quantitative score comparisons were conducted, as were qualitative analyses of clinicians' behavioral observations. Diagnosis of ASD was confirmed in 85% and ID was confirmed in 89% of participants with DYRK1A syndrome. Individuals with DYRK1A syndrome showed broadly similar social communication behaviors to children with idiopathic ASD and below-average nonverbal IQ, with specific challenges noted in social reciprocity and nonverbal communication. Children with DYRK1A syndrome also showed high rates of sensory-seeking behaviors. Phenotypic characterization of individuals with DYRK1A syndrome may provide additional information on mechanisms contributing to co-occurring ASD and ID and contribute to the identification of genetic predictors of specific ASD traits. En ligne : https://doi.org/10.1002/aur.2995 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510
in Autism Research > 16-8 (August 2023) . - p.1488-1500[article] Characterizing the autism spectrum phenotype in DYRK1A-related syndrome [Texte imprimé et/ou numérique] / Evangeline C. KURTZ-NELSON, Auteur ; Hannah M. REA, Auteur ; Aiva C. PETRICEKS, Auteur ; Caitlin M. HUDAC, Auteur ; Tianyun WANG, Auteur ; Rachel K. EARL, Auteur ; Raphael A. BERNIER, Auteur ; Evan E. EICHLER, Auteur ; Emily NEUHAUS, Auteur . - p.1488-1500.
Langues : Anglais (eng)
in Autism Research > 16-8 (August 2023) . - p.1488-1500
Index. décimale : PER Périodiques Résumé : Abstract Likely gene-disrupting (LGD) variants in DYRK1A are causative of DYRK1A syndrome and associated with autism spectrum disorder (ASD) and intellectual disability (ID). While many individuals with DYRK1A syndrome are diagnosed with ASD, they may present with a unique profile of ASD traits. We present a comprehensive characterization of the ASD profile in children and young adults with LGDs in DYRK1A. Individuals with LGD variants in DYRK1A (n=29) were compared to children who had ASD with no known genetic cause, either with low nonverbal IQ (n=14) or average or above nonverbal IQ (n=41). ASD was assessed using the ADOS-2, ADI-R, SRS-2, SCQ, and RBS-R. Quantitative score comparisons were conducted, as were qualitative analyses of clinicians' behavioral observations. Diagnosis of ASD was confirmed in 85% and ID was confirmed in 89% of participants with DYRK1A syndrome. Individuals with DYRK1A syndrome showed broadly similar social communication behaviors to children with idiopathic ASD and below-average nonverbal IQ, with specific challenges noted in social reciprocity and nonverbal communication. Children with DYRK1A syndrome also showed high rates of sensory-seeking behaviors. Phenotypic characterization of individuals with DYRK1A syndrome may provide additional information on mechanisms contributing to co-occurring ASD and ID and contribute to the identification of genetic predictors of specific ASD traits. En ligne : https://doi.org/10.1002/aur.2995 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 Research Review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder / Kevin A. PELPHREY in Journal of Child Psychology and Psychiatry, 52-6 (June 2011)
[article]
Titre : Research Review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kevin A. PELPHREY, Auteur ; Sarah SHULTZ, Auteur ; Caitlin M. HUDAC, Auteur ; Brent C. VANDER WYK, Auteur Année de publication : 2011 Article en page(s) : p.631-644 Langues : Anglais (eng) Mots-clés : Social perception social cognition autism functional neuroimaging social brain Index. décimale : PER Périodiques Résumé : The expression of autism spectrum disorder (ASD) is highly heterogeneous, owing to the complex interactions between genes, the brain, and behavior throughout development. Here we present a model of ASD that implicates an early and initial failure to develop the specialized functions of one or more of the set of neuroanatomical structures involved in social information processing (i.e., the ‘social brain’). From this early and primary disruption, abnormal brain development is canalized because the individual with an ASD must develop in a highly social world without the specialized neural systems that would ordinarily allow him or her to partake in the fabric of social life, which is woven from the thread of opportunities for social reciprocity and the tools of social engagement. This brain canalization gives rise to other characteristic behavioral deficits in ASD including deficits in communication, restricted interests, and repetitive behaviors. We propose that focused efforts to explore the brain mechanisms underlying the core, pathognomic deficits in the development of mechanisms for social engagement in ASD will greatly elucidate our understanding and treatment of this complex, devastating family of neurodevelopmental disorders. In particular, developmental studies (i.e., longitudinal studies of young children with and without ASD, as well as infants at increased risk for being identified with ASD) of the neural circuitry supporting key aspects of social information processing are likely to provide important insights into the underlying components of the full-syndrome of ASD. These studies could also contribute to the identification of developmental brain endophenotypes to facilitate genetic studies. The potential for this kind of approach is illustrated via examples of functional neuroimaging research from our own laboratory implicating the posterior superior temporal sulcus (STS) as a key player in the set of neural structures giving rise to ASD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02349.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126
in Journal of Child Psychology and Psychiatry > 52-6 (June 2011) . - p.631-644[article] Research Review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder [Texte imprimé et/ou numérique] / Kevin A. PELPHREY, Auteur ; Sarah SHULTZ, Auteur ; Caitlin M. HUDAC, Auteur ; Brent C. VANDER WYK, Auteur . - 2011 . - p.631-644.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-6 (June 2011) . - p.631-644
Mots-clés : Social perception social cognition autism functional neuroimaging social brain Index. décimale : PER Périodiques Résumé : The expression of autism spectrum disorder (ASD) is highly heterogeneous, owing to the complex interactions between genes, the brain, and behavior throughout development. Here we present a model of ASD that implicates an early and initial failure to develop the specialized functions of one or more of the set of neuroanatomical structures involved in social information processing (i.e., the ‘social brain’). From this early and primary disruption, abnormal brain development is canalized because the individual with an ASD must develop in a highly social world without the specialized neural systems that would ordinarily allow him or her to partake in the fabric of social life, which is woven from the thread of opportunities for social reciprocity and the tools of social engagement. This brain canalization gives rise to other characteristic behavioral deficits in ASD including deficits in communication, restricted interests, and repetitive behaviors. We propose that focused efforts to explore the brain mechanisms underlying the core, pathognomic deficits in the development of mechanisms for social engagement in ASD will greatly elucidate our understanding and treatment of this complex, devastating family of neurodevelopmental disorders. In particular, developmental studies (i.e., longitudinal studies of young children with and without ASD, as well as infants at increased risk for being identified with ASD) of the neural circuitry supporting key aspects of social information processing are likely to provide important insights into the underlying components of the full-syndrome of ASD. These studies could also contribute to the identification of developmental brain endophenotypes to facilitate genetic studies. The potential for this kind of approach is illustrated via examples of functional neuroimaging research from our own laboratory implicating the posterior superior temporal sulcus (STS) as a key player in the set of neural structures giving rise to ASD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02349.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126