43 recherche sur le mot-clé 'twins'

EU-AIMS Longitudinal European Autism Project (LEAP): the autism twin cohort / J. ISAKSSON in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 26p. Titre : EU-AIMS Longitudinal European Autism Project (LEAP): the autism twin cohort Type de document : Texte imprimé et/ou numérique Auteurs : J. ISAKSSON, Auteur ; K. TAMMIMIES, Auteur ; J. NEUFELD, Auteur ; Elodie CAUVET, Auteur ; K. LUNDIN, Auteur ; Jan K. BUITELAAR, Auteur ; E. LOTH, Auteur ; D. G. M. MURPHY, Auteur ; W. SPOOREN, Auteur ; Sven BÖLTE, Auteur Article en page(s) : 26p. Langues : Anglais (eng) Mots-clés : Adolescent  Autistic Disorder/diagnosis/epidemiology/genetics  Child  Cohort Studies  Europe  Female  Humans  Longitudinal Studies  Male  Phenotype  Twins, Dizygotic/statistics & numerical data  Twins, Monozygotic/statistics & numerical data  adhd  Autism spectrum disorder  Biomarkers  Brain  Cognition  Genetics  Intervention  Twins Index. décimale : PER Périodiques Résumé : EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has recruited and comprehensively phenotyped a rare sample of 76 monozygotic and dizygotic twins, discordant, or concordant for ASD plus 30 typically developing twins. The aim of this letter is to complete previous descriptions of the LEAP case-control sample, clinically characterize, and investigate the suitability of the sample for ASD twin-control analyses purposes and share some 'lessons learnt.' Among the twins, a diagnosis of ASD is associated with increased symptom levels of ADHD, higher rates of intellectual disability, and lower family income. For the future, we conclude that the LEAP twin cohort offers multiple options for analyses of genetic and shared and non-shared environmental factors to generate new hypotheses for the larger cohort of LEAP singletons, but particularly cross-validate and refine evidence from it. En ligne : https://dx.doi.org/10.1186/s13229-018-0212-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] EU-AIMS Longitudinal European Autism Project (LEAP): the autism twin cohort [Texte imprimé et/ou numérique] / J. ISAKSSON, Auteur ; K. TAMMIMIES, Auteur ; J. NEUFELD, Auteur ; Elodie CAUVET, Auteur ; K. LUNDIN, Auteur ; Jan K. BUITELAAR, Auteur ; E. LOTH, Auteur ; D. G. M. MURPHY, Auteur ; W. SPOOREN, Auteur ; Sven BÖLTE, Auteur . - 26p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 26p. Mots-clés : Adolescent  Autistic Disorder/diagnosis/epidemiology/genetics  Child  Cohort Studies  Europe  Female  Humans  Longitudinal Studies  Male  Phenotype  Twins, Dizygotic/statistics & numerical data  Twins, Monozygotic/statistics & numerical data  adhd  Autism spectrum disorder  Biomarkers  Brain  Cognition  Genetics  Intervention  Twins Index. décimale : PER Périodiques Résumé : EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has recruited and comprehensively phenotyped a rare sample of 76 monozygotic and dizygotic twins, discordant, or concordant for ASD plus 30 typically developing twins. The aim of this letter is to complete previous descriptions of the LEAP case-control sample, clinically characterize, and investigate the suitability of the sample for ASD twin-control analyses purposes and share some 'lessons learnt.' Among the twins, a diagnosis of ASD is associated with increased symptom levels of ADHD, higher rates of intellectual disability, and lower family income. For the future, we conclude that the LEAP twin cohort offers multiple options for analyses of genetic and shared and non-shared environmental factors to generate new hypotheses for the larger cohort of LEAP singletons, but particularly cross-validate and refine evidence from it. En ligne : https://dx.doi.org/10.1186/s13229-018-0212-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

Head Circumferences in Twins With and Without Autism Spectrum Disorders / Wendy FROEHLICH in Journal of Autism and Developmental Disorders, 43-9 (September 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2026-2037 Titre : Head Circumferences in Twins With and Without Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Wendy FROEHLICH, Auteur ; Sue C. CLEVELAND, Auteur ; Andrea TORRES, Auteur ; Jennifer PHILLIPS, Auteur ; Brianne COHEN, Auteur ; Tiffany TORIGOE, Auteur ; Janet MILLER, Auteur ; Angie FEDELE, Auteur ; Jack COLLINS, Auteur ; Karen SMITH, Auteur ; Linda J. LOTSPEICH, Auteur ; Lisa A. CROEN, Auteur ; Sally OZONOFF, Auteur ; Clara LAJONCHERE, Auteur ; Judith K. GRETHER, Auteur ; Joachim F. HALLMAYER, Auteur Article en page(s) : p.2026-2037 Langues : Anglais (eng) Mots-clés : Macrocephaly  Head circumference  Twins  Endophenotype  Genetics Index. décimale : PER Périodiques Résumé : To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4–18, were included. 20 % of males and 27 % of females with an ASD had macrocephaly. Unaffected co-twins showed similar rates (16 % of males and 22 % of females). Statistical analysis revealed no significant difference in HCs between affected and unaffected twins. Twins with ASDs and unaffected co-twins have similar HCs and increased rates of macrocephaly. Correlations demonstrated partial inheritance of HCs. Thus, macrocephaly may represent an endophenotype in ASDs. En ligne : http://dx.doi.org/10.1007/s10803-012-1751-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Head Circumferences in Twins With and Without Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Wendy FROEHLICH, Auteur ; Sue C. CLEVELAND, Auteur ; Andrea TORRES, Auteur ; Jennifer PHILLIPS, Auteur ; Brianne COHEN, Auteur ; Tiffany TORIGOE, Auteur ; Janet MILLER, Auteur ; Angie FEDELE, Auteur ; Jack COLLINS, Auteur ; Karen SMITH, Auteur ; Linda J. LOTSPEICH, Auteur ; Lisa A. CROEN, Auteur ; Sally OZONOFF, Auteur ; Clara LAJONCHERE, Auteur ; Judith K. GRETHER, Auteur ; Joachim F. HALLMAYER, Auteur . - p.2026-2037. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2026-2037 Mots-clés : Macrocephaly  Head circumference  Twins  Endophenotype  Genetics Index. décimale : PER Périodiques Résumé : To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4–18, were included. 20 % of males and 27 % of females with an ASD had macrocephaly. Unaffected co-twins showed similar rates (16 % of males and 22 % of females). Statistical analysis revealed no significant difference in HCs between affected and unaffected twins. Twins with ASDs and unaffected co-twins have similar HCs and increased rates of macrocephaly. Correlations demonstrated partial inheritance of HCs. Thus, macrocephaly may represent an endophenotype in ASDs. En ligne : http://dx.doi.org/10.1007/s10803-012-1751-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

Initiation and stability of self-harm in adolescence and early adulthood: investigating social and aetiological factors in twins / Yasmin I. AHMADZADEH ; Olakunle A. OGINNI ; Jean-Baptiste PINGAULT ; Thomas A. MCADAMS ; Helena M. S. ZAVOS in Journal of Child Psychology and Psychiatry, 66-6 (June 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-6 (June 2025) . - p.857-867 Titre : Initiation and stability of self-harm in adolescence and early adulthood: investigating social and aetiological factors in twins Type de document : Texte imprimé et/ou numérique Auteurs : Yasmin I. AHMADZADEH, Auteur ; Olakunle A. OGINNI, Auteur ; Jean-Baptiste PINGAULT, Auteur ; Thomas A. MCADAMS, Auteur ; Helena M. S. ZAVOS, Auteur Article en page(s) : p.857-867 Langues : Anglais (eng) Mots-clés : Self-harm  twins  aetiology  age of initiation  bullying  socio-demographic factors Index. décimale : PER Périodiques Résumé : Background Almost one in five (18.8%) UK adolescents are estimated to self-harm and many young people initiate self-harm early (average age 13?years). Prevention of self-harm should be informed by knowledge about risk factors (e.g. socio-demographic indices), characteristics (i.e. motivation for self-harm and help-seeking behaviours), as well as relative aetiological genetic and environmental processes. Previous twin studies evidence both genetic and environmental influences on self-harm. However, to date, there has been no genetically informed research on self-harm aetiology across development, nor studies identifying risk factors for initiating self-harm at a younger age. Methods We examined self-harm in the Twins Early Development Study, a birth cohort twin study. Using clustered regression models, we tested associations of socio-demographic factors and victimisation with lifetime self-harm and age of self-harm initiation, both reported at 21. To investigate stability and/or change in genetic and environmental influences on self-harm we interpreted a multivariate Cholesky decomposition across ages ?16, 21, and 26. Results Self-harm was more common in adolescence than early adulthood, and the incidence of self-harm in early adulthood was low (1.4%). The most common motivation for self-harm was ?to get relief from a terrible state of mind? (83.4%). Independent predictors of self-harm and earlier initiation of self-harm were being female, belonging to a gender and/or sexual minority group, and experience of bullying victimisation. Sexual minority status was still significantly associated with self-harm after controlling for familial factors in co-twin control analyses. The Cholesky decomposition showed stability in genetic influences and innovation in non-shared environmental influences on self-harm. Conclusions Adolescence should be a key period for self-harm interventions. Women, sexual, and gender minorities, and those experiencing victimisation may need targeted support early in adolescence. Furthermore, it should be acknowledged that different individuals can be at risk at different stages as environmental factors influencing self-harm change across time. En ligne : https://doi.org/10.1111/jcpp.14096 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556 [article] Initiation and stability of self-harm in adolescence and early adulthood: investigating social and aetiological factors in twins [Texte imprimé et/ou numérique] / Yasmin I. AHMADZADEH, Auteur ; Olakunle A. OGINNI, Auteur ; Jean-Baptiste PINGAULT, Auteur ; Thomas A. MCADAMS, Auteur ; Helena M. S. ZAVOS, Auteur . - p.857-867. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-6 (June 2025) . - p.857-867 Mots-clés : Self-harm  twins  aetiology  age of initiation  bullying  socio-demographic factors Index. décimale : PER Périodiques Résumé : Background Almost one in five (18.8%) UK adolescents are estimated to self-harm and many young people initiate self-harm early (average age 13?years). Prevention of self-harm should be informed by knowledge about risk factors (e.g. socio-demographic indices), characteristics (i.e. motivation for self-harm and help-seeking behaviours), as well as relative aetiological genetic and environmental processes. Previous twin studies evidence both genetic and environmental influences on self-harm. However, to date, there has been no genetically informed research on self-harm aetiology across development, nor studies identifying risk factors for initiating self-harm at a younger age. Methods We examined self-harm in the Twins Early Development Study, a birth cohort twin study. Using clustered regression models, we tested associations of socio-demographic factors and victimisation with lifetime self-harm and age of self-harm initiation, both reported at 21. To investigate stability and/or change in genetic and environmental influences on self-harm we interpreted a multivariate Cholesky decomposition across ages ?16, 21, and 26. Results Self-harm was more common in adolescence than early adulthood, and the incidence of self-harm in early adulthood was low (1.4%). The most common motivation for self-harm was ?to get relief from a terrible state of mind? (83.4%). Independent predictors of self-harm and earlier initiation of self-harm were being female, belonging to a gender and/or sexual minority group, and experience of bullying victimisation. Sexual minority status was still significantly associated with self-harm after controlling for familial factors in co-twin control analyses. The Cholesky decomposition showed stability in genetic influences and innovation in non-shared environmental influences on self-harm. Conclusions Adolescence should be a key period for self-harm interventions. Women, sexual, and gender minorities, and those experiencing victimisation may need targeted support early in adolescence. Furthermore, it should be acknowledged that different individuals can be at risk at different stages as environmental factors influencing self-harm change across time. En ligne : https://doi.org/10.1111/jcpp.14096 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556

2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study / L. MYERS in Journal of Autism and Developmental Disorders, 48-9 (September 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3244-3252 Titre : 2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study Type de document : Texte imprimé et/ou numérique Auteurs : L. MYERS, Auteur ; A. VAN'T WESTEINDE, Auteur ; R. KUJA-HALKOLA, Auteur ; K. TAMMIMIES, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.3244-3252 Langues : Anglais (eng) Mots-clés : 2D:4D ratio  Adhd  Autism  Hormones  Neurodevelopmental disorders  Sex  Twins Index. décimale : PER Périodiques Résumé : The second to fourth digit (2D:4D) ratio is of interest in autism spectrum disorder (ASD). Studies on the relationship of this ratio with other neurodevelopmental disorders (NDDs) are lacking. Investigating the association between the ratio and NDDs in twins can provide insight into genetic and/or environmental factors driving the ratio. Hand images were collected in N = 238 twins with NDDs or typical development from 70 monozygotic and 49 dizygotic pairs to examine ratios and their associations to DSM-5 defined categorical NDDs, autistic traits, zygosity, and sex. There were small associations for males between the ratios and any NDD and ADHD diagnoses. Males had lower ratios than females. Future studies exploring the ratio alongside physical anomalies could provide etiological insight into NDDs. En ligne : http://dx.doi.org/10.1007/s10803-018-3588-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] 2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study [Texte imprimé et/ou numérique] / L. MYERS, Auteur ; A. VAN'T WESTEINDE, Auteur ; R. KUJA-HALKOLA, Auteur ; K. TAMMIMIES, Auteur ; Sven BÖLTE, Auteur . - p.3244-3252. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3244-3252 Mots-clés : 2D:4D ratio  Adhd  Autism  Hormones  Neurodevelopmental disorders  Sex  Twins Index. décimale : PER Périodiques Résumé : The second to fourth digit (2D:4D) ratio is of interest in autism spectrum disorder (ASD). Studies on the relationship of this ratio with other neurodevelopmental disorders (NDDs) are lacking. Investigating the association between the ratio and NDDs in twins can provide insight into genetic and/or environmental factors driving the ratio. Hand images were collected in N = 238 twins with NDDs or typical development from 70 monozygotic and 49 dizygotic pairs to examine ratios and their associations to DSM-5 defined categorical NDDs, autistic traits, zygosity, and sex. There were small associations for males between the ratios and any NDD and ADHD diagnoses. Males had lower ratios than females. Future studies exploring the ratio alongside physical anomalies could provide etiological insight into NDDs. En ligne : http://dx.doi.org/10.1007/s10803-018-3588-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Aetiological overlap between anxiety and attention deficit hyperactivity symptom dimensions in adolescence / Giorgia MICHELINI in Journal of Child Psychology and Psychiatry, 56-4 (April 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-4 (April 2015) . - p.423-431 Titre : Aetiological overlap between anxiety and attention deficit hyperactivity symptom dimensions in adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Giorgia MICHELINI, Auteur ; Thalia C. ELEY, Auteur ; Alice M. GREGORY, Auteur ; Tom A. MCADAMS, Auteur Article en page(s) : p.423-431 Langues : Anglais (eng) Mots-clés : Anxiety  ADH problems  genetics  twins  adolescence Index. décimale : PER Périodiques Résumé : Background Anxiety and attention-deficit/hyperactivity (ADH) problems are common in adolescence, often co-occur, and are characterised by high heterogeneity in their phenotypic expressions. Although it is known that anxiety and ADH problems correlate, the relationships between subtypes of anxiety and ADH problems have been scarcely investigated. Methods Using a large population sample of adolescent twins and siblings we explored the phenotypic and aetiological association between anxiety subtypes (panic/agoraphobia, separation anxiety, social anxiety, physical injury fears, obsessive-compulsive symptoms and generalised anxiety) and the two ADH dimensions (attention problems and hyperactivity/impulsivity). Both phenotypes were assessed using self-report questionnaires. Results The association between ADH problems and anxiety could be entirely attributed to attention problems, not hyperactivity/impulsivity. Most of the correlations between anxiety subtypes and attention problems showed an approximately equal role of genetic and nonshared environmental factors. Conclusions The high heterogeneity within anxiety and ADH problems should be taken into account in order to better understand comorbidity between them. En ligne : http://dx.doi.org/10.1111/jcpp.12318 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Aetiological overlap between anxiety and attention deficit hyperactivity symptom dimensions in adolescence [Texte imprimé et/ou numérique] / Giorgia MICHELINI, Auteur ; Thalia C. ELEY, Auteur ; Alice M. GREGORY, Auteur ; Tom A. MCADAMS, Auteur . - p.423-431. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-4 (April 2015) . - p.423-431 Mots-clés : Anxiety  ADH problems  genetics  twins  adolescence Index. décimale : PER Périodiques Résumé : Background Anxiety and attention-deficit/hyperactivity (ADH) problems are common in adolescence, often co-occur, and are characterised by high heterogeneity in their phenotypic expressions. Although it is known that anxiety and ADH problems correlate, the relationships between subtypes of anxiety and ADH problems have been scarcely investigated. Methods Using a large population sample of adolescent twins and siblings we explored the phenotypic and aetiological association between anxiety subtypes (panic/agoraphobia, separation anxiety, social anxiety, physical injury fears, obsessive-compulsive symptoms and generalised anxiety) and the two ADH dimensions (attention problems and hyperactivity/impulsivity). Both phenotypes were assessed using self-report questionnaires. Results The association between ADH problems and anxiety could be entirely attributed to attention problems, not hyperactivity/impulsivity. Most of the correlations between anxiety subtypes and attention problems showed an approximately equal role of genetic and nonshared environmental factors. Conclusions The high heterogeneity within anxiety and ADH problems should be taken into account in order to better understand comorbidity between them. En ligne : http://dx.doi.org/10.1111/jcpp.12318 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Associations between conduct problems in childhood and adverse outcomes in emerging adulthood: a longitudinal Swedish nationwide twin cohort / Paul LICHTENSTEIN in Journal of Child Psychology and Psychiatry, 61-7 (July 2020)  

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Autism Spectrum Disorder and Mental Health Problems: Patterns of Difficulties and Longitudinal Trajectories in a Population-Based Twin Sample / E. COLVERT in Journal of Autism and Developmental Disorders, 52-3 (March 2022)  

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Autism spectrum disorder and obstetric optimality: a twin study and meta-analysis of sibling studies / S. GÓMEZ-VALLEJO in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

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Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study / Sebastian LUNDSTROM in Journal of Child Psychology and Psychiatry, 56-6 (June 2015)  

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Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs / Henrik LARSSON in Journal of Child Psychology and Psychiatry, 53-1 (January 2012)  

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