Bio-availability and dissolution of three phenytoin preparations for children / Sally HODGES in Developmental Medicine & Child Neurology, 28-6 (December 1986)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 28-6 (December 1986) . - p.708-712 Titre : Bio-availability and dissolution of three phenytoin preparations for children Type de document : Texte imprimé et/ou numérique Auteurs : Sally HODGES, Auteur ; W. I. FORSYTHE, Auteur ; D. GILLIES, Auteur ; H. REMINGTON, Auteur ; A. CAWOOD, Auteur Année de publication : 1986 Article en page(s) : p.708-712 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A study of bio-availability of three drug companies' brands of phenytoin preparations (50mg capsule/tablets) was undertaken on 30 children with tonic-clonic or complex partial seizures. Eight children were excluded because of non-compliance and three because of abnormally high serum levels. Phenytoin capsules (Parke Davis) and tablets (Boots) produced significantly higher serum-level profiles than phenytoin tablets (Evans). Seizure frequencies did not differ significantly with the three brands of phenytoin. Dissolution of the three preparations tested in vitro was different. As a result of this study the authors recommend that children remain on the same manufacturer's brand of phenytoin throughout their treatment. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=620 [article] Bio-availability and dissolution of three phenytoin preparations for children [Texte imprimé et/ou numérique] / Sally HODGES, Auteur ; W. I. FORSYTHE, Auteur ; D. GILLIES, Auteur ; H. REMINGTON, Auteur ; A. CAWOOD, Auteur . - 1986 . - p.708-712. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 28-6 (December 1986) . - p.708-712 Index. décimale : PER Périodiques Résumé : A study of bio-availability of three drug companies' brands of phenytoin preparations (50mg capsule/tablets) was undertaken on 30 children with tonic-clonic or complex partial seizures. Eight children were excluded because of non-compliance and three because of abnormally high serum levels. Phenytoin capsules (Parke Davis) and tablets (Boots) produced significantly higher serum-level profiles than phenytoin tablets (Evans). Seizure frequencies did not differ significantly with the three brands of phenytoin. Dissolution of the three preparations tested in vitro was different. As a result of this study the authors recommend that children remain on the same manufacturer's brand of phenytoin throughout their treatment. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=620

Carbamazepine serum levels in children with epilepsy: a micro immuno-assay technique / W. I. FORSYTHE in Developmental Medicine & Child Neurology, 21-4 (August 1979)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 21-4 (August 1979) . - p.441-447 Titre : Carbamazepine serum levels in children with epilepsy: a micro immuno-assay technique Type de document : Texte imprimé et/ou numérique Auteurs : W. I. FORSYTHE, Auteur ; M. P. PRENDERGAST, Auteur ; C. TOOTHILL, Auteur ; P. M. G. BROUGHTON, Auteur Année de publication : 1979 Article en page(s) : p.441-447 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In part 1 of this study, 26 children with seizures were given 20 mg/kg/day carbamazepine and five developed side-effects. With this initial dose, equilibrium was reached in the serum within four to six days in 25 of the 26 children. The sudden withdrawal of other anticonvulsants did not usually affect the rise of carbamazepine in serum, unless given in high doses. In Part 2 of the study it was shown that satisfactory levels were obtained in the serum of 38 children given carbamazepine either twice or three times daily, but higher levels were obtained with the latter. The lowest carbamazepine serum level associated with complete control of seizures was 6mg/1. Seizure control was comparable whether carbamazepine was given twice or three times daily. Complete control of temporal-lobe seizures was obtained in nine of 20 children, and of grand mal in 10 of 18 children. Serum levels of carbamazepine remained remarkable constant during the follow-up period of between 10 and 30 months. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 [article] Carbamazepine serum levels in children with epilepsy: a micro immuno-assay technique [Texte imprimé et/ou numérique] / W. I. FORSYTHE, Auteur ; M. P. PRENDERGAST, Auteur ; C. TOOTHILL, Auteur ; P. M. G. BROUGHTON, Auteur . - 1979 . - p.441-447. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 21-4 (August 1979) . - p.441-447 Index. décimale : PER Périodiques Résumé : In part 1 of this study, 26 children with seizures were given 20 mg/kg/day carbamazepine and five developed side-effects. With this initial dose, equilibrium was reached in the serum within four to six days in 25 of the 26 children. The sudden withdrawal of other anticonvulsants did not usually affect the rise of carbamazepine in serum, unless given in high doses. In Part 2 of the study it was shown that satisfactory levels were obtained in the serum of 38 children given carbamazepine either twice or three times daily, but higher levels were obtained with the latter. The lowest carbamazepine serum level associated with complete control of seizures was 6mg/1. Seizure control was comparable whether carbamazepine was given twice or three times daily. Complete control of temporal-lobe seizures was obtained in nine of 20 children, and of grand mal in 10 of 18 children. Serum levels of carbamazepine remained remarkable constant during the follow-up period of between 10 and 30 months. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498

Migraine in childhood; a study of 300 children / Peter J. CONGDON in Developmental Medicine & Child Neurology, 21-2 (April 1979)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 21-2 (April 1979) . - p.209-216 Titre : Migraine in childhood; a study of 300 children Type de document : Texte imprimé et/ou numérique Auteurs : Peter J. CONGDON, Auteur ; W. I. FORSYTHE, Auteur Année de publication : 1979 Article en page(s) : p.209-216 Langues : Anglais (eng) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Migraine in childhood; a study of 300 children [Texte imprimé et/ou numérique] / Peter J. CONGDON, Auteur ; W. I. FORSYTHE, Auteur . - 1979 . - p.209-216. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 21-2 (April 1979) . - p.209-216 Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

One drug for childhood grand mal: medical audit for three-year remissions / W. I. FORSYTHE in Developmental Medicine & Child Neurology, 26-6 (December 1994)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 26-6 (December 1994) . - p.742-748 Titre : One drug for childhood grand mal: medical audit for three-year remissions Type de document : Texte imprimé et/ou numérique Auteurs : W. I. FORSYTHE, Auteur ; M. A. SILLS, Auteur Année de publication : 1984 Article en page(s) : p.742-748 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A comparative study was made of monotherapy for grand mal seizures among four groups of children between three and 14 years of age. The first-choice anticonvulsants were phenobarbitone (N = 159), phenytoin (N = 185), carbamazepine (N = 178) and sodium valproate (N = 63). The proportions in each group with a three-year remission of seizures were, respectively, 22, 34, 40 and 16 per cent. The results were better for children with primary grand mal (25, 39, 45 and 21 per cent) and were worse for those with secondary grand mal (3, 21, 25 and 4 per cent), respectively. 119 of the children obtained no reduction in seizure frequency, and for them there is an urgent need for new and more effective anticonvulsants. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584 [article] One drug for childhood grand mal: medical audit for three-year remissions [Texte imprimé et/ou numérique] / W. I. FORSYTHE, Auteur ; M. A. SILLS, Auteur . - 1984 . - p.742-748. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 26-6 (December 1994) . - p.742-748 Index. décimale : PER Périodiques Résumé : A comparative study was made of monotherapy for grand mal seizures among four groups of children between three and 14 years of age. The first-choice anticonvulsants were phenobarbitone (N = 159), phenytoin (N = 185), carbamazepine (N = 178) and sodium valproate (N = 63). The proportions in each group with a three-year remission of seizures were, respectively, 22, 34, 40 and 16 per cent. The results were better for children with primary grand mal (25, 39, 45 and 21 per cent) and were worse for those with secondary grand mal (3, 21, 25 and 4 per cent), respectively. 119 of the children obtained no reduction in seizure frequency, and for them there is an urgent need for new and more effective anticonvulsants. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584

Phenytoin serum levels in children with epilepsy: a micro immuno-assay technique / W. I. FORSYTHE in Developmental Medicine & Child Neurology, 21-4 (August 1979)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 21-4 (August 1979) . - p.448-454 Titre : Phenytoin serum levels in children with epilepsy: a micro immuno-assay technique Type de document : Texte imprimé et/ou numérique Auteurs : W. I. FORSYTHE, Auteur ; M. P. PRENDERGAST, Auteur ; C. TOOTHILL, Auteur ; P. M. G. BROUGHTON, Auteur Année de publication : 1979 Article en page(s) : p.448-454 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The enzyme multiple immuno-assay technique (EMIT) was used to study phenytoin serum levels in 50 children with seizures. It was found that: (1) a single dose of phenytoin suspension or capsules (5mg/kg/day) produced inadequate serum levels 16 and 24 hours after ingestion, and for this reason single dosage is not recommended; (2) twice-daily dosage of phenytoin suspension or capsules (5mg/kg/day) produced adequate serum levels in most children throughout the 24 hours, and this dosage is recommended; (3) 12 children continued to have seizures but when the dose was increased to 10mg/kg/day six of the 12 obtained control of seizures; (4) phenytoin reached equilibrium in the serum in five days provided the child had not previously been taking phenobarbitone; (5) of 13 children who had been taking phenobarbitone, 10 did not achieve equilibrium of phenytoin in serum for one to four weeks; (6) phenytoin suspension given twice-daily produced satisfactory serum levels provided the bottle was shaken well before dispensing; (7) apart from minor variations, phenytoin maintained its level in serum during the 14 to 30 months follow-up period, whether 5mg or 10mg/kg/day of phenytoin was given. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 [article] Phenytoin serum levels in children with epilepsy: a micro immuno-assay technique [Texte imprimé et/ou numérique] / W. I. FORSYTHE, Auteur ; M. P. PRENDERGAST, Auteur ; C. TOOTHILL, Auteur ; P. M. G. BROUGHTON, Auteur . - 1979 . - p.448-454. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 21-4 (August 1979) . - p.448-454 Index. décimale : PER Périodiques Résumé : The enzyme multiple immuno-assay technique (EMIT) was used to study phenytoin serum levels in 50 children with seizures. It was found that: (1) a single dose of phenytoin suspension or capsules (5mg/kg/day) produced inadequate serum levels 16 and 24 hours after ingestion, and for this reason single dosage is not recommended; (2) twice-daily dosage of phenytoin suspension or capsules (5mg/kg/day) produced adequate serum levels in most children throughout the 24 hours, and this dosage is recommended; (3) 12 children continued to have seizures but when the dose was increased to 10mg/kg/day six of the 12 obtained control of seizures; (4) phenytoin reached equilibrium in the serum in five days provided the child had not previously been taking phenobarbitone; (5) of 13 children who had been taking phenobarbitone, 10 did not achieve equilibrium of phenytoin in serum for one to four weeks; (6) phenytoin suspension given twice-daily produced satisfactory serum levels provided the bottle was shaken well before dispensing; (7) apart from minor variations, phenytoin maintained its level in serum during the 14 to 30 months follow-up period, whether 5mg or 10mg/kg/day of phenytoin was given. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498

Prognosis After Grand Mal Seizures: a Study of 187 Children with Three-Year Remissions / P. EHRHARDT in Developmental Medicine & Child Neurology, 31-5 (October 1989)

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Propanolol ('Inderal') in the treatment of childhood migraine / W. I. FORSYTHE in Developmental Medicine & Child Neurology, 26-6 (December 1994)

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The treatment of childhood epilepsy with sodium valproate / D. HAIGH in Developmental Medicine & Child Neurology, 17-6 (December 1975)

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Treatment of multiple tics and the Tourette syndrome / D. GILLIES in Developmental Medicine & Child Neurology, 26-6 (December 1994)

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