Dépouillements

A unified theory of autism revisited: linkage evidence points to chromosome X using a high-risk subset of AGRE families / Kristina ALLEN-BRADY in Autism Research, 3-2 (April 2010)  

Public ISBD [article]  inAutism Research > 3-2 (April 2010) . - p.47-52 Titre : A unified theory of autism revisited: linkage evidence points to chromosome X using a high-risk subset of AGRE families Type de document : Texte imprimé et/ou numérique Auteurs : Kristina ALLEN-BRADY, Auteur ; William M. MCMAHON, Auteur ; Hilary H. COON, Auteur ; Dale CANNON, Auteur ; Reid ROBISON, Auteur Année de publication : 2010 Article en page(s) : p.47-52 Langues : Anglais (eng) Mots-clés : autism-spectrum-disorder genetic-linkage dominant-model pedigree-structure chromosome-Xp Index. décimale : PER Périodiques Résumé : Zhao et al. [[2007]] in their Unified Theory of Autism hypothesized that incidence of autism in males could be explained by essentially two types of family structures: majority of autism cases are from low-risk autism families with de novo mutations, and a minority of cases are from high-risk multiplex families, where risk to male offspring approximates 50% consistent with a dominant model and high penetrance. Using the Autism Genetic Resource Exchange (AGRE) data set, Zhao et al. identified 86 high-risk families with likely dominant transmission. As genotype data are now available for many members of the AGRE resource, the objective of this manuscript was to determine if dominant linkage evidence for an autism predisposition gene exists in these 86 high-risk families. HumanHap550K Illumina SNP data were available for 92% of 455 total family members in these 86 high-risk families. We performed a linkage analysis using a pruned subset of markers where markers in high linkage disequilibrium were removed. We observed a single suggestive peak (maximum LOD 2.01, maximum HLOD 2.08) under a dominant model on chromosome Xp22.11-p21.2 that encompasses the IL1RAPL1 gene. Mutations or deletions in IL1RAPL1 have been previously reported in three families with autism. In our study, 11 families contributed nominally (P<0.05, HLOD>0.588) to the chromosome X peak. These results demonstrate that identification of a more homogeneous subset of autism cases, which was based on family structure in this study, may help to identify, localize and further our understanding of autism predisposition genes. En ligne : http://dx.doi.org/10.1002/aur.119 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 [article] A unified theory of autism revisited: linkage evidence points to chromosome X using a high-risk subset of AGRE families [Texte imprimé et/ou numérique] / Kristina ALLEN-BRADY, Auteur ; William M. MCMAHON, Auteur ; Hilary H. COON, Auteur ; Dale CANNON, Auteur ; Reid ROBISON, Auteur . - 2010 . - p.47-52. Langues : Anglais (eng) in Autism Research > 3-2 (April 2010) . - p.47-52 Mots-clés : autism-spectrum-disorder genetic-linkage dominant-model pedigree-structure chromosome-Xp Index. décimale : PER Périodiques Résumé : Zhao et al. [[2007]] in their Unified Theory of Autism hypothesized that incidence of autism in males could be explained by essentially two types of family structures: majority of autism cases are from low-risk autism families with de novo mutations, and a minority of cases are from high-risk multiplex families, where risk to male offspring approximates 50% consistent with a dominant model and high penetrance. Using the Autism Genetic Resource Exchange (AGRE) data set, Zhao et al. identified 86 high-risk families with likely dominant transmission. As genotype data are now available for many members of the AGRE resource, the objective of this manuscript was to determine if dominant linkage evidence for an autism predisposition gene exists in these 86 high-risk families. HumanHap550K Illumina SNP data were available for 92% of 455 total family members in these 86 high-risk families. We performed a linkage analysis using a pruned subset of markers where markers in high linkage disequilibrium were removed. We observed a single suggestive peak (maximum LOD 2.01, maximum HLOD 2.08) under a dominant model on chromosome Xp22.11-p21.2 that encompasses the IL1RAPL1 gene. Mutations or deletions in IL1RAPL1 have been previously reported in three families with autism. In our study, 11 families contributed nominally (P<0.05, HLOD>0.588) to the chromosome X peak. These results demonstrate that identification of a more homogeneous subset of autism cases, which was based on family structure in this study, may help to identify, localize and further our understanding of autism predisposition genes. En ligne : http://dx.doi.org/10.1002/aur.119 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102

Reward processing in autism / Ashley A. SCOTT VAN ZEELAND in Autism Research, 3-2 (April 2010)  

Public ISBD [article]  inAutism Research > 3-2 (April 2010) . - p.53-67 Titre : Reward processing in autism Type de document : Texte imprimé et/ou numérique Auteurs : Ashley A. SCOTT VAN ZEELAND, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; Dara G. GHAHREMANI, Auteur ; Russell A. POLDRACK, Auteur Année de publication : 2010 Article en page(s) : p.53-67 Langues : Anglais (eng) Mots-clés : functional-MRI-(fMRI) social-cognition reward learning Index. décimale : PER Périodiques Résumé : The social motivation hypothesis of autism posits that infants with autism do not experience social stimuli as rewarding, thereby leading to a cascade of potentially negative consequences for later development. While possible downstream effects of this hypothesis such as altered face and voice processing have been examined, there has not been a direct investigation of social reward processing in autism. Here we use functional magnetic resonance imaging to examine social and monetary rewarded implicit learning in children with and without autism spectrum disorders (ASD). Sixteen males with ASD and sixteen age- and IQ-matched typically developing (TD) males were scanned while performing two versions of a rewarded implicit learning task. In addition to examining responses to reward, we investigated the neural circuitry supporting rewarded learning and the relationship between these factors and social development. We found diminished neural responses to both social and monetary rewards in ASD, with a pronounced reduction in response to social rewards (SR). Children with ASD also demonstrated a further deficit in frontostriatal response during social, but not monetary, rewarded learning. Moreover, we show a relationship between ventral striatum activity and social reciprocity in TD children. Together, these data support the hypothesis that children with ASD have diminished neural responses to SR, and that this deficit relates to social learning impairments. En ligne : http://dx.doi.org/10.1002/aur.122 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 [article] Reward processing in autism [Texte imprimé et/ou numérique] / Ashley A. SCOTT VAN ZEELAND, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; Dara G. GHAHREMANI, Auteur ; Russell A. POLDRACK, Auteur . - 2010 . - p.53-67. Langues : Anglais (eng) in Autism Research > 3-2 (April 2010) . - p.53-67 Mots-clés : functional-MRI-(fMRI) social-cognition reward learning Index. décimale : PER Périodiques Résumé : The social motivation hypothesis of autism posits that infants with autism do not experience social stimuli as rewarding, thereby leading to a cascade of potentially negative consequences for later development. While possible downstream effects of this hypothesis such as altered face and voice processing have been examined, there has not been a direct investigation of social reward processing in autism. Here we use functional magnetic resonance imaging to examine social and monetary rewarded implicit learning in children with and without autism spectrum disorders (ASD). Sixteen males with ASD and sixteen age- and IQ-matched typically developing (TD) males were scanned while performing two versions of a rewarded implicit learning task. In addition to examining responses to reward, we investigated the neural circuitry supporting rewarded learning and the relationship between these factors and social development. We found diminished neural responses to both social and monetary rewards in ASD, with a pronounced reduction in response to social rewards (SR). Children with ASD also demonstrated a further deficit in frontostriatal response during social, but not monetary, rewarded learning. Moreover, we show a relationship between ventral striatum activity and social reciprocity in TD children. Together, these data support the hypothesis that children with ASD have diminished neural responses to SR, and that this deficit relates to social learning impairments. En ligne : http://dx.doi.org/10.1002/aur.122 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102

Motor-linked implicit learning in persons with autism spectrum disorders / Brittany G. TRAVERS in Autism Research, 3-2 (April 2010)  

Public ISBD [article]  inAutism Research > 3-2 (April 2010) . - p.68-77 Titre : Motor-linked implicit learning in persons with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Brittany G. TRAVERS, Auteur ; Laura GROFER KLINGER, Auteur ; Joanna L. MUSSEY, Auteur ; Mark R. KLINGER, Auteur Année de publication : 2010 Article en page(s) : p.68-77 Langues : Anglais (eng) Mots-clés : neuropsychology implicit-learning sequence-learning autism-spectrum-disorders serial-response-task Index. décimale : PER Périodiques Résumé : Fifteen adolescents and young adults with high-functioning autism spectrum disorders (ASD) and 18 age- and IQ-matched adults with typical development (TD) completed a serial reaction time task (SRT) to examine possible motor-linked implicit learning impairments in persons with ASD. Measures were taken to decrease the role of explicit learning in the SRT. Results showed that participants with ASD demonstrated intact motor-linked implicit learning. Furthermore, the motor-linked implicit learning appeared to take place at a similar rate across trials in the group with ASD compared to the group with TD. These results suggest that persons with ASD are successful in implicit learning of motor-linked behavior. The results of this study, coupled with past findings, suggest that people with ASD may be able to learn motor movements without conscious awareness, especially if the individual is older and is learning fine motor sequences. En ligne : http://dx.doi.org/10.1002/aur.123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 [article] Motor-linked implicit learning in persons with autism spectrum disorders [Texte imprimé et/ou numérique] / Brittany G. TRAVERS, Auteur ; Laura GROFER KLINGER, Auteur ; Joanna L. MUSSEY, Auteur ; Mark R. KLINGER, Auteur . - 2010 . - p.68-77. Langues : Anglais (eng) in Autism Research > 3-2 (April 2010) . - p.68-77 Mots-clés : neuropsychology implicit-learning sequence-learning autism-spectrum-disorders serial-response-task Index. décimale : PER Périodiques Résumé : Fifteen adolescents and young adults with high-functioning autism spectrum disorders (ASD) and 18 age- and IQ-matched adults with typical development (TD) completed a serial reaction time task (SRT) to examine possible motor-linked implicit learning impairments in persons with ASD. Measures were taken to decrease the role of explicit learning in the SRT. Results showed that participants with ASD demonstrated intact motor-linked implicit learning. Furthermore, the motor-linked implicit learning appeared to take place at a similar rate across trials in the group with ASD compared to the group with TD. These results suggest that persons with ASD are successful in implicit learning of motor-linked behavior. The results of this study, coupled with past findings, suggest that people with ASD may be able to learn motor movements without conscious awareness, especially if the individual is older and is learning fine motor sequences. En ligne : http://dx.doi.org/10.1002/aur.123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102

Sensory features and repetitive behaviors in children with autism and developmental delays / Brian A. BOYD in Autism Research, 3-2 (April 2010)  

Public ISBD [article]  inAutism Research > 3-2 (April 2010) . - p.78-87 Titre : Sensory features and repetitive behaviors in children with autism and developmental delays Type de document : Texte imprimé et/ou numérique Auteurs : Brian A. BOYD, Auteur ; Linda R. WATSON, Auteur ; Grace T. BARANEK, Auteur ; Michele D. POE, Auteur ; John SIDERIS, Auteur ; Elena PATTEN, Auteur ; Heather MILLER, Auteur Année de publication : 2010 Article en page(s) : p.78-87 Langues : Anglais (eng) Mots-clés : autism repetitive-behaviors responses-to-sensory-stimuli sensory-symptoms Index. décimale : PER Périodiques Résumé : This study combined parent and observational measures to examine the association between aberrant sensory features and restricted, repetitive behaviors in children with autism (N=67) and those with developmental delays (N=42). Confirmatory factor analysis was used to empirically validate three sensory constructs of interest: hyperresponsiveness, hyporesponsiveness, and sensory seeking. Examining the association between the three derived sensory factor scores and scores on the Repetitive Behavior Scales - Revised revealed the co-occurrence of these behaviors in both clinical groups. Specifically, high levels of hyperresponsive behaviors predicted high levels of repetitive behaviors, and the relationship between these variables remained the same controlling for mental age. We primarily found non-significant associations between hyporesponsiveness or sensory seeking and repetitive behaviors, with the exception that sensory seeking was associated with ritualistic/sameness behaviors. These findings suggest that shared neurobiological mechanisms may underlie hyperresponsive sensory symptoms and repetitive behaviors and have implications for diagnostic classification as well as intervention. En ligne : http://dx.doi.org/10.1002/aur.124 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 [article] Sensory features and repetitive behaviors in children with autism and developmental delays [Texte imprimé et/ou numérique] / Brian A. BOYD, Auteur ; Linda R. WATSON, Auteur ; Grace T. BARANEK, Auteur ; Michele D. POE, Auteur ; John SIDERIS, Auteur ; Elena PATTEN, Auteur ; Heather MILLER, Auteur . - 2010 . - p.78-87. Langues : Anglais (eng) in Autism Research > 3-2 (April 2010) . - p.78-87 Mots-clés : autism repetitive-behaviors responses-to-sensory-stimuli sensory-symptoms Index. décimale : PER Périodiques Résumé : This study combined parent and observational measures to examine the association between aberrant sensory features and restricted, repetitive behaviors in children with autism (N=67) and those with developmental delays (N=42). Confirmatory factor analysis was used to empirically validate three sensory constructs of interest: hyperresponsiveness, hyporesponsiveness, and sensory seeking. Examining the association between the three derived sensory factor scores and scores on the Repetitive Behavior Scales - Revised revealed the co-occurrence of these behaviors in both clinical groups. Specifically, high levels of hyperresponsive behaviors predicted high levels of repetitive behaviors, and the relationship between these variables remained the same controlling for mental age. We primarily found non-significant associations between hyporesponsiveness or sensory seeking and repetitive behaviors, with the exception that sensory seeking was associated with ritualistic/sameness behaviors. These findings suggest that shared neurobiological mechanisms may underlie hyperresponsive sensory symptoms and repetitive behaviors and have implications for diagnostic classification as well as intervention. En ligne : http://dx.doi.org/10.1002/aur.124 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102

Gender discrimination of eyes and mouths by individuals with autism / Catherine A. BEST in Autism Research, 3-2 (April 2010)  

Public ISBD [article]  inAutism Research > 3-2 (April 2010) . - p.88-93 Titre : Gender discrimination of eyes and mouths by individuals with autism Type de document : Texte imprimé et/ou numérique Auteurs : Catherine A. BEST, Auteur ; Nancy J. MINSHEW, Auteur ; Mark S. STRAUSS, Auteur Année de publication : 2010 Article en page(s) : p.88-93 Langues : Anglais (eng) Mots-clés : autism gender-discrimination face-perception facial-features Index. décimale : PER Périodiques Résumé : Evidence remains mixed about whether individuals with autism look less to eyes and whether they look more at mouths. Few studies have examined how spontaneous attention to facial features relates to face processing abilities. This study tested the ability to discriminate gender from facial features, namely eyes and mouths, by comparing accuracy scores of 17 children with autism and 15 adults with autism to 17 typically developing children and 15 typically developing adults. Results indicated that all participants regardless of diagnosis discriminated gender more accurately from eyes than from mouths. However, results indicated that compared to adults without autism, adults with autism were significantly worse at discriminating gender from eyes. En ligne : http://dx.doi.org/10.1002/aur.125 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 [article] Gender discrimination of eyes and mouths by individuals with autism [Texte imprimé et/ou numérique] / Catherine A. BEST, Auteur ; Nancy J. MINSHEW, Auteur ; Mark S. STRAUSS, Auteur . - 2010 . - p.88-93. Langues : Anglais (eng) in Autism Research > 3-2 (April 2010) . - p.88-93 Mots-clés : autism gender-discrimination face-perception facial-features Index. décimale : PER Périodiques Résumé : Evidence remains mixed about whether individuals with autism look less to eyes and whether they look more at mouths. Few studies have examined how spontaneous attention to facial features relates to face processing abilities. This study tested the ability to discriminate gender from facial features, namely eyes and mouths, by comparing accuracy scores of 17 children with autism and 15 adults with autism to 17 typically developing children and 15 typically developing adults. Results indicated that all participants regardless of diagnosis discriminated gender more accurately from eyes than from mouths. However, results indicated that compared to adults without autism, adults with autism were significantly worse at discriminating gender from eyes. En ligne : http://dx.doi.org/10.1002/aur.125 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102

Decreased brain serotonin transporter binding in ASD; intranasal oxytocin administration: effects on computerized social discrimination task and eye-tracking / Edwin H. Jr COOK in Autism Research, 3-2 (April 2010)  

Public ISBD [article]  inAutism Research > 3-2 (April 2010) . - p.94-95 Titre : Decreased brain serotonin transporter binding in ASD; intranasal oxytocin administration: effects on computerized social discrimination task and eye-tracking Type de document : Texte imprimé et/ou numérique Auteurs : Edwin H. Jr COOK, Auteur Année de publication : 2010 Article en page(s) : p.94-95 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.129 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 [article] Decreased brain serotonin transporter binding in ASD; intranasal oxytocin administration: effects on computerized social discrimination task and eye-tracking [Texte imprimé et/ou numérique] / Edwin H. Jr COOK, Auteur . - 2010 . - p.94-95. Langues : Anglais (eng) in Autism Research > 3-2 (April 2010) . - p.94-95 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.129 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102

Lay abstracts in Autism Research, 3-2 (April 2010)  

Public ISBD [article]  inAutism Research > 3-2 (April 2010) . - p.96-97 Titre : Lay abstracts Type de document : Texte imprimé et/ou numérique Année de publication : 2010 Article en page(s) : p.96-97 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.128 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 [article] Lay abstracts [Texte imprimé et/ou numérique] . - 2010 . - p.96-97. Langues : Anglais (eng) in Autism Research > 3-2 (April 2010) . - p.96-97 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.128 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102

Erratum : Independent and dependent contributions of advanced maternal and paternal ages to autism risk / Janie F. SHELTON in Autism Research, 3-2 (April 2010)  

Public ISBD [article]  inAutism Research > 3-2 (April 2010) . - p.98 Titre : Erratum : Independent and dependent contributions of advanced maternal and paternal ages to autism risk Type de document : Texte imprimé et/ou numérique Auteurs : Janie F. SHELTON, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Daniel J. TANCREDI, Auteur Année de publication : 2010 Article en page(s) : p.98 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.135 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 [article] Erratum : Independent and dependent contributions of advanced maternal and paternal ages to autism risk [Texte imprimé et/ou numérique] / Janie F. SHELTON, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Daniel J. TANCREDI, Auteur . - 2010 . - p.98. Langues : Anglais (eng) in Autism Research > 3-2 (April 2010) . - p.98 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.135 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102

The International Meeting for Autism Research in Autism Research, 3-2 (April 2010)  

Public ISBD [article]  inAutism Research > 3-2 (April 2010) . - p.99 Titre : The International Meeting for Autism Research Type de document : Texte imprimé et/ou numérique Année de publication : 2010 Article en page(s) : p.99 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.126 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 [article] The International Meeting for Autism Research [Texte imprimé et/ou numérique] . - 2010 . - p.99. Langues : Anglais (eng) in Autism Research > 3-2 (April 2010) . - p.99 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.126 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102

International Society for Autism Research News in Autism Research, 3-2 (April 2010)  

Public ISBD [article]  inAutism Research > 3-2 (April 2010) . - p.100 Titre : International Society for Autism Research News Type de document : Texte imprimé et/ou numérique Année de publication : 2010 Article en page(s) : p.100 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.127 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 [article] International Society for Autism Research News [Texte imprimé et/ou numérique] . - 2010 . - p.100. Langues : Anglais (eng) in Autism Research > 3-2 (April 2010) . - p.100 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.127 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102