Altered Metabolic Characteristics in Plasma of Young Boys with Autism Spectrum Disorder / Lei WANG in Journal of Autism and Developmental Disorders, 52-11 (November 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4897-4907 Titre : Altered Metabolic Characteristics in Plasma of Young Boys with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Lei WANG, Auteur ; Ruixuan ZHENG, Auteur ; Ying XU, Auteur ; Ziyun ZHOU, Auteur ; Ping GUAN, Auteur ; Yanling WU, Auteur ; Jian ZHOU, Auteur ; Zaohuo CHENG, Auteur ; Lili ZHANG, Auteur Article en page(s) : p.4897-4907 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Biomarkers  Child  Choline  Chromatography, Liquid  Humans  Male  Ornithine  Tandem Mass Spectrometry  Autism Spectrum Disorder (ASD)  Liquid chromatography-tandem mass spectrometry (LC-MS/MS)  Metabolic profile  Plasma Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a serious neurodevelopmental disorder with no clinical biomarker. This study used untargeted metabolomic analysis to identify metabolic characteristics in plasma that can distinguish ASD children. 29 boys with ASD (3.02 Â+ 0.67 years) and 30 typically developing (TD) boys (3.13 Â+ 0.46 years) were recruited. Developmental and behavioral assessments were conducted in ASD group. Samples of plasma were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The association between metabolite concentration and scale score was assessed by Spearman rank correlation. Altered metabolic characteristics were found in boys with ASD. In Receiver Operating Characteristic (ROC) analysis, ornithine had the highest AUC (Area under ROC) value. Furthermore, the concentration of choline and ornithine was negatively correlated with ABC-language score in ASD group. En ligne : http://dx.doi.org/10.1007/s10803-021-05364-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Altered Metabolic Characteristics in Plasma of Young Boys with Autism Spectrum Disorder [texte imprimé] / Lei WANG, Auteur ; Ruixuan ZHENG, Auteur ; Ying XU, Auteur ; Ziyun ZHOU, Auteur ; Ping GUAN, Auteur ; Yanling WU, Auteur ; Jian ZHOU, Auteur ; Zaohuo CHENG, Auteur ; Lili ZHANG, Auteur . - p.4897-4907. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4897-4907 Mots-clés : Autism Spectrum Disorder/diagnosis  Biomarkers  Child  Choline  Chromatography, Liquid  Humans  Male  Ornithine  Tandem Mass Spectrometry  Autism Spectrum Disorder (ASD)  Liquid chromatography-tandem mass spectrometry (LC-MS/MS)  Metabolic profile  Plasma Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a serious neurodevelopmental disorder with no clinical biomarker. This study used untargeted metabolomic analysis to identify metabolic characteristics in plasma that can distinguish ASD children. 29 boys with ASD (3.02 Â+ 0.67 years) and 30 typically developing (TD) boys (3.13 Â+ 0.46 years) were recruited. Developmental and behavioral assessments were conducted in ASD group. Samples of plasma were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The association between metabolite concentration and scale score was assessed by Spearman rank correlation. Altered metabolic characteristics were found in boys with ASD. In Receiver Operating Characteristic (ROC) analysis, ornithine had the highest AUC (Area under ROC) value. Furthermore, the concentration of choline and ornithine was negatively correlated with ABC-language score in ASD group. En ligne : http://dx.doi.org/10.1007/s10803-021-05364-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

Association between Autism Spectrum Disorder and Food Allergy: A Systematic Review and Meta-analysis / Lei WANG in Autism Research, 14-1 (January 2021)  

Public ISBD [article]  inAutism Research > 14-1 (January 2021) . - p.220-230 Titre : Association between Autism Spectrum Disorder and Food Allergy: A Systematic Review and Meta-analysis Type de document : texte imprimé Auteurs : Lei WANG, Auteur ; Weimin SHEN, Auteur ; Hao YAO, Auteur ; Rongying ZHENG, Auteur ; Wenshu CHEN, Auteur ; Weixi ZHANG, Auteur Article en page(s) : p.220-230 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and food allergy (FA) are global public health problems. Several studies have explored the association between ASD and FA, but the conclusions were inconsistent. The aim of this review was to evaluate the relationship between ASD and FA. The PubMed, Embase, and Web of Science databases were searched from inception to February 2, 2020. Studies investigating the association between ASD and FA were included. A random effects model was used to pool risk estimates. Subgroup analysis and sensitivity analysis were used to explore the potential sources of heterogeneity. Fifteen studies with a total of 293,130 participants were included in this review. The pooled prevalence of FA in individuals with ASD was 13% (95% confidence interval (CI): 0.10–0.17), while the pooled prevalence of FA in controls was 5% (95% CI: 0.04–0.07). The pooled odds ratio (OR) for FA in individuals with ASD was 2.45 (95% CI: 2.25–2.67). One study examined the prevalence of ASD in participants with FA. The prevalence of ASD in individuals with FA was 3.5% (95% CI: 0.029–0.042), while the prevalence of ASD in the control group was 1.6% (95% CI: 0.015–0.017). Five study examined the OR of ASD in participants with FA. The OR for ASD in individuals with FA was 1.95 (95% CI: 1.73–2.19). The results of this systematic review and meta-analysis seem to reveal a significant association between ASD and FA. Lay Summary This systematic review and meta-analysis evaluate the relationship between ASD and FA. We found that the prevalence of FA was higher in participants with ASD than in controls and participants with ASD were at risk of developing FA and the prevalence of ASD was higher in participants with FA than in controls and participants with FA were at risk of developing ASD. Additional research such as a prospective cohort study is required to better understand the relationship between ASD and FA. En ligne : http://dx.doi.org/10.1002/aur.2454 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441 [article] Association between Autism Spectrum Disorder and Food Allergy: A Systematic Review and Meta-analysis [texte imprimé] / Lei WANG, Auteur ; Weimin SHEN, Auteur ; Hao YAO, Auteur ; Rongying ZHENG, Auteur ; Wenshu CHEN, Auteur ; Weixi ZHANG, Auteur . - p.220-230. Langues : Anglais (eng) in Autism Research > 14-1 (January 2021) . - p.220-230 Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and food allergy (FA) are global public health problems. Several studies have explored the association between ASD and FA, but the conclusions were inconsistent. The aim of this review was to evaluate the relationship between ASD and FA. The PubMed, Embase, and Web of Science databases were searched from inception to February 2, 2020. Studies investigating the association between ASD and FA were included. A random effects model was used to pool risk estimates. Subgroup analysis and sensitivity analysis were used to explore the potential sources of heterogeneity. Fifteen studies with a total of 293,130 participants were included in this review. The pooled prevalence of FA in individuals with ASD was 13% (95% confidence interval (CI): 0.10–0.17), while the pooled prevalence of FA in controls was 5% (95% CI: 0.04–0.07). The pooled odds ratio (OR) for FA in individuals with ASD was 2.45 (95% CI: 2.25–2.67). One study examined the prevalence of ASD in participants with FA. The prevalence of ASD in individuals with FA was 3.5% (95% CI: 0.029–0.042), while the prevalence of ASD in the control group was 1.6% (95% CI: 0.015–0.017). Five study examined the OR of ASD in participants with FA. The OR for ASD in individuals with FA was 1.95 (95% CI: 1.73–2.19). The results of this systematic review and meta-analysis seem to reveal a significant association between ASD and FA. Lay Summary This systematic review and meta-analysis evaluate the relationship between ASD and FA. We found that the prevalence of FA was higher in participants with ASD than in controls and participants with ASD were at risk of developing FA and the prevalence of ASD was higher in participants with FA than in controls and participants with FA were at risk of developing ASD. Additional research such as a prospective cohort study is required to better understand the relationship between ASD and FA. En ligne : http://dx.doi.org/10.1002/aur.2454 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441

Associations between family, environmental factors, and sleep problems in children with autism spectrum disorder: A cross-sectional study / Liuyan ZHU in Research in Autism, 129 (January 2026)  

Public ISBD [article]  inResearch in Autism > 129 (January 2026) . - 202739 Titre : Associations between family, environmental factors, and sleep problems in children with autism spectrum disorder: A cross-sectional study Type de document : texte imprimé Auteurs : Liuyan ZHU, Auteur ; Guirong ZHANG, Auteur ; Dan YAO, Auteur ; Lei WANG, Auteur ; Lina LV, Auteur ; Jie SHAO, Auteur Année de publication : 2026 Article en page(s) : 202739 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Children’s Sleep Habits Questionnaire  Sleep problems Index. décimale : PER Périodiques Résumé : Background This study aimed to examine sleep issues in children diagnosed with Autism Spectrum Disorders (ASD) in comparison to non-autistic children. Additionally, it sought to explore various environmental and non-environmental factors that may be linked to sleep disturbances in children with ASD. Methods A 14-month cross-sectional study was conducted with 249 participants aged 3-6 years, including 58 children with ASD and 191 non-autistic children. The parents of the participants completed the Children’s Sleep Habits Questionnaire (CSHQ) and a self-developed Chinese version of the Family Environment and Non-Environment Scale Survey. Comparative analyses were performed to examine the total CSHQ scores and subscale scores between the two groups. Additionally, multivariate linear regression analysis was conducted to identify factors associated with the sleep patterns of children with ASD. Results Children with ASD exhibited significantly higher CSHQ total scores than non-autistic children. Distinctive sleep disturbances in ASD children included prolonged sleep onset delay and contextual sleep behaviors such as falling asleep in a car. Conversely, non-autistic children showed higher rates of sleep anxiety and post-sleep negative mood. Multivariate linear regression analysis identified several significant factors associated with sleep patterns in children with ASD, including the father's weekly alcohol consumption, parental personality traits, opportunities for social interaction with friends and relatives, mode of delivery, and weaning time. Further examination indicated that sleep duration was closely linked to weaning time and gestational age. Additionally, bedtime resistance, daytime sleepiness, and nighttime awakenings were significantly correlated with the age. Moreover, the frequency of outdoor activities during the first year of life, along with age, was found to be associated with parasomnias, sleep onset delays, sleep-disordered breathing, and daytime sleepiness. Conclusions The study concluded that sleep problems are more prevalent in children with ASD. The findings suggest that both environmental and non-environmental factors are correlated with sleep issues in children with ASD. Future research should explore longitudinal relationships to better understand the causal pathways involved. En ligne : https://doi.org/10.1016/j.reia.2025.202739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Associations between family, environmental factors, and sleep problems in children with autism spectrum disorder: A cross-sectional study [texte imprimé] / Liuyan ZHU, Auteur ; Guirong ZHANG, Auteur ; Dan YAO, Auteur ; Lei WANG, Auteur ; Lina LV, Auteur ; Jie SHAO, Auteur . - 2026 . - 202739. Langues : Anglais (eng) in Research in Autism > 129 (January 2026) . - 202739 Mots-clés : Autism Spectrum Disorder  Children’s Sleep Habits Questionnaire  Sleep problems Index. décimale : PER Périodiques Résumé : Background This study aimed to examine sleep issues in children diagnosed with Autism Spectrum Disorders (ASD) in comparison to non-autistic children. Additionally, it sought to explore various environmental and non-environmental factors that may be linked to sleep disturbances in children with ASD. Methods A 14-month cross-sectional study was conducted with 249 participants aged 3-6 years, including 58 children with ASD and 191 non-autistic children. The parents of the participants completed the Children’s Sleep Habits Questionnaire (CSHQ) and a self-developed Chinese version of the Family Environment and Non-Environment Scale Survey. Comparative analyses were performed to examine the total CSHQ scores and subscale scores between the two groups. Additionally, multivariate linear regression analysis was conducted to identify factors associated with the sleep patterns of children with ASD. Results Children with ASD exhibited significantly higher CSHQ total scores than non-autistic children. Distinctive sleep disturbances in ASD children included prolonged sleep onset delay and contextual sleep behaviors such as falling asleep in a car. Conversely, non-autistic children showed higher rates of sleep anxiety and post-sleep negative mood. Multivariate linear regression analysis identified several significant factors associated with sleep patterns in children with ASD, including the father's weekly alcohol consumption, parental personality traits, opportunities for social interaction with friends and relatives, mode of delivery, and weaning time. Further examination indicated that sleep duration was closely linked to weaning time and gestational age. Additionally, bedtime resistance, daytime sleepiness, and nighttime awakenings were significantly correlated with the age. Moreover, the frequency of outdoor activities during the first year of life, along with age, was found to be associated with parasomnias, sleep onset delays, sleep-disordered breathing, and daytime sleepiness. Conclusions The study concluded that sleep problems are more prevalent in children with ASD. The findings suggest that both environmental and non-environmental factors are correlated with sleep issues in children with ASD. Future research should explore longitudinal relationships to better understand the causal pathways involved. En ligne : https://doi.org/10.1016/j.reia.2025.202739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

RETRACTED ARTICLE: Improve Students' Fast Reading Ability Based on Visual Positioning Technology / Jing JIANG in Journal of Autism and Developmental Disorders, 54-4 (April 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-4 (April 2024) . - p.1620-1620 Titre : RETRACTED ARTICLE: Improve Students' Fast Reading Ability Based on Visual Positioning Technology Type de document : texte imprimé Auteurs : Jing JIANG, Auteur ; Qun ZHENG, Auteur ; Yinhui LIANG, Auteur ; Fudong LI, Auteur ; Bin JIANG, Auteur ; Lei WANG, Auteur ; Ting WANG, Auteur Article en page(s) : p.1620-1620 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-023-06081-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 [article] RETRACTED ARTICLE: Improve Students' Fast Reading Ability Based on Visual Positioning Technology [texte imprimé] / Jing JIANG, Auteur ; Qun ZHENG, Auteur ; Yinhui LIANG, Auteur ; Fudong LI, Auteur ; Bin JIANG, Auteur ; Lei WANG, Auteur ; Ting WANG, Auteur . - p.1620-1620. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-4 (April 2024) . - p.1620-1620 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-023-06081-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526

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