[article]
| Titre : |
The effect of omega-3 fatty acid supplementation on autism spectrum disorder: A meta-analysis |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Jia-Qi JING, Auteur ; Li-Xin YI, Auteur ; Chang-Jiang YANG, Auteur |
| Article en page(s) : |
p.202642 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Omega-3 fatty acid ASD Meta-analysis |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Omega-3 therapy for ASD is often used as a complementary and alternative medical approach, however, its impact on the core symptoms of ASD is controversial. Therefore, accurately determining the role of Omega-3 in ASD can establish a foundation for parents and doctors to formulate treatment plans. The current study aimed to include randomized controlled trials and provide a meta-analysis to evaluate the impact of Omega-3 fatty acids on the core symptoms of ASD. Method We searched the papers published in the Web of Science, PubMed, Medline, Scopus, EBSCO, SpringerLink, and Wiley Online Library databases until 10th April 2024 with 11 articles included. The meta-analysis evaluated the overall effects of Omega-3 fatty acids on core ASD behaviors and the effects on hyperactivity behavior, stereotype behavior, communication difficulty, and emotional difficulty. Results Results indicated that, compared to placebo, the Omega-3 fatty acids had a small and non-significant effect on the overall behavior [SMD= ?0.1, 95 % CI (?0.36,0.17), p = 0.47], with the same effect on hyperactivity behavior [SMD= ?0.24, 95 % CI (?0.55,0.08), p = 0.14], stereotyped behavior [SMD= ?0.2, 95 % CI (?0.47,0.07), p = 0.15], communication difficulty [SMD= ?0.09, 95 % CI (?0.42,0.24), p = 0.60], and emotional difficulty [SMD= ?0.15, 95 % CI (?0.45,0.14), p = 0.3]. Conclusions Overall, Omega-3 fatty acids have a minor and insignificant effect on ASD behaviors, which may be related to treatment protocol and appropriateness of participants. In the future, more large-scale and rigorous randomized controlled trials are needed to further obtain more convincing conclusions. |
| En ligne : |
https://doi.org/10.1016/j.reia.2025.202642 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 |
in Research in Autism > 126 (August 2025) . - p.202642
[article] The effect of omega-3 fatty acid supplementation on autism spectrum disorder: A meta-analysis [Texte imprimé et/ou numérique] / Jia-Qi JING, Auteur ; Li-Xin YI, Auteur ; Chang-Jiang YANG, Auteur . - p.202642. Langues : Anglais ( eng) in Research in Autism > 126 (August 2025) . - p.202642
| Mots-clés : |
Omega-3 fatty acid ASD Meta-analysis |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Omega-3 therapy for ASD is often used as a complementary and alternative medical approach, however, its impact on the core symptoms of ASD is controversial. Therefore, accurately determining the role of Omega-3 in ASD can establish a foundation for parents and doctors to formulate treatment plans. The current study aimed to include randomized controlled trials and provide a meta-analysis to evaluate the impact of Omega-3 fatty acids on the core symptoms of ASD. Method We searched the papers published in the Web of Science, PubMed, Medline, Scopus, EBSCO, SpringerLink, and Wiley Online Library databases until 10th April 2024 with 11 articles included. The meta-analysis evaluated the overall effects of Omega-3 fatty acids on core ASD behaviors and the effects on hyperactivity behavior, stereotype behavior, communication difficulty, and emotional difficulty. Results Results indicated that, compared to placebo, the Omega-3 fatty acids had a small and non-significant effect on the overall behavior [SMD= ?0.1, 95 % CI (?0.36,0.17), p = 0.47], with the same effect on hyperactivity behavior [SMD= ?0.24, 95 % CI (?0.55,0.08), p = 0.14], stereotyped behavior [SMD= ?0.2, 95 % CI (?0.47,0.07), p = 0.15], communication difficulty [SMD= ?0.09, 95 % CI (?0.42,0.24), p = 0.60], and emotional difficulty [SMD= ?0.15, 95 % CI (?0.45,0.14), p = 0.3]. Conclusions Overall, Omega-3 fatty acids have a minor and insignificant effect on ASD behaviors, which may be related to treatment protocol and appropriateness of participants. In the future, more large-scale and rigorous randomized controlled trials are needed to further obtain more convincing conclusions. |
| En ligne : |
https://doi.org/10.1016/j.reia.2025.202642 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 |
|
The effect of omega-3 fatty acid supplementation on autism spectrum disorder: A meta-analysis in Research in Autism, 126 (August 2025)
