[article] 
inJournal of Autism and Developmental Disorders > 53-11 (November 2023) . - p.4390-4411

Titre :	Altered Developmental Trajectory in Male and Female Rats in a Prenatal Valproic Acid Exposure Model of Autism Spectrum Disorder
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Kumari ANSHU, Auteur ; Ajay Kumar NAIR, Auteur ; Shoba SRINATH, Auteur ; T. Rao LAXMI, Auteur
Article en page(s) :	p.4390-4411
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	Early motor and sensory developmental delays precede Autism Spectrum Disorder (ASD) diagnosis and may serve as early indicators of ASD. The literature on sensorimotor development in animal models is sparse, male centered, and has mixed findings. We characterized early development in a prenatal valproic acid (VPA) model of ASD and found sex-specific developmental delays in VPA rats. We created a developmental composite score combining 15 test readouts, yielding a reliable gestalt measure spanning physical, sensory, and motor development, that effectively discriminated between VPA and control groups. Considering the heterogeneity in ASD phenotype, the developmental composite offers a robust metric that can enable comparison across different animal models of ASD and can serve as an outcome measure for early intervention studies.
En ligne :	https://doi.org/10.1007/s10803-022-05684-y
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512

[article] Altered Developmental Trajectory in Male and Female Rats in a Prenatal Valproic Acid Exposure Model of Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Kumari ANSHU, Auteur ; Ajay Kumar NAIR, Auteur ; Shoba SRINATH, Auteur ; T. Rao LAXMI, Auteur . - p.4390-4411.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-11 (November 2023) . - p.4390-4411

Index. décimale :	PER Périodiques
Résumé :	Early motor and sensory developmental delays precede Autism Spectrum Disorder (ASD) diagnosis and may serve as early indicators of ASD. The literature on sensorimotor development in animal models is sparse, male centered, and has mixed findings. We characterized early development in a prenatal valproic acid (VPA) model of ASD and found sex-specific developmental delays in VPA rats. We created a developmental composite score combining 15 test readouts, yielding a reliable gestalt measure spanning physical, sensory, and motor development, that effectively discriminated between VPA and control groups. Considering the heterogeneity in ASD phenotype, the developmental composite offers a robust metric that can enable comparison across different animal models of ASD and can serve as an outcome measure for early intervention studies.
En ligne :	https://doi.org/10.1007/s10803-022-05684-y
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512