[article]
| Titre : |
Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Olivia SURGENT, Auteur ; Ali RIAZ, Auteur ; Karla K. AUSDERAU, Auteur ; Nagesh ADLURU, Auteur ; Gregory R. KIRK, Auteur ; Jose GUERRERO-GONZALEZ, Auteur ; Emily C. SKALETSKI, Auteur ; Steven R. KECSKEMETI, Auteur ; Douglas C. DEAN III, Auteur ; Susan ELLIS WEISMER, Auteur ; Andrew L. ALEXANDER, Auteur ; Brittany G. TRAVERS, Auteur |
| Article en page(s) : |
48 p. |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Humans Child White Matter Brain Quality of Life Autistic Disorder Brain Stem Autism Brainstem Dti Sensory features Voxel-based analysis White matter TherVoyant). While both companies are involved in developing MRI-based surgery techniques, neither are associated with any current areas of his research, including the present publication. All other authors report no biomedical financial interests of potential conflicts of interest. |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Elevated or reduced responses to sensory stimuli, known as sensory features, are common in autistic individuals and often impact quality of life. Little is known about the neurobiological basis of sensory features in autistic children. However, the brainstem may offer critical insights as it has been associated with both basic sensory processing and core features of autism. METHODS: Diffusion-weighted imaging (DWI) and parent-report of sensory features were acquired from 133 children (61 autistic children with and 72 non-autistic children, 6-11Â years-old). Leveraging novel DWI processing techniques, we investigated the relationship between sensory features and white matter microstructure properties (free-water-elimination-corrected fractional anisotropy [FA] and mean diffusivity [MD]) in precisely delineated brainstem white matter tracts. Follow-up analyses assessed relationships between microstructure and sensory response patterns/modalities and analyzed whole brain white matter using voxel-based analysis. RESULTS: Results revealed distinct relationships between brainstem microstructure and sensory features in autistic children compared to non-autistic children. In autistic children, more prominent sensory features were generally associated with lower MD. Further, in autistic children, sensory hyporesponsiveness and tactile responsivity were strongly associated with white matter microstructure in nearly all brainstem tracts. Follow-up voxel-based analyses confirmed that these relationships were more prominent in the brainstem/cerebellum, with additional sensory-brain findings in the autistic group in the white matter of the primary motor and somatosensory cortices, the occipital lobe, the inferior parietal lobe, and the thalamic projections. LIMITATIONS: All participants communicated via spoken language and acclimated to the sensory environment of an MRI session, which should be considered when assessing the generalizability of this work to the whole of the autism spectrum. CONCLUSIONS: These findings suggest unique brainstem white matter contributions to sensory features in autistic children compared to non-autistic children. The brainstem correlates of sensory features underscore the potential reflex-like nature of behavioral responses to sensory stimuli in autism and have implications for how we conceptualize and address sensory features in autistic populations. |
| En ligne : |
http://dx.doi.org/10.1186/s13229-022-00524-3 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 |
in Molecular Autism > 13 (2022) . - 48 p.
[article] Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children [Texte imprimé et/ou numérique] / Olivia SURGENT, Auteur ; Ali RIAZ, Auteur ; Karla K. AUSDERAU, Auteur ; Nagesh ADLURU, Auteur ; Gregory R. KIRK, Auteur ; Jose GUERRERO-GONZALEZ, Auteur ; Emily C. SKALETSKI, Auteur ; Steven R. KECSKEMETI, Auteur ; Douglas C. DEAN III, Auteur ; Susan ELLIS WEISMER, Auteur ; Andrew L. ALEXANDER, Auteur ; Brittany G. TRAVERS, Auteur . - 48 p. Langues : Anglais ( eng) in Molecular Autism > 13 (2022) . - 48 p.
| Mots-clés : |
Humans Child White Matter Brain Quality of Life Autistic Disorder Brain Stem Autism Brainstem Dti Sensory features Voxel-based analysis White matter TherVoyant). While both companies are involved in developing MRI-based surgery techniques, neither are associated with any current areas of his research, including the present publication. All other authors report no biomedical financial interests of potential conflicts of interest. |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Elevated or reduced responses to sensory stimuli, known as sensory features, are common in autistic individuals and often impact quality of life. Little is known about the neurobiological basis of sensory features in autistic children. However, the brainstem may offer critical insights as it has been associated with both basic sensory processing and core features of autism. METHODS: Diffusion-weighted imaging (DWI) and parent-report of sensory features were acquired from 133 children (61 autistic children with and 72 non-autistic children, 6-11Â years-old). Leveraging novel DWI processing techniques, we investigated the relationship between sensory features and white matter microstructure properties (free-water-elimination-corrected fractional anisotropy [FA] and mean diffusivity [MD]) in precisely delineated brainstem white matter tracts. Follow-up analyses assessed relationships between microstructure and sensory response patterns/modalities and analyzed whole brain white matter using voxel-based analysis. RESULTS: Results revealed distinct relationships between brainstem microstructure and sensory features in autistic children compared to non-autistic children. In autistic children, more prominent sensory features were generally associated with lower MD. Further, in autistic children, sensory hyporesponsiveness and tactile responsivity were strongly associated with white matter microstructure in nearly all brainstem tracts. Follow-up voxel-based analyses confirmed that these relationships were more prominent in the brainstem/cerebellum, with additional sensory-brain findings in the autistic group in the white matter of the primary motor and somatosensory cortices, the occipital lobe, the inferior parietal lobe, and the thalamic projections. LIMITATIONS: All participants communicated via spoken language and acclimated to the sensory environment of an MRI session, which should be considered when assessing the generalizability of this work to the whole of the autism spectrum. CONCLUSIONS: These findings suggest unique brainstem white matter contributions to sensory features in autistic children compared to non-autistic children. The brainstem correlates of sensory features underscore the potential reflex-like nature of behavioral responses to sensory stimuli in autism and have implications for how we conceptualize and address sensory features in autistic populations. |
| En ligne : |
http://dx.doi.org/10.1186/s13229-022-00524-3 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 |
|
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