Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults / Jinni SU in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.1763-1775 Titre : Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults Type de document : texte imprimé Auteurs : Jinni SU, Auteur ; Sally I.Chun KUO, Auteur ; Fazil ALIEV, Auteur ; Jill A. RABINOWITZ, Auteur ; Belal JAMIL, Auteur ; Grace CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Meredith FRANCIS, Auteur ; Victor HESSELBROCK, Auteur ; Chella KAMARAJAN, Auteur ; Sivan KINREICH, Auteur ; John KRAMER, Auteur ; Donbing LAI, Auteur ; Vivia V. MCCUTCHEON, Auteur ; Jacquelyn MEYERS, Auteur ; Ashwini PANDEY, Auteur ; Gayathri PANDEY, Auteur ; Martin H. PLAWECKI, Auteur ; Marc SCHUCKIT, Auteur ; Jay TISCHFIELD, Auteur ; Danielle M. DICK, Auteur Article en page(s) : p.1763-1775 Langues : Anglais (eng) Mots-clés : COGA  alcohol use  gene-environment interaction  polygenic scores  social support Index. décimale : PER Périodiques Résumé : Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use. En ligne : https://dx.doi.org/10.1017/S0954579423001141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults [texte imprimé] / Jinni SU, Auteur ; Sally I.Chun KUO, Auteur ; Fazil ALIEV, Auteur ; Jill A. RABINOWITZ, Auteur ; Belal JAMIL, Auteur ; Grace CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Meredith FRANCIS, Auteur ; Victor HESSELBROCK, Auteur ; Chella KAMARAJAN, Auteur ; Sivan KINREICH, Auteur ; John KRAMER, Auteur ; Donbing LAI, Auteur ; Vivia V. MCCUTCHEON, Auteur ; Jacquelyn MEYERS, Auteur ; Ashwini PANDEY, Auteur ; Gayathri PANDEY, Auteur ; Martin H. PLAWECKI, Auteur ; Marc SCHUCKIT, Auteur ; Jay TISCHFIELD, Auteur ; Danielle M. DICK, Auteur . - p.1763-1775. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.1763-1775 Mots-clés : COGA  alcohol use  gene-environment interaction  polygenic scores  social support Index. décimale : PER Périodiques Résumé : Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use. En ligne : https://dx.doi.org/10.1017/S0954579423001141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

Polygenic and environmental influences on the course of African Americans' alcohol use from early adolescence through young adulthood / Jill A. RABINOWITZ in Development and Psychopathology, 32-2 (May 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-2 (May 2020) . - p.703-718 Titre : Polygenic and environmental influences on the course of African Americans' alcohol use from early adolescence through young adulthood Type de document : texte imprimé Auteurs : Jill A. RABINOWITZ, Auteur ; Rashelle J. MUSCI, Auteur ; Beth REBOUSSIN, Auteur ; Adam J. MILAM, Auteur ; Kelly S. BENKE, Auteur ; George R. UHL, Auteur ; Danielle Y. SISTO, Auteur ; Nicholas S. IALONGO, Auteur ; Brion MAHER, Auteur Article en page(s) : p.703-718 Langues : Anglais (eng) Mots-clés : alcohol use classes  antisocial behavior polygenic risk score  community disadvantage  internalizing symptoms polygenic risk score  parental monitoring Index. décimale : PER Périodiques Résumé : The study examined (a) whether alcohol use subgroups could be identified among African Americans assessed from adolescence through early adulthood, and (b) whether subgroup membership was associated with the interaction between internalizing symptoms and antisocial behavior polygenic risk scores (PRSs) and environmental characteristics (i.e., parental monitoring, community disadvantage). Participants (N = 436) were initially recruited for an elementary school-based prevention trial in a Mid-Atlantic city. Youths reported on the frequency of their past year alcohol use from ages 14-26. DNA was obtained from participants at age 21. Internalizing symptoms and antisocial behavior PRSs were created based on a genome-wide association study (GWAS) conducted by Benke et al. (2014) and Tielbeek et al. (2017), respectively. Parental monitoring and community disadvantage were assessed at age 12. Four classes of past year alcohol use were identified: (a) early-onset, increasing; (b) late-onset, moderate use; (c) low steady; and (d) early-onset, decreasing. In high community disadvantaged settings, participants with a higher internalizing symptoms PRS were more likely to be in the early-onset, decreasing class than the low steady class. When exposed to elevated community disadvantage, participants with a higher antisocial behavior PRS were more likely to be in the early-onset, increasing class than the early-onset, decreasing and late-onset, moderate use classes. En ligne : http://dx.doi.org/10.1017/s0954579419000701 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Polygenic and environmental influences on the course of African Americans' alcohol use from early adolescence through young adulthood [texte imprimé] / Jill A. RABINOWITZ, Auteur ; Rashelle J. MUSCI, Auteur ; Beth REBOUSSIN, Auteur ; Adam J. MILAM, Auteur ; Kelly S. BENKE, Auteur ; George R. UHL, Auteur ; Danielle Y. SISTO, Auteur ; Nicholas S. IALONGO, Auteur ; Brion MAHER, Auteur . - p.703-718. Langues : Anglais (eng) in Development and Psychopathology > 32-2 (May 2020) . - p.703-718 Mots-clés : alcohol use classes  antisocial behavior polygenic risk score  community disadvantage  internalizing symptoms polygenic risk score  parental monitoring Index. décimale : PER Périodiques Résumé : The study examined (a) whether alcohol use subgroups could be identified among African Americans assessed from adolescence through early adulthood, and (b) whether subgroup membership was associated with the interaction between internalizing symptoms and antisocial behavior polygenic risk scores (PRSs) and environmental characteristics (i.e., parental monitoring, community disadvantage). Participants (N = 436) were initially recruited for an elementary school-based prevention trial in a Mid-Atlantic city. Youths reported on the frequency of their past year alcohol use from ages 14-26. DNA was obtained from participants at age 21. Internalizing symptoms and antisocial behavior PRSs were created based on a genome-wide association study (GWAS) conducted by Benke et al. (2014) and Tielbeek et al. (2017), respectively. Parental monitoring and community disadvantage were assessed at age 12. Four classes of past year alcohol use were identified: (a) early-onset, increasing; (b) late-onset, moderate use; (c) low steady; and (d) early-onset, decreasing. In high community disadvantaged settings, participants with a higher internalizing symptoms PRS were more likely to be in the early-onset, decreasing class than the low steady class. When exposed to elevated community disadvantage, participants with a higher antisocial behavior PRS were more likely to be in the early-onset, increasing class than the early-onset, decreasing and late-onset, moderate use classes. En ligne : http://dx.doi.org/10.1017/s0954579419000701 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

A systematic review and meta-analysis of the impact of environmental disadvantage on youth delayed reward discounting / Julia W. FELTON in Development and Psychopathology, 38-2 (May 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-2 (May 2026) . - p.945-960 Titre : A systematic review and meta-analysis of the impact of environmental disadvantage on youth delayed reward discounting Type de document : texte imprimé Auteurs : Julia W. FELTON, Auteur ; Geoffrey KAHN, Auteur ; Jaclyn JOHNSON, Auteur ; Hira ALI, Auteur ; Souad SALEH, Auteur ; Nadya HABIB, Auteur ; Brion MAHER, Auteur ; Justin C. STRICKLAND, Auteur ; Jeewon CHEONG, Auteur ; Richard YI, Auteur ; Jill A. RABINOWITZ, Auteur Article en page(s) : p.945-960 Langues : Anglais (eng) Mots-clés : Adolescents  adversity  children  delay discounting  environment  stress Index. décimale : PER Périodiques Résumé : Delayed reward discounting (DRD), the tendency to prefer smaller rewards available immediately relative to larger rewards available after a delay, is associated with numerous health outcomes across the lifespan. Emerging literature points to the central role of early environments, specifically factors reflecting harshness (including lack of resources) and unpredictability (exposure to instability and stressful events) in the development of DRD. Yet, existing research uses disparate indicators of environmental risk and often draws on small samples resulting in conflicting findings, making comparisons across studies challenging. The current systematic review examined environmental factors that may place youth at greatest risk for heightened DRD and subsequent negative health outcomes. Search results identified 28 articles reflecting 20 unique samples. Additionally, meta-analyses were conducted to examine overall effects for the two most commonly examined environmental predictors (family income and family history of substance use disorder). Results suggest small-to-medium associations of environmental risk with DRD, with smaller associations observed for more distal predictors of harshness (e.g., family income) and larger associations among more proximal indicators of environmental instability (e.g., harsh parenting and parental pathology). Findings highlight the role of environmental factors on DRD development and may inform future interventions. En ligne : https://dx.doi.org/10.1017/S0954579425100886 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] A systematic review and meta-analysis of the impact of environmental disadvantage on youth delayed reward discounting [texte imprimé] / Julia W. FELTON, Auteur ; Geoffrey KAHN, Auteur ; Jaclyn JOHNSON, Auteur ; Hira ALI, Auteur ; Souad SALEH, Auteur ; Nadya HABIB, Auteur ; Brion MAHER, Auteur ; Justin C. STRICKLAND, Auteur ; Jeewon CHEONG, Auteur ; Richard YI, Auteur ; Jill A. RABINOWITZ, Auteur . - p.945-960. Langues : Anglais (eng) in Development and Psychopathology > 38-2 (May 2026) . - p.945-960 Mots-clés : Adolescents  adversity  children  delay discounting  environment  stress Index. décimale : PER Périodiques Résumé : Delayed reward discounting (DRD), the tendency to prefer smaller rewards available immediately relative to larger rewards available after a delay, is associated with numerous health outcomes across the lifespan. Emerging literature points to the central role of early environments, specifically factors reflecting harshness (including lack of resources) and unpredictability (exposure to instability and stressful events) in the development of DRD. Yet, existing research uses disparate indicators of environmental risk and often draws on small samples resulting in conflicting findings, making comparisons across studies challenging. The current systematic review examined environmental factors that may place youth at greatest risk for heightened DRD and subsequent negative health outcomes. Search results identified 28 articles reflecting 20 unique samples. Additionally, meta-analyses were conducted to examine overall effects for the two most commonly examined environmental predictors (family income and family history of substance use disorder). Results suggest small-to-medium associations of environmental risk with DRD, with smaller associations observed for more distal predictors of harshness (e.g., family income) and larger associations among more proximal indicators of environmental instability (e.g., harsh parenting and parental pathology). Findings highlight the role of environmental factors on DRD development and may inform future interventions. En ligne : https://dx.doi.org/10.1017/S0954579425100886 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

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