95 recherche sur le mot-clé 'fMRI'

Advanced ASD detection through facial and fMRI data integration with attention guidance / B. MAGESH KUMAR in Research in Autism, 130 (February 2026)  

Public ISBD [article]  inResearch in Autism > 130 (February 2026) . - p.202766 Titre : Advanced ASD detection through facial and fMRI data integration with attention guidance Type de document : texte imprimé Auteurs : B. MAGESH KUMAR, Auteur ; K. PREMALATHA, Auteur ; S. JOTHIMANI, Auteur Article en page(s) : p.202766 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Multimodal Fusion  FMRI  Facial Images  Attention Mechanism  Deep Learning  Neuroimaging Index. décimale : PER Périodiques Résumé : Diagnosing Autism Spectrum Disorder (ASD) quickly and reliably has long frustrated clinicians because the condition arises from intricate brain development and depends almost entirely on behavioural signs. To overcome this problem, we present a mixed deep-learning system that pairs facial-image analysis with resting-fMRI scans to more precisely detect ASD. Each input type passes through its pre-processing chain, winning out over noise, misalignment, and across-subject differences that can cloud analysis. Facial pictures are aligned using keypoint landmarks and contrast enhancement, while fMRI volumes undergo motion correction, Gaussian smoothing, and ICA-AROMA-based artifact cleaning. Critical characteristics are then extracted from the two channels by distinct convolutional networks and integrated by an attention-driven fusion layer that learns to highlight the most informative areas. As a result, the final multimodal classifier can use complementary facial and neural cues to produce more distinct lines between normal and abnormal development. Experimental evaluation, conducted using stratified 5-fold cross-validation, demonstrated that the proposed multimodal framework achieved a test accuracy of 95.24 %, precision of 95.00 %, recall of 95.50 %, and F1-score of 95.25 %, outperforming the unimodal baseline. Visualization of intermediate feature maps confirmed that the Model focuses on salient regions in both facial and neurofunctional modalities. These results highlight the potential of the proposed multimodal approach as a reliable and interpretable diagnostic tool for clinical detection of ASD. En ligne : https://doi.org/10.1016/j.reia.2025.202766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579 [article] Advanced ASD detection through facial and fMRI data integration with attention guidance [texte imprimé] / B. MAGESH KUMAR, Auteur ; K. PREMALATHA, Auteur ; S. JOTHIMANI, Auteur . - p.202766. Langues : Anglais (eng) in Research in Autism > 130 (February 2026) . - p.202766 Mots-clés : Autism Spectrum Disorder  Multimodal Fusion  FMRI  Facial Images  Attention Mechanism  Deep Learning  Neuroimaging Index. décimale : PER Périodiques Résumé : Diagnosing Autism Spectrum Disorder (ASD) quickly and reliably has long frustrated clinicians because the condition arises from intricate brain development and depends almost entirely on behavioural signs. To overcome this problem, we present a mixed deep-learning system that pairs facial-image analysis with resting-fMRI scans to more precisely detect ASD. Each input type passes through its pre-processing chain, winning out over noise, misalignment, and across-subject differences that can cloud analysis. Facial pictures are aligned using keypoint landmarks and contrast enhancement, while fMRI volumes undergo motion correction, Gaussian smoothing, and ICA-AROMA-based artifact cleaning. Critical characteristics are then extracted from the two channels by distinct convolutional networks and integrated by an attention-driven fusion layer that learns to highlight the most informative areas. As a result, the final multimodal classifier can use complementary facial and neural cues to produce more distinct lines between normal and abnormal development. Experimental evaluation, conducted using stratified 5-fold cross-validation, demonstrated that the proposed multimodal framework achieved a test accuracy of 95.24 %, precision of 95.00 %, recall of 95.50 %, and F1-score of 95.25 %, outperforming the unimodal baseline. Visualization of intermediate feature maps confirmed that the Model focuses on salient regions in both facial and neurofunctional modalities. These results highlight the potential of the proposed multimodal approach as a reliable and interpretable diagnostic tool for clinical detection of ASD. En ligne : https://doi.org/10.1016/j.reia.2025.202766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579

An fMRI study of facial emotion processing in children and adolescents with 22q11.2 deletion syndrome / Rayna AZUMA in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.1 Titre : An fMRI study of facial emotion processing in children and adolescents with 22q11.2 deletion syndrome Type de document : texte imprimé Auteurs : Rayna AZUMA, Auteur ; Quinton DEELEY, Auteur ; Linda E. CAMPBELL, Auteur ; Eileen DALY, Auteur ; Vincent GIAMPIETRO, Auteur ; Michael BRAMMER, Auteur ; Kieran C. MURPHY, Auteur ; Declan G.M. MURPHY, Auteur Article en page(s) : p.1 Langues : Anglais (eng) Mots-clés : 22q11.2 deletion syndrome (22q11DS)  Children  Emotion  Social cognition  Velo-cardio-facial syndrome (VCFS)  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: 22q11.2 deletion syndrome (22q11DS, velo-cardio-facial syndrome [VCFS]) is a genetic disorder associated with interstitial deletions of chromosome 22q11.2. In addition to high rates of neuropsychiatric disorders, children with 22q11DS have impairments of face processing, as well as IQ-independent deficits in visuoperceptual function and social and abstract reasoning. These face-processing deficits may contribute to the social impairments of 22q11DS. However, their neurobiological basis is poorly understood. METHODS: We used event-related functional magnetic resonance imaging (fMRI) to examine neural responses when children with 22q11DS (aged 9-17 years) and healthy controls (aged 8-17 years) incidentally processed neutral expressions and mild (50%) and intense (100%) expressions of fear and disgust. We included 28 right-handed children and adolescents: 14 with 22q11DS and 14 healthy (including nine siblings) controls. RESULTS: Within groups, contrasts showed that individuals significantly activated 'face responsive' areas when viewing neutral faces, including fusiform-extrastriate cortices. Further, within both groups, there was a significant positive linear trend in activation of fusiform-extrastriate cortices and cerebellum to increasing intensities of fear. There were, however, also between-group differences. Children with 22q11DS generally showed reduced activity as compared to controls in brain regions involved in social cognition and emotion processing across emotion types and intensities, including fusiform-extrastriate cortices, anterior cingulate cortex (Brodmann area (BA) 24/32), and superomedial prefrontal cortices (BA 6). Also, an exploratory correlation analysis showed that within 22q11DS children reduced activation was associated with behavioural impairment-social difficulties (measured using the Total Difficulties Score from the Strengths and Difficulties Questionnaire [SDQ]) were significantly negatively correlated with brain activity during fear and disgust processing (respectively) in the left precentral gyrus (BA 4) and in the left fusiform gyrus (FG, BA 19), right lingual gyrus (BA 18), and bilateral cerebellum. CONCLUSIONS: Regions involved in face processing, including fusiform-extrastriate cortices, anterior cingulate gyri, and superomedial prefrontal cortices (BA 6), are activated by facial expressions of fearful, disgusted, and neutral expressions in children with 22q11DS but generally to a lesser degree than in controls. Hypoactivation in these regions may partly explain the social impairments of children with 22q11DS. En ligne : http://dx.doi.org/10.1186/1866-1955-7-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 [article] An fMRI study of facial emotion processing in children and adolescents with 22q11.2 deletion syndrome [texte imprimé] / Rayna AZUMA, Auteur ; Quinton DEELEY, Auteur ; Linda E. CAMPBELL, Auteur ; Eileen DALY, Auteur ; Vincent GIAMPIETRO, Auteur ; Michael BRAMMER, Auteur ; Kieran C. MURPHY, Auteur ; Declan G.M. MURPHY, Auteur . - p.1. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.1 Mots-clés : 22q11.2 deletion syndrome (22q11DS)  Children  Emotion  Social cognition  Velo-cardio-facial syndrome (VCFS)  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: 22q11.2 deletion syndrome (22q11DS, velo-cardio-facial syndrome [VCFS]) is a genetic disorder associated with interstitial deletions of chromosome 22q11.2. In addition to high rates of neuropsychiatric disorders, children with 22q11DS have impairments of face processing, as well as IQ-independent deficits in visuoperceptual function and social and abstract reasoning. These face-processing deficits may contribute to the social impairments of 22q11DS. However, their neurobiological basis is poorly understood. METHODS: We used event-related functional magnetic resonance imaging (fMRI) to examine neural responses when children with 22q11DS (aged 9-17 years) and healthy controls (aged 8-17 years) incidentally processed neutral expressions and mild (50%) and intense (100%) expressions of fear and disgust. We included 28 right-handed children and adolescents: 14 with 22q11DS and 14 healthy (including nine siblings) controls. RESULTS: Within groups, contrasts showed that individuals significantly activated 'face responsive' areas when viewing neutral faces, including fusiform-extrastriate cortices. Further, within both groups, there was a significant positive linear trend in activation of fusiform-extrastriate cortices and cerebellum to increasing intensities of fear. There were, however, also between-group differences. Children with 22q11DS generally showed reduced activity as compared to controls in brain regions involved in social cognition and emotion processing across emotion types and intensities, including fusiform-extrastriate cortices, anterior cingulate cortex (Brodmann area (BA) 24/32), and superomedial prefrontal cortices (BA 6). Also, an exploratory correlation analysis showed that within 22q11DS children reduced activation was associated with behavioural impairment-social difficulties (measured using the Total Difficulties Score from the Strengths and Difficulties Questionnaire [SDQ]) were significantly negatively correlated with brain activity during fear and disgust processing (respectively) in the left precentral gyrus (BA 4) and in the left fusiform gyrus (FG, BA 19), right lingual gyrus (BA 18), and bilateral cerebellum. CONCLUSIONS: Regions involved in face processing, including fusiform-extrastriate cortices, anterior cingulate gyri, and superomedial prefrontal cortices (BA 6), are activated by facial expressions of fearful, disgusted, and neutral expressions in children with 22q11DS but generally to a lesser degree than in controls. Hypoactivation in these regions may partly explain the social impairments of children with 22q11DS. En ligne : http://dx.doi.org/10.1186/1866-1955-7-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347

Deactivation in anterior cingulate cortex during facial processing in young individuals with high familial risk and early development of depression: fMRI findings from the Scottish Bipolar Family Study / Stella W.Y. CHAN in Journal of Child Psychology and Psychiatry, 57-11 (November 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1277-1286 Titre : Deactivation in anterior cingulate cortex during facial processing in young individuals with high familial risk and early development of depression: fMRI findings from the Scottish Bipolar Family Study Type de document : texte imprimé Auteurs : Stella W.Y. CHAN, Auteur ; Jessika E. SUSSMANN, Auteur ; Liana ROMANIUK, Auteur ; Tiffany STEWART, Auteur ; Stephen M. LAWRIE, Auteur ; Jeremy HALL, Auteur ; Andrew M. MCINTOSH, Auteur ; Heather C. WHALLEY, Auteur Article en page(s) : p.1277-1286 Langues : Anglais (eng) Mots-clés : Mood disorder  major depressive disorder  fMRI  anterior cingulate  facial recognition  familial risk Index. décimale : PER Périodiques Résumé : Background Studies have identified perturbations in facial processing in bipolar disorder and major depressive disorder (MDD), but their relationship to genetic risk and early development of illness is unclear. Methods The Scottish Bipolar Family Study is a prospective longitudinal investigation examining young individuals (age 16–25) at familial risk of mood disorder. Participants underwent functional MRI using an implicit facial processing task employing angry and neutral faces. An explicit facial expression recognition task was completed outside the scanner. Clinical outcomes obtained 2 years after the scan were used to categorise participants into controls (n = 54), high-risk individuals who had developed MDD (HR MDD; n = 30) and high-risk individuals who remained well (HR Well, n = 43). Results All groups demonstrated activation patterns typically observed during facial processing, including activation of the amygdala, hippocampus, fusiform gyrus and middle frontal regions. Notably, the HR MDD group showed reduced activation of the anterior cingulate gyrus versus both the control and HR Well group for angry faces, and versus the HR Well group for neutral faces. Outside the scanner, the HR MDD group was less accurate in recognising fearful expressions than the HR Well group. Conclusions Here, we demonstrate functional abnormalities of the anterior cingulate cortex alongside facial emotional recognition deficits in high-risk individuals in the early stages of depression compared with both controls and at-risk individuals who remained well. These neural changes were associated with a current or future diagnosis of MDD and were not simply associated with increased familial risk. En ligne : http://dx.doi.org/10.1111/jcpp.12591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Deactivation in anterior cingulate cortex during facial processing in young individuals with high familial risk and early development of depression: fMRI findings from the Scottish Bipolar Family Study [texte imprimé] / Stella W.Y. CHAN, Auteur ; Jessika E. SUSSMANN, Auteur ; Liana ROMANIUK, Auteur ; Tiffany STEWART, Auteur ; Stephen M. LAWRIE, Auteur ; Jeremy HALL, Auteur ; Andrew M. MCINTOSH, Auteur ; Heather C. WHALLEY, Auteur . - p.1277-1286. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1277-1286 Mots-clés : Mood disorder  major depressive disorder  fMRI  anterior cingulate  facial recognition  familial risk Index. décimale : PER Périodiques Résumé : Background Studies have identified perturbations in facial processing in bipolar disorder and major depressive disorder (MDD), but their relationship to genetic risk and early development of illness is unclear. Methods The Scottish Bipolar Family Study is a prospective longitudinal investigation examining young individuals (age 16–25) at familial risk of mood disorder. Participants underwent functional MRI using an implicit facial processing task employing angry and neutral faces. An explicit facial expression recognition task was completed outside the scanner. Clinical outcomes obtained 2 years after the scan were used to categorise participants into controls (n = 54), high-risk individuals who had developed MDD (HR MDD; n = 30) and high-risk individuals who remained well (HR Well, n = 43). Results All groups demonstrated activation patterns typically observed during facial processing, including activation of the amygdala, hippocampus, fusiform gyrus and middle frontal regions. Notably, the HR MDD group showed reduced activation of the anterior cingulate gyrus versus both the control and HR Well group for angry faces, and versus the HR Well group for neutral faces. Outside the scanner, the HR MDD group was less accurate in recognising fearful expressions than the HR Well group. Conclusions Here, we demonstrate functional abnormalities of the anterior cingulate cortex alongside facial emotional recognition deficits in high-risk individuals in the early stages of depression compared with both controls and at-risk individuals who remained well. These neural changes were associated with a current or future diagnosis of MDD and were not simply associated with increased familial risk. En ligne : http://dx.doi.org/10.1111/jcpp.12591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

Effects of sensory distraction and salience priming on emotion identification in autism: an fMRI study / Genevieve PATTERSON in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : Effects of sensory distraction and salience priming on emotion identification in autism: an fMRI study Type de document : texte imprimé Auteurs : Genevieve PATTERSON, Auteur ; Kaitlin K. CUMMINGS, Auteur ; Jiwon JUNG, Auteur ; Nana J. OKADA, Auteur ; Nim TOTTENHAM, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; Shulamite A. GREEN, Auteur Langues : Anglais (eng) Mots-clés : Adolescent  Amygdala  Autism Spectrum Disorder/diagnostic imaging  Autistic Disorder  Child  Emotions  Humans  Magnetic Resonance Imaging  Autism  Emotion  Sensory over-responsivity  Sensory processing  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Social interaction often occurs in noisy environments with many extraneous sensory stimuli. This is especially relevant for youth with autism spectrum disorders (ASD) who commonly experience sensory over-responsivity (SOR) in addition to social challenges. However, the relationship between SOR and social difficulties is still poorly understood and thus rarely addressed in interventions. This study investigated the effect of auditory sensory distracters on neural processing of emotion identification in youth with ASD and the effects of increasing attention to social cues by priming participants with their own emotional faces. METHODS: While undergoing functional magnetic resonance imaging (fMRI), 30 youth with ASD and 24 typically developing (TD) age-matched controls (ages 8-17 years) identified faces as happy or angry with and without simultaneously hearing aversive environmental noises. Halfway through the task, participants also viewed videos of their own emotional faces. The relationship between parent-rated auditory SOR and brain responses during the task was also examined. RESULTS: Despite showing comparable behavioral performance on the task, ASD and TD youth demonstrated distinct patterns of neural activity. Compared to TD, ASD youth showed greater increases in amygdala, insula, and primary sensory regions when identifying emotions with noises compared to no sounds. After viewing videos of their own emotion faces, ASD youth showed greater increases in medial prefrontal cortex activation compared to TD youth. Within ASD youth, lower SOR was associated with reduced increased activity in subcortical regions after the prime and greater increased activity in the ventromedial prefrontal cortex after the prime, particularly in trials with noises. CONCLUSIONS: The results suggest that the sensory environment plays an important role in how ASD youth process social information. Additionally, we demonstrated that increasing attention to relevant social cues helps ASD youth engage frontal regions involved in higher-order social cognition, a mechanism that could be targeted in interventions. Importantly, the effect of the intervention may depend on individual differences in SOR, supporting the importance of pre-screening youth for sensory challenges prior to social interventions. En ligne : https://dx.doi.org/10.1186/s11689-021-09391-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Effects of sensory distraction and salience priming on emotion identification in autism: an fMRI study [texte imprimé] / Genevieve PATTERSON, Auteur ; Kaitlin K. CUMMINGS, Auteur ; Jiwon JUNG, Auteur ; Nana J. OKADA, Auteur ; Nim TOTTENHAM, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; Shulamite A. GREEN, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Adolescent  Amygdala  Autism Spectrum Disorder/diagnostic imaging  Autistic Disorder  Child  Emotions  Humans  Magnetic Resonance Imaging  Autism  Emotion  Sensory over-responsivity  Sensory processing  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Social interaction often occurs in noisy environments with many extraneous sensory stimuli. This is especially relevant for youth with autism spectrum disorders (ASD) who commonly experience sensory over-responsivity (SOR) in addition to social challenges. However, the relationship between SOR and social difficulties is still poorly understood and thus rarely addressed in interventions. This study investigated the effect of auditory sensory distracters on neural processing of emotion identification in youth with ASD and the effects of increasing attention to social cues by priming participants with their own emotional faces. METHODS: While undergoing functional magnetic resonance imaging (fMRI), 30 youth with ASD and 24 typically developing (TD) age-matched controls (ages 8-17 years) identified faces as happy or angry with and without simultaneously hearing aversive environmental noises. Halfway through the task, participants also viewed videos of their own emotional faces. The relationship between parent-rated auditory SOR and brain responses during the task was also examined. RESULTS: Despite showing comparable behavioral performance on the task, ASD and TD youth demonstrated distinct patterns of neural activity. Compared to TD, ASD youth showed greater increases in amygdala, insula, and primary sensory regions when identifying emotions with noises compared to no sounds. After viewing videos of their own emotion faces, ASD youth showed greater increases in medial prefrontal cortex activation compared to TD youth. Within ASD youth, lower SOR was associated with reduced increased activity in subcortical regions after the prime and greater increased activity in the ventromedial prefrontal cortex after the prime, particularly in trials with noises. CONCLUSIONS: The results suggest that the sensory environment plays an important role in how ASD youth process social information. Additionally, we demonstrated that increasing attention to relevant social cues helps ASD youth engage frontal regions involved in higher-order social cognition, a mechanism that could be targeted in interventions. Importantly, the effect of the intervention may depend on individual differences in SOR, supporting the importance of pre-screening youth for sensory challenges prior to social interventions. En ligne : https://dx.doi.org/10.1186/s11689-021-09391-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

Emotional maltreatment and neglect impact neural activation upon exclusion in early and mid-adolescence: An event-related fMRI study / Charlotte C. SCHULZ in Development and Psychopathology, 34-2 (May 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-2 (May 2022) . - 573-585 Titre : Emotional maltreatment and neglect impact neural activation upon exclusion in early and mid-adolescence: An event-related fMRI study Type de document : texte imprimé Auteurs : Charlotte C. SCHULZ, Auteur ; Kai VON KLITZING, Auteur ; Lorenz DESERNO, Auteur ; Margaret A. SHERIDAN, Auteur ; Michael J. CROWLEY, Auteur ; Margerete J.S. SCHOETT, Auteur ; Ferdinand HOFFMANN, Auteur ; Arno VILLRINGER, Auteur ; Pascal VRTIÄŒKA, Auteur ; Lars O. WHITE, Auteur Article en page(s) : 573-585 Langues : Anglais (eng) Mots-clés : adolescence  emotional maltreatment  neglect  fMRI  social exclusion Index. décimale : PER Périodiques Résumé : Child maltreatment gives rise to atypical patterns of social functioning with peers which might be particularly pronounced in early adolescence when peer influence typically peaks. Yet, few neuroimaging studies in adolescents use peer interaction paradigms to parse neural correlates of distinct maltreatment exposures. This fMRI study examines effects of abuse, neglect, and emotional maltreatment (EM) among 98 youth (n = 58 maltreated; n = 40 matched controls) using an event-related Cyberball paradigm affording assessment of both social exclusion and inclusion across early and mid-adolescence ( 13.5 years, n = 50; >13.5 years, n = 48). Younger adolescents showed increased activation to social exclusion versus inclusion in regions implicated in mentalizing (e.g., superior temporal gyrus). Individual exposure-specific analyses suggested that neglect and EM coincided with less reduction of activation to social exclusion relative to inclusion in the dorsal anterior cingulate cortex/pre-supplementary motor area (dACC/pre-SMA) among younger versus older adolescents. Integrative follow-up analyses showed that EM accounted for this dACC/pre-SMA activation pattern over and above other exposures. Moreover, age-independent results within respective exposure groups revealed that greater magnitude of neglect predicted blunted exclusion-related activity in the parahippocampal gyrus, while EM predicted increased activation to social exclusion in the precuneus/posterior cingulate cortex. En ligne : http://dx.doi.org/10.1017/s0954579421001681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Emotional maltreatment and neglect impact neural activation upon exclusion in early and mid-adolescence: An event-related fMRI study [texte imprimé] / Charlotte C. SCHULZ, Auteur ; Kai VON KLITZING, Auteur ; Lorenz DESERNO, Auteur ; Margaret A. SHERIDAN, Auteur ; Michael J. CROWLEY, Auteur ; Margerete J.S. SCHOETT, Auteur ; Ferdinand HOFFMANN, Auteur ; Arno VILLRINGER, Auteur ; Pascal VRTIÄŒKA, Auteur ; Lars O. WHITE, Auteur . - 573-585. Langues : Anglais (eng) in Development and Psychopathology > 34-2 (May 2022) . - 573-585 Mots-clés : adolescence  emotional maltreatment  neglect  fMRI  social exclusion Index. décimale : PER Périodiques Résumé : Child maltreatment gives rise to atypical patterns of social functioning with peers which might be particularly pronounced in early adolescence when peer influence typically peaks. Yet, few neuroimaging studies in adolescents use peer interaction paradigms to parse neural correlates of distinct maltreatment exposures. This fMRI study examines effects of abuse, neglect, and emotional maltreatment (EM) among 98 youth (n = 58 maltreated; n = 40 matched controls) using an event-related Cyberball paradigm affording assessment of both social exclusion and inclusion across early and mid-adolescence ( 13.5 years, n = 50; >13.5 years, n = 48). Younger adolescents showed increased activation to social exclusion versus inclusion in regions implicated in mentalizing (e.g., superior temporal gyrus). Individual exposure-specific analyses suggested that neglect and EM coincided with less reduction of activation to social exclusion relative to inclusion in the dorsal anterior cingulate cortex/pre-supplementary motor area (dACC/pre-SMA) among younger versus older adolescents. Integrative follow-up analyses showed that EM accounted for this dACC/pre-SMA activation pattern over and above other exposures. Moreover, age-independent results within respective exposure groups revealed that greater magnitude of neglect predicted blunted exclusion-related activity in the parahippocampal gyrus, while EM predicted increased activation to social exclusion in the precuneus/posterior cingulate cortex. En ligne : http://dx.doi.org/10.1017/s0954579421001681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing / Vanessa B. PUETZ in Development and Psychopathology, 35-3 (August 2023)  

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Impact of chronic intranasal oxytocin administration on face expression processing in autistic children: a randomized controlled trial using fMRI / Nicky DANIELS ; Stephanie VAN DER DONCK ; Tiffany TANG ; Jellina PRINSEN ; Elahe' YARGHOLI ; Jean STEYAERT ; Kaat ALAERTS ; Bart BOETS in Molecular Autism, 15 (2024)  

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Oscillatory motor patterning is impaired in neurofibromatosis type 1: a behavioural, EEG and fMRI study / Gilberto SILVA in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

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Typical and Atypical Neurodevelopment for Face Specialization: An fMRI Study / Jane E. JOSEPH in Journal of Autism and Developmental Disorders, 45-6 (June 2015)  

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ADHD-related sex differences in fronto-subcortical intrinsic functional connectivity and associations with delay discounting / Keri S. ROSCH in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

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