Dépouillements

A pharmacogenetic study of escitalopram in autism spectrum disorders / Thomas OWLEY in Autism Research, 3-1 (February 2010)  

Public ISBD [article]  inAutism Research > 3-1 (February 2010) . - p.1-7 Titre : A pharmacogenetic study of escitalopram in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Thomas OWLEY, Auteur ; Edwin H. Jr COOK, Auteur ; Bennett L. LEVENTHAL, Auteur ; Camille W. BRUNE, Auteur ; Jeff SALT, Auteur ; Laura WALTON, Auteur ; Steve GUTER, Auteur ; Nelson AYUYAO, Auteur ; Robert D. GIBBONS, Auteur Année de publication : 2010 Article en page(s) : p.1-7 Langues : Anglais (eng) Mots-clés : autistic-disorder escitalopram pharmacogenetics open-label drug-treatment Index. décimale : PER Périodiques Résumé : Objective: To determine the effect of serotonin transporter polymorphism promoter region (5-HTTPLR) genotypic variation (low, intermediate, and high expression groups) on response to escitalopram treatment of children and adolescents with autism spectrum disorders (ASDs). Method: The study used a forced titration, open label design, with genotype blind until study completion. Participants were children and adolescents aged 4-17 years of age with a confirmed ASD (autistic disorder, Asperger's disorder, or pervasive developmental disorder, not otherwise specified). Results: There was an interaction between genotype group and time on the Aberrant Behavior Checklist (ABC) Irritability Subscale (primary outcome variable) (linear maximum marginal likelihood estimation=-4.84, Z=-2.89, SE=1.67, P=0.004). Examination of baseline to last visit revealed that a genotype grouping based on a previous study of platelet 5-HT uptake revealed less response in the genotype group that had S/S genotype for 5-HTTLPR and did not have a diplotype in intron 1 previously shown to be associated with increased platelet 5-HT uptake. Conclusion: This genotype-blind, prospective pharmacogenetic study found the group of subjects with associated with the lowest platelet 5-HT uptake from previous study had the smallest reduction in ABC-Irritability scores after open label treatment with escitalopram. Replication is necessary to confirm these findings. En ligne : http://dx.doi.org/10.1002/aur.109 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=993 [article] A pharmacogenetic study of escitalopram in autism spectrum disorders [Texte imprimé et/ou numérique] / Thomas OWLEY, Auteur ; Edwin H. Jr COOK, Auteur ; Bennett L. LEVENTHAL, Auteur ; Camille W. BRUNE, Auteur ; Jeff SALT, Auteur ; Laura WALTON, Auteur ; Steve GUTER, Auteur ; Nelson AYUYAO, Auteur ; Robert D. GIBBONS, Auteur . - 2010 . - p.1-7. Langues : Anglais (eng) in Autism Research > 3-1 (February 2010) . - p.1-7 Mots-clés : autistic-disorder escitalopram pharmacogenetics open-label drug-treatment Index. décimale : PER Périodiques Résumé : Objective: To determine the effect of serotonin transporter polymorphism promoter region (5-HTTPLR) genotypic variation (low, intermediate, and high expression groups) on response to escitalopram treatment of children and adolescents with autism spectrum disorders (ASDs). Method: The study used a forced titration, open label design, with genotype blind until study completion. Participants were children and adolescents aged 4-17 years of age with a confirmed ASD (autistic disorder, Asperger's disorder, or pervasive developmental disorder, not otherwise specified). Results: There was an interaction between genotype group and time on the Aberrant Behavior Checklist (ABC) Irritability Subscale (primary outcome variable) (linear maximum marginal likelihood estimation=-4.84, Z=-2.89, SE=1.67, P=0.004). Examination of baseline to last visit revealed that a genotype grouping based on a previous study of platelet 5-HT uptake revealed less response in the genotype group that had S/S genotype for 5-HTTLPR and did not have a diplotype in intron 1 previously shown to be associated with increased platelet 5-HT uptake. Conclusion: This genotype-blind, prospective pharmacogenetic study found the group of subjects with associated with the lowest platelet 5-HT uptake from previous study had the smallest reduction in ABC-Irritability scores after open label treatment with escitalopram. Replication is necessary to confirm these findings. En ligne : http://dx.doi.org/10.1002/aur.109 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=993

MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism / Timothy P.L. ROBERTS in Autism Research, 3-1 (February 2010)  

Public ISBD [article]  inAutism Research > 3-1 (February 2010) . - p.8-18 Titre : MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism Type de document : Texte imprimé et/ou numérique Auteurs : Timothy P.L. ROBERTS, Auteur ; Susan E. LEVY, Auteur ; Gwenda L. SCHMIDT, Auteur ; J. Christopher EDGAR, Auteur ; Deborah M. ZARNOW, Auteur ; Mike GANDAL, Auteur ; Saba QASMIEH, Auteur ; Sarah WOLDOFF, Auteur ; Lisa BLASKEY, Auteur ; Justin F. MONROE, Auteur ; Mike REY, Auteur ; Sarah Y. KHAN, Auteur ; Katelyn M. CANNON, Auteur Année de publication : 2010 Article en page(s) : p.8-18 Langues : Anglais (eng) Mots-clés : autism-spectrum-disorders M50 M100 magnetoencephalography language-impairment auditory-evoked-response Index. décimale : PER Périodiques Résumé : Motivated by auditory and speech deficits in autism spectrum disorders (ASD), the frequency dependence of superior temporal gyrus (STG) 50 msec (M50) and 100 msec (M100) neuromagnetic auditory evoked field responses in children with ASD and typically developing controls were evaluated. Whole-cortex magnetoencephalography (MEG) was obtained from 17 typically developing children and 25 children with ASD. Subjects were presented tones with frequencies of 200, 300, 500, and 1,000 Hz, and left and right STG M50 and M100 STG activity was examined. No M50 latency or amplitude Group differences were observed. In the right hemisphere, a Group×Frequency ANOVA on M100 latency produced a main effect for Group (P=0.01), with an average M100 latency delay of 11 msec in children with ASD. In addition, only in the control group was the expected association of earlier M100 latencies in older than younger children observed. Group latency differences remained significant when hierarchical regression analyses partialed out M100 variance associated with age, IQ, and language ability (all P-values <0.05). Examining the right-hemisphere 500 Hz condition (where the largest latency differences were observed), a sensitivity of 75%, a specificity of 81%, and a positive predictive value (PPV) of 86% was obtained at a threshold of 116 msec. The M100 latency delay indicates disruption of encoding simple sensory information. Given similar findings in language impaired and nonlanguage impaired ASD subjects, a right-hemisphere M100 latency delay appears to be an electrophysiological endophenotype for autism. En ligne : http://dx.doi.org/10.1002/aur.111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=993 [article] MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism [Texte imprimé et/ou numérique] / Timothy P.L. ROBERTS, Auteur ; Susan E. LEVY, Auteur ; Gwenda L. SCHMIDT, Auteur ; J. Christopher EDGAR, Auteur ; Deborah M. ZARNOW, Auteur ; Mike GANDAL, Auteur ; Saba QASMIEH, Auteur ; Sarah WOLDOFF, Auteur ; Lisa BLASKEY, Auteur ; Justin F. MONROE, Auteur ; Mike REY, Auteur ; Sarah Y. KHAN, Auteur ; Katelyn M. CANNON, Auteur . - 2010 . - p.8-18. Langues : Anglais (eng) in Autism Research > 3-1 (February 2010) . - p.8-18 Mots-clés : autism-spectrum-disorders M50 M100 magnetoencephalography language-impairment auditory-evoked-response Index. décimale : PER Périodiques Résumé : Motivated by auditory and speech deficits in autism spectrum disorders (ASD), the frequency dependence of superior temporal gyrus (STG) 50 msec (M50) and 100 msec (M100) neuromagnetic auditory evoked field responses in children with ASD and typically developing controls were evaluated. Whole-cortex magnetoencephalography (MEG) was obtained from 17 typically developing children and 25 children with ASD. Subjects were presented tones with frequencies of 200, 300, 500, and 1,000 Hz, and left and right STG M50 and M100 STG activity was examined. No M50 latency or amplitude Group differences were observed. In the right hemisphere, a Group×Frequency ANOVA on M100 latency produced a main effect for Group (P=0.01), with an average M100 latency delay of 11 msec in children with ASD. In addition, only in the control group was the expected association of earlier M100 latencies in older than younger children observed. Group latency differences remained significant when hierarchical regression analyses partialed out M100 variance associated with age, IQ, and language ability (all P-values <0.05). Examining the right-hemisphere 500 Hz condition (where the largest latency differences were observed), a sensitivity of 75%, a specificity of 81%, and a positive predictive value (PPV) of 86% was obtained at a threshold of 116 msec. The M100 latency delay indicates disruption of encoding simple sensory information. Given similar findings in language impaired and nonlanguage impaired ASD subjects, a right-hemisphere M100 latency delay appears to be an electrophysiological endophenotype for autism. En ligne : http://dx.doi.org/10.1002/aur.111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=993

Geographic distribution of autism in California: A retrospective birth cohort analysis / Karla C. VAN METER in Autism Research, 3-1 (February 2010)  

Public ISBD [article]  inAutism Research > 3-1 (February 2010) . - p.19-29 Titre : Geographic distribution of autism in California: A retrospective birth cohort analysis Type de document : Texte imprimé et/ou numérique Auteurs : Karla C. VAN METER, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Lasse E. CHRISTIANSEN, Auteur ; Lora D. DELWICHE, Auteur ; Rahman AZARI, Auteur ; Tim E. CARPENTER, Auteur Année de publication : 2010 Article en page(s) : p.19-29 Langues : Anglais (eng) Mots-clés : autism cluster environmental epidemiology scan-tests spatial geographic sociodemographic Index. décimale : PER Périodiques Résumé : Prenatal environmental exposures are among the risk factors being explored for associations with autism. We applied a new procedure combining multiple scan cluster detection tests to identify geographically defined areas of increased autism incidence. This procedure can serve as a first hypothesis-generating step aimed at localized environmental exposures, but would not be useful for assessing widely distributed exposures, such as household products, nor for exposures from nonpoint sources, such as traffic. Geocoded mothers' residences on 2,453,717 California birth records, 1996-2000, were analyzed including 9,900 autism cases recorded in the California Department of Developmental Services (DDS) database through February 2006 which were matched to their corresponding birth records. We analyzed each of the 21 DDS Regional Center (RC) catchment areas separately because of the wide variation in diagnostic practices. Ten clusters of increased autism risk were identified in eight RC regions, and one Potential Cluster in each of two other RC regions. After determination of clusters, multiple mixed Poisson regression models were fit to assess differences in known demographic autism risk factors between the births within and outside areas of elevated autism incidence, independent of case status. Adjusted for other covariates, the majority of areas of autism clustering were characterized by high parental education, e.g. relative risks >4 for college-graduate vs. nonhigh-school graduate parents. This geographic association possibly occurs because RCs do not actively conduct case finding and parents with lower education are, for various reasons, less likely to successfully seek services. En ligne : http://dx.doi.org/10.1002/aur.110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=993 [article] Geographic distribution of autism in California: A retrospective birth cohort analysis [Texte imprimé et/ou numérique] / Karla C. VAN METER, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Lasse E. CHRISTIANSEN, Auteur ; Lora D. DELWICHE, Auteur ; Rahman AZARI, Auteur ; Tim E. CARPENTER, Auteur . - 2010 . - p.19-29. Langues : Anglais (eng) in Autism Research > 3-1 (February 2010) . - p.19-29 Mots-clés : autism cluster environmental epidemiology scan-tests spatial geographic sociodemographic Index. décimale : PER Périodiques Résumé : Prenatal environmental exposures are among the risk factors being explored for associations with autism. We applied a new procedure combining multiple scan cluster detection tests to identify geographically defined areas of increased autism incidence. This procedure can serve as a first hypothesis-generating step aimed at localized environmental exposures, but would not be useful for assessing widely distributed exposures, such as household products, nor for exposures from nonpoint sources, such as traffic. Geocoded mothers' residences on 2,453,717 California birth records, 1996-2000, were analyzed including 9,900 autism cases recorded in the California Department of Developmental Services (DDS) database through February 2006 which were matched to their corresponding birth records. We analyzed each of the 21 DDS Regional Center (RC) catchment areas separately because of the wide variation in diagnostic practices. Ten clusters of increased autism risk were identified in eight RC regions, and one Potential Cluster in each of two other RC regions. After determination of clusters, multiple mixed Poisson regression models were fit to assess differences in known demographic autism risk factors between the births within and outside areas of elevated autism incidence, independent of case status. Adjusted for other covariates, the majority of areas of autism clustering were characterized by high parental education, e.g. relative risks >4 for college-graduate vs. nonhigh-school graduate parents. This geographic association possibly occurs because RCs do not actively conduct case finding and parents with lower education are, for various reasons, less likely to successfully seek services. En ligne : http://dx.doi.org/10.1002/aur.110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=993

Independent and dependent contributions of advanced maternal and paternal ages to autism risk / Janie F. SHELTON in Autism Research, 3-1 (February 2010)  

Public ISBD [article]  inAutism Research > 3-1 (February 2010) . - p.30-39 Titre : Independent and dependent contributions of advanced maternal and paternal ages to autism risk Type de document : Texte imprimé et/ou numérique Auteurs : Janie F. SHELTON, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Daniel J. TANCREDI, Auteur Année de publication : 2010 Article en page(s) : p.30-39 Langues : Anglais (eng) Mots-clés : autism maternal-age paternal-age effect-measure-modification attributable-risk advanced-maternal-age advanced-paternal-age interaction Index. décimale : PER Périodiques Résumé : Reports on autism and parental age have yielded conflicting results on whether mothers, fathers, or both, contribute to increased risk. We analyzed restricted strata of parental age in a 10-year California birth cohort to determine the independent or dependent effect from each parent. Autism cases from California Department of Developmental Services records were linked to State birth files (1990-1999). Only singleton births with complete data on parental age and education were included (n=4,947,935, cases=12,159). In multivariate logistic regression models, advancing maternal age increased risk for autism monotonically regardless of the paternal age. Compared with mothers 25-29 years of age, the adjusted odds ratio (aOR) for mothers 40+ years was 1.51 (95% CI: 1.35-1.70), or compared with mothers <25 years of age, aOR=1.77 (95% CI, 1.56-2.00). In contrast, autism risk was associated with advancing paternal age primarily among mothers <30: aOR=1.59 (95% CI, 1.37-1.85) comparing fathers 40+ vs. 25-29 years of age. However, among mothers >30, the aOR was 1.13 (95% CI, 1.01-1.27) for fathers 40+ vs. 25-29 years of age, almost identical to the aOR for fathers <25 years. Based on the first examination of heterogeneity in parental age effects, it appears that women's risk for delivering a child who develops autism increases throughout their reproductive years whereas father's age confers increased risk for autism when mothers are <30, but has little effect when mothers are past age 30. We also calculated that the recent trend towards delayed childbearing contributed approximately a 4.6% increase in autism diagnoses in California over the decade. En ligne : http://dx.doi.org/10.1002/aur.116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=993 [article] Independent and dependent contributions of advanced maternal and paternal ages to autism risk [Texte imprimé et/ou numérique] / Janie F. SHELTON, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Daniel J. TANCREDI, Auteur . - 2010 . - p.30-39. Langues : Anglais (eng) in Autism Research > 3-1 (February 2010) . - p.30-39 Mots-clés : autism maternal-age paternal-age effect-measure-modification attributable-risk advanced-maternal-age advanced-paternal-age interaction Index. décimale : PER Périodiques Résumé : Reports on autism and parental age have yielded conflicting results on whether mothers, fathers, or both, contribute to increased risk. We analyzed restricted strata of parental age in a 10-year California birth cohort to determine the independent or dependent effect from each parent. Autism cases from California Department of Developmental Services records were linked to State birth files (1990-1999). Only singleton births with complete data on parental age and education were included (n=4,947,935, cases=12,159). In multivariate logistic regression models, advancing maternal age increased risk for autism monotonically regardless of the paternal age. Compared with mothers 25-29 years of age, the adjusted odds ratio (aOR) for mothers 40+ years was 1.51 (95% CI: 1.35-1.70), or compared with mothers <25 years of age, aOR=1.77 (95% CI, 1.56-2.00). In contrast, autism risk was associated with advancing paternal age primarily among mothers <30: aOR=1.59 (95% CI, 1.37-1.85) comparing fathers 40+ vs. 25-29 years of age. However, among mothers >30, the aOR was 1.13 (95% CI, 1.01-1.27) for fathers 40+ vs. 25-29 years of age, almost identical to the aOR for fathers <25 years. Based on the first examination of heterogeneity in parental age effects, it appears that women's risk for delivering a child who develops autism increases throughout their reproductive years whereas father's age confers increased risk for autism when mothers are <30, but has little effect when mothers are past age 30. We also calculated that the recent trend towards delayed childbearing contributed approximately a 4.6% increase in autism diagnoses in California over the decade. En ligne : http://dx.doi.org/10.1002/aur.116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=993

Reduction of increased repetitive self-grooming in ASD mouse model by metabotropic 5 glutamate receptor antagonism; randomized controlled trial of early start denver model / Edwin H. Jr COOK in Autism Research, 3-1 (February 2010)  

Public ISBD [article]  inAutism Research > 3-1 (February 2010) . - p.40-42 Titre : Reduction of increased repetitive self-grooming in ASD mouse model by metabotropic 5 glutamate receptor antagonism; randomized controlled trial of early start denver model Type de document : Texte imprimé et/ou numérique Auteurs : Edwin H. Jr COOK, Auteur Année de publication : 2010 Article en page(s) : p.40-42 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.118 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=994 [article] Reduction of increased repetitive self-grooming in ASD mouse model by metabotropic 5 glutamate receptor antagonism; randomized controlled trial of early start denver model [Texte imprimé et/ou numérique] / Edwin H. Jr COOK, Auteur . - 2010 . - p.40-42. Langues : Anglais (eng) in Autism Research > 3-1 (February 2010) . - p.40-42 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.118 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=994

Lay Abstracts in Autism Research, 3-1 (February 2010)  

Public ISBD [article]  inAutism Research > 3-1 (February 2010) . - p.43-44 Titre : Lay Abstracts Type de document : Texte imprimé et/ou numérique Année de publication : 2010 Article en page(s) : p.43-44 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.117 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=994 [article] Lay Abstracts [Texte imprimé et/ou numérique] . - 2010 . - p.43-44. Langues : Anglais (eng) in Autism Research > 3-1 (February 2010) . - p.43-44 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.117 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=994

The International Meeting for Autism Research in Autism Research, 3-1 (February 2010)  

Public ISBD [article]  inAutism Research > 3-1 (February 2010) . - p.45 Titre : The International Meeting for Autism Research Type de document : Texte imprimé et/ou numérique Année de publication : 2010 Article en page(s) : p.45 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.120 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=994 [article] The International Meeting for Autism Research [Texte imprimé et/ou numérique] . - 2010 . - p.45. Langues : Anglais (eng) in Autism Research > 3-1 (February 2010) . - p.45 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.120 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=994

International Society for Autism Research News in Autism Research, 3-1 (February 2010)  

Public ISBD [article]  inAutism Research > 3-1 (February 2010) . - p.46 Titre : International Society for Autism Research News Type de document : Texte imprimé et/ou numérique Année de publication : 2010 Article en page(s) : p.46 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.121 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=994 [article] International Society for Autism Research News [Texte imprimé et/ou numérique] . - 2010 . - p.46. Langues : Anglais (eng) in Autism Research > 3-1 (February 2010) . - p.46 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.121 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=994