[article] 
inDevelopment and Psychopathology > 34-5 (December 2022) . - p.1816-1826

Titre :	Gene–environment interaction using polygenic scores: Do polygenic scores for psychopathology moderate predictions from environmental risk to behavior problems?
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Robert PLOMIN, Auteur ; Agnieszka GIDZIELA, Auteur ; Margherita MALANCHINI, Auteur ; Sophie VON STUMM, Auteur
Article en page(s) :	p.1816-1826
Langues :	Anglais (eng)
Mots-clés :	behavior problems  genotype–environment interaction  polygenic scores  twins
Index. décimale :	PER Périodiques
Résumé :	The DNA revolution has energized research on interactions between genes and environments (GxE) by creating indices of G (polygenic scores) that are powerful predictors of behavioral traits. Here, we test the extent to which polygenic scores for attention-deficit/hyperactivity disorder and neuroticism moderate associations between parent reports of their children’s environmental risk (E) at ages 3 and 4 and teacher ratings of behavior problems (hyperactivity/inattention, conduct problems, emotional symptoms, and peer relationship problems) at ages 7, 9 and 12. The sampling frame included up to 6687 twins from the Twins Early Development Study. Our analyses focused on relative effect sizes of G, E and GxE in predicting behavior problems. G, E and GxE predicted up to 2%, 2% and 0.4%, respectively, of the variance in externalizing behavior problems (hyperactivity/inattention and conduct problems) across ages 7, 9 and 12, with no clear developmental trends. G and E predictions of emotional symptoms and peer relationship problems were weaker. A quarter (12 of 48) of our tests of GxE were nominally significant (p = .05). Increasing the predictive power of G and E would enhance the search for GxE.
En ligne :	http://dx.doi.org/10.1017/S0954579422000931
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

[article] Gene–environment interaction using polygenic scores: Do polygenic scores for psychopathology moderate predictions from environmental risk to behavior problems? [Texte imprimé et/ou numérique] / Robert PLOMIN, Auteur ; Agnieszka GIDZIELA, Auteur ; Margherita MALANCHINI, Auteur ; Sophie VON STUMM, Auteur . - p.1816-1826.
Langues : Anglais (eng)
in Development and Psychopathology > 34-5 (December 2022) . - p.1816-1826

Mots-clés :	behavior problems  genotype–environment interaction  polygenic scores  twins
Index. décimale :	PER Périodiques
Résumé :	The DNA revolution has energized research on interactions between genes and environments (GxE) by creating indices of G (polygenic scores) that are powerful predictors of behavioral traits. Here, we test the extent to which polygenic scores for attention-deficit/hyperactivity disorder and neuroticism moderate associations between parent reports of their children’s environmental risk (E) at ages 3 and 4 and teacher ratings of behavior problems (hyperactivity/inattention, conduct problems, emotional symptoms, and peer relationship problems) at ages 7, 9 and 12. The sampling frame included up to 6687 twins from the Twins Early Development Study. Our analyses focused on relative effect sizes of G, E and GxE in predicting behavior problems. G, E and GxE predicted up to 2%, 2% and 0.4%, respectively, of the variance in externalizing behavior problems (hyperactivity/inattention and conduct problems) across ages 7, 9 and 12, with no clear developmental trends. G and E predictions of emotional symptoms and peer relationship problems were weaker. A quarter (12 of 48) of our tests of GxE were nominally significant (p = .05). Increasing the predictive power of G and E would enhance the search for GxE.
En ligne :	http://dx.doi.org/10.1017/S0954579422000931
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492