Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder / Yan LI in Journal of Autism and Developmental Disorders, 50-10 (October 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3800-3809 Titre : Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur Article en page(s) : p.3800-3809 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Deleted in colorectal carcinoma gene  Haplotype analysis  Single nucleotide polymorphisms  Susceptibility Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case-control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T-A haplotype (rs2229082-rs2270954), T-A-T-C haplotype (rs2229082-rs2270954-rs2292043-rs2292044), C-G-T-C-T haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043), C-G-T-C-T-G haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044), and G-G-T-C-C-C-C haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044-rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04417-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur . - p.3800-3809. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3800-3809 Mots-clés : Autism spectrum disorder  Deleted in colorectal carcinoma gene  Haplotype analysis  Single nucleotide polymorphisms  Susceptibility Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case-control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T-A haplotype (rs2229082-rs2270954), T-A-T-C haplotype (rs2229082-rs2270954-rs2292043-rs2292044), C-G-T-C-T haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043), C-G-T-C-T-G haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044), and G-G-T-C-C-C-C haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044-rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04417-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

rs1007893 and rs2070435 in DIP2A are associated with visual-reaction-behavior phenotype in Chinese Han population with autism spectrum disorder / Yan LI in Research in Autism Spectrum Disorders, 70 (February 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 70 (February 2020) . - p.101475 Titre : rs1007893 and rs2070435 in DIP2A are associated with visual-reaction-behavior phenotype in Chinese Han population with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Jikang SHI, Auteur ; Heran CUI, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur Article en page(s) : p.101475 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Disco-interacting protein 2 homolog agene  Single nucleotide polymorphisms  Behavior phenotype Index. décimale : PER Périodiques Résumé : Background The disco-interacting protein 2 homolog A gene (DIP2A) has been reported as a novel candidate gene of Autism spectrum disorder (ASD). Associations between single nucleotide polymorphisms (SNPs) and ASD behavior phenotypes provide an opportunity to timely treat an infant with potential ASD by earlier intervention targeting a specific behavior phenotype. Methods The association of SNPs (rs8130538, rs1007893, rs34736293, rs7279002, rs2070435, rs2255397, rs1107065,rs2248636) of DIP2A with both ASD susceptibility and ASD behaviour phenotypes were investigated in Chinese Han population using a case- control study on the basis of 231 ASD cases and 242 controls. Results The allele frequencies and genotype distributions of the eight SNPs of DIP2A in the cases were not different from those in the controls; the eight DIP2A SNPs were not associated with ASD risk under the five geneticmodels; and haplotypes were not different between the cases and the controls Conclusions We identified that rs1007893 and rs2070435 in DIP2A are associated with "visual reaction" behavior phenotype in Chinese Han population. En ligne : https://doi.org/10.1016/j.rasd.2019.101475 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414 [article] rs1007893 and rs2070435 in DIP2A are associated with visual-reaction-behavior phenotype in Chinese Han population with autism spectrum disorder [Texte imprimé et/ou numérique] / Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Jikang SHI, Auteur ; Heran CUI, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur . - p.101475. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 70 (February 2020) . - p.101475 Mots-clés : Autism spectrum disorder  Disco-interacting protein 2 homolog agene  Single nucleotide polymorphisms  Behavior phenotype Index. décimale : PER Périodiques Résumé : Background The disco-interacting protein 2 homolog A gene (DIP2A) has been reported as a novel candidate gene of Autism spectrum disorder (ASD). Associations between single nucleotide polymorphisms (SNPs) and ASD behavior phenotypes provide an opportunity to timely treat an infant with potential ASD by earlier intervention targeting a specific behavior phenotype. Methods The association of SNPs (rs8130538, rs1007893, rs34736293, rs7279002, rs2070435, rs2255397, rs1107065,rs2248636) of DIP2A with both ASD susceptibility and ASD behaviour phenotypes were investigated in Chinese Han population using a case- control study on the basis of 231 ASD cases and 242 controls. Results The allele frequencies and genotype distributions of the eight SNPs of DIP2A in the cases were not different from those in the controls; the eight DIP2A SNPs were not associated with ASD risk under the five geneticmodels; and haplotypes were not different between the cases and the controls Conclusions We identified that rs1007893 and rs2070435 in DIP2A are associated with "visual reaction" behavior phenotype in Chinese Han population. En ligne : https://doi.org/10.1016/j.rasd.2019.101475 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414

---

1 (1 - 2 / 2)