[article] 
inJournal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3800-3809

Titre :	Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur
Article en page(s) :	p.3800-3809
Langues :	Anglais (eng)
Mots-clés :	Autism spectrum disorder  Deleted in colorectal carcinoma gene  Haplotype analysis  Single nucleotide polymorphisms  Susceptibility
Index. décimale :	PER Périodiques
Résumé :	Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case-control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T-A haplotype (rs2229082-rs2270954), T-A-T-C haplotype (rs2229082-rs2270954-rs2292043-rs2292044), C-G-T-C-T haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043), C-G-T-C-T-G haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044), and G-G-T-C-C-C-C haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044-rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD.
En ligne :	http://dx.doi.org/10.1007/s10803-020-04417-3
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

[article] Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur . - p.3800-3809.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3800-3809

Mots-clés :	Autism spectrum disorder  Deleted in colorectal carcinoma gene  Haplotype analysis  Single nucleotide polymorphisms  Susceptibility
Index. décimale :	PER Périodiques
Résumé :	Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case-control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T-A haplotype (rs2229082-rs2270954), T-A-T-C haplotype (rs2229082-rs2270954-rs2292043-rs2292044), C-G-T-C-T haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043), C-G-T-C-T-G haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044), and G-G-T-C-C-C-C haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044-rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD.
En ligne :	http://dx.doi.org/10.1007/s10803-020-04417-3
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432