Associations Between Comorbidities, Developmental Status, and Disease Severity in Children With Autism Spectrum Disorder: A Multicenter Cross-Sectional Study in China / Dizhou PANG in Autism Research, 19-6 (June 2026)  

Public ISBD [article]  inAutism Research > 19-6 (June 2026) . - p.e70253 Titre : Associations Between Comorbidities, Developmental Status, and Disease Severity in Children With Autism Spectrum Disorder: A Multicenter Cross-Sectional Study in China Type de document : texte imprimé Auteurs : Dizhou PANG, Auteur ; Guiqin DUAN, Auteur ; Qing SHANG, Auteur ; Huichun ZHANG, Auteur ; Binbin WANG, Auteur ; Huaili DING, Auteur ; Huihui KANG, Auteur ; Yue ZHAO, Auteur ; Yuxia LU, Auteur ; Gai TIAN, Auteur ; Li ZHANG, Auteur ; Wu JIANG, Auteur ; Ganyu WANG, Auteur ; Cailing LIANG, Auteur ; Lingling ZHANG, Auteur ; Bingbing LI, Auteur ; Zhenghua LI, Auteur ; Chunlan SONG, Auteur ; Yanyan YANG, Auteur ; Yazhe WANG, Auteur ; Kaichen YUE, Auteur ; Yongbin LANG, Auteur ; Jiatian LIU, Auteur ; Xiaoli ZHANG, Auteur ; Yiran XU, Auteur ; Changlian ZHU, Auteur Article en page(s) : p.e70253 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  childhood autism rating scale  comorbidities  disease severity  Gesell developmental schedule  intellectual developmental disorders  Wechsler intelligence scales Index. décimale : PER Périodiques Résumé : ABSTRACT Children with autism spectrum disorder (ASD) frequently present with co-occurring conditions that can influence autism symptom severity and complicate clinical management. However, studies with clinician-confirmed diagnoses in non-Western populations remain limited. In this multicenter cross-sectional study, 1279 children aged 3?14?years with DSM-5-confirmed ASD were recruited from eight medical centers in China. Autism symptom severity was assessed using the Childhood Autism Rating Scale (CARS). Comorbidities were identified through clinical evaluation and specialized assessments, and developmental status was measured using the Gesell Developmental Schedule (GDS) and Wechsler Intelligence Scales. Associations with CARS scores were analyzed using generalized linear regression. Of participants, 96.6% had at least one comorbidity and 71.2% had multiple comorbidities. Common conditions were intellectual developmental disorders (IDD) (87.3%), food selectivity (45.3%), insomnia disorder (16.9%), developmental regression (15.6%), and behavioral problems (14.6%). Patterns differed by sex and age: gastrointestinal problem and sleep-related interventions were more common in girls, whereas food selectivity was more common in boys. Older children showed higher rates of tic disorders, asthma, epilepsy, and offensive language, although these findings should be interpreted cautiously because the subgroup aged ≥?6?years was small. In adjusted analyses, IDD, food selectivity, pica, insomnia disorder, and developmental regression were associated with higher CARS scores, whereas higher GDS and Wechsler scores were associated with lower CARS scores. In this Chinese cohort, comorbidities were prevalent and showed distinct sex- and age-related patterns. Several comorbidities were associated with greater autism symptom severity, underscoring the importance of comprehensive developmental and medical assessment in ASD care. En ligne : https://doi.org/10.1002/aur.70253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Associations Between Comorbidities, Developmental Status, and Disease Severity in Children With Autism Spectrum Disorder: A Multicenter Cross-Sectional Study in China [texte imprimé] / Dizhou PANG, Auteur ; Guiqin DUAN, Auteur ; Qing SHANG, Auteur ; Huichun ZHANG, Auteur ; Binbin WANG, Auteur ; Huaili DING, Auteur ; Huihui KANG, Auteur ; Yue ZHAO, Auteur ; Yuxia LU, Auteur ; Gai TIAN, Auteur ; Li ZHANG, Auteur ; Wu JIANG, Auteur ; Ganyu WANG, Auteur ; Cailing LIANG, Auteur ; Lingling ZHANG, Auteur ; Bingbing LI, Auteur ; Zhenghua LI, Auteur ; Chunlan SONG, Auteur ; Yanyan YANG, Auteur ; Yazhe WANG, Auteur ; Kaichen YUE, Auteur ; Yongbin LANG, Auteur ; Jiatian LIU, Auteur ; Xiaoli ZHANG, Auteur ; Yiran XU, Auteur ; Changlian ZHU, Auteur . - p.e70253. Langues : Anglais (eng) in Autism Research > 19-6 (June 2026) . - p.e70253 Mots-clés : autism spectrum disorder  childhood autism rating scale  comorbidities  disease severity  Gesell developmental schedule  intellectual developmental disorders  Wechsler intelligence scales Index. décimale : PER Périodiques Résumé : ABSTRACT Children with autism spectrum disorder (ASD) frequently present with co-occurring conditions that can influence autism symptom severity and complicate clinical management. However, studies with clinician-confirmed diagnoses in non-Western populations remain limited. In this multicenter cross-sectional study, 1279 children aged 3?14?years with DSM-5-confirmed ASD were recruited from eight medical centers in China. Autism symptom severity was assessed using the Childhood Autism Rating Scale (CARS). Comorbidities were identified through clinical evaluation and specialized assessments, and developmental status was measured using the Gesell Developmental Schedule (GDS) and Wechsler Intelligence Scales. Associations with CARS scores were analyzed using generalized linear regression. Of participants, 96.6% had at least one comorbidity and 71.2% had multiple comorbidities. Common conditions were intellectual developmental disorders (IDD) (87.3%), food selectivity (45.3%), insomnia disorder (16.9%), developmental regression (15.6%), and behavioral problems (14.6%). Patterns differed by sex and age: gastrointestinal problem and sleep-related interventions were more common in girls, whereas food selectivity was more common in boys. Older children showed higher rates of tic disorders, asthma, epilepsy, and offensive language, although these findings should be interpreted cautiously because the subgroup aged ≥?6?years was small. In adjusted analyses, IDD, food selectivity, pica, insomnia disorder, and developmental regression were associated with higher CARS scores, whereas higher GDS and Wechsler scores were associated with lower CARS scores. In this Chinese cohort, comorbidities were prevalent and showed distinct sex- and age-related patterns. Several comorbidities were associated with greater autism symptom severity, underscoring the importance of comprehensive developmental and medical assessment in ASD care. En ligne : https://doi.org/10.1002/aur.70253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

The Influence of Irrelevant Visual Distractors on Eye Movement Control in Chinese Children with Autism Spectrum Disorder: Evidence from the Remote Distractor Paradigm / Li ZHANG in Journal of Autism and Developmental Disorders, 50-2 (February 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-2 (February 2020) . - p.500-512 Titre : The Influence of Irrelevant Visual Distractors on Eye Movement Control in Chinese Children with Autism Spectrum Disorder: Evidence from the Remote Distractor Paradigm Type de document : texte imprimé Auteurs : Li ZHANG, Auteur ; Guoli YAN, Auteur ; Li ZHOU, Auteur ; Zebo LAN, Auteur ; Valerie BENSON, Auteur Article en page(s) : p.500-512 Langues : Anglais (eng) Mots-clés : Asd  Eye movement control  Remote distractor effect  Visual distractor Index. décimale : PER Périodiques Résumé : The current study examined eye movement control in autistic (ASD) children. Simple targets were presented in isolation, or with central, parafoveal, or peripheral distractors synchronously. Sixteen children with ASD (47-81 months) and nineteen age and IQ matched typically developing children were instructed to look to the target as accurately and quickly as possible. Both groups showed high proportions (40%) of saccadic errors towards parafoveal and peripheral distractors. For correctly executed eye movements to the targets, centrally presented distractors produced the longest latencies (time taken to initiate eye movements), followed by parafoveal and peripheral distractor conditions. Central distractors had a greater effect in the ASD group, indicating evidence for potential atypical voluntary attentional control in ASD children. En ligne : http://dx.doi.org/10.1007/s10803-019-04271-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416 [article] The Influence of Irrelevant Visual Distractors on Eye Movement Control in Chinese Children with Autism Spectrum Disorder: Evidence from the Remote Distractor Paradigm [texte imprimé] / Li ZHANG, Auteur ; Guoli YAN, Auteur ; Li ZHOU, Auteur ; Zebo LAN, Auteur ; Valerie BENSON, Auteur . - p.500-512. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-2 (February 2020) . - p.500-512 Mots-clés : Asd  Eye movement control  Remote distractor effect  Visual distractor Index. décimale : PER Périodiques Résumé : The current study examined eye movement control in autistic (ASD) children. Simple targets were presented in isolation, or with central, parafoveal, or peripheral distractors synchronously. Sixteen children with ASD (47-81 months) and nineteen age and IQ matched typically developing children were instructed to look to the target as accurately and quickly as possible. Both groups showed high proportions (40%) of saccadic errors towards parafoveal and peripheral distractors. For correctly executed eye movements to the targets, centrally presented distractors produced the longest latencies (time taken to initiate eye movements), followed by parafoveal and peripheral distractor conditions. Central distractors had a greater effect in the ASD group, indicating evidence for potential atypical voluntary attentional control in ASD children. En ligne : http://dx.doi.org/10.1007/s10803-019-04271-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416

The Relationship Between Parenting Stress and Parental Burnout Among Chinese Parents of Children with ASD: A Moderated Mediation Model / Shuyu LIU in Journal of Autism and Developmental Disorders, 54-4 (April 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-4 (April 2024) . - p.1527-1537 Titre : The Relationship Between Parenting Stress and Parental Burnout Among Chinese Parents of Children with ASD: A Moderated Mediation Model Type de document : texte imprimé Auteurs : Shuyu LIU, Auteur ; Li ZHANG, Auteur ; Jintian YI, Auteur ; Sige LIU, Auteur ; DAN LI, Auteur ; Dehua WU, Auteur ; Huazhan YIN, Auteur Article en page(s) : p.1527-1537 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study investigated the role of resilience as a mediator and the place of residence as a moderator of parenting stress and parental burnout. The Parenting Stress Index-Short Form, Parental Burnout Assessment, and Connor-Davidson Resilience Scale were administered to 249 Chinese parents of children with ASD (M = 33.95 years, SD = 7.6). Results show that resilience partially mediates the relation between parenting stress and parental burnout. Besides, both the effect of parenting stress on parental burnout and the mediating effect of resilience are moderated by rural/urban residence. This study highlights parenting stress is a risk factor for parental burnout and resilience is the potential mechanism underlying this relation. These findings provide implications for family services for parents of children with ASD. En ligne : https://doi.org/10.1007/s10803-022-05854-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 [article] The Relationship Between Parenting Stress and Parental Burnout Among Chinese Parents of Children with ASD: A Moderated Mediation Model [texte imprimé] / Shuyu LIU, Auteur ; Li ZHANG, Auteur ; Jintian YI, Auteur ; Sige LIU, Auteur ; DAN LI, Auteur ; Dehua WU, Auteur ; Huazhan YIN, Auteur . - p.1527-1537. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-4 (April 2024) . - p.1527-1537 Index. décimale : PER Périodiques Résumé : This study investigated the role of resilience as a mediator and the place of residence as a moderator of parenting stress and parental burnout. The Parenting Stress Index-Short Form, Parental Burnout Assessment, and Connor-Davidson Resilience Scale were administered to 249 Chinese parents of children with ASD (M = 33.95 years, SD = 7.6). Results show that resilience partially mediates the relation between parenting stress and parental burnout. Besides, both the effect of parenting stress on parental burnout and the mediating effect of resilience are moderated by rural/urban residence. This study highlights parenting stress is a risk factor for parental burnout and resilience is the potential mechanism underlying this relation. These findings provide implications for family services for parents of children with ASD. En ligne : https://doi.org/10.1007/s10803-022-05854-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526

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