[article]
| Titre : |
Psychiatric comorbidities in adults with autism spectrum disorder: A systematic review and prevalence meta-analysis |
| Type de document : |
texte imprimé |
| Auteurs : |
Emmanuely Macedo Santana DE-NARDIN, Auteur ; Renata Maria Silva SANTOS, Auteur ; Samuel Andreata PRATES, Auteur ; Igor da Cruz SILVA, Auteur ; Alice Mi LEE, Auteur ; Lorena da Fonseca VIANNA LAGE, Auteur ; Marco Aurélio ROMANO-SILVA, Auteur ; Debora Marques de MIRANDA, Auteur |
| Article en page(s) : |
p.203018 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism Comorbidities Quality of life Adult Depression Meta-analysis Substance-use |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Psychiatric comorbidities are expected to be highly prevalent among autistic adults; however, uncertainty remains regarding which conditions are most common and their prevalence rates. Objective To pool prevalence estimates of psychiatric comorbidities in adults with autism spectrum disorder and identify factors contributing to between-study variability. Methods We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and prospectively registered the protocol. The search strategy was developed using the PECO framework and applied across five databases. Results Of 6381 records identified, 11 studies met the inclusion criteria. Random-effects meta-analysis yielded pooled prevalence estimates of 26.5% (95% CI: 14.2–44.1%; I² = 91.3%) for depressive symptoms and 24.4% (95% CI: 9.8–49.0%; I² = 94.8%) for substance use disorders; the latter decreased to 17% (95% CI: 10–27%) in sensitivity analysis. Anxiety prevalence ranged from 14% to 73% across three studies, but extreme heterogeneity (I² = 98%) precluded a meaningful pooled estimate. Other comorbidities assessed included post-traumatic stress and obsessive-compulsive symptoms. Samples were highly heterogeneous and were predominantly recruited from specialized centers. Conclusion Available studies of psychiatric comorbidities in autistic adults remain heterogeneous. Nevertheless, clinically relevant patterns emerged, particularly for depression and substance use disorders, with pooled prevalence estimates of 26.5% and 24.4%, respectively, before sensitivity analysis. Anxiety, obsessive-compulsive disorder, and post-traumatic stress disorder were also frequently reported, although their estimates could not be pooled. These comorbidities may contribute to greater overall clinical complexity. |
| En ligne : |
https://dx.doi.org/https://doi.org/10.1016/j.reia.2026.203018 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 |
in Research in Autism > 138 (October 2026) . - p.203018
[article] Psychiatric comorbidities in adults with autism spectrum disorder: A systematic review and prevalence meta-analysis [texte imprimé] / Emmanuely Macedo Santana DE-NARDIN, Auteur ; Renata Maria Silva SANTOS, Auteur ; Samuel Andreata PRATES, Auteur ; Igor da Cruz SILVA, Auteur ; Alice Mi LEE, Auteur ; Lorena da Fonseca VIANNA LAGE, Auteur ; Marco Aurélio ROMANO-SILVA, Auteur ; Debora Marques de MIRANDA, Auteur . - p.203018. Langues : Anglais ( eng) in Research in Autism > 138 (October 2026) . - p.203018
| Mots-clés : |
Autism Comorbidities Quality of life Adult Depression Meta-analysis Substance-use |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Psychiatric comorbidities are expected to be highly prevalent among autistic adults; however, uncertainty remains regarding which conditions are most common and their prevalence rates. Objective To pool prevalence estimates of psychiatric comorbidities in adults with autism spectrum disorder and identify factors contributing to between-study variability. Methods We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and prospectively registered the protocol. The search strategy was developed using the PECO framework and applied across five databases. Results Of 6381 records identified, 11 studies met the inclusion criteria. Random-effects meta-analysis yielded pooled prevalence estimates of 26.5% (95% CI: 14.2–44.1%; I² = 91.3%) for depressive symptoms and 24.4% (95% CI: 9.8–49.0%; I² = 94.8%) for substance use disorders; the latter decreased to 17% (95% CI: 10–27%) in sensitivity analysis. Anxiety prevalence ranged from 14% to 73% across three studies, but extreme heterogeneity (I² = 98%) precluded a meaningful pooled estimate. Other comorbidities assessed included post-traumatic stress and obsessive-compulsive symptoms. Samples were highly heterogeneous and were predominantly recruited from specialized centers. Conclusion Available studies of psychiatric comorbidities in autistic adults remain heterogeneous. Nevertheless, clinically relevant patterns emerged, particularly for depression and substance use disorders, with pooled prevalence estimates of 26.5% and 24.4%, respectively, before sensitivity analysis. Anxiety, obsessive-compulsive disorder, and post-traumatic stress disorder were also frequently reported, although their estimates could not be pooled. These comorbidities may contribute to greater overall clinical complexity. |
| En ligne : |
https://dx.doi.org/https://doi.org/10.1016/j.reia.2026.203018 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 |
|  |
Psychiatric comorbidities in adults with autism spectrum disorder: A systematic review and prevalence meta-analysis in Research in Autism, 138 (October 2026)
