Bio-availability and dissolution of three phenytoin preparations for children / Sally HODGES in Developmental Medicine & Child Neurology, 28-6 (December 1986)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 28-6 (December 1986) . - p.708-712 Titre : Bio-availability and dissolution of three phenytoin preparations for children Type de document : Texte imprimé et/ou numérique Auteurs : Sally HODGES, Auteur ; W. I. FORSYTHE, Auteur ; D. GILLIES, Auteur ; H. REMINGTON, Auteur ; A. CAWOOD, Auteur Année de publication : 1986 Article en page(s) : p.708-712 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A study of bio-availability of three drug companies' brands of phenytoin preparations (50mg capsule/tablets) was undertaken on 30 children with tonic-clonic or complex partial seizures. Eight children were excluded because of non-compliance and three because of abnormally high serum levels. Phenytoin capsules (Parke Davis) and tablets (Boots) produced significantly higher serum-level profiles than phenytoin tablets (Evans). Seizure frequencies did not differ significantly with the three brands of phenytoin. Dissolution of the three preparations tested in vitro was different. As a result of this study the authors recommend that children remain on the same manufacturer's brand of phenytoin throughout their treatment. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=620 [article] Bio-availability and dissolution of three phenytoin preparations for children [Texte imprimé et/ou numérique] / Sally HODGES, Auteur ; W. I. FORSYTHE, Auteur ; D. GILLIES, Auteur ; H. REMINGTON, Auteur ; A. CAWOOD, Auteur . - 1986 . - p.708-712. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 28-6 (December 1986) . - p.708-712 Index. décimale : PER Périodiques Résumé : A study of bio-availability of three drug companies' brands of phenytoin preparations (50mg capsule/tablets) was undertaken on 30 children with tonic-clonic or complex partial seizures. Eight children were excluded because of non-compliance and three because of abnormally high serum levels. Phenytoin capsules (Parke Davis) and tablets (Boots) produced significantly higher serum-level profiles than phenytoin tablets (Evans). Seizure frequencies did not differ significantly with the three brands of phenytoin. Dissolution of the three preparations tested in vitro was different. As a result of this study the authors recommend that children remain on the same manufacturer's brand of phenytoin throughout their treatment. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=620

Propanolol ('Inderal') in the treatment of childhood migraine / W. I. FORSYTHE in Developmental Medicine & Child Neurology, 26-6 (December 1994)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 26-6 (December 1994) . - p.737-741 Titre : Propanolol ('Inderal') in the treatment of childhood migraine Type de document : Texte imprimé et/ou numérique Auteurs : W. I. FORSYTHE, Auteur ; D. GILLIES, Auteur ; M. A. SILLS, Auteur Année de publication : 1984 Article en page(s) : p.737-741 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In a double-blind crossover study of 39 children with established migraine, there was no difference between treatment with propanolol and placebo as regards frequency, severity or average duration of migraine attacks. There was some evidence that propanolol increased the average length of headaches. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584 [article] Propanolol ('Inderal') in the treatment of childhood migraine [Texte imprimé et/ou numérique] / W. I. FORSYTHE, Auteur ; D. GILLIES, Auteur ; M. A. SILLS, Auteur . - 1984 . - p.737-741. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 26-6 (December 1994) . - p.737-741 Index. décimale : PER Périodiques Résumé : In a double-blind crossover study of 39 children with established migraine, there was no difference between treatment with propanolol and placebo as regards frequency, severity or average duration of migraine attacks. There was some evidence that propanolol increased the average length of headaches. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584

Rubinstein-Taybi syndrome: further evidence of a genetic aetiology / D. GILLIES in Developmental Medicine & Child Neurology, 27-6 (December 1985)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 27-6 (December 1985) . - p.751-755 Titre : Rubinstein-Taybi syndrome: further evidence of a genetic aetiology Type de document : Texte imprimé et/ou numérique Auteurs : D. GILLIES, Auteur ; S. H. ROUSSOUNIS, Auteur Année de publication : 1985 Article en page(s) : p.751-755 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Two families are described with Rubinstein-Taybi syndrome. In one family the syndrome is seen in its full form in the index case and his uncle; three cousins of the index case also show varying degrees of expression of the disorder. In the other family a brother and sister are affected. This case report illustrates the varying expression of the disorder and the change in facial appearance with age. A polygenic basis of inheritance is supported and it is suggested that the typical facial appearance in infancy is the best means of identifying the disorder, as broad thumbs and toes may not be apparent or may be only a borderline abnormality. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=598 [article] Rubinstein-Taybi syndrome: further evidence of a genetic aetiology [Texte imprimé et/ou numérique] / D. GILLIES, Auteur ; S. H. ROUSSOUNIS, Auteur . - 1985 . - p.751-755. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 27-6 (December 1985) . - p.751-755 Index. décimale : PER Périodiques Résumé : Two families are described with Rubinstein-Taybi syndrome. In one family the syndrome is seen in its full form in the index case and his uncle; three cousins of the index case also show varying degrees of expression of the disorder. In the other family a brother and sister are affected. This case report illustrates the varying expression of the disorder and the change in facial appearance with age. A polygenic basis of inheritance is supported and it is suggested that the typical facial appearance in infancy is the best means of identifying the disorder, as broad thumbs and toes may not be apparent or may be only a borderline abnormality. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=598

Treatment of multiple tics and the Tourette syndrome / D. GILLIES in Developmental Medicine & Child Neurology, 26-6 (December 1994)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 26-6 (December 1994) . - p.830-833 Titre : Treatment of multiple tics and the Tourette syndrome Type de document : Texte imprimé et/ou numérique Auteurs : D. GILLIES, Auteur ; W. I. FORSYTHE, Auteur Année de publication : 1984 Article en page(s) : p.830-833 Langues : Anglais (eng) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Treatment of multiple tics and the Tourette syndrome [Texte imprimé et/ou numérique] / D. GILLIES, Auteur ; W. I. FORSYTHE, Auteur . - 1984 . - p.830-833. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 26-6 (December 1994) . - p.830-833 Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

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