Head circumference, body growth and development quotient in autism spectrum disorders are related in Chongqing, China / Hua WEI in Research in Autism Spectrum Disorders, 54 (October 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 54 (October 2018) . - p.83-89 Titre : Head circumference, body growth and development quotient in autism spectrum disorders are related in Chongqing, China Type de document : Texte imprimé et/ou numérique Auteurs : Hua WEI, Auteur ; Qian CHENG, Auteur ; Qixia MEI, Auteur ; Xuan ZHANG, Auteur ; Li CHEN, Auteur ; Xiao LIU, Auteur ; Ying DAI, Auteur ; Ting YU, Auteur ; Yan LI, Auteur ; Yu ZHANG, Auteur ; Jie CHEN, Auteur ; Yongjie MIAO, Auteur ; Tingyu LI, Auteur Article en page(s) : p.83-89 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Head circumference  Body height  Body weight  Development quotient Index. décimale : PER Périodiques Résumé : Background It is unclear whether increased head circumference (HC) is actually an artifact of an overall overgrowth phenomenon or specific to the brain at all in autism spectrum disorders. This study compared the head circumferences, body weight and height of ASD children with a control group. We also discuss whether HC, body weight and height are correlated with development quotients in ASD children. Method We recruited 83 children with ASD (aged 2–5 years); they were gender and age matched to typically developing children in Chongqing (China) from 2013 to 2015. Their head circumference, body weight and height were collected. The ASD group was tested for the developmental quotient (DQ), which includes gross motor, fine motor, linguistic, personal-social and adaptive functioning. Results Our results showed that head circumference in the ASD group is significantly different from HC in the control group. The rate of macrocephaly was higher in the children with ASD compared with the control group. Some domains of DQ have statistically significant negative correlation with head circumference, weight and height. After adjusting for confounding factors, the fine motor was associated negatively with HC. Personal-social ability was associated negatively with weight. Gross motor was correlated negatively with the height. Conclusions Based on our results, we found significant HC differences in ASD group while lack of effect of either height or weight at the age of 2–5. HC, weight and height were separately negative correlated with some domains of development quotients. Further research is needed to understand the relationship between physical indicators and development level in autism. En ligne : https://doi.org/10.1016/j.rasd.2018.07.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Head circumference, body growth and development quotient in autism spectrum disorders are related in Chongqing, China [Texte imprimé et/ou numérique] / Hua WEI, Auteur ; Qian CHENG, Auteur ; Qixia MEI, Auteur ; Xuan ZHANG, Auteur ; Li CHEN, Auteur ; Xiao LIU, Auteur ; Ying DAI, Auteur ; Ting YU, Auteur ; Yan LI, Auteur ; Yu ZHANG, Auteur ; Jie CHEN, Auteur ; Yongjie MIAO, Auteur ; Tingyu LI, Auteur . - p.83-89. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 54 (October 2018) . - p.83-89 Mots-clés : Autism spectrum disorder  Head circumference  Body height  Body weight  Development quotient Index. décimale : PER Périodiques Résumé : Background It is unclear whether increased head circumference (HC) is actually an artifact of an overall overgrowth phenomenon or specific to the brain at all in autism spectrum disorders. This study compared the head circumferences, body weight and height of ASD children with a control group. We also discuss whether HC, body weight and height are correlated with development quotients in ASD children. Method We recruited 83 children with ASD (aged 2–5 years); they were gender and age matched to typically developing children in Chongqing (China) from 2013 to 2015. Their head circumference, body weight and height were collected. The ASD group was tested for the developmental quotient (DQ), which includes gross motor, fine motor, linguistic, personal-social and adaptive functioning. Results Our results showed that head circumference in the ASD group is significantly different from HC in the control group. The rate of macrocephaly was higher in the children with ASD compared with the control group. Some domains of DQ have statistically significant negative correlation with head circumference, weight and height. After adjusting for confounding factors, the fine motor was associated negatively with HC. Personal-social ability was associated negatively with weight. Gross motor was correlated negatively with the height. Conclusions Based on our results, we found significant HC differences in ASD group while lack of effect of either height or weight at the age of 2–5. HC, weight and height were separately negative correlated with some domains of development quotients. Further research is needed to understand the relationship between physical indicators and development level in autism. En ligne : https://doi.org/10.1016/j.rasd.2018.07.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China / Ting YANG ; Jie CHEN ; Li CHEN ; Ying DAI ; Hua WEI ; Feiyong JIA ; Lijie WU ; Yan HAO ; Ling LI ; Jie ZHANG ; Xiaoyan KE ; Mingji YI ; Qi HONG ; Jinjin CHEN ; Shuanfeng FANG ; Yichao WANG ; Qi WANG ; Chunhua JIN ; Tingyu LI in Research in Autism Spectrum Disorders, 111 (March 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 111 (March 2024) . - p.102309 Titre : Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China Type de document : Texte imprimé et/ou numérique Auteurs : Ting YANG, Auteur ; Jie CHEN, Auteur ; Li CHEN, Auteur ; Ying DAI, Auteur ; Hua WEI, Auteur ; Feiyong JIA, Auteur ; Lijie WU, Auteur ; Yan HAO, Auteur ; Ling LI, Auteur ; Jie ZHANG, Auteur ; Xiaoyan KE, Auteur ; Mingji YI, Auteur ; Qi HONG, Auteur ; Jinjin CHEN, Auteur ; Shuanfeng FANG, Auteur ; Yichao WANG, Auteur ; Qi WANG, Auteur ; Chunhua JIN, Auteur ; Tingyu LI, Auteur Article en page(s) : p.102309 Mots-clés : Vitamin D  Multivitamin  Pregnancy  Autism spectrum disorder  Symptom  Children Index. décimale : PER Périodiques Résumé : Background We aimed to investigate the relationship between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of autism spectrum disorder (ASD) and symptoms in offspring with ASD. Methods This study enrolled 1321 children with ASD and 1200 typically developing (TD) children under 7 years old in China. Maternal vitamin supplements were classified for vitamin D, multivitamin (with or without vitamin D), and none (no use of vitamin D or multivitamin). For children with ASD, symptoms were assessed with the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS) and Childhood Autism Rating Scale (CARS), and neurodevelopmental levels were evaluated with the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016). Results Maternal vitamin D and multivitamin supplementation during pregnancy were both significantly associated with a decreased risk of ASD in offspring (P = 0.024 and P < 0.001). The ASD children born to mothers with gestational multivitamin supplementation had lower CARS [? = ?1.342 (?2.275, ?0.409), P = 0.005] and communication warning behavior [? = ?6.631 (?9.899, ?3.363), P < 0.001] scores and higher personal-social quotient [? = 3.347 (0.190, 6.504), P = 0.038] than children born to mothers without supplementation. Maternal vitamin D supplementation was not associated with symptoms and development quotients in ASD children (P > 0.05). Conclusions This study supports a protective association between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of ASD in offspring. Maternal multivitamin supplementation may potentially moderate the symptoms and personal-social ability in ASD children. Further studies are needed on the role of maternal nutrition in the etiology and autistic symptoms and the underlying molecular mechanisms. En ligne : https://doi.org/10.1016/j.rasd.2023.102309 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=521 [article] Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China [Texte imprimé et/ou numérique] / Ting YANG, Auteur ; Jie CHEN, Auteur ; Li CHEN, Auteur ; Ying DAI, Auteur ; Hua WEI, Auteur ; Feiyong JIA, Auteur ; Lijie WU, Auteur ; Yan HAO, Auteur ; Ling LI, Auteur ; Jie ZHANG, Auteur ; Xiaoyan KE, Auteur ; Mingji YI, Auteur ; Qi HONG, Auteur ; Jinjin CHEN, Auteur ; Shuanfeng FANG, Auteur ; Yichao WANG, Auteur ; Qi WANG, Auteur ; Chunhua JIN, Auteur ; Tingyu LI, Auteur . - p.102309. in Research in Autism Spectrum Disorders > 111 (March 2024) . - p.102309 Mots-clés : Vitamin D  Multivitamin  Pregnancy  Autism spectrum disorder  Symptom  Children Index. décimale : PER Périodiques Résumé : Background We aimed to investigate the relationship between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of autism spectrum disorder (ASD) and symptoms in offspring with ASD. Methods This study enrolled 1321 children with ASD and 1200 typically developing (TD) children under 7 years old in China. Maternal vitamin supplements were classified for vitamin D, multivitamin (with or without vitamin D), and none (no use of vitamin D or multivitamin). For children with ASD, symptoms were assessed with the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS) and Childhood Autism Rating Scale (CARS), and neurodevelopmental levels were evaluated with the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016). Results Maternal vitamin D and multivitamin supplementation during pregnancy were both significantly associated with a decreased risk of ASD in offspring (P = 0.024 and P < 0.001). The ASD children born to mothers with gestational multivitamin supplementation had lower CARS [? = ?1.342 (?2.275, ?0.409), P = 0.005] and communication warning behavior [? = ?6.631 (?9.899, ?3.363), P < 0.001] scores and higher personal-social quotient [? = 3.347 (0.190, 6.504), P = 0.038] than children born to mothers without supplementation. Maternal vitamin D supplementation was not associated with symptoms and development quotients in ASD children (P > 0.05). Conclusions This study supports a protective association between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of ASD in offspring. Maternal multivitamin supplementation may potentially moderate the symptoms and personal-social ability in ASD children. Further studies are needed on the role of maternal nutrition in the etiology and autistic symptoms and the underlying molecular mechanisms. En ligne : https://doi.org/10.1016/j.rasd.2023.102309 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=521

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