Annual Research Review: DNA methylation as a mediator in the association between risk exposure and child and adolescent psychopathology / Edward D. BARKER in Journal of Child Psychology and Psychiatry, 59-4 (April 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-4 (April 2018) . - p.303-322 Titre : Annual Research Review: DNA methylation as a mediator in the association between risk exposure and child and adolescent psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Edward D. BARKER, Auteur ; E. WALTON, Auteur ; Charlotte A. M. CECIL, Auteur Article en page(s) : p.303-322 Langues : Anglais (eng) Mots-clés : DNA methylation  adolescence  childhood  developmental psychopathology  environmental risk  epigenetics  externalising problems  internalising problems Index. décimale : PER Périodiques Résumé : BACKGROUND: DNA methylation (DNAm) is a potential mechanism for propagating the effects of environmental exposures on child and adolescent mental health. In recent years, this field has experienced steady growth. METHODS: We provide a strategic review of the current child and adolescent literature to evaluate evidence for a mediating role of DNAm in the link between environmental risks and psychopathological outcomes, with a focus on internalising and externalising difficulties. RESULTS: Based on the studies presented, we conclude that there is preliminary evidence to support that (a) environmental factors, such as diet, neurotoxic exposures and stress, influence offspring DNAm, and that (b) variability in DNAm, in turn, is associated with child and adolescent psychopathology. Overall, very few studies have examined DNAm in relation to both exposures and outcomes, and almost all analyses have been correlational in nature. CONCLUSIONS: DNAm holds potential as a biomarker indexing both environmental risk exposure and vulnerability for child psychopathology. However, the extent to which it may represent a causal mediator is not clear. In future, collection of prospective risk exposure, DNAm and outcomes - as well as functional characterisation of epigenetic findings - will assist in determining the role of DNAm in the link between risk exposure and psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12782 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=353 [article] Annual Research Review: DNA methylation as a mediator in the association between risk exposure and child and adolescent psychopathology [Texte imprimé et/ou numérique] / Edward D. BARKER, Auteur ; E. WALTON, Auteur ; Charlotte A. M. CECIL, Auteur . - p.303-322. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-4 (April 2018) . - p.303-322 Mots-clés : DNA methylation  adolescence  childhood  developmental psychopathology  environmental risk  epigenetics  externalising problems  internalising problems Index. décimale : PER Périodiques Résumé : BACKGROUND: DNA methylation (DNAm) is a potential mechanism for propagating the effects of environmental exposures on child and adolescent mental health. In recent years, this field has experienced steady growth. METHODS: We provide a strategic review of the current child and adolescent literature to evaluate evidence for a mediating role of DNAm in the link between environmental risks and psychopathological outcomes, with a focus on internalising and externalising difficulties. RESULTS: Based on the studies presented, we conclude that there is preliminary evidence to support that (a) environmental factors, such as diet, neurotoxic exposures and stress, influence offspring DNAm, and that (b) variability in DNAm, in turn, is associated with child and adolescent psychopathology. Overall, very few studies have examined DNAm in relation to both exposures and outcomes, and almost all analyses have been correlational in nature. CONCLUSIONS: DNAm holds potential as a biomarker indexing both environmental risk exposure and vulnerability for child psychopathology. However, the extent to which it may represent a causal mediator is not clear. In future, collection of prospective risk exposure, DNAm and outcomes - as well as functional characterisation of epigenetic findings - will assist in determining the role of DNAm in the link between risk exposure and psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12782 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=353

Co-occurring problems of early onset persistent, childhood limited, and adolescent onset conduct problem youth / Edward D. BARKER in Journal of Child Psychology and Psychiatry, 51-11 (November 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-11 (November 2010) . - p.1217-1226 Titre : Co-occurring problems of early onset persistent, childhood limited, and adolescent onset conduct problem youth Type de document : Texte imprimé et/ou numérique Auteurs : Edward D. BARKER, Auteur ; Barbara MAUGHAN, Auteur ; Bonamy R. OLIVER, Auteur Année de publication : 2010 Article en page(s) : p.1217-1226 Langues : Anglais (eng) Mots-clés : Conduct-problems sex-differences early-onset-persistent childhood-limited adolescent-onset trajectories Index. décimale : PER Périodiques Résumé : Background:  It is increasingly recognized that youth who follow early onset persistent (EOP), childhood limited (CL) and adolescent onset (AO) trajectories of conduct problems show somewhat varying patterns of risk (in childhood) and adjustment problems (in adolescence and adulthood). Little, however, is known about how other adjustment problems differentially co-develop with the EOP, CL and AO trajectories across the childhood and adolescent years. Method:  Using data from the Avon Longitudinal Study of Parents and Children, an epidemiological, longitudinal cohort of boys and girls, we estimated growth curves for parent-reported hyperactivity, emotional difficulties, peer relational problems, and prosocial behaviors conditional on trajectories of conduct problems (i.e., EOP, CL and AO) from ages 4 to 13 years. At ages 7–8 years, DSM-IV-based diagnoses of conduct disorder, oppositional-defiant disorder, attention deficit/hyperactivity disorder (ADHD), anxiety, depression were examined by conduct problems trajectory. Results:  Overall, the development of hyperactivity, emotional difficulties, peer relational problems, and prosocial behaviors mirrored the development of conduct problems, showing similar trajectories. Conclusions:  Results indicated that the problems of EOP youth were persistent across domains, CL youth showed decreased behavior problems while increasing in prosocial behaviors, and AO youth increased in adjustment problems after 10 years of age. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02240.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=110 [article] Co-occurring problems of early onset persistent, childhood limited, and adolescent onset conduct problem youth [Texte imprimé et/ou numérique] / Edward D. BARKER, Auteur ; Barbara MAUGHAN, Auteur ; Bonamy R. OLIVER, Auteur . - 2010 . - p.1217-1226. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-11 (November 2010) . - p.1217-1226 Mots-clés : Conduct-problems sex-differences early-onset-persistent childhood-limited adolescent-onset trajectories Index. décimale : PER Périodiques Résumé : Background:  It is increasingly recognized that youth who follow early onset persistent (EOP), childhood limited (CL) and adolescent onset (AO) trajectories of conduct problems show somewhat varying patterns of risk (in childhood) and adjustment problems (in adolescence and adulthood). Little, however, is known about how other adjustment problems differentially co-develop with the EOP, CL and AO trajectories across the childhood and adolescent years. Method:  Using data from the Avon Longitudinal Study of Parents and Children, an epidemiological, longitudinal cohort of boys and girls, we estimated growth curves for parent-reported hyperactivity, emotional difficulties, peer relational problems, and prosocial behaviors conditional on trajectories of conduct problems (i.e., EOP, CL and AO) from ages 4 to 13 years. At ages 7–8 years, DSM-IV-based diagnoses of conduct disorder, oppositional-defiant disorder, attention deficit/hyperactivity disorder (ADHD), anxiety, depression were examined by conduct problems trajectory. Results:  Overall, the development of hyperactivity, emotional difficulties, peer relational problems, and prosocial behaviors mirrored the development of conduct problems, showing similar trajectories. Conclusions:  Results indicated that the problems of EOP youth were persistent across domains, CL youth showed decreased behavior problems while increasing in prosocial behaviors, and AO youth increased in adjustment problems after 10 years of age. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02240.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=110

Development of male proactive and reactive physical aggression during adolescence / Edward D. BARKER in Journal of Child Psychology and Psychiatry, 47-8 (August 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-8 (August 2006) . - p.783–790 Titre : Development of male proactive and reactive physical aggression during adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Edward D. BARKER, Auteur ; Richard E. TREMBLAY, Auteur ; Frank VITARO, Auteur ; Eric LACOURSE, Auteur ; Daniel S. NAGIN, Auteur Année de publication : 2006 Article en page(s) : p.783–790 Langues : Anglais (eng) Mots-clés : Proactive reactive gang-membership dual-trajectories Index. décimale : PER Périodiques Résumé : Background: Different developmental courses have been postulated for proactive and reactive aggression. Objective: Investigated the developmental course of proactive and reactive aggression in a large sample of adolescent boys from low socioeconomic areas. Method: A dual group-based joint trajectory method was used to identify distinct trajectories as well as similarities and differences in intra-individual changes. Results: The trajectories for proactive and reactive aggression were similar: the majority of individuals followed infrequent and desisting trajectories. Contrary to expectations, very few adolescents followed trajectories of increasing proactive aggression. Reactive aggression was more common than proactive aggression. The overlap in trajectory group membership of individuals following trajectories of high peaking proactive and reactive aggression was nearly 100%. Across a period of 5 years, the boys on the high peaking trajectories were twice as likely to have affiliated with gangs. Conclusions: The developmental courses of proactive and reactive aggression are similar during adolescence. Males who tend to frequently use one form of aggression throughout adolescence also tend to frequently use the other and are at an increased risk for contemporaneous delinquent lifestyles. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01585.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=764 [article] Development of male proactive and reactive physical aggression during adolescence [Texte imprimé et/ou numérique] / Edward D. BARKER, Auteur ; Richard E. TREMBLAY, Auteur ; Frank VITARO, Auteur ; Eric LACOURSE, Auteur ; Daniel S. NAGIN, Auteur . - 2006 . - p.783–790. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-8 (August 2006) . - p.783–790 Mots-clés : Proactive reactive gang-membership dual-trajectories Index. décimale : PER Périodiques Résumé : Background: Different developmental courses have been postulated for proactive and reactive aggression. Objective: Investigated the developmental course of proactive and reactive aggression in a large sample of adolescent boys from low socioeconomic areas. Method: A dual group-based joint trajectory method was used to identify distinct trajectories as well as similarities and differences in intra-individual changes. Results: The trajectories for proactive and reactive aggression were similar: the majority of individuals followed infrequent and desisting trajectories. Contrary to expectations, very few adolescents followed trajectories of increasing proactive aggression. Reactive aggression was more common than proactive aggression. The overlap in trajectory group membership of individuals following trajectories of high peaking proactive and reactive aggression was nearly 100%. Across a period of 5 years, the boys on the high peaking trajectories were twice as likely to have affiliated with gangs. Conclusions: The developmental courses of proactive and reactive aggression are similar during adolescence. Males who tend to frequently use one form of aggression throughout adolescence also tend to frequently use the other and are at an increased risk for contemporaneous delinquent lifestyles. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01585.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=764

Developmental trajectories of DSM-IV symptoms of attention-deficit/hyperactivity disorder: genetic effects, family risk and associated psychopathology / Henrik LARSSON in Journal of Child Psychology and Psychiatry, 52-9 (September 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-9 (September 2011) . - p.954-963 Titre : Developmental trajectories of DSM-IV symptoms of attention-deficit/hyperactivity disorder: genetic effects, family risk and associated psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Henrik LARSSON, Auteur ; Rezin DILSHAD, Auteur ; Paul LICHTENSTEIN, Auteur ; Edward D. BARKER, Auteur Année de publication : 2011 Article en page(s) : p.954-963 Langues : Anglais (eng) Mots-clés : ADHD  twins  family factors  comorbidity  development Index. décimale : PER Périodiques Résumé : Background:  DSM-IV specifies three ADHD subtypes; the combined, the hyperactive-impulsive and the inattentive. Little is known about the developmental relationships underlying these subtypes. The objective of this study was to describe the development of parent-reported hyperactivity-impulsivity and inattention symptoms from childhood to adolescence and to study their associations with genetic factors, family risk, and later adjustment problems in early adulthood. Method:  Data in this study comes from 1,450 twin pairs participating in a population-based, longitudinal twin study. Developmental trajectories were defined using parent-ratings of hyperactivity-impulsivity and inattention symptoms at age 8–9, 13–14, and 16–17. Twin methods were used to explore genetic influences on trajectories. Family risk measures included low socioeconomic status, large family size and divorce. Self-ratings of externalizing and internalizing problems in early adulthood were used to examine adjustment problems related to the different trajectory combinations. Results:  We found two hyperactivity-impulsivity trajectories (low, high/decreasing) and two inattention trajectories (low, high/increasing). Twin modeling revealed a substantial genetic component underlying both the hyperactivity-impulsivity and the inattention trajectory. Joint trajectory analyses identified four groups of adolescents with distinct developmental patterns of hyperactivity-impulsivity and inattention: a low/low group, a primarily hyperactive, a primarily inattentive and a combined (high/high) trajectory type. These trajectory combinations showed discriminant relations to adjustment problems in early adulthood. The hyperactive, inattentive and combined trajectory subtypes were associated with higher rates of family risk environments compared to the low/low group. Conclusion:  Study results showed that for those on a high trajectory, hyperactivity decreased whereas inattention increased. The combinations of these trajectories lend developmental insight into how children shift from (i) a combined to inattentive subtype, and (ii) a hyperactive-impulsive to a combined subtype. This study suggests that ADHD subtypes cannot be viewed as discrete and stable categories. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02379.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] Developmental trajectories of DSM-IV symptoms of attention-deficit/hyperactivity disorder: genetic effects, family risk and associated psychopathology [Texte imprimé et/ou numérique] / Henrik LARSSON, Auteur ; Rezin DILSHAD, Auteur ; Paul LICHTENSTEIN, Auteur ; Edward D. BARKER, Auteur . - 2011 . - p.954-963. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-9 (September 2011) . - p.954-963 Mots-clés : ADHD  twins  family factors  comorbidity  development Index. décimale : PER Périodiques Résumé : Background:  DSM-IV specifies three ADHD subtypes; the combined, the hyperactive-impulsive and the inattentive. Little is known about the developmental relationships underlying these subtypes. The objective of this study was to describe the development of parent-reported hyperactivity-impulsivity and inattention symptoms from childhood to adolescence and to study their associations with genetic factors, family risk, and later adjustment problems in early adulthood. Method:  Data in this study comes from 1,450 twin pairs participating in a population-based, longitudinal twin study. Developmental trajectories were defined using parent-ratings of hyperactivity-impulsivity and inattention symptoms at age 8–9, 13–14, and 16–17. Twin methods were used to explore genetic influences on trajectories. Family risk measures included low socioeconomic status, large family size and divorce. Self-ratings of externalizing and internalizing problems in early adulthood were used to examine adjustment problems related to the different trajectory combinations. Results:  We found two hyperactivity-impulsivity trajectories (low, high/decreasing) and two inattention trajectories (low, high/increasing). Twin modeling revealed a substantial genetic component underlying both the hyperactivity-impulsivity and the inattention trajectory. Joint trajectory analyses identified four groups of adolescents with distinct developmental patterns of hyperactivity-impulsivity and inattention: a low/low group, a primarily hyperactive, a primarily inattentive and a combined (high/high) trajectory type. These trajectory combinations showed discriminant relations to adjustment problems in early adulthood. The hyperactive, inattentive and combined trajectory subtypes were associated with higher rates of family risk environments compared to the low/low group. Conclusion:  Study results showed that for those on a high trajectory, hyperactivity decreased whereas inattention increased. The combinations of these trajectories lend developmental insight into how children shift from (i) a combined to inattentive subtype, and (ii) a hyperactive-impulsive to a combined subtype. This study suggests that ADHD subtypes cannot be viewed as discrete and stable categories. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02379.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

Dimensions of Psychopathy and their Relationships to Cognitive Functioning in Children / Nathalie FONTAINE in Journal of Clinical Child & Adolescent Psychology, 37-3 (July-September 2008)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 37-3 (July-September 2008) . - p.690-696 Titre : Dimensions of Psychopathy and their Relationships to Cognitive Functioning in Children Type de document : Texte imprimé et/ou numérique Auteurs : Nathalie FONTAINE, Auteur ; Edward D. BARKER, Auteur ; Essi VIDING, Auteur ; Randall T. SALEKIN, Auteur Année de publication : 2008 Article en page(s) : p.690-696 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Individuals with psychopathic traits are hypothesized to be free of intellectual deficits and possibly even to exhibit good cognitive abilities. Previous studies, based on clinical and incarcerated youth, have shown inconsistent findings. We investigated the relationships between different dimensions of psychopathy (callous/unemotional traits, narcissism, impulsivity) and cognitive abilities in a large population-based sample of children (age 9, N = 4,713). Findings indicated a positive relationship between narcissism and both verbal and nonverbal abilities, even after accounting for conduct problems and hyperactivity. Callous/unemotional traits and impulsivity were negatively related to both types of cognitive abilities but did not remain significant after accounting for conduct problems and hyperactivity. Interactions between gender and the dimensions of psychopathy were not significant. En ligne : http://dx.doi.org/10.1080/15374410802148111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] Dimensions of Psychopathy and their Relationships to Cognitive Functioning in Children [Texte imprimé et/ou numérique] / Nathalie FONTAINE, Auteur ; Edward D. BARKER, Auteur ; Essi VIDING, Auteur ; Randall T. SALEKIN, Auteur . - 2008 . - p.690-696. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 37-3 (July-September 2008) . - p.690-696 Index. décimale : PER Périodiques Résumé : Individuals with psychopathic traits are hypothesized to be free of intellectual deficits and possibly even to exhibit good cognitive abilities. Previous studies, based on clinical and incarcerated youth, have shown inconsistent findings. We investigated the relationships between different dimensions of psychopathy (callous/unemotional traits, narcissism, impulsivity) and cognitive abilities in a large population-based sample of children (age 9, N = 4,713). Findings indicated a positive relationship between narcissism and both verbal and nonverbal abilities, even after accounting for conduct problems and hyperactivity. Callous/unemotional traits and impulsivity were negatively related to both types of cognitive abilities but did not remain significant after accounting for conduct problems and hyperactivity. Interactions between gender and the dimensions of psychopathy were not significant. En ligne : http://dx.doi.org/10.1080/15374410802148111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

Double disadvantage: the influence of childhood maltreatment and community violence exposure on adolescent mental health / Charlotte A. M. CECIL in Journal of Child Psychology and Psychiatry, 55-7 (July 2014)  

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Editorial: Does the polygenic revolution herald a watershed in the study of GE interplay in developmental psychopathology? Some considerations for the Special Issue reader / Edward D. BARKER in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

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Epigenetic profiling of social communication trajectories and co-occurring mental health problems: a prospective, methylome-wide association study / Jolien RIJLAARSDAM in Development and Psychopathology, 34-3 (August 2022)  

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Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence / Edward D. BARKER in Development and Psychopathology, 30-3 (August 2018)  

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Irritable oppositional defiance and callous unemotional traits: is the association partially explained by peer victimization? / Edward D. BARKER in Journal of Child Psychology and Psychiatry, 53-11 (November 2012)  

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Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio / Esther WALTON in Journal of Child Psychology and Psychiatry, 58-12 (December 2017)  

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Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study / Charlotte A. M. CECIL in Development and Psychopathology, 30-2 (May 2018)  

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Not in education, employment and training: pathways from toddler difficult temperament / Tom C.H. WU in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

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Pathways explaining the reduction of adult criminal behaviour by a randomized preventive intervention for disruptive kindergarten children / Frank VITARO in Journal of Child Psychology and Psychiatry, 53-7 (July 2012)  

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Pathways from maternal depressive symptoms to adolescent depressive symptoms: the unique contribution of irritability symptoms / Yvonne M. WHELAN in Journal of Child Psychology and Psychiatry, 56-10 (October 2015)  

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