Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD / Calvin P. SJAARDA in Research in Autism Spectrum Disorders, 60 (April 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 60 (April 2019) . - p.25-35 Titre : Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Calvin P. SJAARDA, Auteur ; Mark A. SABBAGH, Auteur ; Shalandra WOOD, Auteur ; Jessica WARD-KING, Auteur ; Amy J. M. MCNAUGHTON, Auteur ; Melissa L. HUDSON, Auteur ; Mingda TAO, Auteur ; Muhammad AYUB, Auteur ; Xudong LIU, Auteur Article en page(s) : p.25-35 Langues : Anglais (eng) Mots-clés : ASD  Autism  Electroencephalogram  DAT1  Dopamine  Face processing Index. décimale : PER Périodiques Résumé : Background Individuals with autism spectrum disorder (ASD) have reduced interest in human faces and atypical event-related brain potentials (ERPs) in response to face stimuli, suggesting that face processing may be a functional marker of ASD susceptibility. Method This report explored the visual processing of individuals with ASD (n?=?50) compared with their first-degree relatives (n?=?117) using electroencephalogram (EEG), and associated EEG response with specific polymorphisms in the COMT, OXTR, SLC6A4 and DAT1 genes. Results Polymorphisms in the COMT and OXTR genes were not associated with any specific EEG response; on the other hand, the 5-HTTLPR polymorphism located upstream of SLC6A4 was associated with increased latency of the P1 component of the EEG response, and DAT1 genotype correlated with reduced amplitude of the N170 component in male participants with ASD. Conclusion These results suggest an interaction between DAT1 genotype and male participants with ASD characterized by reduced cognitive performance when processing faces as measured by EEG. Identifying ASD functional markers and grouping individuals with shared genetic biomarkers or endophenotypes may facilitate greater understanding of the heterogeneity underlying ASD leading to improved diagnosis and treatment of ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.12.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387 [article] Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD [Texte imprimé et/ou numérique] / Calvin P. SJAARDA, Auteur ; Mark A. SABBAGH, Auteur ; Shalandra WOOD, Auteur ; Jessica WARD-KING, Auteur ; Amy J. M. MCNAUGHTON, Auteur ; Melissa L. HUDSON, Auteur ; Mingda TAO, Auteur ; Muhammad AYUB, Auteur ; Xudong LIU, Auteur . - p.25-35. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 60 (April 2019) . - p.25-35 Mots-clés : ASD  Autism  Electroencephalogram  DAT1  Dopamine  Face processing Index. décimale : PER Périodiques Résumé : Background Individuals with autism spectrum disorder (ASD) have reduced interest in human faces and atypical event-related brain potentials (ERPs) in response to face stimuli, suggesting that face processing may be a functional marker of ASD susceptibility. Method This report explored the visual processing of individuals with ASD (n?=?50) compared with their first-degree relatives (n?=?117) using electroencephalogram (EEG), and associated EEG response with specific polymorphisms in the COMT, OXTR, SLC6A4 and DAT1 genes. Results Polymorphisms in the COMT and OXTR genes were not associated with any specific EEG response; on the other hand, the 5-HTTLPR polymorphism located upstream of SLC6A4 was associated with increased latency of the P1 component of the EEG response, and DAT1 genotype correlated with reduced amplitude of the N170 component in male participants with ASD. Conclusion These results suggest an interaction between DAT1 genotype and male participants with ASD characterized by reduced cognitive performance when processing faces as measured by EEG. Identifying ASD functional markers and grouping individuals with shared genetic biomarkers or endophenotypes may facilitate greater understanding of the heterogeneity underlying ASD leading to improved diagnosis and treatment of ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.12.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387

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