A Killer Immunoglobulin - Like Receptor Gene - Content Haplotype and A Cognate Human Leukocyte Antigen Ligand are Associated with Autism / Anthony TORRES in Autism - Open Access, 6-2 ([01/03/2016])  

Public ISBD [article]  inAutism - Open Access > 6-2 [01/03/2016] . - 8 p. Titre : A Killer Immunoglobulin - Like Receptor Gene - Content Haplotype and A Cognate Human Leukocyte Antigen Ligand are Associated with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Anthony TORRES, Auteur ; Jonna WESTOVER, Auteur ; Michael BENSON, Auteur ; Randall JOHNSON, Auteur ; Annelise DYKES, Auteur Article en page(s) : 8 p. Langues : Anglais (eng) Mots-clés : Autism  Killer - cell immunoglobulin - like receptors(KIR)  Human leukocyte antigen (HLA) alleles  Transmission disequilibrium test (TDT)  KIR gene Index. décimale : PER Périodiques Résumé : The killing activity of natural killer cells is largely regulated by the binding of class I human leukocyte antigen cognate ligands to killer cell immunoglobulin - like receptor proteins. The killer cell immunoglobulin - like receptor gene - complex contains genes that activate and others that inhibit the killing state of natural killer cells depending on the binding of specific human leukocyte antigen cognate ligands. It has been suggested in previous publications that activating human leukocyte antigen / killer - cell immunoglobulin - like receptor complexes are increased in people with autism. We present data, which suggests that an activating cB01 / tA01 killer cell immunoglobulin – like receptor gene - content haplotype and the cognate ligand human leukocyte antigen - C1k that activates this haplotype is significantly increased in autism. This is an important observation suggesting that the interaction between two proteins encoded on different chromosomes increases natural killer cell killing in autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] A Killer Immunoglobulin - Like Receptor Gene - Content Haplotype and A Cognate Human Leukocyte Antigen Ligand are Associated with Autism [Texte imprimé et/ou numérique] / Anthony TORRES, Auteur ; Jonna WESTOVER, Auteur ; Michael BENSON, Auteur ; Randall JOHNSON, Auteur ; Annelise DYKES, Auteur . - 8 p. Langues : Anglais (eng) in Autism - Open Access > 6-2 [01/03/2016] . - 8 p. Mots-clés : Autism  Killer - cell immunoglobulin - like receptors(KIR)  Human leukocyte antigen (HLA) alleles  Transmission disequilibrium test (TDT)  KIR gene Index. décimale : PER Périodiques Résumé : The killing activity of natural killer cells is largely regulated by the binding of class I human leukocyte antigen cognate ligands to killer cell immunoglobulin - like receptor proteins. The killer cell immunoglobulin - like receptor gene - complex contains genes that activate and others that inhibit the killing state of natural killer cells depending on the binding of specific human leukocyte antigen cognate ligands. It has been suggested in previous publications that activating human leukocyte antigen / killer - cell immunoglobulin - like receptor complexes are increased in people with autism. We present data, which suggests that an activating cB01 / tA01 killer cell immunoglobulin – like receptor gene - content haplotype and the cognate ligand human leukocyte antigen - C1k that activates this haplotype is significantly increased in autism. This is an important observation suggesting that the interaction between two proteins encoded on different chromosomes increases natural killer cell killing in autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

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