Brief Report: Abnormal Association Between the Thalamus and Brain Size in Asperger’s Disorder / Antonio Y. HARDAN in Journal of Autism and Developmental Disorders, 38-2 (February 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.390-394 Titre : Brief Report: Abnormal Association Between the Thalamus and Brain Size in Asperger’s Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Antonio Y. HARDAN, Auteur ; Nadine M. MELHEM, Auteur ; Nancy J. MINSHEW, Auteur ; Ragy R. GIRGIS, Auteur ; Jason ADAMS, Auteur ; Andrew R. GILBERT, Auteur ; Matcheri S. KESHAVAN, Auteur Année de publication : 2008 Article en page(s) : p.390-394 Langues : Anglais (eng) Mots-clés : Asperger’s-disorder Thalamus MRI Brain-size Autism Volume Index. décimale : PER Périodiques Résumé : The objective of this study was to examine the relationship between thalamic volume and brain size in individuals with Asperger’s disorder (ASP). Volumetric measurements of the thalamus were performed on MRI scans obtained from 12 individuals with ASP (age range: 10–35 years) and 12 healthy controls (age range: 9–33 years). A positive correlation was found between total brain volume and thalamic size in controls, but not in ASP subjects. This occurred in the absence of differences in mean thalamic volumes between the study groups. Findings from this investigation point to an abnormal relationship between the thalamus and its projection areas in ASP and are consistent with similar studies in autism, supporting that these disorders are qualitatively similar and possibly quantitatively different. En ligne : http://dx.doi.org/10.1007/s10803-007-0385-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=319 [article] Brief Report: Abnormal Association Between the Thalamus and Brain Size in Asperger’s Disorder [Texte imprimé et/ou numérique] / Antonio Y. HARDAN, Auteur ; Nadine M. MELHEM, Auteur ; Nancy J. MINSHEW, Auteur ; Ragy R. GIRGIS, Auteur ; Jason ADAMS, Auteur ; Andrew R. GILBERT, Auteur ; Matcheri S. KESHAVAN, Auteur . - 2008 . - p.390-394. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.390-394 Mots-clés : Asperger’s-disorder Thalamus MRI Brain-size Autism Volume Index. décimale : PER Périodiques Résumé : The objective of this study was to examine the relationship between thalamic volume and brain size in individuals with Asperger’s disorder (ASP). Volumetric measurements of the thalamus were performed on MRI scans obtained from 12 individuals with ASP (age range: 10–35 years) and 12 healthy controls (age range: 9–33 years). A positive correlation was found between total brain volume and thalamic size in controls, but not in ASP subjects. This occurred in the absence of differences in mean thalamic volumes between the study groups. Findings from this investigation point to an abnormal relationship between the thalamus and its projection areas in ASP and are consistent with similar studies in autism, supporting that these disorders are qualitatively similar and possibly quantitatively different. En ligne : http://dx.doi.org/10.1007/s10803-007-0385-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=319

Corpus Callosum Volume and Neurocognition in Autism / Christopher J. KEARY in Journal of Autism and Developmental Disorders, 39-6 (June 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-6 (June 2009) . - p.834-841 Titre : Corpus Callosum Volume and Neurocognition in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Christopher J. KEARY, Auteur ; Nancy J. MINSHEW, Auteur ; Antonio Y. HARDAN, Auteur ; Matcheri S. KESHAVAN, Auteur ; Rahul BANSAL, Auteur ; Dhruman GORADIA, Auteur ; Serguei FEDOROV, Auteur Année de publication : 2009 Article en page(s) : p.834-841 Langues : Anglais (eng) Mots-clés : Autism Corpus-callosum Volume MRI Connectivity Neuropsychological-tests Index. décimale : PER Périodiques Résumé : The corpus callosum has recently been considered as an index of interhemispheric connectivity. This study applied a novel volumetric method to examine the size of the corpus callosum in 32 individuals with autism and 34 age-, gender- and IQ-matched controls and to investigate the relationship between this structure and cognitive measures linked to interhemispheric functioning. Participants with autism displayed reductions in total corpus callosum volume and in several of its subdivisions. Relationships were also observed between volumetric alterations and performance on several cognitive tests including the Tower of Hanoi test. These findings provide further evidence for anatomical alterations in the corpus callosum in autism, but warrant additional studies examining the relationship of this structure and specific measures of interhemispheric connectivity. En ligne : http://dx.doi.org/10.1007/s10803-009-0689-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=758 [article] Corpus Callosum Volume and Neurocognition in Autism [Texte imprimé et/ou numérique] / Christopher J. KEARY, Auteur ; Nancy J. MINSHEW, Auteur ; Antonio Y. HARDAN, Auteur ; Matcheri S. KESHAVAN, Auteur ; Rahul BANSAL, Auteur ; Dhruman GORADIA, Auteur ; Serguei FEDOROV, Auteur . - 2009 . - p.834-841. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-6 (June 2009) . - p.834-841 Mots-clés : Autism Corpus-callosum Volume MRI Connectivity Neuropsychological-tests Index. décimale : PER Périodiques Résumé : The corpus callosum has recently been considered as an index of interhemispheric connectivity. This study applied a novel volumetric method to examine the size of the corpus callosum in 32 individuals with autism and 34 age-, gender- and IQ-matched controls and to investigate the relationship between this structure and cognitive measures linked to interhemispheric functioning. Participants with autism displayed reductions in total corpus callosum volume and in several of its subdivisions. Relationships were also observed between volumetric alterations and performance on several cognitive tests including the Tower of Hanoi test. These findings provide further evidence for anatomical alterations in the corpus callosum in autism, but warrant additional studies examining the relationship of this structure and specific measures of interhemispheric connectivity. En ligne : http://dx.doi.org/10.1007/s10803-009-0689-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=758

Dysplasticity, metaplasticity, and schizophrenia: Implications for risk, illness, and novel interventions / Matcheri S. KESHAVAN in Development and Psychopathology, 27-2 (May 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-2 (May 2015) . - p.615-635 Titre : Dysplasticity, metaplasticity, and schizophrenia: Implications for risk, illness, and novel interventions Type de document : Texte imprimé et/ou numérique Auteurs : Matcheri S. KESHAVAN, Auteur ; Urvakhsh Meherwan MEHTA, Auteur ; Jaya L. PADMANABHAN, Auteur ; Jai L. SHAH, Auteur Article en page(s) : p.615-635 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In this paper, we review the history of the concept of neuroplasticity as it relates to the understanding of neuropsychiatric disorders, using schizophrenia as a case in point. We briefly review the myriad meanings of the term neuroplasticity, and its neuroscientific basis. We then review the evidence for aberrant neuroplasticity and metaplasticity associated with schizophrenia as well as the risk for developing this illness, and discuss the implications of such understanding for prevention and therapeutic interventions. We argue that the failure and/or altered timing of plasticity of critical brain circuits might underlie cognitive and deficit symptoms, and may also lead to aberrant plastic reorganization in other circuits, leading to affective dysregulation and eventually psychosis. This “dysplastic” model of schizophrenia can suggest testable etiology and treatment-relevant questions for the future. En ligne : http://dx.doi.org/10.1017/S095457941500019X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Dysplasticity, metaplasticity, and schizophrenia: Implications for risk, illness, and novel interventions [Texte imprimé et/ou numérique] / Matcheri S. KESHAVAN, Auteur ; Urvakhsh Meherwan MEHTA, Auteur ; Jaya L. PADMANABHAN, Auteur ; Jai L. SHAH, Auteur . - p.615-635. Langues : Anglais (eng) in Development and Psychopathology > 27-2 (May 2015) . - p.615-635 Index. décimale : PER Périodiques Résumé : In this paper, we review the history of the concept of neuroplasticity as it relates to the understanding of neuropsychiatric disorders, using schizophrenia as a case in point. We briefly review the myriad meanings of the term neuroplasticity, and its neuroscientific basis. We then review the evidence for aberrant neuroplasticity and metaplasticity associated with schizophrenia as well as the risk for developing this illness, and discuss the implications of such understanding for prevention and therapeutic interventions. We argue that the failure and/or altered timing of plasticity of critical brain circuits might underlie cognitive and deficit symptoms, and may also lead to aberrant plastic reorganization in other circuits, leading to affective dysregulation and eventually psychosis. This “dysplastic” model of schizophrenia can suggest testable etiology and treatment-relevant questions for the future. En ligne : http://dx.doi.org/10.1017/S095457941500019X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

A Two-Year Longitudinal MRI Study of the Corpus Callosum in Autism / Thomas W. FRAZIER in Journal of Autism and Developmental Disorders, 42-11 (November 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2312-2322 Titre : A Two-Year Longitudinal MRI Study of the Corpus Callosum in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Thomas W. FRAZIER, Auteur ; Matcheri S. KESHAVAN, Auteur ; Nancy J. MINSHEW, Auteur ; Antonio Y. HARDAN, Auteur Article en page(s) : p.2312-2322 Langues : Anglais (eng) Mots-clés : Magnetic resonance imaging  Autism  Corpus callosum  Rostral body Index. décimale : PER Périodiques Résumé : A growing body of literature has identified size reductions of the corpus callosum (CC) in autism. However, to our knowledge, no published studies have reported on the growth of CC volumes in youth with autism. Volumes of the total CC and its sub-divisions were obtained from 23 male children with autism and 23 age- and gender-matched controls at baseline and 2-year follow-up. Persistent reductions in total CC volume were observed in participants with autism relative to controls. Only the rostral body subdivision showed a normalization of size over time. Persistent reductions are consistent with the diagnostic stability and life-long impairment observed in many individuals with autism. Multi-modal imaging studies are needed to identify specific fiber tracks contributing to CC reductions. En ligne : http://dx.doi.org/10.1007/s10803-012-1478-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] A Two-Year Longitudinal MRI Study of the Corpus Callosum in Autism [Texte imprimé et/ou numérique] / Thomas W. FRAZIER, Auteur ; Matcheri S. KESHAVAN, Auteur ; Nancy J. MINSHEW, Auteur ; Antonio Y. HARDAN, Auteur . - p.2312-2322. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2312-2322 Mots-clés : Magnetic resonance imaging  Autism  Corpus callosum  Rostral body Index. décimale : PER Périodiques Résumé : A growing body of literature has identified size reductions of the corpus callosum (CC) in autism. However, to our knowledge, no published studies have reported on the growth of CC volumes in youth with autism. Volumes of the total CC and its sub-divisions were obtained from 23 male children with autism and 23 age- and gender-matched controls at baseline and 2-year follow-up. Persistent reductions in total CC volume were observed in participants with autism relative to controls. Only the rostral body subdivision showed a normalization of size over time. Persistent reductions are consistent with the diagnostic stability and life-long impairment observed in many individuals with autism. Multi-modal imaging studies are needed to identify specific fiber tracks contributing to CC reductions. En ligne : http://dx.doi.org/10.1007/s10803-012-1478-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

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