16 recherche sur le mot-clé 'Comorbidities'

Children with autism spectrum disorder from China and the Netherlands: Age of diagnosis, gender and comorbidities / Ke WANG in Research in Autism Spectrum Disorders, 54 (October 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 54 (October 2018) . - p.76-82 Titre : Children with autism spectrum disorder from China and the Netherlands: Age of diagnosis, gender and comorbidities Type de document : Texte imprimé et/ou numérique Auteurs : Ke WANG, Auteur ; Chongying WANG, Auteur ; Dehua GUO, Auteur ; Marlies VAN WIJNGAARDEN, Auteur ; Sander BEGEER, Auteur Article en page(s) : p.76-82 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Age of diagnosis  Gender  Comorbidities Index. décimale : PER Périodiques Résumé : Background In recent years, an increasing number of studies have highlighted progress in ASD clinical practice and scientific research in China (Zheng & Zheng, 2015). However, little is known about the differences between clinical or scientific approaches to ASD between China and other countries. In our study we explored the impact of gender, comorbidity, parental educational and vocational status on the age of diagnosis in two samples of children with ASD from China and the Netherlands. Method 433 children with ASD aged between 6 to 14 from China and 492 age matched children with ASD from the Netherlands were investigated based on national databases on individuals with ASD. Results We found a lower diagnosis age in China compared to the Netherlands. The Chinese sample showed a higher male/female ratio and a higher proportion of co-morbid ADHD diagnoses, but lower age of first concern, diagnosis age and shorter delay from first concern to diagnosis. In the Dutch sample only, co-morbid ADHD resulted in lower age of first concern. The differential impact of comorbidity and gender across both countries may be related to cultural and clinical variations. Conclusions This study may help us understand ASD from a cross-cultural perspective. En ligne : https://doi.org/10.1016/j.rasd.2018.07.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Children with autism spectrum disorder from China and the Netherlands: Age of diagnosis, gender and comorbidities [Texte imprimé et/ou numérique] / Ke WANG, Auteur ; Chongying WANG, Auteur ; Dehua GUO, Auteur ; Marlies VAN WIJNGAARDEN, Auteur ; Sander BEGEER, Auteur . - p.76-82. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 54 (October 2018) . - p.76-82 Mots-clés : Autism spectrum disorder  Age of diagnosis  Gender  Comorbidities Index. décimale : PER Périodiques Résumé : Background In recent years, an increasing number of studies have highlighted progress in ASD clinical practice and scientific research in China (Zheng & Zheng, 2015). However, little is known about the differences between clinical or scientific approaches to ASD between China and other countries. In our study we explored the impact of gender, comorbidity, parental educational and vocational status on the age of diagnosis in two samples of children with ASD from China and the Netherlands. Method 433 children with ASD aged between 6 to 14 from China and 492 age matched children with ASD from the Netherlands were investigated based on national databases on individuals with ASD. Results We found a lower diagnosis age in China compared to the Netherlands. The Chinese sample showed a higher male/female ratio and a higher proportion of co-morbid ADHD diagnoses, but lower age of first concern, diagnosis age and shorter delay from first concern to diagnosis. In the Dutch sample only, co-morbid ADHD resulted in lower age of first concern. The differential impact of comorbidity and gender across both countries may be related to cultural and clinical variations. Conclusions This study may help us understand ASD from a cross-cultural perspective. En ligne : https://doi.org/10.1016/j.rasd.2018.07.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Clinical Pattern of Autism in Nigeria / Doris N. IZUWAH in Autism Research, 9-3 (March 2016)  

Public ISBD [article]  inAutism Research > 9-3 (March 2016) . - p.376-381 Titre : Clinical Pattern of Autism in Nigeria Type de document : Texte imprimé et/ou numérique Auteurs : Doris N. IZUWAH, Auteur ; Boma A. N. OKOH, Auteur ; Edward A. D. ALIKOR, Auteur Article en page(s) : p.376-381 Langues : Anglais (eng) Mots-clés : autism  clinical presentation  comorbidities  diagnosis  Nigeria Index. décimale : PER Périodiques Résumé : Autism, a global disorder has been widely studied in the Western world. However, there are limited studies on its occurrence, risk factors, and presentation in developing countries such as Nigeria. This retrospective study highlights the pattern of presentation of autism and presence of some risk factors in 75 Nigerian cases referred to a private autism center. The diagnosis of autism was made using Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM IV), International Classification of Diseases Fourth edition, the Modified Checklist for Autism in Toddlers, Autism Treatment Evaluation Checklist, and Childhood Autism Rating Scale. There were 60 males and 15 females with a male to female ratio of 4:1. The mean age at presentation to the center was 6.87?±?4.20 years and majority (91.9%) belonged to a high socioeconomic class. Already established risk factors, clinical features, and comorbidities of autism present among the study group were similar to findings in individuals with autism in other parts of the world. Autism Res 2016, 9: 376–381. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1531 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 [article] Clinical Pattern of Autism in Nigeria [Texte imprimé et/ou numérique] / Doris N. IZUWAH, Auteur ; Boma A. N. OKOH, Auteur ; Edward A. D. ALIKOR, Auteur . - p.376-381. Langues : Anglais (eng) in Autism Research > 9-3 (March 2016) . - p.376-381 Mots-clés : autism  clinical presentation  comorbidities  diagnosis  Nigeria Index. décimale : PER Périodiques Résumé : Autism, a global disorder has been widely studied in the Western world. However, there are limited studies on its occurrence, risk factors, and presentation in developing countries such as Nigeria. This retrospective study highlights the pattern of presentation of autism and presence of some risk factors in 75 Nigerian cases referred to a private autism center. The diagnosis of autism was made using Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM IV), International Classification of Diseases Fourth edition, the Modified Checklist for Autism in Toddlers, Autism Treatment Evaluation Checklist, and Childhood Autism Rating Scale. There were 60 males and 15 females with a male to female ratio of 4:1. The mean age at presentation to the center was 6.87?±?4.20 years and majority (91.9%) belonged to a high socioeconomic class. Already established risk factors, clinical features, and comorbidities of autism present among the study group were similar to findings in individuals with autism in other parts of the world. Autism Res 2016, 9: 376–381. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1531 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285

Comorbidity and autism: Trends, topics and future directions / Johnny L. MATSON in Research in Autism Spectrum Disorders, 7-10 (October 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-10 (October 2013) . - p.1228-1233 Titre : Comorbidity and autism: Trends, topics and future directions Type de document : Texte imprimé et/ou numérique Auteurs : Johnny L. MATSON, Auteur ; Rachel L. GOLDIN, Auteur Article en page(s) : p.1228-1233 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Comorbidities  Intellectual disabilities  Co-occurring Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are common, life-long disorders. Symptoms of ASD often co-occur with other difficulties that also tend to be chronic and debilitating. Common co-occurring difficulties include intellectual disabilities, physical conditions, comorbid psychopathologies and challenging behaviors. However, the idea of comorbidities among individuals with ASD is still a relatively new notion. Thus, a new field of research is developing examining comorbidities with ASD. This field is developing rapidly but is still lacking. This paper highlights the most common forms of comorbid disorders, and the future direction of research on comorbidities among individuals with ASD is discussed. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.07.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Comorbidity and autism: Trends, topics and future directions [Texte imprimé et/ou numérique] / Johnny L. MATSON, Auteur ; Rachel L. GOLDIN, Auteur . - p.1228-1233. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-10 (October 2013) . - p.1228-1233 Mots-clés : Autism spectrum disorders  Comorbidities  Intellectual disabilities  Co-occurring Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are common, life-long disorders. Symptoms of ASD often co-occur with other difficulties that also tend to be chronic and debilitating. Common co-occurring difficulties include intellectual disabilities, physical conditions, comorbid psychopathologies and challenging behaviors. However, the idea of comorbidities among individuals with ASD is still a relatively new notion. Thus, a new field of research is developing examining comorbidities with ASD. This field is developing rapidly but is still lacking. This paper highlights the most common forms of comorbid disorders, and the future direction of research on comorbidities among individuals with ASD is discussed. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.07.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities / Stephania ASSIMOPOULOS in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1189-1208 Titre : Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities Type de document : Texte imprimé et/ou numérique Auteurs : Stephania ASSIMOPOULOS, Auteur ; Christopher HAMMILL, Auteur ; Darren J. FERNANDES, Auteur ; Tara LEIGH SPENCER NOAKES, Auteur ; Yu-Qing ZHOU, Auteur ; Lauryl M J. NUTTER, Auteur ; Jacob ELLEGOOD, Auteur ; Evdokia ANAGNOSTOU, Auteur ; John G. SLED, Auteur ; Jason P. LERCH, Auteur Article en page(s) : p.1189-1208 Langues : Anglais (eng) Mots-clés : autism  cardiac phenotype/cardiology  comorbidities  genetic mouse models  phenotyping  ultrasound biomicroscopy Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked on a functional and genetic level. Most work has investigated CHD-related neurodevelopmental abnormalities. Cardiac abnormalities in ASD have been less studied. We investigated the prevalence of cardiac comorbidities relative to ASD genetic contributors. Using high frequency ultrasound imaging, we screened 9 ASD-related genetic mouse models (Arid1b((+/-)) , Chd8((+/-)) , 16p11.2 (deletion), Sgsh((+/-)) , Sgsh((-/-)) , Shank3 ?exon 4-9((+/-)) , Shank3 ?exon 4-9((-/-)) , Fmr1((-/-)) , Vps13b((+/-)) ), and pooled wild-type littermates (WTs). We measured heart rate (HR), aorta diameter (AoD), thickness and thickening of the left-ventricular (LV) anterior and posterior walls, LV chamber diameter, fractional shortening, stroke volume and cardiac output, mitral inflow Peak E and A velocity ratio, ascending aorta velocity time integral (VTI). Mutant groups presented small-scale alterations in cardiac structure and function compared to WTs (LV anterior wall thickness and thickening, chamber diameter and fractional shortening, HR). A greater number of significant differences was observed among mutant groups than between mutant groups and WTs. Mutant groups differed primarily in structural measures (LV chamber diameter and anterior wall thickness, HR, AoD). The mutant groups with most differences to WTs were 16p11.2 (deletion), Fmr1((-/-)) , Arid1b((+/-)) . The mutant groups with most differences from other mutant groups were 16p11.2 (deletion), Sgsh((+/-)) , Fmr1((-/-)) . Our results recapitulate the associated clinical findings. The characteristic ASD heterogeneity was recapitulated in the cardiac phenotype. The type of abnormal measures (morphological, functional) can highlight common underlying mechanisms. Clinically, knowledge of cardiac abnormalities in ASD can be essential as even non-lethal abnormalities impact normal development. LAY SUMMARY: Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked functionally and genetically. ASD cardiac phenotyping is limited. We assessed the cardiac phenotype of 9 ASD-related mouse models. We found subtle heterogenous cardiac abnormalities compared to controls, with more differences within ASD than between ASD and controls, mirroring clinical findings. Clinically, knowing the cardiac abnormalities in ASD is vital as even non-lethal cardiac abnormalities can impact development. En ligne : http://dx.doi.org/10.1002/aur.2728 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities [Texte imprimé et/ou numérique] / Stephania ASSIMOPOULOS, Auteur ; Christopher HAMMILL, Auteur ; Darren J. FERNANDES, Auteur ; Tara LEIGH SPENCER NOAKES, Auteur ; Yu-Qing ZHOU, Auteur ; Lauryl M J. NUTTER, Auteur ; Jacob ELLEGOOD, Auteur ; Evdokia ANAGNOSTOU, Auteur ; John G. SLED, Auteur ; Jason P. LERCH, Auteur . - p.1189-1208. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1189-1208 Mots-clés : autism  cardiac phenotype/cardiology  comorbidities  genetic mouse models  phenotyping  ultrasound biomicroscopy Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked on a functional and genetic level. Most work has investigated CHD-related neurodevelopmental abnormalities. Cardiac abnormalities in ASD have been less studied. We investigated the prevalence of cardiac comorbidities relative to ASD genetic contributors. Using high frequency ultrasound imaging, we screened 9 ASD-related genetic mouse models (Arid1b((+/-)) , Chd8((+/-)) , 16p11.2 (deletion), Sgsh((+/-)) , Sgsh((-/-)) , Shank3 ?exon 4-9((+/-)) , Shank3 ?exon 4-9((-/-)) , Fmr1((-/-)) , Vps13b((+/-)) ), and pooled wild-type littermates (WTs). We measured heart rate (HR), aorta diameter (AoD), thickness and thickening of the left-ventricular (LV) anterior and posterior walls, LV chamber diameter, fractional shortening, stroke volume and cardiac output, mitral inflow Peak E and A velocity ratio, ascending aorta velocity time integral (VTI). Mutant groups presented small-scale alterations in cardiac structure and function compared to WTs (LV anterior wall thickness and thickening, chamber diameter and fractional shortening, HR). A greater number of significant differences was observed among mutant groups than between mutant groups and WTs. Mutant groups differed primarily in structural measures (LV chamber diameter and anterior wall thickness, HR, AoD). The mutant groups with most differences to WTs were 16p11.2 (deletion), Fmr1((-/-)) , Arid1b((+/-)) . The mutant groups with most differences from other mutant groups were 16p11.2 (deletion), Sgsh((+/-)) , Fmr1((-/-)) . Our results recapitulate the associated clinical findings. The characteristic ASD heterogeneity was recapitulated in the cardiac phenotype. The type of abnormal measures (morphological, functional) can highlight common underlying mechanisms. Clinically, knowledge of cardiac abnormalities in ASD can be essential as even non-lethal abnormalities impact normal development. LAY SUMMARY: Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked functionally and genetically. ASD cardiac phenotyping is limited. We assessed the cardiac phenotype of 9 ASD-related mouse models. We found subtle heterogenous cardiac abnormalities compared to controls, with more differences within ASD than between ASD and controls, mirroring clinical findings. Clinically, knowing the cardiac abnormalities in ASD is vital as even non-lethal cardiac abnormalities can impact development. En ligne : http://dx.doi.org/10.1002/aur.2728 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Low but Increasing Prevalence of Autism Spectrum Disorders in a French Area from Register-Based Data / Marit Maria Elisabeth VAN BAKEL in Journal of Autism and Developmental Disorders, 45-10 (October 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-10 (October 2015) . - p.3255-3261 Titre : Low but Increasing Prevalence of Autism Spectrum Disorders in a French Area from Register-Based Data Type de document : Texte imprimé et/ou numérique Auteurs : Marit Maria Elisabeth VAN BAKEL, Auteur ; Malika DELOBEL-AYOUB, Auteur ; Christine CANS, Auteur ; Brigitte ASSOULINE, Auteur ; Pierre-Simon JOUK, Auteur ; Jean-Philippe RAYNAUD, Auteur ; Catherine ARNAUD, Auteur Article en page(s) : p.3255-3261 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Population register  Prevalence  Comorbidities Index. décimale : PER Périodiques Résumé : Register-based prevalence rates of childhood autism (CA), Asperger’s syndrome (AS) and other autism spectrum disorders (ASD) were calculated among children aged 7 years old of the 1997–2003 birth cohorts, living in four counties in France. The proportion of children presenting comorbidities was reported. 1123 children with ASD were recorded (M/F ratio: 4.1), representing an overall prevalence rate of 36.5/10,000 children (95 % CI 34.4–38.7): 8.8/10,000 for CA (95 % CI 7.8–9.9), 1.7/10,000 for AS (95 % CI 1.3–2.3) and 25.9/10,000 for other ASD (95 % CI 24.2–27.8). ASD prevalence significantly increased (p < 0.0001) during the period under study. The proportion of children with an intellectual disability was 47.3 %, all other comorbidities were present in less than 5 % of the cases. En ligne : http://dx.doi.org/10.1007/s10803-015-2486-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 [article] Low but Increasing Prevalence of Autism Spectrum Disorders in a French Area from Register-Based Data [Texte imprimé et/ou numérique] / Marit Maria Elisabeth VAN BAKEL, Auteur ; Malika DELOBEL-AYOUB, Auteur ; Christine CANS, Auteur ; Brigitte ASSOULINE, Auteur ; Pierre-Simon JOUK, Auteur ; Jean-Philippe RAYNAUD, Auteur ; Catherine ARNAUD, Auteur . - p.3255-3261. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-10 (October 2015) . - p.3255-3261 Mots-clés : Autism spectrum disorder  Population register  Prevalence  Comorbidities Index. décimale : PER Périodiques Résumé : Register-based prevalence rates of childhood autism (CA), Asperger’s syndrome (AS) and other autism spectrum disorders (ASD) were calculated among children aged 7 years old of the 1997–2003 birth cohorts, living in four counties in France. The proportion of children presenting comorbidities was reported. 1123 children with ASD were recorded (M/F ratio: 4.1), representing an overall prevalence rate of 36.5/10,000 children (95 % CI 34.4–38.7): 8.8/10,000 for CA (95 % CI 7.8–9.9), 1.7/10,000 for AS (95 % CI 1.3–2.3) and 25.9/10,000 for other ASD (95 % CI 24.2–27.8). ASD prevalence significantly increased (p < 0.0001) during the period under study. The proportion of children with an intellectual disability was 47.3 %, all other comorbidities were present in less than 5 % of the cases. En ligne : http://dx.doi.org/10.1007/s10803-015-2486-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267

Phenotypic differences in individuals with autism spectrum disorder born preterm and at term gestation / Katherine BOWERS in Autism, 19-6 (August 2015)  

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Prevalence of sensory impairments, physical and intellectual disabilities, and mental health in children and young people with self/proxy-reported autism: Observational study of a whole country population / E. RYDZEWSKA in Autism, 23-5 (July 2019)  

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An investigation of the diet, exercise, sleep, BMI, and health outcomes of autistic adults / E. WEIR in Molecular Autism, 12 (2021)  

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Autistic Traits and Abnormal Sensory Experiences in Adults / Jamie HORDER in Journal of Autism and Developmental Disorders, 44-6 (June 2014)  

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Behavioral inhibition and activation as a modifier process in autism spectrum disorder: Examination of self-reported BIS/BAS and alpha EEG asymmetry / H. K. SCHILTZ in Autism Research, 11-12 (December 2018)  

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