Camouflaging in Autistic Adults is Modulated by Autistic and Neurotypical Characteristics of Interaction Partners / Ren FUNAWATARI in Journal of Autism and Developmental Disorders, 55-10 (October 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-10 (October 2025) . - p.3678-3688 Titre : Camouflaging in Autistic Adults is Modulated by Autistic and Neurotypical Characteristics of Interaction Partners Type de document : texte imprimé Auteurs : Ren FUNAWATARI, Auteur ; Motofumi SUMIYA, Auteur ; Toshiki IWABUCHI, Auteur ; Tomoko NISHIMURA, Auteur ; Hidetsugu KOMEDA, Auteur ; Atsushi SENJU, Auteur Article en page(s) : p.3678-3688 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Many autistic people reportedly engage in camouflaging to navigate everyday social interactions; however, the function of this behavior remains largely unknown. We hypothesized that autistic people camouflage more toward neurotypical others than toward autistic others, employing it as a strategy to “fit in” within the neurotypical-majority community. This study aimed to empirically investigate this hypothesis for the first time. Autistic and neurotypical participants took part in a web-based survey. Data from 48 autistic and 137 neurotypical participants were analyzed. Camouflaging toward autistic and neurotypical others was separately measured using the modified Camouflaging Autistic Traits Questionnaire (CAT-Q). For each CAT-Q item, a sentence describing a hypothetical interaction partner with autistic or neurotypical characteristics was added, creating respective sentence conditions. The interaction effect of the participants’ characteristics and sentence conditions was analyzed using a multilevel regression analysis, accounting for differing individual baselines. The analysis revealed an interaction effect between participants’ characteristics and sentence conditions. The autistic group showed significantly more camouflaging in the autistic sentence condition than in the neurotypical sentence condition. Conversely, the neurotypical group did not differ significantly in camouflaging levels in the sentence conditions. Contrary to our hypothesis, autistic people demonstrated more camouflaging toward autistic others than toward neurotypical others. This finding questions the assumption that autistic people camouflage to assimilate into a neurotypical-majority society. Instead, it could be conceptualized as a more general social strategy used by autistic people aiming to improve their relationships with others. En ligne : https://doi.org/10.1007/s10803-024-06481-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 [article] Camouflaging in Autistic Adults is Modulated by Autistic and Neurotypical Characteristics of Interaction Partners [texte imprimé] / Ren FUNAWATARI, Auteur ; Motofumi SUMIYA, Auteur ; Toshiki IWABUCHI, Auteur ; Tomoko NISHIMURA, Auteur ; Hidetsugu KOMEDA, Auteur ; Atsushi SENJU, Auteur . - p.3678-3688. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-10 (October 2025) . - p.3678-3688 Index. décimale : PER Périodiques Résumé : Many autistic people reportedly engage in camouflaging to navigate everyday social interactions; however, the function of this behavior remains largely unknown. We hypothesized that autistic people camouflage more toward neurotypical others than toward autistic others, employing it as a strategy to “fit in” within the neurotypical-majority community. This study aimed to empirically investigate this hypothesis for the first time. Autistic and neurotypical participants took part in a web-based survey. Data from 48 autistic and 137 neurotypical participants were analyzed. Camouflaging toward autistic and neurotypical others was separately measured using the modified Camouflaging Autistic Traits Questionnaire (CAT-Q). For each CAT-Q item, a sentence describing a hypothetical interaction partner with autistic or neurotypical characteristics was added, creating respective sentence conditions. The interaction effect of the participants’ characteristics and sentence conditions was analyzed using a multilevel regression analysis, accounting for differing individual baselines. The analysis revealed an interaction effect between participants’ characteristics and sentence conditions. The autistic group showed significantly more camouflaging in the autistic sentence condition than in the neurotypical sentence condition. Conversely, the neurotypical group did not differ significantly in camouflaging levels in the sentence conditions. Contrary to our hypothesis, autistic people demonstrated more camouflaging toward autistic others than toward neurotypical others. This finding questions the assumption that autistic people camouflage to assimilate into a neurotypical-majority society. Instead, it could be conceptualized as a more general social strategy used by autistic people aiming to improve their relationships with others. En ligne : https://doi.org/10.1007/s10803-024-06481-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568

Sensory Processing Patterns and Fusiform Activity During Face Processing in Autism Spectrum Disorder / Ayaka KUNO-FUJITA in Autism Research, 13-5 (May 2020)  

Public ISBD [article]  inAutism Research > 13-5 (May 2020) . - p.741-750 Titre : Sensory Processing Patterns and Fusiform Activity During Face Processing in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Ayaka KUNO-FUJITA, Auteur ; Toshiki IWABUCHI, Auteur ; Keisuke WAKUSAWA, Auteur ; Hiroyuki ITO, Auteur ; Katsuaki SUZUKI, Auteur ; Akira SHIGETOMI, Auteur ; Kosaka HIROTAKA, Auteur ; Masatsugu TSUJII, Auteur ; Kenji J. TSUCHIYA, Auteur Article en page(s) : p.741-750 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  fMRI  face processing  fusiform gyrus  sensory processing  sensory profile Index. décimale : PER Périodiques Résumé : A growing body of evidence has indicated that individuals with autism spectrum disorder (ASD) exhibit abnormal reactions to sensory stimuli and impaired face processing. Although behavioral studies have reported that individual differences in sensory processing patterns are correlated with performance in face processing tasks, the neural substrates underlying the association between sensory processing patterns and face processing remain unknown. Using functional magnetic resonance imaging, the present study examined the relationships between sensory processing patterns assessed with the Adolescent/Adult Sensory Profile (AASP) and brain activity during a one-back task with two types of stimuli (face or house pictures). We enrolled 18 Japanese adults with ASD and 19 age- and IQ-matched controls. Sensation Avoiding scores, which were assessed using the AASP, were positively correlated with right fusiform activity during the presentation of pictures of faces in the ASD group, but not in the control group. This suggests that abnormal sensory processing patterns in ASD are associated with abnormal face-related brain activity, possibly resulting in impaired face processing. Autism Res 2020, 13: 741-750. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Sensory abnormalities are one of the most common symptoms in people with autism spectrum disorder (ASD). This study shows that individuals with ASD who react abnormally to sensory stimuli also exhibit atypical brain activity when recognizing faces. Abnormal sensory processing may partly explain the difficulty that people diagnosed with ASD have in identifying others' faces. En ligne : http://dx.doi.org/10.1002/aur.2283 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Sensory Processing Patterns and Fusiform Activity During Face Processing in Autism Spectrum Disorder [texte imprimé] / Ayaka KUNO-FUJITA, Auteur ; Toshiki IWABUCHI, Auteur ; Keisuke WAKUSAWA, Auteur ; Hiroyuki ITO, Auteur ; Katsuaki SUZUKI, Auteur ; Akira SHIGETOMI, Auteur ; Kosaka HIROTAKA, Auteur ; Masatsugu TSUJII, Auteur ; Kenji J. TSUCHIYA, Auteur . - p.741-750. Langues : Anglais (eng) in Autism Research > 13-5 (May 2020) . - p.741-750 Mots-clés : autism spectrum disorder  fMRI  face processing  fusiform gyrus  sensory processing  sensory profile Index. décimale : PER Périodiques Résumé : A growing body of evidence has indicated that individuals with autism spectrum disorder (ASD) exhibit abnormal reactions to sensory stimuli and impaired face processing. Although behavioral studies have reported that individual differences in sensory processing patterns are correlated with performance in face processing tasks, the neural substrates underlying the association between sensory processing patterns and face processing remain unknown. Using functional magnetic resonance imaging, the present study examined the relationships between sensory processing patterns assessed with the Adolescent/Adult Sensory Profile (AASP) and brain activity during a one-back task with two types of stimuli (face or house pictures). We enrolled 18 Japanese adults with ASD and 19 age- and IQ-matched controls. Sensation Avoiding scores, which were assessed using the AASP, were positively correlated with right fusiform activity during the presentation of pictures of faces in the ASD group, but not in the control group. This suggests that abnormal sensory processing patterns in ASD are associated with abnormal face-related brain activity, possibly resulting in impaired face processing. Autism Res 2020, 13: 741-750. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Sensory abnormalities are one of the most common symptoms in people with autism spectrum disorder (ASD). This study shows that individuals with ASD who react abnormally to sensory stimuli also exhibit atypical brain activity when recognizing faces. Abnormal sensory processing may partly explain the difficulty that people diagnosed with ASD have in identifying others' faces. En ligne : http://dx.doi.org/10.1002/aur.2283 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder / Toshiki IWABUCHI in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2451-2462 Titre : Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Toshiki IWABUCHI, Auteur ; Takaharu HIRAI, Auteur ; Naoko UMEDA, Auteur ; Hideto YOGO, Auteur ; Yuuta NISHIMIYA, Auteur ; Yuuki NISHIGAKI, Auteur ; Masaru WATANABE, Auteur ; Hidenori YAMASUE, Auteur ; Masatsugu TSUJII, Auteur ; Kenji J. TSUCHIYA, Auteur ; Hideo MATSUZAKI, Auteur Article en page(s) : p.2451-2462 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  glutathione  magnetic resonance spectroscopy  myelin map  resting-state functional connectivity Index. décimale : PER Périodiques Résumé : ABSTRACT Recent studies have implicated oxidative stress in the pathophysiology of autism spectrum disorder (ASD). Postmortem brain studies have revealed decreased levels of the reduced form of glutathione (GSH), an important antioxidant, in some brain regions in individuals with ASD; however, in vivo evidence is lacking. Using proton magnetic resonance spectroscopy, T1-weighted/T2-weighted ratio-derived myelin maps, resting-state functional magnetic resonance imaging (MRI), and cognitive tasks, we examined whether brain GSH levels are lower in individuals with ASD than in those with typical development (TD) and explored ASD-specific association patterns between brain GSH levels, myelination, functional connectivity, and behavioral characteristics. Data from 30 adults with ASD and 27 adults with TD were analyzed. Contrary to our hypothesis, GSH levels in the left temporoparietal junction (TPJ) were higher in the ASD group than in the TD group. Using individual myelin maps, we found a significant group difference in the correlation between left middle frontal gyrus (MFG) myelination and left TPJ GSH levels. Multivariate pattern analysis of resting-state functional MRI revealed that whole-brain functional connectivity patterns from the left MFG differed between the groups in their association with left MFG myelination. Finally, we found a significant group difference in the correlation between emotion recognition ability and the functional connectivity of the left MFG with the bilateral occipitoparietal junction. In conclusion, our findings demonstrate an ASD-specific pattern of associations between left TPJ GSH levels, left MFG myelination, whole-brain functional connectivity patterns of the left MFG, and cognitive phenotype, which suggests compensatory neural mechanisms in ASD. En ligne : https://doi.org/10.1002/aur.70134 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder [texte imprimé] / Toshiki IWABUCHI, Auteur ; Takaharu HIRAI, Auteur ; Naoko UMEDA, Auteur ; Hideto YOGO, Auteur ; Yuuta NISHIMIYA, Auteur ; Yuuki NISHIGAKI, Auteur ; Masaru WATANABE, Auteur ; Hidenori YAMASUE, Auteur ; Masatsugu TSUJII, Auteur ; Kenji J. TSUCHIYA, Auteur ; Hideo MATSUZAKI, Auteur . - p.2451-2462. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2451-2462 Mots-clés : autism spectrum disorder  glutathione  magnetic resonance spectroscopy  myelin map  resting-state functional connectivity Index. décimale : PER Périodiques Résumé : ABSTRACT Recent studies have implicated oxidative stress in the pathophysiology of autism spectrum disorder (ASD). Postmortem brain studies have revealed decreased levels of the reduced form of glutathione (GSH), an important antioxidant, in some brain regions in individuals with ASD; however, in vivo evidence is lacking. Using proton magnetic resonance spectroscopy, T1-weighted/T2-weighted ratio-derived myelin maps, resting-state functional magnetic resonance imaging (MRI), and cognitive tasks, we examined whether brain GSH levels are lower in individuals with ASD than in those with typical development (TD) and explored ASD-specific association patterns between brain GSH levels, myelination, functional connectivity, and behavioral characteristics. Data from 30 adults with ASD and 27 adults with TD were analyzed. Contrary to our hypothesis, GSH levels in the left temporoparietal junction (TPJ) were higher in the ASD group than in the TD group. Using individual myelin maps, we found a significant group difference in the correlation between left middle frontal gyrus (MFG) myelination and left TPJ GSH levels. Multivariate pattern analysis of resting-state functional MRI revealed that whole-brain functional connectivity patterns from the left MFG differed between the groups in their association with left MFG myelination. Finally, we found a significant group difference in the correlation between emotion recognition ability and the functional connectivity of the left MFG with the bilateral occipitoparietal junction. In conclusion, our findings demonstrate an ASD-specific pattern of associations between left TPJ GSH levels, left MFG myelination, whole-brain functional connectivity patterns of the left MFG, and cognitive phenotype, which suggests compensatory neural mechanisms in ASD. En ligne : https://doi.org/10.1002/aur.70134 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

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