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Early life adversity, inflammation, and immune function: An initial test of adaptive response models of immunological programming / Katja CUNNINGHAM in Development and Psychopathology, 34-2 (May 2022)
[article]
Titre : Early life adversity, inflammation, and immune function: An initial test of adaptive response models of immunological programming Type de document : Texte imprimé et/ou numérique Auteurs : Katja CUNNINGHAM, Auteur ; Summer MENGELKOCH, Auteur ; Jeffrey GASSEN, Auteur ; Sarah E. HILL, Auteur Article en page(s) : 539-555 Langues : Anglais (eng) Mots-clés : early life adversity immunological programming inflammation socioeconomic status Index. décimale : PER Périodiques Résumé : Much research indicates that exposure to early life adversity (ELA) predicts chronic inflammatory activity, increasing one?s risk of developing diseases of aging later in life. Despite its costs, researchers have proposed that chronic inflammation may be favored in this context because it would help promote immunological vigilance in environments with an elevated risk of infection and injury. Although intuitively appealing, the assumption that exaggerated inflammatory activity predicts favorable immunological outcomes among those exposed to ELA has not been tested. Here, we seek to address this gap, examining the links between exposure to ELA, inflammation, and immune function. Consistent with others? work, results revealed that those from low socioeconomic status (SES) childhood environments exhibited exaggerated unstimulated inflammatory activity relative to what was observed among those from higher SES childhood environments. Further, results revealed that ? although levels of inflammation predicted the magnitude of immunological responses in those from higher SES backgrounds ? for those who grew up in low SES environments, higher levels of inflammation were unrelated to the magnitude of immunological responses. Results suggest that exaggerated inflammatory activity in the context of ELA may not predict improved ability to manage acute immunological threats. En ligne : http://dx.doi.org/10.1017/s095457942100170x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474
in Development and Psychopathology > 34-2 (May 2022) . - 539-555[article] Early life adversity, inflammation, and immune function: An initial test of adaptive response models of immunological programming [Texte imprimé et/ou numérique] / Katja CUNNINGHAM, Auteur ; Summer MENGELKOCH, Auteur ; Jeffrey GASSEN, Auteur ; Sarah E. HILL, Auteur . - 539-555.
Langues : Anglais (eng)
in Development and Psychopathology > 34-2 (May 2022) . - 539-555
Mots-clés : early life adversity immunological programming inflammation socioeconomic status Index. décimale : PER Périodiques Résumé : Much research indicates that exposure to early life adversity (ELA) predicts chronic inflammatory activity, increasing one?s risk of developing diseases of aging later in life. Despite its costs, researchers have proposed that chronic inflammation may be favored in this context because it would help promote immunological vigilance in environments with an elevated risk of infection and injury. Although intuitively appealing, the assumption that exaggerated inflammatory activity predicts favorable immunological outcomes among those exposed to ELA has not been tested. Here, we seek to address this gap, examining the links between exposure to ELA, inflammation, and immune function. Consistent with others? work, results revealed that those from low socioeconomic status (SES) childhood environments exhibited exaggerated unstimulated inflammatory activity relative to what was observed among those from higher SES childhood environments. Further, results revealed that ? although levels of inflammation predicted the magnitude of immunological responses in those from higher SES backgrounds ? for those who grew up in low SES environments, higher levels of inflammation were unrelated to the magnitude of immunological responses. Results suggest that exaggerated inflammatory activity in the context of ELA may not predict improved ability to manage acute immunological threats. En ligne : http://dx.doi.org/10.1017/s095457942100170x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 Glucocorticoid receptor signaling in leukocytes after early life adversity / Martha M. C. ELWENSPOEK in Development and Psychopathology, 32-3 (August 2020)
[article]
Titre : Glucocorticoid receptor signaling in leukocytes after early life adversity Type de document : Texte imprimé et/ou numérique Auteurs : Martha M. C. ELWENSPOEK, Auteur ; Xenia HENGESCH, Auteur ; Fleur A. D. LEENEN, Auteur ; Krystel SIAS, Auteur ; Sara Beatriz FERNANDES, Auteur ; Violetta K. SCHAAN, Auteur ; Sophie B. MÉRIAUX, Auteur ; Stephanie SCHMITZ, Auteur ; Fanny BONNEMBERGER, Auteur ; Hartmut SCHÄCHINGER, Auteur ; Claus VÖGELE, Auteur ; Claude P. MULLER, Auteur ; Jonathan D. TURNER, Auteur Article en page(s) : p.853-863 Langues : Anglais (eng) Mots-clés : DNA methylation Fkbp5 Gilz Nr3c1 early life adversity glucocorticoid receptor Index. décimale : PER Périodiques Résumé : Early life adversity (ELA) has been associated with inflammation and immunosenescence, as well as hyporeactivity of the HPA axis. Because the immune system and the HPA axis are tightly intertwined around the glucocorticoid receptor (GR), we examined peripheral GR functionality in the EpiPath cohort among participants who either had been exposed to ELA (separation from parents and/or institutionalization followed by adoption; n = 40) or had been reared by their biological parents (n = 72).Expression of the strict GR target genes FKBP5 and GILZ as well as total and 1F and 1H GR transcripts were similar between groups. Furthermore, there were no differences in GR sensitivity, examined by the effects of dexamethasone on IL6 production in LPS-stimulated whole blood. Although we did not find differences in methylation at the GR 1F exon or promoter region, we identified a region of the GR 1H promoter (CpG 1-9) that showed lower methylation levels in ELA.Our results suggest that peripheral GR signaling was unperturbed in our cohort and the observed immune phenotype does not appear to be secondary to an altered GR response to the perturbed HPA axis and glucocorticoid (GC) profile, although we are limited in our measures of GR activity and time points. En ligne : http://dx.doi.org/10.1017/s0954579419001147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429
in Development and Psychopathology > 32-3 (August 2020) . - p.853-863[article] Glucocorticoid receptor signaling in leukocytes after early life adversity [Texte imprimé et/ou numérique] / Martha M. C. ELWENSPOEK, Auteur ; Xenia HENGESCH, Auteur ; Fleur A. D. LEENEN, Auteur ; Krystel SIAS, Auteur ; Sara Beatriz FERNANDES, Auteur ; Violetta K. SCHAAN, Auteur ; Sophie B. MÉRIAUX, Auteur ; Stephanie SCHMITZ, Auteur ; Fanny BONNEMBERGER, Auteur ; Hartmut SCHÄCHINGER, Auteur ; Claus VÖGELE, Auteur ; Claude P. MULLER, Auteur ; Jonathan D. TURNER, Auteur . - p.853-863.
Langues : Anglais (eng)
in Development and Psychopathology > 32-3 (August 2020) . - p.853-863
Mots-clés : DNA methylation Fkbp5 Gilz Nr3c1 early life adversity glucocorticoid receptor Index. décimale : PER Périodiques Résumé : Early life adversity (ELA) has been associated with inflammation and immunosenescence, as well as hyporeactivity of the HPA axis. Because the immune system and the HPA axis are tightly intertwined around the glucocorticoid receptor (GR), we examined peripheral GR functionality in the EpiPath cohort among participants who either had been exposed to ELA (separation from parents and/or institutionalization followed by adoption; n = 40) or had been reared by their biological parents (n = 72).Expression of the strict GR target genes FKBP5 and GILZ as well as total and 1F and 1H GR transcripts were similar between groups. Furthermore, there were no differences in GR sensitivity, examined by the effects of dexamethasone on IL6 production in LPS-stimulated whole blood. Although we did not find differences in methylation at the GR 1F exon or promoter region, we identified a region of the GR 1H promoter (CpG 1-9) that showed lower methylation levels in ELA.Our results suggest that peripheral GR signaling was unperturbed in our cohort and the observed immune phenotype does not appear to be secondary to an altered GR response to the perturbed HPA axis and glucocorticoid (GC) profile, although we are limited in our measures of GR activity and time points. En ligne : http://dx.doi.org/10.1017/s0954579419001147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 Sexual orientation disparities in the developmental trajectories of emotional and behavioral difficulties from childhood to early adolescence / Yin XU in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)
[article]
Titre : Sexual orientation disparities in the developmental trajectories of emotional and behavioral difficulties from childhood to early adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Yin XU, Auteur ; Qazi RAHMAN, Auteur Article en page(s) : p.1505-1512 Langues : Anglais (eng) Mots-clés : Infant, Newborn Adolescent Female Child, Preschool Humans Male Child Cohort Studies Sexual Behavior Heterosexuality/psychology Sexual and Gender Minorities Surveys and Questionnaires Mcs Sexual orientation developmental trajectory early life adversity emotional and behavioral difficulties sexual minority Index. décimale : PER Périodiques Résumé : BACKGROUND: Lesbian, gay, bisexual, and asexual adolescents are at increased risk of poor mental health outcomes but it remains unknown whether this disparity emerges from early childhood and through to adolescence. This study tested sexual orientation disparities in the developmental trajectories of emotional and behavioral difficulties from ages 5 to 14 years, and the influence of early life adversities upon them. METHODS: The Millennium Cohort Study, a British birth cohort, was used (4,838 boys and 5,016 girls). Parent-report emotional and behavioral difficulties at ages 5, 7, 11, and 14 were measured using the Strength and Difficulties Questionnaire. Sexual orientation was measured via sexual attraction at age 17. Early life adversities in the first 5 years of life, including parental age at birth, birthweight, duration of breastfeeding, parent-child relationship quality, and parental absence, were collected prospectively. RESULTS: Latent growth modeling suggested that, for both sexes, sexual orientation disparities in emotional and behavioral difficulties increased from age 5 to 14 years. Homosexual and bisexual girls displayed significantly greater emotional and behavioral difficulties than heterosexual girls at ages 7, 11, and 14. Homosexual and bisexual boys displayed significantly greater emotional and behavioral difficulties than heterosexual boys at ages 11 and 14. Asexual boys and girls displayed significantly greater emotional and behavioral difficulties than their heterosexual counterparts at all four ages. For both sexes, sexual orientation disparities in emotional and behavioral difficulties only reduced slightly in magnitude after controlling for early life adversities. CONCLUSIONS: Sexual minority disparities in emotional and behavioral difficulties increased from childhood to early adolescence, possibly due to the accumulation of susceptibility to minority-related stressors. Sex and early life adversity may contribute to these developmental disparities. En ligne : http://dx.doi.org/10.1111/jcpp.13603 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1505-1512[article] Sexual orientation disparities in the developmental trajectories of emotional and behavioral difficulties from childhood to early adolescence [Texte imprimé et/ou numérique] / Yin XU, Auteur ; Qazi RAHMAN, Auteur . - p.1505-1512.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1505-1512
Mots-clés : Infant, Newborn Adolescent Female Child, Preschool Humans Male Child Cohort Studies Sexual Behavior Heterosexuality/psychology Sexual and Gender Minorities Surveys and Questionnaires Mcs Sexual orientation developmental trajectory early life adversity emotional and behavioral difficulties sexual minority Index. décimale : PER Périodiques Résumé : BACKGROUND: Lesbian, gay, bisexual, and asexual adolescents are at increased risk of poor mental health outcomes but it remains unknown whether this disparity emerges from early childhood and through to adolescence. This study tested sexual orientation disparities in the developmental trajectories of emotional and behavioral difficulties from ages 5 to 14 years, and the influence of early life adversities upon them. METHODS: The Millennium Cohort Study, a British birth cohort, was used (4,838 boys and 5,016 girls). Parent-report emotional and behavioral difficulties at ages 5, 7, 11, and 14 were measured using the Strength and Difficulties Questionnaire. Sexual orientation was measured via sexual attraction at age 17. Early life adversities in the first 5 years of life, including parental age at birth, birthweight, duration of breastfeeding, parent-child relationship quality, and parental absence, were collected prospectively. RESULTS: Latent growth modeling suggested that, for both sexes, sexual orientation disparities in emotional and behavioral difficulties increased from age 5 to 14 years. Homosexual and bisexual girls displayed significantly greater emotional and behavioral difficulties than heterosexual girls at ages 7, 11, and 14. Homosexual and bisexual boys displayed significantly greater emotional and behavioral difficulties than heterosexual boys at ages 11 and 14. Asexual boys and girls displayed significantly greater emotional and behavioral difficulties than their heterosexual counterparts at all four ages. For both sexes, sexual orientation disparities in emotional and behavioral difficulties only reduced slightly in magnitude after controlling for early life adversities. CONCLUSIONS: Sexual minority disparities in emotional and behavioral difficulties increased from childhood to early adolescence, possibly due to the accumulation of susceptibility to minority-related stressors. Sex and early life adversity may contribute to these developmental disparities. En ligne : http://dx.doi.org/10.1111/jcpp.13603 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 Does rapid rebound height growth come at a neurocognitive cost for previously institutionalized youth? / Brie M. REID in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)
[article]
Titre : Does rapid rebound height growth come at a neurocognitive cost for previously institutionalized youth? Type de document : Texte imprimé et/ou numérique Auteurs : Brie M. REID, Auteur ; Danruo ZHONG, Auteur ; Bonny DONZELLA, Auteur ; Mariann HOWLAND, Auteur ; Bao MOUA, Auteur ; Megan R. GUNNAR, Auteur Article en page(s) : p.1434-1444 Langues : Anglais (eng) Mots-clés : Child Adolescent Humans Child, Preschool Infant Attention Deficit Disorder with Hyperactivity/epidemiology Parents/psychology Child, Institutionalized Schools Iron Developmental origins attention problems catch-up growth early childhood early life adversity Index. décimale : PER Périodiques Résumé : BACKGROUND: Height growth faltering is associated with less optimal behavioral outcomes and educational achievement. Although catch-up growth after growth delay may result in developmental gains, it may also present as a double-edged sword, with consequences for neurocognitive functioning such as symptoms of inattention and hyperactivity. As previously institutionalized (PI) children experience height delays at adoption and catch-up growth after adoption, they provide a cohort to test associations between catch-up growth and attention deficit hyperactivity disorder (ADHD) symptoms. METHODS: This study used latent growth curve modeling to examine how catch-up in height-for-age growth is related to attention problems in a population of PI youth followed from adoption in infancy through kindergarten. Participants were assessed within three months of arrival into their families (age at entry: 18-36 months). Anthropometrics were measured four times, approximately 7 months apart. Two visits measured behavioral outcomes with parent and teacher reports of ADHD, internalizing, and externalizing symptoms at age 5 and kindergarten. RESULTS: The slope of growth in height z-scores, but not the intercept, was positively associated with parent- and teacher-reported ADHD symptoms in children. A one standard deviation increase in the slope of height z-scores across four assessments was associated with a 0.252 standard deviation increase in ADHD symptoms after controlling for internalizing and externalizing problems, iron status, duration of institutional care, sex, and age. The slope of growth was also associated with internalizing but not externalizing symptoms. CONCLUSIONS: This study demonstrates that PI children exhibit individual trajectories of height growth postadoption. Higher rates of change in height-for-age growth were associated with increased ADHD symptoms. These results suggest that catch-up growth comes 'at the cost' of poor attention regulation and hyperactive behavior. En ligne : http://dx.doi.org/10.1111/jcpp.13594 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1434-1444[article] Does rapid rebound height growth come at a neurocognitive cost for previously institutionalized youth? [Texte imprimé et/ou numérique] / Brie M. REID, Auteur ; Danruo ZHONG, Auteur ; Bonny DONZELLA, Auteur ; Mariann HOWLAND, Auteur ; Bao MOUA, Auteur ; Megan R. GUNNAR, Auteur . - p.1434-1444.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1434-1444
Mots-clés : Child Adolescent Humans Child, Preschool Infant Attention Deficit Disorder with Hyperactivity/epidemiology Parents/psychology Child, Institutionalized Schools Iron Developmental origins attention problems catch-up growth early childhood early life adversity Index. décimale : PER Périodiques Résumé : BACKGROUND: Height growth faltering is associated with less optimal behavioral outcomes and educational achievement. Although catch-up growth after growth delay may result in developmental gains, it may also present as a double-edged sword, with consequences for neurocognitive functioning such as symptoms of inattention and hyperactivity. As previously institutionalized (PI) children experience height delays at adoption and catch-up growth after adoption, they provide a cohort to test associations between catch-up growth and attention deficit hyperactivity disorder (ADHD) symptoms. METHODS: This study used latent growth curve modeling to examine how catch-up in height-for-age growth is related to attention problems in a population of PI youth followed from adoption in infancy through kindergarten. Participants were assessed within three months of arrival into their families (age at entry: 18-36 months). Anthropometrics were measured four times, approximately 7 months apart. Two visits measured behavioral outcomes with parent and teacher reports of ADHD, internalizing, and externalizing symptoms at age 5 and kindergarten. RESULTS: The slope of growth in height z-scores, but not the intercept, was positively associated with parent- and teacher-reported ADHD symptoms in children. A one standard deviation increase in the slope of height z-scores across four assessments was associated with a 0.252 standard deviation increase in ADHD symptoms after controlling for internalizing and externalizing problems, iron status, duration of institutional care, sex, and age. The slope of growth was also associated with internalizing but not externalizing symptoms. CONCLUSIONS: This study demonstrates that PI children exhibit individual trajectories of height growth postadoption. Higher rates of change in height-for-age growth were associated with increased ADHD symptoms. These results suggest that catch-up growth comes 'at the cost' of poor attention regulation and hyperactive behavior. En ligne : http://dx.doi.org/10.1111/jcpp.13594 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490