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Brief Report: Odour Awareness in Young Children with Autism Spectrum Disorders / Hirokazu KUMAZAKI in Journal of Autism and Developmental Disorders, 50-5 (May 2020)
[article]
Titre : Brief Report: Odour Awareness in Young Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Hirokazu KUMAZAKI, Auteur ; Masako OKAMOTO, Auteur ; Yuko YOSHIMURA, Auteur ; Takashi IKEDA, Auteur ; Chiaki HASEGAWA, Auteur ; Daisuke N. SAITO, Auteur ; Ryoichiro IWANAGA, Auteur ; Sara TOMIYAMA, Auteur ; Kyung-Min AN, Auteur ; Yoshio MINABE, Auteur ; Mitsuru KIKUCHI, Auteur Article en page(s) : p.1809-1815 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Odour awareness Olfactory Self-report Vabs ii Index. décimale : PER Périodiques Résumé : The elucidation of odour awareness in children with autism spectrum disorders (ASD) is important. We compared the odour awareness of young children with ASD with those of typical development (TD) children using the Children's Olfactory Behavior in Everyday Life (COBEL) questionnaire, which is a self-report measure that mainly assesses odour awareness. Forty-five young boys (aged 5-6 years), including 20 children with ASD and 25 TD children, participated in this study. The total COBEL score of the young children with ASD was lower than that of the TD children (p < 0.01). Moreover, the total COBEL score was significantly correlated with the total VABS II score (p < 0.05). Our results improve understanding of the odour awareness in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3710-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422
in Journal of Autism and Developmental Disorders > 50-5 (May 2020) . - p.1809-1815[article] Brief Report: Odour Awareness in Young Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Hirokazu KUMAZAKI, Auteur ; Masako OKAMOTO, Auteur ; Yuko YOSHIMURA, Auteur ; Takashi IKEDA, Auteur ; Chiaki HASEGAWA, Auteur ; Daisuke N. SAITO, Auteur ; Ryoichiro IWANAGA, Auteur ; Sara TOMIYAMA, Auteur ; Kyung-Min AN, Auteur ; Yoshio MINABE, Auteur ; Mitsuru KIKUCHI, Auteur . - p.1809-1815.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-5 (May 2020) . - p.1809-1815
Mots-clés : Autism spectrum disorders Odour awareness Olfactory Self-report Vabs ii Index. décimale : PER Périodiques Résumé : The elucidation of odour awareness in children with autism spectrum disorders (ASD) is important. We compared the odour awareness of young children with ASD with those of typical development (TD) children using the Children's Olfactory Behavior in Everyday Life (COBEL) questionnaire, which is a self-report measure that mainly assesses odour awareness. Forty-five young boys (aged 5-6 years), including 20 children with ASD and 25 TD children, participated in this study. The total COBEL score of the young children with ASD was lower than that of the TD children (p < 0.01). Moreover, the total COBEL score was significantly correlated with the total VABS II score (p < 0.05). Our results improve understanding of the odour awareness in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3710-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 Brief Report: Significant Differences in Perceived Odor Pleasantness Found in Children with ASD / Michal HRDLICKA in Journal of Autism and Developmental Disorders, 41-4 (April 2011)
[article]
Titre : Brief Report: Significant Differences in Perceived Odor Pleasantness Found in Children with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Michal HRDLICKA, Auteur ; Jan VODICKA, Auteur ; Marketa HAVLOVICOVA, Auteur ; Tomas URBANEK, Auteur ; Marek BLATNY, Auteur ; Iva DUDOVA, Auteur Année de publication : 2011 Article en page(s) : p.524-527 Langues : Anglais (eng) Mots-clés : Autism Asperger’s syndrome Sensory abnormalities Olfactory Pleasantness Sniffin’ Sticks Index. décimale : PER Périodiques Résumé : The aim of our study was to explore possible differences in estimation of odor pleasantness in children with autism spectrum disorders (ASD) compared to controls. Thirty-five patients with Asperger’s syndrome and high functioning autism (mean age 10.8 ± 3.6 years; 31 boys) were compared with 35 healthy control subjects (mean age 10.4 ± 2.4 years; 28 boys). Odor pleasantness was assessed on a 5-point scale using the Sniffin’ Sticks test (Identification part of the test). Patients with ASD, compared to healthy controls, perceived the smell of cinnamon and pineapple as significantly less pleasant (p < 0.05); at the trend level, the same was true of cloves (p < 0.1). The possibility of olfactory dysfunctions as an autism biomarker is discussed. En ligne : http://dx.doi.org/10.1007/s10803-010-1084-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119
in Journal of Autism and Developmental Disorders > 41-4 (April 2011) . - p.524-527[article] Brief Report: Significant Differences in Perceived Odor Pleasantness Found in Children with ASD [Texte imprimé et/ou numérique] / Michal HRDLICKA, Auteur ; Jan VODICKA, Auteur ; Marketa HAVLOVICOVA, Auteur ; Tomas URBANEK, Auteur ; Marek BLATNY, Auteur ; Iva DUDOVA, Auteur . - 2011 . - p.524-527.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 41-4 (April 2011) . - p.524-527
Mots-clés : Autism Asperger’s syndrome Sensory abnormalities Olfactory Pleasantness Sniffin’ Sticks Index. décimale : PER Périodiques Résumé : The aim of our study was to explore possible differences in estimation of odor pleasantness in children with autism spectrum disorders (ASD) compared to controls. Thirty-five patients with Asperger’s syndrome and high functioning autism (mean age 10.8 ± 3.6 years; 31 boys) were compared with 35 healthy control subjects (mean age 10.4 ± 2.4 years; 28 boys). Odor pleasantness was assessed on a 5-point scale using the Sniffin’ Sticks test (Identification part of the test). Patients with ASD, compared to healthy controls, perceived the smell of cinnamon and pineapple as significantly less pleasant (p < 0.05); at the trend level, the same was true of cloves (p < 0.1). The possibility of olfactory dysfunctions as an autism biomarker is discussed. En ligne : http://dx.doi.org/10.1007/s10803-010-1084-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119 Relationship Between Odor Identification and Visual Distractors in Children with Autism Spectrum Disorders / H. KUMAZAKI in Journal of Autism and Developmental Disorders, 48-7 (July 2018)
[article]
Titre : Relationship Between Odor Identification and Visual Distractors in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : H. KUMAZAKI, Auteur ; M. KIKUCHI, Auteur ; Y. YOSHIMURA, Auteur ; M. MIYAO, Auteur ; K. I. OKADA, Auteur ; M. MIMURA, Auteur ; Y. MINABE, Auteur Article en page(s) : p.2590-2592 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Identification Odor Olfactory Visual distractor Index. décimale : PER Périodiques Résumé : Understanding the nature of olfactory abnormalities is crucial for optimal interventions in children with autism spectrum disorders (ASD). However, previous studies that have investigated odor identification in children with ASD have produced inconsistent results. The ability to correctly identify an odor relies heavily on visual inputs in the general population. We tested odor identification in eight children with ASD and eight age-matched children with typical development (TD). After confirming that all children were able to identify each odor without visual input, we measured odor identification under the visual-distractor condition. Odor identification was hindered by visual distractors for all children with ASD but was not affected in all children with TD. Our results improve understanding of odor identification in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3511-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367
in Journal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2590-2592[article] Relationship Between Odor Identification and Visual Distractors in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / H. KUMAZAKI, Auteur ; M. KIKUCHI, Auteur ; Y. YOSHIMURA, Auteur ; M. MIYAO, Auteur ; K. I. OKADA, Auteur ; M. MIMURA, Auteur ; Y. MINABE, Auteur . - p.2590-2592.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2590-2592
Mots-clés : Autism spectrum disorders Identification Odor Olfactory Visual distractor Index. décimale : PER Périodiques Résumé : Understanding the nature of olfactory abnormalities is crucial for optimal interventions in children with autism spectrum disorders (ASD). However, previous studies that have investigated odor identification in children with ASD have produced inconsistent results. The ability to correctly identify an odor relies heavily on visual inputs in the general population. We tested odor identification in eight children with ASD and eight age-matched children with typical development (TD). After confirming that all children were able to identify each odor without visual input, we measured odor identification under the visual-distractor condition. Odor identification was hindered by visual distractors for all children with ASD but was not affected in all children with TD. Our results improve understanding of odor identification in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3511-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger's Versus Healthy Controls: A Cross-Sectional Analysis / Marta DEL VALLE RUBIDO in Journal of Autism and Developmental Disorders, 50-12 (December 2020)
[article]
Titre : Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger's Versus Healthy Controls: A Cross-Sectional Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Marta DEL VALLE RUBIDO, Auteur ; Eric HOLLANDER, Auteur ; James T MCCRACKEN, Auteur ; Frederick SHIC, Auteur ; Jana NOELDEKE, Auteur ; Lauren BOAK, Auteur ; Omar KHWAJA, Auteur ; Shamil SADIKHOV, Auteur ; Paulo FONTOURA, Auteur ; Daniel UMBRICHT, Auteur Article en page(s) : p.4412-4430 Langues : Anglais (eng) Mots-clés : Biomarker Eye movement Olfactory Social cognition Curemark, Coronado Biosciences, Forest, Simons Foundation, Foundation for Prader Willi Research, and the Orphan Products Division of the Food and Drug Administration, and has intellectual property relating to oxytocin and autism. FS has provided consultation to Roche and Janssen Pharmaceutical and has received research grants from Roche, NIH, and the Simons Foundation. JTM has served as a consultant for Roche and Dart Neuroscience, has received research grants from Roche, and has received study drug from Shire and AstraZeneca. FS has received research funding from Roche and Janssen Pharmaceuticals. MVR, DU, JN, LB, OK, SS and PF are full-time employees of F. Hoffmann-La Roche. Index. décimale : PER Périodiques Résumé : Biomarkers for autism spectrum disorder (ASD) are lacking but would facilitate drug development for the core deficits of the disorder. We evaluated markers proposed for characterization of differences in social communication and interaction in adults with ASD versus healthy controls (HC) for utility as biomarkers. Data pooled from an observational study and baseline data from a placebo-controlled study were analyzed. Between-group differences were observed in eye-tracking tasks for activity monitoring, biomotion, human activity preference, composite score (p?=?0.0001-0.037) and pupillometry (various tasks, p?=?0.017-0.05). Impaired olfaction was more common in the ASD sample versus HC (p?=?0.018). Our preliminary results suggest the potential use for stratification and response sub-analyses outcome-prediction of specific eye-tracking tasks, pupillometry and olfaction tests in ASD trials. En ligne : http://dx.doi.org/10.1007/s10803-020-04493-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434
in Journal of Autism and Developmental Disorders > 50-12 (December 2020) . - p.4412-4430[article] Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger's Versus Healthy Controls: A Cross-Sectional Analysis [Texte imprimé et/ou numérique] / Marta DEL VALLE RUBIDO, Auteur ; Eric HOLLANDER, Auteur ; James T MCCRACKEN, Auteur ; Frederick SHIC, Auteur ; Jana NOELDEKE, Auteur ; Lauren BOAK, Auteur ; Omar KHWAJA, Auteur ; Shamil SADIKHOV, Auteur ; Paulo FONTOURA, Auteur ; Daniel UMBRICHT, Auteur . - p.4412-4430.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-12 (December 2020) . - p.4412-4430
Mots-clés : Biomarker Eye movement Olfactory Social cognition Curemark, Coronado Biosciences, Forest, Simons Foundation, Foundation for Prader Willi Research, and the Orphan Products Division of the Food and Drug Administration, and has intellectual property relating to oxytocin and autism. FS has provided consultation to Roche and Janssen Pharmaceutical and has received research grants from Roche, NIH, and the Simons Foundation. JTM has served as a consultant for Roche and Dart Neuroscience, has received research grants from Roche, and has received study drug from Shire and AstraZeneca. FS has received research funding from Roche and Janssen Pharmaceuticals. MVR, DU, JN, LB, OK, SS and PF are full-time employees of F. Hoffmann-La Roche. Index. décimale : PER Périodiques Résumé : Biomarkers for autism spectrum disorder (ASD) are lacking but would facilitate drug development for the core deficits of the disorder. We evaluated markers proposed for characterization of differences in social communication and interaction in adults with ASD versus healthy controls (HC) for utility as biomarkers. Data pooled from an observational study and baseline data from a placebo-controlled study were analyzed. Between-group differences were observed in eye-tracking tasks for activity monitoring, biomotion, human activity preference, composite score (p?=?0.0001-0.037) and pupillometry (various tasks, p?=?0.017-0.05). Impaired olfaction was more common in the ASD sample versus HC (p?=?0.018). Our preliminary results suggest the potential use for stratification and response sub-analyses outcome-prediction of specific eye-tracking tasks, pupillometry and olfaction tests in ASD trials. En ligne : http://dx.doi.org/10.1007/s10803-020-04493-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 In Search of Biomarkers for Autism Spectrum Disorder / Marta DEL VALLE RUBIDO in Autism Research, 11-11 (November 2018)
[article]
Titre : In Search of Biomarkers for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Marta DEL VALLE RUBIDO, Auteur ; J. T. MCCRACKEN, Auteur ; E. HOLLANDER, Auteur ; F. SHIC, Auteur ; J. NOELDEKE, Auteur ; Lauren BOAK, Auteur ; O. KHWAJA, Auteur ; S. SADIKHOV, Auteur ; P. FONTOURA, Auteur ; D. UMBRICHT, Auteur Article en page(s) : p.1567-1579 Langues : Anglais (eng) Mots-clés : biomarker eye movement olfactory social cognition Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) lacks validated measures of core social functions across development stages suitable for clinical trials. We assessed the concurrent validity between ASD clinical measures and putative biomarkers of core deficits, and their feasibility of implementation in human studies. Datasets from two adult ASD studies were combined (observational study [n = 19] and interventional study baseline data [n = 19]). Potential biomarkers included eye-tracking, olfaction, and auditory and visual emotion recognition assessed via the Affective Speech Recognition test (ASR) and Reading-the-Mind-in-the-Eyes Test (RMET). Current functioning was assessed with intelligence quotient (IQ), adaptive skill testing, and behavioral ratings. Autism severity was determined by the Autism Diagnostic Observation Scale-2 and Social Communication Interaction Test (SCIT). Exploratory measures showed varying significant associations across ASD severity, adaptive skills, and behavior. Eye tracking endpoints showed little relationship to adaptive ability but correlated with severity and behavior. ASR scores significantly correlated with most adaptive behavior domains, as well as severity. Olfaction predicted visual and auditory emotion recognition. SCIT scores related moderately to multiple severity domains, and was the only measure not related with IQ. RMET accuracy was less related to ASD features. Eye tracking, SCIT, and ASR showed high test-retest reliability. We documented associations of proximal biomarkers of social functioning with multiple ASD dimensions. With the exception of SCIT, most correlations were modest, limiting utility as proxy measures of social communication. Feasibility and reliability were high for eye-tracking, ASR, and SCIT. Overall, several novel experimental paradigms showed potential as social biomarkers or surrogate markers in ASD. Autism Research 2018, 11: 1567-1579. (c) 2018 The Authors. Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: More accurate measurements of treatment effects are needed to help the development of new drug treatments for autism spectrum disorders (ASD). This study evaluates the relationship between assessments designed to measure behaviors associated with social communication and cognition in ASD with clinical and diagnostic assessments of symptom severity as well as their implementation. The assessments including eye-tracking, auditory and visual social stimuli recognition, and olfaction identification showed potential for use in the evaluation of treatments for social difficulties in ASD. En ligne : http://dx.doi.org/10.1002/aur.2026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370
in Autism Research > 11-11 (November 2018) . - p.1567-1579[article] In Search of Biomarkers for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Marta DEL VALLE RUBIDO, Auteur ; J. T. MCCRACKEN, Auteur ; E. HOLLANDER, Auteur ; F. SHIC, Auteur ; J. NOELDEKE, Auteur ; Lauren BOAK, Auteur ; O. KHWAJA, Auteur ; S. SADIKHOV, Auteur ; P. FONTOURA, Auteur ; D. UMBRICHT, Auteur . - p.1567-1579.
Langues : Anglais (eng)
in Autism Research > 11-11 (November 2018) . - p.1567-1579
Mots-clés : biomarker eye movement olfactory social cognition Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) lacks validated measures of core social functions across development stages suitable for clinical trials. We assessed the concurrent validity between ASD clinical measures and putative biomarkers of core deficits, and their feasibility of implementation in human studies. Datasets from two adult ASD studies were combined (observational study [n = 19] and interventional study baseline data [n = 19]). Potential biomarkers included eye-tracking, olfaction, and auditory and visual emotion recognition assessed via the Affective Speech Recognition test (ASR) and Reading-the-Mind-in-the-Eyes Test (RMET). Current functioning was assessed with intelligence quotient (IQ), adaptive skill testing, and behavioral ratings. Autism severity was determined by the Autism Diagnostic Observation Scale-2 and Social Communication Interaction Test (SCIT). Exploratory measures showed varying significant associations across ASD severity, adaptive skills, and behavior. Eye tracking endpoints showed little relationship to adaptive ability but correlated with severity and behavior. ASR scores significantly correlated with most adaptive behavior domains, as well as severity. Olfaction predicted visual and auditory emotion recognition. SCIT scores related moderately to multiple severity domains, and was the only measure not related with IQ. RMET accuracy was less related to ASD features. Eye tracking, SCIT, and ASR showed high test-retest reliability. We documented associations of proximal biomarkers of social functioning with multiple ASD dimensions. With the exception of SCIT, most correlations were modest, limiting utility as proxy measures of social communication. Feasibility and reliability were high for eye-tracking, ASR, and SCIT. Overall, several novel experimental paradigms showed potential as social biomarkers or surrogate markers in ASD. Autism Research 2018, 11: 1567-1579. (c) 2018 The Authors. Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: More accurate measurements of treatment effects are needed to help the development of new drug treatments for autism spectrum disorders (ASD). This study evaluates the relationship between assessments designed to measure behaviors associated with social communication and cognition in ASD with clinical and diagnostic assessments of symptom severity as well as their implementation. The assessments including eye-tracking, auditory and visual social stimuli recognition, and olfaction identification showed potential for use in the evaluation of treatments for social difficulties in ASD. En ligne : http://dx.doi.org/10.1002/aur.2026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370