Disentangling the perceptual underpinnings of autism: Evidence from a face aftereffects experiment / Julius Hennig ; Arne Doose ; Clara Marie Breier ; Alexander Soutschek ; Nicole Beyer ; Stefan Schweinberger ; Ingeborg Kamp-Becker ; Luise POUSTKA ; Katja Albertowski ; Veit ROESSNER ; Stefan EHRLICH in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.349-361 Titre : Disentangling the perceptual underpinnings of autism: Evidence from a face aftereffects experiment : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Julius Hennig, Auteur ; Arne Doose, Auteur ; Clara Marie Breier, Auteur ; Alexander Soutschek, Auteur ; Nicole Beyer, Auteur ; Stefan Schweinberger, Auteur ; Ingeborg Kamp-Becker, Auteur ; Luise POUSTKA, Auteur ; Katja Albertowski, Auteur ; Veit ROESSNER, Auteur ; Stefan EHRLICH, Auteur Article en page(s) : p.349-361 Langues : Anglais (eng) Mots-clés : autism face aftereffects gender processing hierarchical drift diffusion modeling perceptual processing Index. décimale : PER Périodiques Résumé : Abstract Existing literature has documented diminished norm-based adaptation (aftereffects) across several perceptual domains in autism. However, the exact underlying mechanisms, such as sensory dominance possibly caused by imprecise priors and/or increased sensory precision, remain elusive. The ?Bayesian brain? framework offers refined methods to investigate these mechanisms. This study utilized both model-free (frequentist statistics) and model-based (hierarchical Drift Diffusion Modeling) analytical approaches to compare gender face aftereffects in male adolescents with autism (n?=?29) to neurotypical controls (n?=?39) using a behavioral choice experiment. Contrary to our initial hypotheses, our analyses did not find support for imprecise priors or increased sensory precision within the autistic group. Instead, we observed generally decreased drift rates towards male but not female stimuli in the autistic group. Thus, our findings suggest a lack of own-gender bias in face processing among the autistic participants. These findings align with more recent behavioral and neurophysiological research observing intact priors in individuals with autism, suggesting that other mechanisms may better explain the perceptual challenges in autism. Our study contributes to the ongoing discourse on perceptual processing in autism, emphasizing the necessity for more nuanced analytical approaches in order to unravel the complexity of this condition. En ligne : https://doi.org/10.1002/aur.3283 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Disentangling the perceptual underpinnings of autism: Evidence from a face aftereffects experiment : Autism Research [Texte imprimé et/ou numérique] / Julius Hennig, Auteur ; Arne Doose, Auteur ; Clara Marie Breier, Auteur ; Alexander Soutschek, Auteur ; Nicole Beyer, Auteur ; Stefan Schweinberger, Auteur ; Ingeborg Kamp-Becker, Auteur ; Luise POUSTKA, Auteur ; Katja Albertowski, Auteur ; Veit ROESSNER, Auteur ; Stefan EHRLICH, Auteur . - p.349-361. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.349-361 Mots-clés : autism face aftereffects gender processing hierarchical drift diffusion modeling perceptual processing Index. décimale : PER Périodiques Résumé : Abstract Existing literature has documented diminished norm-based adaptation (aftereffects) across several perceptual domains in autism. However, the exact underlying mechanisms, such as sensory dominance possibly caused by imprecise priors and/or increased sensory precision, remain elusive. The ?Bayesian brain? framework offers refined methods to investigate these mechanisms. This study utilized both model-free (frequentist statistics) and model-based (hierarchical Drift Diffusion Modeling) analytical approaches to compare gender face aftereffects in male adolescents with autism (n?=?29) to neurotypical controls (n?=?39) using a behavioral choice experiment. Contrary to our initial hypotheses, our analyses did not find support for imprecise priors or increased sensory precision within the autistic group. Instead, we observed generally decreased drift rates towards male but not female stimuli in the autistic group. Thus, our findings suggest a lack of own-gender bias in face processing among the autistic participants. These findings align with more recent behavioral and neurophysiological research observing intact priors in individuals with autism, suggesting that other mechanisms may better explain the perceptual challenges in autism. Our study contributes to the ongoing discourse on perceptual processing in autism, emphasizing the necessity for more nuanced analytical approaches in order to unravel the complexity of this condition. En ligne : https://doi.org/10.1002/aur.3283 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Dynamic functional connectivity in anorexia nervosa: alterations in states of low connectivity and state transitions / Eva MENNIGEN ; Daniel GEISLER ; Nico W. POLLER ; Katrin GRAMATKE ; Vince D. CALHOUN ; Veit ROESSNER ; Joseph A. KING ; Stefan EHRLICH in Journal of Child Psychology and Psychiatry, 65-10 (October 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1299-1310 Titre : Dynamic functional connectivity in anorexia nervosa: alterations in states of low connectivity and state transitions Type de document : Texte imprimé et/ou numérique Auteurs : Eva MENNIGEN, Auteur ; Daniel GEISLER, Auteur ; Nico W. POLLER, Auteur ; Katrin GRAMATKE, Auteur ; Vince D. CALHOUN, Auteur ; Veit ROESSNER, Auteur ; Joseph A. KING, Auteur ; Stefan EHRLICH, Auteur Article en page(s) : p.1299-1310 Langues : Anglais (eng) Mots-clés : Eating disorder  anorexia nervosa  dynamic functional connectivity  resting state Index. décimale : PER Périodiques Résumé : Background The onset of anorexia nervosa (AN) frequently occurs during adolescence and is associated with preoccupation with body weight and shape and extreme underweight. Altered resting state functional connectivity in the brain has been described in individuals with AN, but only from a static perspective. The current study investigated the temporal dynamics of functional connectivity in adolescents with AN and how it relates to clinical features. Method 99 female patients acutely ill with AN and 99 pairwise age-matched female healthy control (HC) participants were included in the study. Using resting-state functional MRI data and an established sliding-window analytic approach, we identified dynamic resting-state functional connectivity states and extracted dynamic indices such as dwell time (the duration spent in a state), fraction time (the proportion of the total time occupied by a state), and number of transitions (number of switches) from one state to another, to test for group differences. Results Individuals with AN had relatively reduced fraction time in a mildly connected state with pronounced connectivity within the default mode network (DMN) and an overall reduced number of transitions between states. Conclusions These findings revealed by a dynamic, but not static analytic approach might hint towards a more ?rigid? connectivity, a phenomenon commonly observed in internalizing mental disorders, and in AN possibly related to a reduction in energetic costs as a result of nutritional deprivation. En ligne : https://doi.org/10.1111/jcpp.13970 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Dynamic functional connectivity in anorexia nervosa: alterations in states of low connectivity and state transitions [Texte imprimé et/ou numérique] / Eva MENNIGEN, Auteur ; Daniel GEISLER, Auteur ; Nico W. POLLER, Auteur ; Katrin GRAMATKE, Auteur ; Vince D. CALHOUN, Auteur ; Veit ROESSNER, Auteur ; Joseph A. KING, Auteur ; Stefan EHRLICH, Auteur . - p.1299-1310. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1299-1310 Mots-clés : Eating disorder  anorexia nervosa  dynamic functional connectivity  resting state Index. décimale : PER Périodiques Résumé : Background The onset of anorexia nervosa (AN) frequently occurs during adolescence and is associated with preoccupation with body weight and shape and extreme underweight. Altered resting state functional connectivity in the brain has been described in individuals with AN, but only from a static perspective. The current study investigated the temporal dynamics of functional connectivity in adolescents with AN and how it relates to clinical features. Method 99 female patients acutely ill with AN and 99 pairwise age-matched female healthy control (HC) participants were included in the study. Using resting-state functional MRI data and an established sliding-window analytic approach, we identified dynamic resting-state functional connectivity states and extracted dynamic indices such as dwell time (the duration spent in a state), fraction time (the proportion of the total time occupied by a state), and number of transitions (number of switches) from one state to another, to test for group differences. Results Individuals with AN had relatively reduced fraction time in a mildly connected state with pronounced connectivity within the default mode network (DMN) and an overall reduced number of transitions between states. Conclusions These findings revealed by a dynamic, but not static analytic approach might hint towards a more ?rigid? connectivity, a phenomenon commonly observed in internalizing mental disorders, and in AN possibly related to a reduction in energetic costs as a result of nutritional deprivation. En ligne : https://doi.org/10.1111/jcpp.13970 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio / Esther WALTON in Journal of Child Psychology and Psychiatry, 58-12 (December 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1341-1350 Titre : Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio Type de document : Texte imprimé et/ou numérique Auteurs : Esther WALTON, Auteur ; Charlotte A. M. CECIL, Auteur ; Matthew SUDERMAN, Auteur ; Jingyu LIU, Auteur ; Jessica A TURNER, Auteur ; Vince D. CALHOUN, Auteur ; Stefan EHRLICH, Auteur ; Caroline L. RELTON, Auteur ; Edward D. BARKER, Auteur Article en page(s) : p.1341-1350 Langues : Anglais (eng) Mots-clés : DNA methylation  methylome-wide  amygdala  hippocampus  longitudinal  Avon Longitudinal Study of Parents and Children Index. décimale : PER Périodiques Résumé : Background The ratio between amygdala:hippocampal (AH) volume has been associated with multiple psychiatric problems, including anxiety and aggression. Yet, little is known about its biological underpinnings. Here, we used a methylome-wide approach to test (a) whether DNA methylation in early life (birth, age 7) prospectively associates with total AH volume ratio in early adulthood, and (b) whether significant DNA methylation markers are influenced by prenatal risk factors. Methods Analyses were based on a subsample (n = 109 males) from the Avon Longitudinal Study of Parents and Children, which included measures of prenatal risk, DNA methylation (Infinium Illumina 450k), T1-weighted brain scans and psychopathology in early adulthood (age 18–21). Amygdala and hippocampus measures were derived using Freesurfer 5.3.0. Methylation markers related to AH volume ratio across time were identified using longitudinal multilevel modeling. Results Amygdala:hippocampal volume ratio correlated positively with age 18 psychosis-like symptoms (p = .007). Methylation of a probe in the gene SP6 associated longitudinally with (a) higher AH volume ratio (FDR q-value = .01) and (b) higher stressful life events during pregnancy (p = .046). SP6 is expressed in the hippocampus and amygdala and has been implicated in cognitive decline in Alzheimer's disease. The association between SP6 DNA methylation, AH volume ratio and psychopathology was replicated in an independent dataset of 101 patients with schizophrenia and 111 healthy controls. Conclusions Our findings suggest that epigenetic alterations in genes implicated in neurodevelopment may contribute to a brain-based biomarker of psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326 [article] Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio [Texte imprimé et/ou numérique] / Esther WALTON, Auteur ; Charlotte A. M. CECIL, Auteur ; Matthew SUDERMAN, Auteur ; Jingyu LIU, Auteur ; Jessica A TURNER, Auteur ; Vince D. CALHOUN, Auteur ; Stefan EHRLICH, Auteur ; Caroline L. RELTON, Auteur ; Edward D. BARKER, Auteur . - p.1341-1350. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1341-1350 Mots-clés : DNA methylation  methylome-wide  amygdala  hippocampus  longitudinal  Avon Longitudinal Study of Parents and Children Index. décimale : PER Périodiques Résumé : Background The ratio between amygdala:hippocampal (AH) volume has been associated with multiple psychiatric problems, including anxiety and aggression. Yet, little is known about its biological underpinnings. Here, we used a methylome-wide approach to test (a) whether DNA methylation in early life (birth, age 7) prospectively associates with total AH volume ratio in early adulthood, and (b) whether significant DNA methylation markers are influenced by prenatal risk factors. Methods Analyses were based on a subsample (n = 109 males) from the Avon Longitudinal Study of Parents and Children, which included measures of prenatal risk, DNA methylation (Infinium Illumina 450k), T1-weighted brain scans and psychopathology in early adulthood (age 18–21). Amygdala and hippocampus measures were derived using Freesurfer 5.3.0. Methylation markers related to AH volume ratio across time were identified using longitudinal multilevel modeling. Results Amygdala:hippocampal volume ratio correlated positively with age 18 psychosis-like symptoms (p = .007). Methylation of a probe in the gene SP6 associated longitudinally with (a) higher AH volume ratio (FDR q-value = .01) and (b) higher stressful life events during pregnancy (p = .046). SP6 is expressed in the hippocampus and amygdala and has been implicated in cognitive decline in Alzheimer's disease. The association between SP6 DNA methylation, AH volume ratio and psychopathology was replicated in an independent dataset of 101 patients with schizophrenia and 111 healthy controls. Conclusions Our findings suggest that epigenetic alterations in genes implicated in neurodevelopment may contribute to a brain-based biomarker of psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326

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