Systematic Review: Distribution of Age and Intervention Modalities in Therapeutic Clinical Trials for Autism Spectrum Disorder / Alan S. LEWIS in Journal of Autism and Developmental Disorders, 50-6 (June 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.2208-2216 Titre : Systematic Review: Distribution of Age and Intervention Modalities in Therapeutic Clinical Trials for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Alan S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur Article en page(s) : p.2208-2216 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism  Clinical trial  Disparity  Systematic review Index. décimale : PER Périodiques Résumé : The prevalence of ASD remains relatively stable across the lifespan, necessitating a quantitative understanding of how intervention clinical research is applied across age groups. Here we report a systematic review of treatment studies between 2013 and 2017, enrolling 11,213 subjects with ASD in 218 studies. Individuals under 18 years old constituted the majority of studies (84%) and subjects (92%). Subjects under 18 years old were more likely to be enrolled in behavioral studies (OR (CI)?=?1.34 (1.17-1.54)), and less likely to be enrolled in pharmacological (OR?=?0.60 (0.52-0.69)) studies than subjects ??18 years old. Identified disparities in both intervention modalities and outcome measures should serve to guide future research priorities. En ligne : http://dx.doi.org/10.1007/s10803-019-03942-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425 [article] Systematic Review: Distribution of Age and Intervention Modalities in Therapeutic Clinical Trials for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Alan S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur . - p.2208-2216. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.2208-2216 Mots-clés : Adolescent  Adult  Autism  Clinical trial  Disparity  Systematic review Index. décimale : PER Périodiques Résumé : The prevalence of ASD remains relatively stable across the lifespan, necessitating a quantitative understanding of how intervention clinical research is applied across age groups. Here we report a systematic review of treatment studies between 2013 and 2017, enrolling 11,213 subjects with ASD in 218 studies. Individuals under 18 years old constituted the majority of studies (84%) and subjects (92%). Subjects under 18 years old were more likely to be enrolled in behavioral studies (OR (CI)?=?1.34 (1.17-1.54)), and less likely to be enrolled in pharmacological (OR?=?0.60 (0.52-0.69)) studies than subjects ??18 years old. Identified disparities in both intervention modalities and outcome measures should serve to guide future research priorities. En ligne : http://dx.doi.org/10.1007/s10803-019-03942-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425

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