[article] 
inJournal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.3208-3219

Titre :	Social and emotional characteristics of girls and young women with DDX3X-associated intellectual disability: a descriptive and comparative study
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Elise NG-CORDELL, Auteur ; Anna KOLESNIK-TAYLOR, Auteur ; Sinéad O?BRIEN, Auteur ; Duncan ASTLE, Auteur ; Gaia SCERIF, Auteur ; Kate BAKER, Auteur
Article en page(s) :	p.3208-3219
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	DDX3X variants are a common cause of intellectual disability (ID) in females, and have been associated with autism spectrum disorder and emotional-behavioural difficulties. In this study, we compared phenotypic data for 23 females with DDX3X variants, to 23 females with ID and other genetic diagnoses. We found a wide range of adaptive, social and emotional function within the DDX3X group. Autism characteristics did not differ between DDX3X and comparison groups, while levels of anxiety and self-injurious behaviour (SIB) were significantly higher in the DDX3X group. Within the DDX3X group, adaptive function, autism characteristics, anxiety and SIB scores were positively correlated, with evidence for group-specific associations with SIB. Future work is warranted to explore the multilevel mechanisms contributing to social and emotional development in individuals with DDX3X variants.
En ligne :	https://doi.org/10.1007/s10803-022-05527-w
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

[article] Social and emotional characteristics of girls and young women with DDX3X-associated intellectual disability: a descriptive and comparative study [Texte imprimé et/ou numérique] / Elise NG-CORDELL, Auteur ; Anna KOLESNIK-TAYLOR, Auteur ; Sinéad O?BRIEN, Auteur ; Duncan ASTLE, Auteur ; Gaia SCERIF, Auteur ; Kate BAKER, Auteur . - p.3208-3219.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.3208-3219

Index. décimale :	PER Périodiques
Résumé :	DDX3X variants are a common cause of intellectual disability (ID) in females, and have been associated with autism spectrum disorder and emotional-behavioural difficulties. In this study, we compared phenotypic data for 23 females with DDX3X variants, to 23 females with ID and other genetic diagnoses. We found a wide range of adaptive, social and emotional function within the DDX3X group. Autism characteristics did not differ between DDX3X and comparison groups, while levels of anxiety and self-injurious behaviour (SIB) were significantly higher in the DDX3X group. Within the DDX3X group, adaptive function, autism characteristics, anxiety and SIB scores were positively correlated, with evidence for group-specific associations with SIB. Future work is warranted to explore the multilevel mechanisms contributing to social and emotional development in individuals with DDX3X variants.
En ligne :	https://doi.org/10.1007/s10803-022-05527-w
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508