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Résultat de la recherche
44 recherche sur le mot-clé 'amygdala'




Amygdala responses to threat in violence-exposed children depend on trauma context and maternal caregiving / Jennifer S. STEVENS in Development and Psychopathology, 35-3 (August 2023)
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Titre : Amygdala responses to threat in violence-exposed children depend on trauma context and maternal caregiving Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer S. STEVENS, Auteur ; Sanne J. H. VAN ROOIJ, Auteur ; Anais F. STENSON, Auteur ; Timothy D. ELY, Auteur ; Abigail POWERS, Auteur ; Aimee CLIFFORD, Auteur ; Ye Ji KIM, Auteur ; Rebecca HINRICHS, Auteur ; Nim TOTTENHAM, Auteur ; Tanja JOVANOVIC, Auteur Article en page(s) : p.1159-1170 Langues : Anglais (eng) Mots-clés : amygdala habituation maternal buffering resilience violence exposure Index. décimale : PER Périodiques Résumé : Early life adversity (ELA) has been linked with increased arousal responses to threat, including increased amygdala reactivity. Effects of ELA on brain function are well recognized, and emerging evidence suggests that caregivers may influence how environmental stressors impact children?s brain function. We investigated the hypothesis that positive interaction between mother and child can buffer against ELA effects on children?s neural responses to threat, and related symptoms. N = 53 mother-child pairs (children ages 8-14 years) were recruited from an urban population at high risk for violence exposure. Maternal caregiving was measured using the Parenting Questionnaire and in a cooperation challenge task. Children viewed fearful and neutral face stimuli during functional magnetic resonance imaging. Children who experienced greater violence at home showed amygdala sensitization, whereas children experiencing more school and community violence showed amygdala habituation. Sensitization was in turn linked with externalizing symptoms. However, maternal warmth was associated with a normalization of amygdala sensitization in children, and fewer externalizing behaviors prospectively up to 1 year later. Findings suggested that the effects of violence exposure on threat-related neural circuitry depend on trauma context (inside or outside the home) and that primary caregivers can increase resilience. En ligne : http://dx.doi.org/10.1017/S0954579421001085 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510
in Development and Psychopathology > 35-3 (August 2023) . - p.1159-1170[article] Amygdala responses to threat in violence-exposed children depend on trauma context and maternal caregiving [Texte imprimé et/ou numérique] / Jennifer S. STEVENS, Auteur ; Sanne J. H. VAN ROOIJ, Auteur ; Anais F. STENSON, Auteur ; Timothy D. ELY, Auteur ; Abigail POWERS, Auteur ; Aimee CLIFFORD, Auteur ; Ye Ji KIM, Auteur ; Rebecca HINRICHS, Auteur ; Nim TOTTENHAM, Auteur ; Tanja JOVANOVIC, Auteur . - p.1159-1170.
Langues : Anglais (eng)
in Development and Psychopathology > 35-3 (August 2023) . - p.1159-1170
Mots-clés : amygdala habituation maternal buffering resilience violence exposure Index. décimale : PER Périodiques Résumé : Early life adversity (ELA) has been linked with increased arousal responses to threat, including increased amygdala reactivity. Effects of ELA on brain function are well recognized, and emerging evidence suggests that caregivers may influence how environmental stressors impact children?s brain function. We investigated the hypothesis that positive interaction between mother and child can buffer against ELA effects on children?s neural responses to threat, and related symptoms. N = 53 mother-child pairs (children ages 8-14 years) were recruited from an urban population at high risk for violence exposure. Maternal caregiving was measured using the Parenting Questionnaire and in a cooperation challenge task. Children viewed fearful and neutral face stimuli during functional magnetic resonance imaging. Children who experienced greater violence at home showed amygdala sensitization, whereas children experiencing more school and community violence showed amygdala habituation. Sensitization was in turn linked with externalizing symptoms. However, maternal warmth was associated with a normalization of amygdala sensitization in children, and fewer externalizing behaviors prospectively up to 1 year later. Findings suggested that the effects of violence exposure on threat-related neural circuitry depend on trauma context (inside or outside the home) and that primary caregivers can increase resilience. En ligne : http://dx.doi.org/10.1017/S0954579421001085 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety / J. D. HERRINGTON in Journal of Autism and Developmental Disorders, 47-12 (December 2017)
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Titre : Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety Type de document : Texte imprimé et/ou numérique Auteurs : J. D. HERRINGTON, Auteur ; B. B. MADDOX, Auteur ; Connor M. KERNS, Auteur ; K. RUMP, Auteur ; J. A. WORLEY, Auteur ; J. C. BUSH, Auteur ; A. J. MCVEY, Auteur ; Robert T. SCHULTZ, Auteur ; J. S. MILLER, Auteur Année de publication : 2017 Article en page(s) : p.3682-3691 Langues : Anglais (eng) Mots-clés : Amygdala Anxiety disorders Brain morphometry Comorbidity Index. décimale : PER Périodiques Résumé : Recent studies suggest that longstanding findings of abnormal amygdala morphology in ASD may be related to symptoms of anxiety. To test this hypothesis, fifty-three children with ASD (mean age = 11.9) underwent structural MRI and were divided into subgroups to compare those with at least one anxiety disorder diagnosis (n = 29) to those without (n = 24) and to a typically developing control group (TDC; n = 37). Groups were matched on age and intellectual level. The ASD and anxiety group showed decreased right amygdala volume (controlled for total brain volume) relative to ASD without anxiety (p = .04) and TDCs (p = .068). Results suggest that youth with ASD and co-occurring anxiety have a distinct neurodevelopmental trajectory. En ligne : http://dx.doi.org/10.1007/s10803-017-3206-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=325
in Journal of Autism and Developmental Disorders > 47-12 (December 2017) . - p.3682-3691[article] Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety [Texte imprimé et/ou numérique] / J. D. HERRINGTON, Auteur ; B. B. MADDOX, Auteur ; Connor M. KERNS, Auteur ; K. RUMP, Auteur ; J. A. WORLEY, Auteur ; J. C. BUSH, Auteur ; A. J. MCVEY, Auteur ; Robert T. SCHULTZ, Auteur ; J. S. MILLER, Auteur . - 2017 . - p.3682-3691.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-12 (December 2017) . - p.3682-3691
Mots-clés : Amygdala Anxiety disorders Brain morphometry Comorbidity Index. décimale : PER Périodiques Résumé : Recent studies suggest that longstanding findings of abnormal amygdala morphology in ASD may be related to symptoms of anxiety. To test this hypothesis, fifty-three children with ASD (mean age = 11.9) underwent structural MRI and were divided into subgroups to compare those with at least one anxiety disorder diagnosis (n = 29) to those without (n = 24) and to a typically developing control group (TDC; n = 37). Groups were matched on age and intellectual level. The ASD and anxiety group showed decreased right amygdala volume (controlled for total brain volume) relative to ASD without anxiety (p = .04) and TDCs (p = .068). Results suggest that youth with ASD and co-occurring anxiety have a distinct neurodevelopmental trajectory. En ligne : http://dx.doi.org/10.1007/s10803-017-3206-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=325 Connectivity-Based Parcellation of the Amygdala Predicts Social Skills in Adolescents with Autism Spectrum Disorder / A. RAUSCH in Journal of Autism and Developmental Disorders, 48-2 (February 2018)
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Titre : Connectivity-Based Parcellation of the Amygdala Predicts Social Skills in Adolescents with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. RAUSCH, Auteur ; W. ZHANG, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; W. B. GROEN, Auteur ; K. V. HAAK, Auteur Article en page(s) : p.572-582 Langues : Anglais (eng) Mots-clés : Amygdala Autism spectrum disorder Functional connectivity Parcellation Prefrontal Index. décimale : PER Périodiques Résumé : Amygdala dysfunction plays a role in the social impairments in autism spectrum disorders (ASD), but it is unclear which of its subregions are abnormal in ASD. This study compared the volume and functional connectivity (FC) strength of three FC-defined amygdala subregions between ASD and controls, and assessed their relation to social skills in ASD. A subregion associated with the social perception network was enlarged in ASD (F1 = 7.842, p = .008) and its volume correlated significantly with symptom severity (social skills: r = .548, p = .009). Posthoc analysis revealed that the enlargement was driven by the vmPFC amygdala network. These findings refine our understanding of abnormal amygdala connectivity in ASD and may inform future strategies for therapeutic interventions targeting the amygdalofrontal pathway. En ligne : https://doi.org/10.1007/s10803-017-3370-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=338
in Journal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.572-582[article] Connectivity-Based Parcellation of the Amygdala Predicts Social Skills in Adolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / A. RAUSCH, Auteur ; W. ZHANG, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; W. B. GROEN, Auteur ; K. V. HAAK, Auteur . - p.572-582.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.572-582
Mots-clés : Amygdala Autism spectrum disorder Functional connectivity Parcellation Prefrontal Index. décimale : PER Périodiques Résumé : Amygdala dysfunction plays a role in the social impairments in autism spectrum disorders (ASD), but it is unclear which of its subregions are abnormal in ASD. This study compared the volume and functional connectivity (FC) strength of three FC-defined amygdala subregions between ASD and controls, and assessed their relation to social skills in ASD. A subregion associated with the social perception network was enlarged in ASD (F1 = 7.842, p = .008) and its volume correlated significantly with symptom severity (social skills: r = .548, p = .009). Posthoc analysis revealed that the enlargement was driven by the vmPFC amygdala network. These findings refine our understanding of abnormal amygdala connectivity in ASD and may inform future strategies for therapeutic interventions targeting the amygdalofrontal pathway. En ligne : https://doi.org/10.1007/s10803-017-3370-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=338 An amygdala-centered hyper-connectivity signature of threatening face processing predicts anxiety in youths with autism spectrum conditions / Y. C. CHEN in Autism Research, 14-11 (November 2021)
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Titre : An amygdala-centered hyper-connectivity signature of threatening face processing predicts anxiety in youths with autism spectrum conditions Type de document : Texte imprimé et/ou numérique Auteurs : Y. C. CHEN, Auteur ; C. CHEN, Auteur ; R. M. MARTÍNEZ, Auteur ; Y. T. FAN, Auteur ; C. C. LIU, Auteur ; C. Y. CHEN, Auteur ; Y. CHENG, Auteur Article en page(s) : p.2287-2299 Langues : Anglais (eng) Mots-clés : Adolescent Amygdala/diagnostic imaging Anxiety/complications Autism Spectrum Disorder/complications/diagnostic imaging Autistic Disorder Case-Control Studies Facial Recognition Humans Magnetic Resonance Imaging amygdala autism spectrum condition (ASC) explicit implicit threat Index. décimale : PER Périodiques Résumé : Anxiety is exceedingly prevalent among individuals with an autism spectrum condition (ASC). While recent literature postulates anxiety as a mechanism encompassing an underlying amygdala-related elevated baseline level of arousal even to nonthreatening cues, whether this same mechanism contributes to anxiety in those with an ASC and supports the transdiagnostic nature of anxiety remains elusive. In this case-control study of 51 youths (26 ASC), we assessed autism and anxiety via the Autism-Spectrum Quotient and the State-Trait Anxiety Inventory, respectively. Hemodynamic responses, including amygdala reactivity, to explicit and implicit (backwardly masked) perception of threatening faces were acquired using functional Magnetic Resonance Imaging (fMRI). For explicit fear, ASC individuals showed significantly greater negative correlations between the amygdala and the attentional deployment-parietal network. For implicit fear, ASC individuals showed significantly stronger correlations of the amygdala with the prefrontal networks, temporal pole, and hippocampus. Additionally, an fMRI-based neurologic signature for anxiety in ASCs was identified via the LibSVM machine learning model using amygdala-centered functional connectivity during the emotional processing of explicit and implicit stimuli. Hypervigilance to implicit threat in ASCs comorbid with anxiety might exacerbate explicit threat reactivity; hence the use of attentional avoidance patterns to restrict affective hyperarousal for explicitly perceived socioemotional stimuli. Consequently, developing an attention-independent behavioral/neural marker identifying anxiety in ASCs is highly warranted. LAY SUMMARY: This study identifies a dissociation of amygdala reactivity dependent on explicit and implicit threat processing. Implicit anxiety in individuals with an autism spectrum condition (ASC) could outweigh explicitly induced threat. When explicitly perceiving socioemotional stimuli, ASC individuals with anxiety might use attentional avoidance patterns to restrict affective hyperarousal. En ligne : http://dx.doi.org/10.1002/aur.2595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-11 (November 2021) . - p.2287-2299[article] An amygdala-centered hyper-connectivity signature of threatening face processing predicts anxiety in youths with autism spectrum conditions [Texte imprimé et/ou numérique] / Y. C. CHEN, Auteur ; C. CHEN, Auteur ; R. M. MARTÍNEZ, Auteur ; Y. T. FAN, Auteur ; C. C. LIU, Auteur ; C. Y. CHEN, Auteur ; Y. CHENG, Auteur . - p.2287-2299.
Langues : Anglais (eng)
in Autism Research > 14-11 (November 2021) . - p.2287-2299
Mots-clés : Adolescent Amygdala/diagnostic imaging Anxiety/complications Autism Spectrum Disorder/complications/diagnostic imaging Autistic Disorder Case-Control Studies Facial Recognition Humans Magnetic Resonance Imaging amygdala autism spectrum condition (ASC) explicit implicit threat Index. décimale : PER Périodiques Résumé : Anxiety is exceedingly prevalent among individuals with an autism spectrum condition (ASC). While recent literature postulates anxiety as a mechanism encompassing an underlying amygdala-related elevated baseline level of arousal even to nonthreatening cues, whether this same mechanism contributes to anxiety in those with an ASC and supports the transdiagnostic nature of anxiety remains elusive. In this case-control study of 51 youths (26 ASC), we assessed autism and anxiety via the Autism-Spectrum Quotient and the State-Trait Anxiety Inventory, respectively. Hemodynamic responses, including amygdala reactivity, to explicit and implicit (backwardly masked) perception of threatening faces were acquired using functional Magnetic Resonance Imaging (fMRI). For explicit fear, ASC individuals showed significantly greater negative correlations between the amygdala and the attentional deployment-parietal network. For implicit fear, ASC individuals showed significantly stronger correlations of the amygdala with the prefrontal networks, temporal pole, and hippocampus. Additionally, an fMRI-based neurologic signature for anxiety in ASCs was identified via the LibSVM machine learning model using amygdala-centered functional connectivity during the emotional processing of explicit and implicit stimuli. Hypervigilance to implicit threat in ASCs comorbid with anxiety might exacerbate explicit threat reactivity; hence the use of attentional avoidance patterns to restrict affective hyperarousal for explicitly perceived socioemotional stimuli. Consequently, developing an attention-independent behavioral/neural marker identifying anxiety in ASCs is highly warranted. LAY SUMMARY: This study identifies a dissociation of amygdala reactivity dependent on explicit and implicit threat processing. Implicit anxiety in individuals with an autism spectrum condition (ASC) could outweigh explicitly induced threat. When explicitly perceiving socioemotional stimuli, ASC individuals with anxiety might use attentional avoidance patterns to restrict affective hyperarousal. En ligne : http://dx.doi.org/10.1002/aur.2595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 Autistic and non-autistic individuals show the same amygdala activity during emotional face processing / Benedikt P LANGENBACH in Molecular Autism, 15 (2024)
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Titre : Autistic and non-autistic individuals show the same amygdala activity during emotional face processing Type de document : Texte imprimé et/ou numérique Auteurs : Benedikt P LANGENBACH, Auteur ; Dominik GROTEGERD, Auteur ; Peter C R MULDERS, Auteur ; Indira TENDOLKAR, Auteur ; Jasper VAN OORT, Auteur ; Fleur DUYSER, Auteur ; Philip VAN EIJNDHOVEN, Auteur ; Janna N VRIJSEN, Auteur ; Udo DANNLOWSKI, Auteur ; Zarah KAMPMANN, Auteur ; Katja KOELKEBECK, Auteur Article en page(s) : 2p. Langues : Anglais (eng) Mots-clés : Humans Autistic Disorder Autism Spectrum Disorder Facial Recognition Emotions Amygdala/diagnostic imaging Amygdala Autism Emotion processing Face processing fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic and non-autistic individuals often differ in how they perceive and show emotions, especially in their ability and inclination to infer other people's feelings from subtle cues like facial expressions. Prominent theories of autism have suggested that these differences stem from alterations in amygdala functioning and that amygdala hypoactivation causes problems with emotion recognition. Thus far, however, empirical investigations of this hypothesis have yielded mixed results and largely relied on relatively small samples. METHODS: In a sample of 72 autistic and 79 non-autistic participants, we conducted a study in which we used the Hariri paradigm to test whether amygdala activation during emotional face processing is altered in autism spectrum disorder, and whether common mental disorders like depression, ADHD or anxiety disorders influence any potential alterations in activation patterns. RESULTS: We found no evidence for differences in amygdala activation, neither when comparing autistic and non-autistic participants, nor when taking into account mental disorders or the overall level of functional impairment. LIMITATIONS: Because we used one basic emotion processing task in a Dutch sample, results might not generalise to other tasks and other populations. CONCLUSIONS: Our results challenge the view that autistic and non-autistic processing of emotional faces in the amygdala is vastly different and call for a more nuanced view of differences between non-autistic and autistic emotion processing. En ligne : https://dx.doi.org/10.1186/s13229-024-00582-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537
in Molecular Autism > 15 (2024) . - 2p.[article] Autistic and non-autistic individuals show the same amygdala activity during emotional face processing [Texte imprimé et/ou numérique] / Benedikt P LANGENBACH, Auteur ; Dominik GROTEGERD, Auteur ; Peter C R MULDERS, Auteur ; Indira TENDOLKAR, Auteur ; Jasper VAN OORT, Auteur ; Fleur DUYSER, Auteur ; Philip VAN EIJNDHOVEN, Auteur ; Janna N VRIJSEN, Auteur ; Udo DANNLOWSKI, Auteur ; Zarah KAMPMANN, Auteur ; Katja KOELKEBECK, Auteur . - 2p.
Langues : Anglais (eng)
in Molecular Autism > 15 (2024) . - 2p.
Mots-clés : Humans Autistic Disorder Autism Spectrum Disorder Facial Recognition Emotions Amygdala/diagnostic imaging Amygdala Autism Emotion processing Face processing fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic and non-autistic individuals often differ in how they perceive and show emotions, especially in their ability and inclination to infer other people's feelings from subtle cues like facial expressions. Prominent theories of autism have suggested that these differences stem from alterations in amygdala functioning and that amygdala hypoactivation causes problems with emotion recognition. Thus far, however, empirical investigations of this hypothesis have yielded mixed results and largely relied on relatively small samples. METHODS: In a sample of 72 autistic and 79 non-autistic participants, we conducted a study in which we used the Hariri paradigm to test whether amygdala activation during emotional face processing is altered in autism spectrum disorder, and whether common mental disorders like depression, ADHD or anxiety disorders influence any potential alterations in activation patterns. RESULTS: We found no evidence for differences in amygdala activation, neither when comparing autistic and non-autistic participants, nor when taking into account mental disorders or the overall level of functional impairment. LIMITATIONS: Because we used one basic emotion processing task in a Dutch sample, results might not generalise to other tasks and other populations. CONCLUSIONS: Our results challenge the view that autistic and non-autistic processing of emotional faces in the amygdala is vastly different and call for a more nuanced view of differences between non-autistic and autistic emotion processing. En ligne : https://dx.doi.org/10.1186/s13229-024-00582-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537 Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome / Clodagh M. MURPHY in Autism Research, 5-1 (February 2012)
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PermalinkBrief Report: Atypical Visual Exploration in Autism Spectrum Disorder Cannot be Attributed to the Amygdala / S. WANG in Journal of Autism and Developmental Disorders, 49-6 (June 2019)
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PermalinkContext-dependent amygdala-prefrontal connectivity in youths with autism spectrum disorder / Isaac Ray CHRISTIAN in Research in Autism Spectrum Disorders, 91 (March 2022)
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PermalinkDelay aversion in attention deficit/hyperactivity disorder is mediated by amygdala and prefrontal cortex hyper-activation / J. VAN DESSEL in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)
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PermalinkDifferential amygdala response to lower face in patients with autistic spectrum disorders: An fMRI study / Makoto ISHITOBI in Research in Autism Spectrum Disorders, 5-2 (April-June 2011)
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