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Auteur Yayuk JOFFRES |
Documents disponibles écrits par cet auteur (1)
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Neurocognitive risk markers in pediatric obsessive-compulsive disorder / Juliana NEGREIROS in Journal of Child Psychology and Psychiatry, 61-5 (May 2020)
[article]
Titre : Neurocognitive risk markers in pediatric obsessive-compulsive disorder Type de document : Texte imprimé et/ou numérique Auteurs : Juliana NEGREIROS, Auteur ; Laura BELSCHNER, Auteur ; John R. BEST, Auteur ; Sarah LIN, Auteur ; Diana FRANCO YAMIN, Auteur ; Yayuk JOFFRES, Auteur ; Robert R. SELLES, Auteur ; Fern JASPERS-FAYER, Auteur ; Lynn D. MILLER, Auteur ; Todd S. WOODWARD, Auteur ; William G. HONER, Auteur ; S. Evelyn STEWART, Auteur Article en page(s) : p.605-613 Langues : Anglais (eng) Mots-clés : Cognitive Obsessive-compulsive disorder biomarker genetics pediatrics Index. décimale : PER Périodiques Résumé : BACKGROUND: Obsessive-compulsive disorder (OCD) has complex genetic underpinnings, particularly in its early-onset form, which places siblings at a 10-fold increased risk of developing the disorder. Examination for neurocognitive markers preceding pediatric OCD onset has not been conducted, although markers have been identified in adult OCD. This study compared neurocognition across groups of OCD-affected youth (n = 87), unaffected siblings of those with early-onset OCD (n = 67), and healthy controls (HC; n = 79). METHODS: A total of 233 participants aged 6-18 years old completed standardized neurocognitive tests of cognitive flexibility, decision making, planning, response inhibition, spatial working memory, attention, recognition nonverbal memory, and intelligence. They were administered the Anxiety Disorders Interview Schedule-Parent version (ADIS-P) and completed self-report anxiety and OCD questionnaires. Linear mixed-effects models tested for differences between groups, adjusting for age, gender, IQ, state anxiety, and ethnicity, and accounting for random effects of family membership. RESULTS: OCD-affected youth and unaffected siblings performed significantly worse on planning in comparison to HCs (Cohen's d = 0.74; 95% CI = [0.11, 1.36]; Cohen's d = 0.75; 95% CI = [0.12, 1.38], respectively; omnibus group effect p = .007). No other significant between-group differences were identified. CONCLUSIONS: Neurocognitive performance differences between groups identified planning as a preexisting trait marker of pediatric OCD, while no other domain presented as a marker of pediatric OCD. This differs from adult OCD, which is associated with broader cognitive impairments. Investigating longitudinal trajectories and predictive significance of neurocognition in those affected by, and at risk for, early-onset OCD is warranted. Ideally, this will enhance individualized risk stratification and inform future prevention and early intervention strategies. En ligne : http://dx.doi.org/10.1111/jcpp.13153 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422
in Journal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.605-613[article] Neurocognitive risk markers in pediatric obsessive-compulsive disorder [Texte imprimé et/ou numérique] / Juliana NEGREIROS, Auteur ; Laura BELSCHNER, Auteur ; John R. BEST, Auteur ; Sarah LIN, Auteur ; Diana FRANCO YAMIN, Auteur ; Yayuk JOFFRES, Auteur ; Robert R. SELLES, Auteur ; Fern JASPERS-FAYER, Auteur ; Lynn D. MILLER, Auteur ; Todd S. WOODWARD, Auteur ; William G. HONER, Auteur ; S. Evelyn STEWART, Auteur . - p.605-613.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.605-613
Mots-clés : Cognitive Obsessive-compulsive disorder biomarker genetics pediatrics Index. décimale : PER Périodiques Résumé : BACKGROUND: Obsessive-compulsive disorder (OCD) has complex genetic underpinnings, particularly in its early-onset form, which places siblings at a 10-fold increased risk of developing the disorder. Examination for neurocognitive markers preceding pediatric OCD onset has not been conducted, although markers have been identified in adult OCD. This study compared neurocognition across groups of OCD-affected youth (n = 87), unaffected siblings of those with early-onset OCD (n = 67), and healthy controls (HC; n = 79). METHODS: A total of 233 participants aged 6-18 years old completed standardized neurocognitive tests of cognitive flexibility, decision making, planning, response inhibition, spatial working memory, attention, recognition nonverbal memory, and intelligence. They were administered the Anxiety Disorders Interview Schedule-Parent version (ADIS-P) and completed self-report anxiety and OCD questionnaires. Linear mixed-effects models tested for differences between groups, adjusting for age, gender, IQ, state anxiety, and ethnicity, and accounting for random effects of family membership. RESULTS: OCD-affected youth and unaffected siblings performed significantly worse on planning in comparison to HCs (Cohen's d = 0.74; 95% CI = [0.11, 1.36]; Cohen's d = 0.75; 95% CI = [0.12, 1.38], respectively; omnibus group effect p = .007). No other significant between-group differences were identified. CONCLUSIONS: Neurocognitive performance differences between groups identified planning as a preexisting trait marker of pediatric OCD, while no other domain presented as a marker of pediatric OCD. This differs from adult OCD, which is associated with broader cognitive impairments. Investigating longitudinal trajectories and predictive significance of neurocognition in those affected by, and at risk for, early-onset OCD is warranted. Ideally, this will enhance individualized risk stratification and inform future prevention and early intervention strategies. En ligne : http://dx.doi.org/10.1111/jcpp.13153 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422