[article]
Titre : |
Association between family history of suicide attempt and neurocognitive functioning in community youth |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
Jason D. JONES, Auteur ; Rhonda C. BOYD, Auteur ; Monica E. CALKINS, Auteur ; Tyler M. MOORE, Auteur ; Annisa AHMED, Auteur ; Ran BARZILAY, Auteur ; Tami D. BENTON, Auteur ; Raquel E. GUR, Auteur ; Ruben C. GUR, Auteur |
Article en page(s) : |
p.58-65 |
Langues : |
Anglais (eng) |
Mots-clés : |
Family history cognition endophenotype suicide |
Index. décimale : |
PER Périodiques |
Résumé : |
BACKGROUND: Suicidal behavior is highly familial. Neurocognitive deficits have been proposed as an endophenotype for suicide risk that may contribute to the familial transmission of suicide. Yet, there is a lack of research on the neurocognitive functioning of first-degree biological relatives of suicide attempters. The aim of the present study is to conduct the largest investigation to date of neurocognitive functioning in community youth with a family history of a fatal or nonfatal suicide attempt (FH). METHODS: Participants aged 8-21 years from the Philadelphia Neurodevelopmental Cohort completed detailed clinical and neurocognitive evaluations. A subsample of 501 participants with a FH was matched to a comparison group of 3,006 participants without a family history of suicide attempt (no-FH) on age, sex, race, and lifetime depression. RESULTS: After adjusting for multiple comparisons and including relevant clinical and demographic covariates, youth with a FH had significantly lower executive function factor scores (F[1,3432] = 6.63, p = .010) and performed worse on individual tests of attention (F[1,3382] = 7.08, p = .008) and language reasoning (F[1,3387] = 5.12, p = .024) than no-FH youth. CONCLUSIONS: Youth with a FH show small differences in executive function, attention, and language reasoning compared to youth without a FH. Further research is warranted to investigate neurocognitive functioning as an endophenotype for suicide risk. Implications for the prevention and treatment of suicidal behaviors are discussed. |
En ligne : |
http://dx.doi.org/10.1111/jcpp.13239 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=435 |
in Journal of Child Psychology and Psychiatry > 62-1 (January 2021) . - p.58-65
[article] Association between family history of suicide attempt and neurocognitive functioning in community youth [Texte imprimé et/ou numérique] / Jason D. JONES, Auteur ; Rhonda C. BOYD, Auteur ; Monica E. CALKINS, Auteur ; Tyler M. MOORE, Auteur ; Annisa AHMED, Auteur ; Ran BARZILAY, Auteur ; Tami D. BENTON, Auteur ; Raquel E. GUR, Auteur ; Ruben C. GUR, Auteur . - p.58-65. Langues : Anglais ( eng) in Journal of Child Psychology and Psychiatry > 62-1 (January 2021) . - p.58-65
Mots-clés : |
Family history cognition endophenotype suicide |
Index. décimale : |
PER Périodiques |
Résumé : |
BACKGROUND: Suicidal behavior is highly familial. Neurocognitive deficits have been proposed as an endophenotype for suicide risk that may contribute to the familial transmission of suicide. Yet, there is a lack of research on the neurocognitive functioning of first-degree biological relatives of suicide attempters. The aim of the present study is to conduct the largest investigation to date of neurocognitive functioning in community youth with a family history of a fatal or nonfatal suicide attempt (FH). METHODS: Participants aged 8-21 years from the Philadelphia Neurodevelopmental Cohort completed detailed clinical and neurocognitive evaluations. A subsample of 501 participants with a FH was matched to a comparison group of 3,006 participants without a family history of suicide attempt (no-FH) on age, sex, race, and lifetime depression. RESULTS: After adjusting for multiple comparisons and including relevant clinical and demographic covariates, youth with a FH had significantly lower executive function factor scores (F[1,3432] = 6.63, p = .010) and performed worse on individual tests of attention (F[1,3382] = 7.08, p = .008) and language reasoning (F[1,3387] = 5.12, p = .024) than no-FH youth. CONCLUSIONS: Youth with a FH show small differences in executive function, attention, and language reasoning compared to youth without a FH. Further research is warranted to investigate neurocognitive functioning as an endophenotype for suicide risk. Implications for the prevention and treatment of suicidal behaviors are discussed. |
En ligne : |
http://dx.doi.org/10.1111/jcpp.13239 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=435 |
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