Correction to: Exploring Social Biomarkers in HighFunctioning Adults with Autism and Asperger's Versus Healthy Controls: A CrossSectional Analysis / Marta DEL VALLE RUBIDO in Journal of Autism and Developmental Disorders, 50-12 (December 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-12 (December 2020) . - p.4431-4432 Titre : Correction to: Exploring Social Biomarkers in HighFunctioning Adults with Autism and Asperger's Versus Healthy Controls: A CrossSectional Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Marta DEL VALLE RUBIDO, Auteur ; Eric HOLLANDER, Auteur ; James T MCCRACKEN, Auteur ; Frederick SHIC, Auteur ; Jana NOELDEKE, Auteur ; Lauren BOAK, Auteur ; Omar KHWAJA, Auteur ; Shamil SADIKHOV, Auteur ; Paulo FONTOURA, Auteur ; Daniel UMBRICHT, Auteur Article en page(s) : p.4431-4432 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The original version of this article unfortunately contained a mistake in CI values in Table 2. En ligne : http://dx.doi.org/10.1007/s10803-020-04522-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Correction to: Exploring Social Biomarkers in HighFunctioning Adults with Autism and Asperger's Versus Healthy Controls: A CrossSectional Analysis [Texte imprimé et/ou numérique] / Marta DEL VALLE RUBIDO, Auteur ; Eric HOLLANDER, Auteur ; James T MCCRACKEN, Auteur ; Frederick SHIC, Auteur ; Jana NOELDEKE, Auteur ; Lauren BOAK, Auteur ; Omar KHWAJA, Auteur ; Shamil SADIKHOV, Auteur ; Paulo FONTOURA, Auteur ; Daniel UMBRICHT, Auteur . - p.4431-4432. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-12 (December 2020) . - p.4431-4432 Index. décimale : PER Périodiques Résumé : The original version of this article unfortunately contained a mistake in CI values in Table 2. En ligne : http://dx.doi.org/10.1007/s10803-020-04522-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger's Versus Healthy Controls: A Cross-Sectional Analysis / Marta DEL VALLE RUBIDO in Journal of Autism and Developmental Disorders, 50-12 (December 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-12 (December 2020) . - p.4412-4430 Titre : Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger's Versus Healthy Controls: A Cross-Sectional Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Marta DEL VALLE RUBIDO, Auteur ; Eric HOLLANDER, Auteur ; James T MCCRACKEN, Auteur ; Frederick SHIC, Auteur ; Jana NOELDEKE, Auteur ; Lauren BOAK, Auteur ; Omar KHWAJA, Auteur ; Shamil SADIKHOV, Auteur ; Paulo FONTOURA, Auteur ; Daniel UMBRICHT, Auteur Article en page(s) : p.4412-4430 Langues : Anglais (eng) Mots-clés : Biomarker  Eye movement  Olfactory  Social cognition  Curemark, Coronado Biosciences, Forest, Simons Foundation, Foundation for Prader  Willi Research, and the Orphan Products Division of the Food and Drug  Administration, and has intellectual property relating to oxytocin and autism. FS  has provided consultation to Roche and Janssen Pharmaceutical and has received  research grants from Roche, NIH, and the Simons Foundation. JTM has served as a  consultant for Roche and Dart Neuroscience, has received research grants from Roche,  and has received study drug from Shire and AstraZeneca. FS has received research  funding from Roche and Janssen Pharmaceuticals. MVR, DU, JN, LB, OK, SS and PF are  full-time employees of F. Hoffmann-La Roche. Index. décimale : PER Périodiques Résumé : Biomarkers for autism spectrum disorder (ASD) are lacking but would facilitate drug development for the core deficits of the disorder. We evaluated markers proposed for characterization of differences in social communication and interaction in adults with ASD versus healthy controls (HC) for utility as biomarkers. Data pooled from an observational study and baseline data from a placebo-controlled study were analyzed. Between-group differences were observed in eye-tracking tasks for activity monitoring, biomotion, human activity preference, composite score (p?=?0.0001-0.037) and pupillometry (various tasks, p?=?0.017-0.05). Impaired olfaction was more common in the ASD sample versus HC (p?=?0.018). Our preliminary results suggest the potential use for stratification and response sub-analyses outcome-prediction of specific eye-tracking tasks, pupillometry and olfaction tests in ASD trials. En ligne : http://dx.doi.org/10.1007/s10803-020-04493-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger's Versus Healthy Controls: A Cross-Sectional Analysis [Texte imprimé et/ou numérique] / Marta DEL VALLE RUBIDO, Auteur ; Eric HOLLANDER, Auteur ; James T MCCRACKEN, Auteur ; Frederick SHIC, Auteur ; Jana NOELDEKE, Auteur ; Lauren BOAK, Auteur ; Omar KHWAJA, Auteur ; Shamil SADIKHOV, Auteur ; Paulo FONTOURA, Auteur ; Daniel UMBRICHT, Auteur . - p.4412-4430. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-12 (December 2020) . - p.4412-4430 Mots-clés : Biomarker  Eye movement  Olfactory  Social cognition  Curemark, Coronado Biosciences, Forest, Simons Foundation, Foundation for Prader  Willi Research, and the Orphan Products Division of the Food and Drug  Administration, and has intellectual property relating to oxytocin and autism. FS  has provided consultation to Roche and Janssen Pharmaceutical and has received  research grants from Roche, NIH, and the Simons Foundation. JTM has served as a  consultant for Roche and Dart Neuroscience, has received research grants from Roche,  and has received study drug from Shire and AstraZeneca. FS has received research  funding from Roche and Janssen Pharmaceuticals. MVR, DU, JN, LB, OK, SS and PF are  full-time employees of F. Hoffmann-La Roche. Index. décimale : PER Périodiques Résumé : Biomarkers for autism spectrum disorder (ASD) are lacking but would facilitate drug development for the core deficits of the disorder. We evaluated markers proposed for characterization of differences in social communication and interaction in adults with ASD versus healthy controls (HC) for utility as biomarkers. Data pooled from an observational study and baseline data from a placebo-controlled study were analyzed. Between-group differences were observed in eye-tracking tasks for activity monitoring, biomotion, human activity preference, composite score (p?=?0.0001-0.037) and pupillometry (various tasks, p?=?0.017-0.05). Impaired olfaction was more common in the ASD sample versus HC (p?=?0.018). Our preliminary results suggest the potential use for stratification and response sub-analyses outcome-prediction of specific eye-tracking tasks, pupillometry and olfaction tests in ASD trials. En ligne : http://dx.doi.org/10.1007/s10803-020-04493-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

"Reading the Mind in the Eyes" in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study / Matias BALTAZAR in Autism Research, 14-2 (February 2021)  

Public ISBD [article]  inAutism Research > 14-2 (February 2021) . - p.380-388 Titre : "Reading the Mind in the Eyes" in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study Type de document : Texte imprimé et/ou numérique Auteurs : Matias BALTAZAR, Auteur ; Marie-Maude GEOFFRAY, Auteur ; Christopher H. CHATHAM, Auteur ; Manuel P. BOUVARD, Auteur ; Axelle MARTINEZ TERUEL, Auteur ; David MONNET, Auteur ; Isabelle SCHEID, Auteur ; Eleonora MURZI, Auteur ; Sandrine COUFFIN-CADIERGUES, Auteur ; Daniel UMBRICHT, Auteur ; Lorraine MURTAGH, Auteur ; Richard DELORME, Auteur ; Myriam LY LE-MOAL, Auteur ; Marion LEBOYER, Auteur ; Anouck AMESTOY, Auteur Article en page(s) : p.380-388 Langues : Anglais (eng) Mots-clés : Generalized Linear Mixed Model  Reading the Mind in the Eyes  autism spectrum disorders  difficulty  valence Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are heterogeneous and complex neurodevelopmental conditions that urgently need reliable and sensitive measures to inform diagnosis properly. The Reading the Mind in the Eyes Task (or Eyes Test from now on) is widely used for this purpose. A recent study showed that subcategories of items of the children version of the Eyes Test could be especially discriminative to distinguish ASD and control children. Here, we analyzed the performance on the Eyes Test of 30 high functioning (IQ?>?70) adults with ASD and 29 controls from the InFoR cohort multicentric study, using a Generalized Linear Mixed Model. We found that valence and difficulty modulate the performance on the Eyes Test, with easy and positive items being the most discriminative to distinguish ASD and controls. In particular, we suggest this result might be actionable to discriminate ASD patients from controls in subgroups where their overall scores show less difference with controls. We propose for future research the computation of two additional indexes when using the Eyes Test: the first focusing on the easy and positive items (applying a threshold of 70% of correct responses for these items, above which people are at very low risk of having ASD) and the second focusing on the performance gain from difficult to easy items (with a progression of less than 15% showing high risk of having ASD). Our findings open the possibility for a major change in how the Eyes Test is used to inform diagnosis in ASD. LAY SUMMARY: The Eyes Test is used worldwide to inform autism spectrum disorders (ASD) diagnosis. We show here that ASD and neurotypical adults show the most difference in performance on subgroups of items: ASD adults do not improve as expected when comparing easy and difficult items, and they do not show an improvement for items displaying a positive feeling. We advise clinicians to focus on these comparisons to increase the property of the test to distinguish people with ASD from neurotypical adults. En ligne : http://dx.doi.org/10.1002/aur.2390 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441 [article] "Reading the Mind in the Eyes" in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study [Texte imprimé et/ou numérique] / Matias BALTAZAR, Auteur ; Marie-Maude GEOFFRAY, Auteur ; Christopher H. CHATHAM, Auteur ; Manuel P. BOUVARD, Auteur ; Axelle MARTINEZ TERUEL, Auteur ; David MONNET, Auteur ; Isabelle SCHEID, Auteur ; Eleonora MURZI, Auteur ; Sandrine COUFFIN-CADIERGUES, Auteur ; Daniel UMBRICHT, Auteur ; Lorraine MURTAGH, Auteur ; Richard DELORME, Auteur ; Myriam LY LE-MOAL, Auteur ; Marion LEBOYER, Auteur ; Anouck AMESTOY, Auteur . - p.380-388. Langues : Anglais (eng) in Autism Research > 14-2 (February 2021) . - p.380-388 Mots-clés : Generalized Linear Mixed Model  Reading the Mind in the Eyes  autism spectrum disorders  difficulty  valence Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are heterogeneous and complex neurodevelopmental conditions that urgently need reliable and sensitive measures to inform diagnosis properly. The Reading the Mind in the Eyes Task (or Eyes Test from now on) is widely used for this purpose. A recent study showed that subcategories of items of the children version of the Eyes Test could be especially discriminative to distinguish ASD and control children. Here, we analyzed the performance on the Eyes Test of 30 high functioning (IQ?>?70) adults with ASD and 29 controls from the InFoR cohort multicentric study, using a Generalized Linear Mixed Model. We found that valence and difficulty modulate the performance on the Eyes Test, with easy and positive items being the most discriminative to distinguish ASD and controls. In particular, we suggest this result might be actionable to discriminate ASD patients from controls in subgroups where their overall scores show less difference with controls. We propose for future research the computation of two additional indexes when using the Eyes Test: the first focusing on the easy and positive items (applying a threshold of 70% of correct responses for these items, above which people are at very low risk of having ASD) and the second focusing on the performance gain from difficult to easy items (with a progression of less than 15% showing high risk of having ASD). Our findings open the possibility for a major change in how the Eyes Test is used to inform diagnosis in ASD. LAY SUMMARY: The Eyes Test is used worldwide to inform autism spectrum disorders (ASD) diagnosis. We show here that ASD and neurotypical adults show the most difference in performance on subgroups of items: ASD adults do not improve as expected when comparing easy and difficult items, and they do not show an improvement for items displaying a positive feeling. We advise clinicians to focus on these comparisons to increase the property of the test to distinguish people with ASD from neurotypical adults. En ligne : http://dx.doi.org/10.1002/aur.2390 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441

Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways / Julian TILLMANN ; Freddy CLIQUET ; Frédérique AMSELLEM ; Anna MARUANI ; Claire LEBLOND ; Anita BEGGIATO ; David GERMANAUD ; Anouck AMESTOY ; Myriam LY-LE MOAL ; Daniel UMBRICHT ; Christopher CHATHAM ; Lorraine MURTAGH ; Manuel BOUVARD ; Marion LEBOYER ; Tony CHARMAN ; Thomas BOURGERON ; Richard DELORME ; Guillaume DUMAS ; EU-AIMS LEAP Group in Autism Research, 16-2 (February 2023)  

Public ISBD [article]  inAutism Research > 16-2 (February 2023) . - p.364-378 Titre : Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways Type de document : Texte imprimé et/ou numérique Auteurs : Julian TILLMANN, Auteur ; Freddy CLIQUET, Auteur ; Frédérique AMSELLEM, Auteur ; Anna MARUANI, Auteur ; Claire LEBLOND, Auteur ; Anita BEGGIATO, Auteur ; David GERMANAUD, Auteur ; Anouck AMESTOY, Auteur ; Myriam LY-LE MOAL, Auteur ; Daniel UMBRICHT, Auteur ; Christopher CHATHAM, Auteur ; Lorraine MURTAGH, Auteur ; Manuel BOUVARD, Auteur ; Marion LEBOYER, Auteur ; Tony CHARMAN, Auteur ; Thomas BOURGERON, Auteur ; Richard DELORME, Auteur ; Guillaume DUMAS, Auteur ; EU-AIMS LEAP Group, Auteur Article en page(s) : p.364-378 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract As an integral part of autism spectrum symptoms, sensory processing issues including both hypo and hyper sensory sensitivities. These sensory specificities may result from an excitation/inhibition imbalance with a poorly understood of their level of convergence with genetic alterations in GABA-ergic and glutamatergic pathways. In our study, we aimed to characterize the hypo/hyper-sensory profile among autistic individuals. We then explored its link with the burden of deleterious mutations in a subset of individuals with available whole-genome sequencing data. To characterize the hypo/hyper-sensory profile, the differential Short Sensory Profile (dSSP) was defined as a normalized and centralized hypo/hypersensitivity ratio from the Short Sensory Profile (SSP). Including 1136 participants (533 autistic individuals, 210 first-degree relatives, and 267 controls) from two independent study samples (PARIS and LEAP), we observed a statistically significant dSSP mean difference between autistic individuals and controls, driven mostly by a high dSSP variability, with an intermediated profile represented by relatives. Our genetic analysis tended to associate the dSSP and the hyposensitivity with mutations of the GABAergic pathway. The major limitation was the dSSP difficulty to discriminate subjects with a similar quantum of hypo- and hyper-sensory symptoms to those with no such symptoms, resulting both in a similar ratio score of 0. However, the dSSP could be a relevant clinical score, and combined with additional sensory descriptions, genetics and endophenotypic substrates, will improve the exploration of the underlying neurobiological mechanisms of sensory processing differences in autism spectrum. En ligne : https://doi.org/10.1002/aur.2861 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=496 [article] Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways [Texte imprimé et/ou numérique] / Julian TILLMANN, Auteur ; Freddy CLIQUET, Auteur ; Frédérique AMSELLEM, Auteur ; Anna MARUANI, Auteur ; Claire LEBLOND, Auteur ; Anita BEGGIATO, Auteur ; David GERMANAUD, Auteur ; Anouck AMESTOY, Auteur ; Myriam LY-LE MOAL, Auteur ; Daniel UMBRICHT, Auteur ; Christopher CHATHAM, Auteur ; Lorraine MURTAGH, Auteur ; Manuel BOUVARD, Auteur ; Marion LEBOYER, Auteur ; Tony CHARMAN, Auteur ; Thomas BOURGERON, Auteur ; Richard DELORME, Auteur ; Guillaume DUMAS, Auteur ; EU-AIMS LEAP Group, Auteur . - p.364-378. Langues : Anglais (eng) in Autism Research > 16-2 (February 2023) . - p.364-378 Index. décimale : PER Périodiques Résumé : Abstract As an integral part of autism spectrum symptoms, sensory processing issues including both hypo and hyper sensory sensitivities. These sensory specificities may result from an excitation/inhibition imbalance with a poorly understood of their level of convergence with genetic alterations in GABA-ergic and glutamatergic pathways. In our study, we aimed to characterize the hypo/hyper-sensory profile among autistic individuals. We then explored its link with the burden of deleterious mutations in a subset of individuals with available whole-genome sequencing data. To characterize the hypo/hyper-sensory profile, the differential Short Sensory Profile (dSSP) was defined as a normalized and centralized hypo/hypersensitivity ratio from the Short Sensory Profile (SSP). Including 1136 participants (533 autistic individuals, 210 first-degree relatives, and 267 controls) from two independent study samples (PARIS and LEAP), we observed a statistically significant dSSP mean difference between autistic individuals and controls, driven mostly by a high dSSP variability, with an intermediated profile represented by relatives. Our genetic analysis tended to associate the dSSP and the hyposensitivity with mutations of the GABAergic pathway. The major limitation was the dSSP difficulty to discriminate subjects with a similar quantum of hypo- and hyper-sensory symptoms to those with no such symptoms, resulting both in a similar ratio score of 0. However, the dSSP could be a relevant clinical score, and combined with additional sensory descriptions, genetics and endophenotypic substrates, will improve the exploration of the underlying neurobiological mechanisms of sensory processing differences in autism spectrum. En ligne : https://doi.org/10.1002/aur.2861 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=496

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