Developmental epigenomic effects of maternal financial problems / Cyrielle HOLUKA in Development and Psychopathology, 37-2 (May 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-2 (May 2025) . - p.1004-1017 Titre : Developmental epigenomic effects of maternal financial problems Type de document : Texte imprimé et/ou numérique Auteurs : Cyrielle HOLUKA, Auteur ; Giorgia MENTA, Auteur ; Juan Carlos CARO, Auteur ; Claus VÖGELE, Auteur ; Conchita D?AMBROSIO, Auteur ; Jonathan D. TURNER, Auteur Article en page(s) : p.1004-1017 Langues : Anglais (eng) Mots-clés : ALSPAC  Aging  DNA methylation  Pace of Ageing  biological pathways  epigenome-wide association studies  financial issues Index. décimale : PER Périodiques Résumé : Early-life adversity as neglect or low socioeconomic status is associated with negative physical/mental health outcomes and plays an important role in health trajectories through life. The early-life environment has been shown to be encoded as changes in epigenetic markers that are retained for many years.We investigated the effect of maternal major financial problems (MFP) and material deprivation (MD) on their children?s epigenome in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Epigenetic aging, measured with epigenetic clocks, was weakly accelerated with increased MFP. In subsequent EWAS, MFP, and MD showed strong, independent programing effects on children?s genomes. MFP in the period from birth to age seven was associated with genome-wide epigenetic modifications on children?s genome visible at age 7 and partially remaining at age 15.These results support the hypothesis that physiological processes at least partially explain associations between early-life adversity and health problems later in life. Both maternal stressors (MFP/MD) had similar effects on biological pathways, providing preliminary evidence for the mechanisms underlying the effects of low socioeconomic status in early life and disease outcomes later in life. Understanding these associations is essential to explain disease susceptibility, overall life trajectories and the transition from health to disease. En ligne : https://dx.doi.org/10.1017/S095457942400083X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552 [article] Developmental epigenomic effects of maternal financial problems [Texte imprimé et/ou numérique] / Cyrielle HOLUKA, Auteur ; Giorgia MENTA, Auteur ; Juan Carlos CARO, Auteur ; Claus VÖGELE, Auteur ; Conchita D?AMBROSIO, Auteur ; Jonathan D. TURNER, Auteur . - p.1004-1017. Langues : Anglais (eng) in Development and Psychopathology > 37-2 (May 2025) . - p.1004-1017 Mots-clés : ALSPAC  Aging  DNA methylation  Pace of Ageing  biological pathways  epigenome-wide association studies  financial issues Index. décimale : PER Périodiques Résumé : Early-life adversity as neglect or low socioeconomic status is associated with negative physical/mental health outcomes and plays an important role in health trajectories through life. The early-life environment has been shown to be encoded as changes in epigenetic markers that are retained for many years.We investigated the effect of maternal major financial problems (MFP) and material deprivation (MD) on their children?s epigenome in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Epigenetic aging, measured with epigenetic clocks, was weakly accelerated with increased MFP. In subsequent EWAS, MFP, and MD showed strong, independent programing effects on children?s genomes. MFP in the period from birth to age seven was associated with genome-wide epigenetic modifications on children?s genome visible at age 7 and partially remaining at age 15.These results support the hypothesis that physiological processes at least partially explain associations between early-life adversity and health problems later in life. Both maternal stressors (MFP/MD) had similar effects on biological pathways, providing preliminary evidence for the mechanisms underlying the effects of low socioeconomic status in early life and disease outcomes later in life. Understanding these associations is essential to explain disease susceptibility, overall life trajectories and the transition from health to disease. En ligne : https://dx.doi.org/10.1017/S095457942400083X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552

Glucocorticoid receptor signaling in leukocytes after early life adversity / Martha M. C. ELWENSPOEK in Development and Psychopathology, 32-3 (August 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-3 (August 2020) . - p.853-863 Titre : Glucocorticoid receptor signaling in leukocytes after early life adversity Type de document : Texte imprimé et/ou numérique Auteurs : Martha M. C. ELWENSPOEK, Auteur ; Xenia HENGESCH, Auteur ; Fleur A. D. LEENEN, Auteur ; Krystel SIAS, Auteur ; Sara Beatriz FERNANDES, Auteur ; Violetta K. SCHAAN, Auteur ; Sophie B. MÉRIAUX, Auteur ; Stephanie SCHMITZ, Auteur ; Fanny BONNEMBERGER, Auteur ; Hartmut SCHÄCHINGER, Auteur ; Claus VÖGELE, Auteur ; Claude P. MULLER, Auteur ; Jonathan D. TURNER, Auteur Article en page(s) : p.853-863 Langues : Anglais (eng) Mots-clés : DNA methylation  Fkbp5  Gilz  Nr3c1  early life adversity  glucocorticoid receptor Index. décimale : PER Périodiques Résumé : Early life adversity (ELA) has been associated with inflammation and immunosenescence, as well as hyporeactivity of the HPA axis. Because the immune system and the HPA axis are tightly intertwined around the glucocorticoid receptor (GR), we examined peripheral GR functionality in the EpiPath cohort among participants who either had been exposed to ELA (separation from parents and/or institutionalization followed by adoption; n = 40) or had been reared by their biological parents (n = 72).Expression of the strict GR target genes FKBP5 and GILZ as well as total and 1F and 1H GR transcripts were similar between groups. Furthermore, there were no differences in GR sensitivity, examined by the effects of dexamethasone on IL6 production in LPS-stimulated whole blood. Although we did not find differences in methylation at the GR 1F exon or promoter region, we identified a region of the GR 1H promoter (CpG 1-9) that showed lower methylation levels in ELA.Our results suggest that peripheral GR signaling was unperturbed in our cohort and the observed immune phenotype does not appear to be secondary to an altered GR response to the perturbed HPA axis and glucocorticoid (GC) profile, although we are limited in our measures of GR activity and time points. En ligne : http://dx.doi.org/10.1017/s0954579419001147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] Glucocorticoid receptor signaling in leukocytes after early life adversity [Texte imprimé et/ou numérique] / Martha M. C. ELWENSPOEK, Auteur ; Xenia HENGESCH, Auteur ; Fleur A. D. LEENEN, Auteur ; Krystel SIAS, Auteur ; Sara Beatriz FERNANDES, Auteur ; Violetta K. SCHAAN, Auteur ; Sophie B. MÉRIAUX, Auteur ; Stephanie SCHMITZ, Auteur ; Fanny BONNEMBERGER, Auteur ; Hartmut SCHÄCHINGER, Auteur ; Claus VÖGELE, Auteur ; Claude P. MULLER, Auteur ; Jonathan D. TURNER, Auteur . - p.853-863. Langues : Anglais (eng) in Development and Psychopathology > 32-3 (August 2020) . - p.853-863 Mots-clés : DNA methylation  Fkbp5  Gilz  Nr3c1  early life adversity  glucocorticoid receptor Index. décimale : PER Périodiques Résumé : Early life adversity (ELA) has been associated with inflammation and immunosenescence, as well as hyporeactivity of the HPA axis. Because the immune system and the HPA axis are tightly intertwined around the glucocorticoid receptor (GR), we examined peripheral GR functionality in the EpiPath cohort among participants who either had been exposed to ELA (separation from parents and/or institutionalization followed by adoption; n = 40) or had been reared by their biological parents (n = 72).Expression of the strict GR target genes FKBP5 and GILZ as well as total and 1F and 1H GR transcripts were similar between groups. Furthermore, there were no differences in GR sensitivity, examined by the effects of dexamethasone on IL6 production in LPS-stimulated whole blood. Although we did not find differences in methylation at the GR 1F exon or promoter region, we identified a region of the GR 1H promoter (CpG 1-9) that showed lower methylation levels in ELA.Our results suggest that peripheral GR signaling was unperturbed in our cohort and the observed immune phenotype does not appear to be secondary to an altered GR response to the perturbed HPA axis and glucocorticoid (GC) profile, although we are limited in our measures of GR activity and time points. En ligne : http://dx.doi.org/10.1017/s0954579419001147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

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