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Auteur Shoba SRINATH |
Documents disponibles écrits par cet auteur (3)
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Altered attentional processing in male and female rats in a prenatal valproic acid exposure model of autism spectrum disorder / Kumari ANSHU in Autism Research, 10-12 (December 2017)
[article]
Titre : Altered attentional processing in male and female rats in a prenatal valproic acid exposure model of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kumari ANSHU, Auteur ; Ajay Kumar NAIR, Auteur ; U. D. KUMARESAN, Auteur ; Bindu M. KUTTY, Auteur ; Shoba SRINATH, Auteur ; T. Rao LAXMI, Auteur Article en page(s) : p.1929-1944 Langues : Anglais (eng) Mots-clés : autism attention 5-choice serial reaction time task sex differences prenatal valproic acid animal models environmental risk factors Index. décimale : PER Périodiques Résumé : Attention is foundational to efficient perception and optimal goal driven behavior. Intact attentional processing is crucial for the development of social and communication skills. Deficits in attention are therefore likely contributors to the core pathophysiology of autism spectrum disorder (ASD). Clinical evidence in ASD is suggestive of impairments in attention and its control, but the underlying mechanisms remain elusive. We examined sustained, spatially divided attention in a prenatal valproic acid (VPA) model of ASD using the 5-choice serial reaction time task (5-CSRTT). As compared to controls, male and female VPA rats had progressively lower accuracy and higher omissions with increasing attentional demands during 5-CSRTT training, and showed further performance decrements when subjected to parametric task manipulations. It is noteworthy that although VPA exposure induced attentional deficits in both sexes, there were task parameter specific sex differences. Importantly, we did not find evidence of impulsivity or motivational deficits in VPA rats but we did find reduced social preference, as well as sensorimotor deficits that suggest pre-attentional information processing impairments. Importantly, with fixed rules, graded difficulty levels, and more time, VPA rats could be successfully trained on the attentional task. To the best of our knowledge, this is the first study examining attentional functions in a VPA model. Our work underscores the need for studying both sexes in ASD animal models and validates the use of the VPA model in the quest for mechanistic understanding of aberrant attentional functions and for evaluating suitable therapeutic targets. Autism Res 2017, 10: 1929–1944. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We studied rats prenatally exposed to valproic acid (VPA), an established rodent model of autism. Both male and female VPA rats had a range of attentional impairments with sex-specific characteristics. Importantly, with fixed rules, graded difficulty levels, and more time, VPA rats could be successfully trained on the attentional task. Our work validates the use of the VPA model in the quest for evaluating suitable therapeutic targets for improving attentional performance. En ligne : http://dx.doi.org/10.1002/aur.1852 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323
in Autism Research > 10-12 (December 2017) . - p.1929-1944[article] Altered attentional processing in male and female rats in a prenatal valproic acid exposure model of autism spectrum disorder [Texte imprimé et/ou numérique] / Kumari ANSHU, Auteur ; Ajay Kumar NAIR, Auteur ; U. D. KUMARESAN, Auteur ; Bindu M. KUTTY, Auteur ; Shoba SRINATH, Auteur ; T. Rao LAXMI, Auteur . - p.1929-1944.
Langues : Anglais (eng)
in Autism Research > 10-12 (December 2017) . - p.1929-1944
Mots-clés : autism attention 5-choice serial reaction time task sex differences prenatal valproic acid animal models environmental risk factors Index. décimale : PER Périodiques Résumé : Attention is foundational to efficient perception and optimal goal driven behavior. Intact attentional processing is crucial for the development of social and communication skills. Deficits in attention are therefore likely contributors to the core pathophysiology of autism spectrum disorder (ASD). Clinical evidence in ASD is suggestive of impairments in attention and its control, but the underlying mechanisms remain elusive. We examined sustained, spatially divided attention in a prenatal valproic acid (VPA) model of ASD using the 5-choice serial reaction time task (5-CSRTT). As compared to controls, male and female VPA rats had progressively lower accuracy and higher omissions with increasing attentional demands during 5-CSRTT training, and showed further performance decrements when subjected to parametric task manipulations. It is noteworthy that although VPA exposure induced attentional deficits in both sexes, there were task parameter specific sex differences. Importantly, we did not find evidence of impulsivity or motivational deficits in VPA rats but we did find reduced social preference, as well as sensorimotor deficits that suggest pre-attentional information processing impairments. Importantly, with fixed rules, graded difficulty levels, and more time, VPA rats could be successfully trained on the attentional task. To the best of our knowledge, this is the first study examining attentional functions in a VPA model. Our work underscores the need for studying both sexes in ASD animal models and validates the use of the VPA model in the quest for mechanistic understanding of aberrant attentional functions and for evaluating suitable therapeutic targets. Autism Res 2017, 10: 1929–1944. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We studied rats prenatally exposed to valproic acid (VPA), an established rodent model of autism. Both male and female VPA rats had a range of attentional impairments with sex-specific characteristics. Importantly, with fixed rules, graded difficulty levels, and more time, VPA rats could be successfully trained on the attentional task. Our work validates the use of the VPA model in the quest for evaluating suitable therapeutic targets for improving attentional performance. En ligne : http://dx.doi.org/10.1002/aur.1852 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 Altered Developmental Trajectory in Male and Female Rats in a Prenatal Valproic Acid Exposure Model of Autism Spectrum Disorder / Kumari ANSHU in Journal of Autism and Developmental Disorders, 53-11 (November 2023)
[article]
Titre : Altered Developmental Trajectory in Male and Female Rats in a Prenatal Valproic Acid Exposure Model of Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kumari ANSHU, Auteur ; Ajay Kumar NAIR, Auteur ; Shoba SRINATH, Auteur ; T. Rao LAXMI, Auteur Article en page(s) : p.4390-4411 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early motor and sensory developmental delays precede Autism Spectrum Disorder (ASD) diagnosis and may serve as early indicators of ASD. The literature on sensorimotor development in animal models is sparse, male centered, and has mixed findings. We characterized early development in a prenatal valproic acid (VPA) model of ASD and found sex-specific developmental delays in VPA rats. We created a developmental composite score combining 15 test readouts, yielding a reliable gestalt measure spanning physical, sensory, and motor development, that effectively discriminated between VPA and control groups. Considering the heterogeneity in ASD phenotype, the developmental composite offers a robust metric that can enable comparison across different animal models of ASD and can serve as an outcome measure for early intervention studies. En ligne : https://doi.org/10.1007/s10803-022-05684-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512
in Journal of Autism and Developmental Disorders > 53-11 (November 2023) . - p.4390-4411[article] Altered Developmental Trajectory in Male and Female Rats in a Prenatal Valproic Acid Exposure Model of Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Kumari ANSHU, Auteur ; Ajay Kumar NAIR, Auteur ; Shoba SRINATH, Auteur ; T. Rao LAXMI, Auteur . - p.4390-4411.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-11 (November 2023) . - p.4390-4411
Index. décimale : PER Périodiques Résumé : Early motor and sensory developmental delays precede Autism Spectrum Disorder (ASD) diagnosis and may serve as early indicators of ASD. The literature on sensorimotor development in animal models is sparse, male centered, and has mixed findings. We characterized early development in a prenatal valproic acid (VPA) model of ASD and found sex-specific developmental delays in VPA rats. We created a developmental composite score combining 15 test readouts, yielding a reliable gestalt measure spanning physical, sensory, and motor development, that effectively discriminated between VPA and control groups. Considering the heterogeneity in ASD phenotype, the developmental composite offers a robust metric that can enable comparison across different animal models of ASD and can serve as an outcome measure for early intervention studies. En ligne : https://doi.org/10.1007/s10803-022-05684-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 Higher anesthetic dose requirement for sedation in children with autism spectrum disorder compared to neuro-atypical controls- a prospective observational study / Sowmyashree Mayur KAKU in Research in Autism Spectrum Disorders, 101 (March 2023)
[article]
Titre : Higher anesthetic dose requirement for sedation in children with autism spectrum disorder compared to neuro-atypical controls- a prospective observational study Type de document : Texte imprimé et/ou numérique Auteurs : Sowmyashree Mayur KAKU, Auteur ; Sonia BANSAL, Auteur ; Umamaheswara GS RAO, Auteur ; Rose Dawn BHARATH, Auteur ; Shoba SRINATH, Auteur ; Satish Chandra GIRIMAJI, Auteur Article en page(s) : 102086 Langues : Anglais (eng) Mots-clés : Sedation MRI Imaging Autism Anesthetic Index. décimale : PER Périodiques Résumé : Introduction Children with Autism Spectrum Disorders (ASD) are known to require general anesthesia or sedation for undergoing procedures like Magnetic Resonance Imaging (MRI). The dose required for sedation may vary depending on multiple factors. The aim of this study was to compare the sedative requirements of children with ASD with those who do not have ASD for undergoing MRI. Methods Thirty-four children with ASD and 31 neuro-atypical controls (children with other neurological disorders undergoing MRI) were recruited into the study. Children were premedicated with injection midazolam 0.1 mg/kg. This was followed by dexmedetomidine 2 mcg/kg over 2 min, followed by 2 mcg/kg/hour infusion inside the MRI gantry. If the above anesthetic was insufficient to make the child immobile, a bolus dose of thiopentone 3 mg/kg was supplemented and this was compared between the two groups. The children were monitored with ECG, and oxygen saturation. Since, these children were on sedative medications, each patient was given a sedation score depending on the number of sedative medications, the child was receiving. Results Twenty one of 34 children in the ASD group required thiopentone for sedation while 5 of 31 in the control group required thiopentone supplementation (p< 0.001). The thiopentone requirement continued to be significantly different between the two groups at each level of sedation score (0, 1, 2 +) (p< 0.004). Conclusion Children with ASD required higher anesthetic dose for sedation compared to neuro-atypical controls for MRI. This study has shown that dexmedetomidine can be safely used for children with autism and additional sedatives are often required for imaging. En ligne : https://doi.org/10.1016/j.rasd.2022.102086 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492
in Research in Autism Spectrum Disorders > 101 (March 2023) . - 102086[article] Higher anesthetic dose requirement for sedation in children with autism spectrum disorder compared to neuro-atypical controls- a prospective observational study [Texte imprimé et/ou numérique] / Sowmyashree Mayur KAKU, Auteur ; Sonia BANSAL, Auteur ; Umamaheswara GS RAO, Auteur ; Rose Dawn BHARATH, Auteur ; Shoba SRINATH, Auteur ; Satish Chandra GIRIMAJI, Auteur . - 102086.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 101 (March 2023) . - 102086
Mots-clés : Sedation MRI Imaging Autism Anesthetic Index. décimale : PER Périodiques Résumé : Introduction Children with Autism Spectrum Disorders (ASD) are known to require general anesthesia or sedation for undergoing procedures like Magnetic Resonance Imaging (MRI). The dose required for sedation may vary depending on multiple factors. The aim of this study was to compare the sedative requirements of children with ASD with those who do not have ASD for undergoing MRI. Methods Thirty-four children with ASD and 31 neuro-atypical controls (children with other neurological disorders undergoing MRI) were recruited into the study. Children were premedicated with injection midazolam 0.1 mg/kg. This was followed by dexmedetomidine 2 mcg/kg over 2 min, followed by 2 mcg/kg/hour infusion inside the MRI gantry. If the above anesthetic was insufficient to make the child immobile, a bolus dose of thiopentone 3 mg/kg was supplemented and this was compared between the two groups. The children were monitored with ECG, and oxygen saturation. Since, these children were on sedative medications, each patient was given a sedation score depending on the number of sedative medications, the child was receiving. Results Twenty one of 34 children in the ASD group required thiopentone for sedation while 5 of 31 in the control group required thiopentone supplementation (p< 0.001). The thiopentone requirement continued to be significantly different between the two groups at each level of sedation score (0, 1, 2 +) (p< 0.004). Conclusion Children with ASD required higher anesthetic dose for sedation compared to neuro-atypical controls for MRI. This study has shown that dexmedetomidine can be safely used for children with autism and additional sedatives are often required for imaging. En ligne : https://doi.org/10.1016/j.rasd.2022.102086 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492