Interpersonal childhood adversity and stress generation in adolescence: Moderation by HPA axis multilocus genetic variation / Meghan HUANG in Development and Psychopathology, 32-3 (August 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-3 (August 2020) . - p.865-878 Titre : Interpersonal childhood adversity and stress generation in adolescence: Moderation by HPA axis multilocus genetic variation Type de document : Texte imprimé et/ou numérique Auteurs : Meghan HUANG, Auteur ; Lisa R. STARR, Auteur Article en page(s) : p.865-878 Langues : Anglais (eng) Mots-clés : HPA axis  childhood adversity  gene–environment interaction  stress generation Index. décimale : PER Périodiques Résumé : Research suggests that childhood adversity (CA) is associated with a wide range of repercussions, including an increased likelihood of interpersonal stress generation. This may be particularly true following interpersonal childhood adversity (ICA) and for youth with high hypothalamic-pituitary-adrenal (HPA) axis-related genetic risk. In the current study, we applied a multilocus genetic profile score (MGPS) approach to measuring HPA axis-related genetic variation and examined its interaction with ICA to predict interpersonal stress generation in a sample of adolescents aged 14-17 (N = 241, Caucasian subsample n = 192). MGPSs were computed using 10 single nucleotide polymorphisms from HPA axis-related genes (CRHR1, NRC31, NRC32, and FKBP5). ICA significantly predicted greater adolescent interpersonal dependent stress. Additionally, MGPS predicted a stronger association between ICA and interpersonal dependent (but not independent or noninterpersonal dependent) stress. No gene-environment interaction (G×E) effects were found for noninterpersonal CA and MGPS in predicting adolescent interpersonal dependent stress. Effects remained after controlling for current depressive symptoms and following stratification by race. Findings extend existing G×E research on stress generation to HPA axis-related genetic variation and demonstrate effects specific to the interpersonal domain. En ligne : http://dx.doi.org/10.1017/s0954579419001123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] Interpersonal childhood adversity and stress generation in adolescence: Moderation by HPA axis multilocus genetic variation [Texte imprimé et/ou numérique] / Meghan HUANG, Auteur ; Lisa R. STARR, Auteur . - p.865-878. Langues : Anglais (eng) in Development and Psychopathology > 32-3 (August 2020) . - p.865-878 Mots-clés : HPA axis  childhood adversity  gene–environment interaction  stress generation Index. décimale : PER Périodiques Résumé : Research suggests that childhood adversity (CA) is associated with a wide range of repercussions, including an increased likelihood of interpersonal stress generation. This may be particularly true following interpersonal childhood adversity (ICA) and for youth with high hypothalamic-pituitary-adrenal (HPA) axis-related genetic risk. In the current study, we applied a multilocus genetic profile score (MGPS) approach to measuring HPA axis-related genetic variation and examined its interaction with ICA to predict interpersonal stress generation in a sample of adolescents aged 14-17 (N = 241, Caucasian subsample n = 192). MGPSs were computed using 10 single nucleotide polymorphisms from HPA axis-related genes (CRHR1, NRC31, NRC32, and FKBP5). ICA significantly predicted greater adolescent interpersonal dependent stress. Additionally, MGPS predicted a stronger association between ICA and interpersonal dependent (but not independent or noninterpersonal dependent) stress. No gene-environment interaction (G×E) effects were found for noninterpersonal CA and MGPS in predicting adolescent interpersonal dependent stress. Effects remained after controlling for current depressive symptoms and following stratification by race. Findings extend existing G×E research on stress generation to HPA axis-related genetic variation and demonstrate effects specific to the interpersonal domain. En ligne : http://dx.doi.org/10.1017/s0954579419001123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

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