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Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice / Stijn VAN DE SOMPELE ; Clemence LIGNEUL ; Camille CHATELAIN ; Christophe BARREA ; Jason P LERCH ; Beatrice M FILIPPI ; Serpil ALKAN ; Elfride DE BAERE ; Jamie JOHNSTON ; Steven J CLAPCOTE in Molecular Autism, 16 (2025)
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[article]
Titre : Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice Type de document : Texte imprimé et/ou numérique Auteurs : Stijn VAN DE SOMPELE, Auteur ; Clemence LIGNEUL, Auteur ; Camille CHATELAIN, Auteur ; Christophe BARREA, Auteur ; Jason P LERCH, Auteur ; Beatrice M FILIPPI, Auteur ; Serpil ALKAN, Auteur ; Elfride DE BAERE, Auteur ; Jamie JOHNSTON, Auteur ; Steven J CLAPCOTE, Auteur Article en page(s) : 14 Langues : Anglais (eng) Mots-clés : Animals Humans Male Female Mice Autistic Disorder/genetics Alleles Intellectual Disability/genetics Pedigree Autism Spectrum Disorder/genetics Child Phenotype Behavior, Animal Membrane Proteins/genetics Social Behavior Mutation Adult Child, Preschool DNA-Binding Proteins Autism spectrum disorder Intellectual disability Olfactory behavior Pdzd8 Social discrimination approved by Ghent University Ethical Committee. The affected individuals were recruited to the study with the informed consent of their mother using a process that adhered to the tenets of the Declaration of Helsinki. The mouse experiments were conducted in compliance with the UK Animals (Scientific Procedures) Act 1986 under UK Home Office licences and approved by the Animal Welfare and Ethical Review Body at the University of Leeds. Consent for publication: Written consent for publication of case reports and images pertaining to the affected individuals was obtained from their mother. Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Intellectual developmental disorder with autism and dysmorphic facies (IDDADF) is a rare syndromic intellectual disability (ID) caused by homozygous disruption of PDZD8 (PDZ domain-containing protein 8), an integral endoplasmic reticulum (ER) protein. All four previously identified IDDADF cases exhibit autistic behavior, with autism spectrum disorder (ASD) diagnosed in three cases. To determine whether autistic behavior is a common outcome of PDZD8 disruption, we studied a third family with biallelic mutation of PDZD8 (family C) and further characterized PDZD8-deficient (Pdzd8(tm1b)) mice that exhibit stereotyped motor behavior relevant to ASD. METHODS: Homozygosity mapping, whole-exome sequencing, and cosegregation analysis were used to identify the PDZD8 variant responsible for IDDADF, including diagnoses of ASD, in consanguineous family C. To assess the in vivo effect of PDZD8 disruption on social responses and related phenotypes, behavioral, structural magnetic resonance imaging, and microscopy analyses were conducted on the Pdzd8(tm1b) mouse line. Metabolic activity was profiled using sealed metabolic cages. RESULTS: The discovery of a third family with IDDADF caused by biallelic disruption of PDZD8 permitted identification of a core clinical phenotype consisting of developmental delay, ID, autism, and facial dysmorphism. In addition to impairments in social recognition and social odor discrimination, Pdzd8(tm1b) mice exhibit increases in locomotor activity (dark phase only) and metabolic rate (both lights-on and dark phases), and decreased plasma triglyceride in males. In the brain, Pdzd8(tm1b) mice exhibit increased levels of accessory olfactory bulb volume, primary olfactory cortex volume, dendritic spine density, and ER stress- and mitochondrial fusion-related transcripts, as well as decreased levels of cerebellar nuclei volume and adult neurogenesis. LIMITATIONS: The total number of known cases of PDZD8-related IDDADF remains low. Some mouse experiments in the study did not use balanced numbers of males and females. The assessment of ER stress and mitochondrial fusion markers did not extend beyond mRNA levels. CONCLUSIONS: Our finding that the Pdzd8(tm1b) mouse model and all six known cases of IDDADF exhibit autistic behavior, with ASD diagnosed in five cases, identifies this trait as a common outcome of biallelic disruption of PDZD8 in humans and mice. Other abnormalities exhibited by Pdzd8(tm1b) mice suggest that the range of comorbidities associated with PDZD8 deficiency may be wider than presently recognized. En ligne : https://dx.doi.org/10.1186/s13229-025-00650-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555
in Molecular Autism > 16 (2025) . - 14[article] Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice [Texte imprimé et/ou numérique] / Stijn VAN DE SOMPELE, Auteur ; Clemence LIGNEUL, Auteur ; Camille CHATELAIN, Auteur ; Christophe BARREA, Auteur ; Jason P LERCH, Auteur ; Beatrice M FILIPPI, Auteur ; Serpil ALKAN, Auteur ; Elfride DE BAERE, Auteur ; Jamie JOHNSTON, Auteur ; Steven J CLAPCOTE, Auteur . - 14.
Langues : Anglais (eng)
in Molecular Autism > 16 (2025) . - 14
Mots-clés : Animals Humans Male Female Mice Autistic Disorder/genetics Alleles Intellectual Disability/genetics Pedigree Autism Spectrum Disorder/genetics Child Phenotype Behavior, Animal Membrane Proteins/genetics Social Behavior Mutation Adult Child, Preschool DNA-Binding Proteins Autism spectrum disorder Intellectual disability Olfactory behavior Pdzd8 Social discrimination approved by Ghent University Ethical Committee. The affected individuals were recruited to the study with the informed consent of their mother using a process that adhered to the tenets of the Declaration of Helsinki. The mouse experiments were conducted in compliance with the UK Animals (Scientific Procedures) Act 1986 under UK Home Office licences and approved by the Animal Welfare and Ethical Review Body at the University of Leeds. Consent for publication: Written consent for publication of case reports and images pertaining to the affected individuals was obtained from their mother. Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Intellectual developmental disorder with autism and dysmorphic facies (IDDADF) is a rare syndromic intellectual disability (ID) caused by homozygous disruption of PDZD8 (PDZ domain-containing protein 8), an integral endoplasmic reticulum (ER) protein. All four previously identified IDDADF cases exhibit autistic behavior, with autism spectrum disorder (ASD) diagnosed in three cases. To determine whether autistic behavior is a common outcome of PDZD8 disruption, we studied a third family with biallelic mutation of PDZD8 (family C) and further characterized PDZD8-deficient (Pdzd8(tm1b)) mice that exhibit stereotyped motor behavior relevant to ASD. METHODS: Homozygosity mapping, whole-exome sequencing, and cosegregation analysis were used to identify the PDZD8 variant responsible for IDDADF, including diagnoses of ASD, in consanguineous family C. To assess the in vivo effect of PDZD8 disruption on social responses and related phenotypes, behavioral, structural magnetic resonance imaging, and microscopy analyses were conducted on the Pdzd8(tm1b) mouse line. Metabolic activity was profiled using sealed metabolic cages. RESULTS: The discovery of a third family with IDDADF caused by biallelic disruption of PDZD8 permitted identification of a core clinical phenotype consisting of developmental delay, ID, autism, and facial dysmorphism. In addition to impairments in social recognition and social odor discrimination, Pdzd8(tm1b) mice exhibit increases in locomotor activity (dark phase only) and metabolic rate (both lights-on and dark phases), and decreased plasma triglyceride in males. In the brain, Pdzd8(tm1b) mice exhibit increased levels of accessory olfactory bulb volume, primary olfactory cortex volume, dendritic spine density, and ER stress- and mitochondrial fusion-related transcripts, as well as decreased levels of cerebellar nuclei volume and adult neurogenesis. LIMITATIONS: The total number of known cases of PDZD8-related IDDADF remains low. Some mouse experiments in the study did not use balanced numbers of males and females. The assessment of ER stress and mitochondrial fusion markers did not extend beyond mRNA levels. CONCLUSIONS: Our finding that the Pdzd8(tm1b) mouse model and all six known cases of IDDADF exhibit autistic behavior, with ASD diagnosed in five cases, identifies this trait as a common outcome of biallelic disruption of PDZD8 in humans and mice. Other abnormalities exhibited by Pdzd8(tm1b) mice suggest that the range of comorbidities associated with PDZD8 deficiency may be wider than presently recognized. En ligne : https://dx.doi.org/10.1186/s13229-025-00650-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 Attentional shifting differences in autism: Domain general, domain specific or both? / S. SKRIPKAUSKAITE in Autism, 25-6 (August 2021)
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Titre : Attentional shifting differences in autism: Domain general, domain specific or both? Type de document : Texte imprimé et/ou numérique Auteurs : S. SKRIPKAUSKAITE, Auteur ; L. SLADE, Auteur ; J. MAYER, Auteur Article en page(s) : p.1721-1733 Langues : Anglais (eng) Mots-clés : Adult Attention Autism Spectrum Disorder Autistic Disorder Humans adults autism eye tracking gap–overlap saccadic latencies Index. décimale : PER Périodiques Résumé : Previous research has shown that autistic individuals look at other people less and orient to them more slowly than others. Yet, it is still unclear if this represents general visual differences (e.g. slower looking at any new information, social or not) or a uniquely social difference (e.g. only slower looking to humans but not objects). Here, we aimed to examine how quickly autistic and non-autistic adults look to and away from social (i.e. faces) and non-social information (i.e. squares and houses). We used an attentional shifting task with two images where sometimes the first image disappears before the new image appears (makes it easier to notice the new image) and other times it stays on the screen when the new image appears. In Experiment 1, we showed schematic faces and squares to 27 autistic and 26 non-autistic adults, and in Experiment 2, we showed photographs of faces and houses to 18 autistic and 17 non-autistic adults. In general, autistic adults looked at the new non-social or social images similarly to non-autistic adults. Yet, only autistic adults looked at new social information faster when the first image disappeared before the new image appeared. This shows that autistic individuals may find it easier to notice new social information if their attention is not already occupied. En ligne : http://dx.doi.org/10.1177/13623613211001619 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451
in Autism > 25-6 (August 2021) . - p.1721-1733[article] Attentional shifting differences in autism: Domain general, domain specific or both? [Texte imprimé et/ou numérique] / S. SKRIPKAUSKAITE, Auteur ; L. SLADE, Auteur ; J. MAYER, Auteur . - p.1721-1733.
Langues : Anglais (eng)
in Autism > 25-6 (August 2021) . - p.1721-1733
Mots-clés : Adult Attention Autism Spectrum Disorder Autistic Disorder Humans adults autism eye tracking gap–overlap saccadic latencies Index. décimale : PER Périodiques Résumé : Previous research has shown that autistic individuals look at other people less and orient to them more slowly than others. Yet, it is still unclear if this represents general visual differences (e.g. slower looking at any new information, social or not) or a uniquely social difference (e.g. only slower looking to humans but not objects). Here, we aimed to examine how quickly autistic and non-autistic adults look to and away from social (i.e. faces) and non-social information (i.e. squares and houses). We used an attentional shifting task with two images where sometimes the first image disappears before the new image appears (makes it easier to notice the new image) and other times it stays on the screen when the new image appears. In Experiment 1, we showed schematic faces and squares to 27 autistic and 26 non-autistic adults, and in Experiment 2, we showed photographs of faces and houses to 18 autistic and 17 non-autistic adults. In general, autistic adults looked at the new non-social or social images similarly to non-autistic adults. Yet, only autistic adults looked at new social information faster when the first image disappeared before the new image appeared. This shows that autistic individuals may find it easier to notice new social information if their attention is not already occupied. En ligne : http://dx.doi.org/10.1177/13623613211001619 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 Attentional shifting differences in autism: Domain general, domain specific or both? / Simona SKRIPKAUSKAITE in Autism, 26-6 (August 2022)
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[article]
Titre : Attentional shifting differences in autism: Domain general, domain specific or both? Type de document : Texte imprimé et/ou numérique Auteurs : Simona SKRIPKAUSKAITE, Auteur ; Lance SLADE, Auteur ; Jennifer MAYER, Auteur Article en page(s) : p.1721-1733 Langues : Anglais (eng) Mots-clés : Adult Attention Autism Spectrum Disorder Autistic Disorder Humans adults autism eye tracking gap–overlap saccadic latencies Index. décimale : PER Périodiques Résumé : Previous research has shown that autistic individuals look at other people less and orient to them more slowly than others. Yet, it is still unclear if this represents general visual differences (e.g. slower looking at any new information, social or not) or a uniquely social difference (e.g. only slower looking to humans but not objects). Here, we aimed to examine how quickly autistic and non-autistic adults look to and away from social (i.e. faces) and non-social information (i.e. squares and houses). We used an attentional shifting task with two images where sometimes the first image disappears before the new image appears (makes it easier to notice the new image) and other times it stays on the screen when the new image appears. In Experiment 1, we showed schematic faces and squares to 27 autistic and 26 non-autistic adults, and in Experiment 2, we showed photographs of faces and houses to 18 autistic and 17 non-autistic adults. In general, autistic adults looked at the new non-social or social images similarly to non-autistic adults. Yet, only autistic adults looked at new social information faster when the first image disappeared before the new image appeared. This shows that autistic individuals may find it easier to notice new social information if their attention is not already occupied. En ligne : http://dx.doi.org/10.1177/13623613211001619 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484
in Autism > 26-6 (August 2022) . - p.1721-1733[article] Attentional shifting differences in autism: Domain general, domain specific or both? [Texte imprimé et/ou numérique] / Simona SKRIPKAUSKAITE, Auteur ; Lance SLADE, Auteur ; Jennifer MAYER, Auteur . - p.1721-1733.
Langues : Anglais (eng)
in Autism > 26-6 (August 2022) . - p.1721-1733
Mots-clés : Adult Attention Autism Spectrum Disorder Autistic Disorder Humans adults autism eye tracking gap–overlap saccadic latencies Index. décimale : PER Périodiques Résumé : Previous research has shown that autistic individuals look at other people less and orient to them more slowly than others. Yet, it is still unclear if this represents general visual differences (e.g. slower looking at any new information, social or not) or a uniquely social difference (e.g. only slower looking to humans but not objects). Here, we aimed to examine how quickly autistic and non-autistic adults look to and away from social (i.e. faces) and non-social information (i.e. squares and houses). We used an attentional shifting task with two images where sometimes the first image disappears before the new image appears (makes it easier to notice the new image) and other times it stays on the screen when the new image appears. In Experiment 1, we showed schematic faces and squares to 27 autistic and 26 non-autistic adults, and in Experiment 2, we showed photographs of faces and houses to 18 autistic and 17 non-autistic adults. In general, autistic adults looked at the new non-social or social images similarly to non-autistic adults. Yet, only autistic adults looked at new social information faster when the first image disappeared before the new image appeared. This shows that autistic individuals may find it easier to notice new social information if their attention is not already occupied. En ligne : http://dx.doi.org/10.1177/13623613211001619 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons / Q. XU in Molecular Autism, 9 (2018)
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[article]
Titre : Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons Type de document : Texte imprimé et/ou numérique Auteurs : Q. XU, Auteur ; Y. Y. LIU, Auteur ; X. WANG, Auteur ; G. H. TAN, Auteur ; H. P. LI, Auteur ; S. W. HULBERT, Auteur ; C. Y. LI, Auteur ; C. C. HU, Auteur ; Z. Q. XIONG, Auteur ; X. XU, Auteur ; Y. H. JIANG, Auteur Article en page(s) : 65 p. Langues : Anglais (eng) Mots-clés : Animals Autistic Disorder/*genetics/pathology Cells, Cultured Cerebral Cortex/cytology/growth & development DNA-Binding Proteins/*genetics/metabolism Humans Mice Mice, Inbred C57BL *Neurogenesis Neurons/cytology/*metabolism/physiology *Autism spectrum disorder (ASD) *chd8 *Chromatin remodeling *Neurite growth *Neurodevelopment Animal Care and Use Committee-approved protocols both at Children's Hospital of Fudan University ethics approval ID: 2015-87 and Duke University. Human postmortem brain tissues: The use of archived human postmortem brain tissues is approved by Institute Review Board at Duke University.Not applicableThe authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Mutations in CHD8, chromodomain helicase DNA-binding protein 8, are among the most replicated and common findings in genetic studies of autism spectrum disorder (ASD). The CHD8 protein is believed to act as a transcriptional regulator by remodeling chromatin structure and recruiting histone H1 to target genes. The mechanism by which deficiency of CHD8 causes ASD has not been fully elucidated. Methods: We examined the expression of CHD8 in human and mouse brains using both immunohistochemistry and RNA in situ hybridization. We performed in utero electroporation, neuronal culture, and biochemical analysis using RNAi to examine the functional consequences of CHD8 deficiency. Results: We discovered that CHD8 is expressed highly in neurons and at low levels in glia cells in both humans and mice. Specifically, CHD8 is localized predominately in the nucleus of both MAP2 and parvalbumin-positive neurons. In the developing mouse brain, expression of Chd8 peaks from E16 to E18 and then decreases significantly at P14 to adulthood. Knockdown of Chd8 results in reduced axon and dendritic growth, disruption of axon projections to the contralateral cortex, and delayed neuronal migration at E18.5 which recovers by P3 and P7. Conclusion: Our findings indicate an important role for CHD8 in dendritic and axon development and neuronal migration and thus offer novel insights to further dissect the underlying molecular and circuit mechanisms of ASD caused by CHD8 deficiency. En ligne : https://dx.doi.org/10.1186/s13229-018-0244-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389
in Molecular Autism > 9 (2018) . - 65 p.[article] Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons [Texte imprimé et/ou numérique] / Q. XU, Auteur ; Y. Y. LIU, Auteur ; X. WANG, Auteur ; G. H. TAN, Auteur ; H. P. LI, Auteur ; S. W. HULBERT, Auteur ; C. Y. LI, Auteur ; C. C. HU, Auteur ; Z. Q. XIONG, Auteur ; X. XU, Auteur ; Y. H. JIANG, Auteur . - 65 p.
Langues : Anglais (eng)
in Molecular Autism > 9 (2018) . - 65 p.
Mots-clés : Animals Autistic Disorder/*genetics/pathology Cells, Cultured Cerebral Cortex/cytology/growth & development DNA-Binding Proteins/*genetics/metabolism Humans Mice Mice, Inbred C57BL *Neurogenesis Neurons/cytology/*metabolism/physiology *Autism spectrum disorder (ASD) *chd8 *Chromatin remodeling *Neurite growth *Neurodevelopment Animal Care and Use Committee-approved protocols both at Children's Hospital of Fudan University ethics approval ID: 2015-87 and Duke University. Human postmortem brain tissues: The use of archived human postmortem brain tissues is approved by Institute Review Board at Duke University.Not applicableThe authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Mutations in CHD8, chromodomain helicase DNA-binding protein 8, are among the most replicated and common findings in genetic studies of autism spectrum disorder (ASD). The CHD8 protein is believed to act as a transcriptional regulator by remodeling chromatin structure and recruiting histone H1 to target genes. The mechanism by which deficiency of CHD8 causes ASD has not been fully elucidated. Methods: We examined the expression of CHD8 in human and mouse brains using both immunohistochemistry and RNA in situ hybridization. We performed in utero electroporation, neuronal culture, and biochemical analysis using RNAi to examine the functional consequences of CHD8 deficiency. Results: We discovered that CHD8 is expressed highly in neurons and at low levels in glia cells in both humans and mice. Specifically, CHD8 is localized predominately in the nucleus of both MAP2 and parvalbumin-positive neurons. In the developing mouse brain, expression of Chd8 peaks from E16 to E18 and then decreases significantly at P14 to adulthood. Knockdown of Chd8 results in reduced axon and dendritic growth, disruption of axon projections to the contralateral cortex, and delayed neuronal migration at E18.5 which recovers by P3 and P7. Conclusion: Our findings indicate an important role for CHD8 in dendritic and axon development and neuronal migration and thus offer novel insights to further dissect the underlying molecular and circuit mechanisms of ASD caused by CHD8 deficiency. En ligne : https://dx.doi.org/10.1186/s13229-018-0244-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 Brief Report: Preferred Processing of Social Stimuli in Autism: A Perception Task / A. MEERMEIER in Journal of Autism and Developmental Disorders, 52-7 (July 2022)
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Titre : Brief Report: Preferred Processing of Social Stimuli in Autism: A Perception Task Type de document : Texte imprimé et/ou numérique Auteurs : A. MEERMEIER, Auteur ; M. JORDING, Auteur ; Y. ALAYOUBI, Auteur ; David H. V. VOGEL, Auteur ; Kai VOGELEY, Auteur ; R. TEPEST, Auteur Article en page(s) : p.3286-3293 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Autistic Disorder Humans Perception Social Perception Image persistence Image recognition Perception task Social stimuli Index. décimale : PER Périodiques Résumé : In this study we investigate whether persons with autism spectrum disorder (ASD) perceive social images differently than control participants (CON) in a graded perception task in which stimuli emerged from noise before dissipating into noise again. We presented either social stimuli (humans) or non-social stimuli (objects or animals). ASD were slower to recognize images during their emergence, but as fast as CON when indicating the dissipation of the image irrespective of its content. Social stimuli were recognized faster and remained discernable longer in both diagnostic groups. Thus, ASD participants show a largely intact preference for the processing of social images. An exploratory analysis of response subsets reveals subtle differences between groups that could be investigated in future studies. En ligne : http://dx.doi.org/10.1007/s10803-021-05195-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3286-3293[article] Brief Report: Preferred Processing of Social Stimuli in Autism: A Perception Task [Texte imprimé et/ou numérique] / A. MEERMEIER, Auteur ; M. JORDING, Auteur ; Y. ALAYOUBI, Auteur ; David H. V. VOGEL, Auteur ; Kai VOGELEY, Auteur ; R. TEPEST, Auteur . - p.3286-3293.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3286-3293
Mots-clés : Autism Spectrum Disorder Autistic Disorder Humans Perception Social Perception Image persistence Image recognition Perception task Social stimuli Index. décimale : PER Périodiques Résumé : In this study we investigate whether persons with autism spectrum disorder (ASD) perceive social images differently than control participants (CON) in a graded perception task in which stimuli emerged from noise before dissipating into noise again. We presented either social stimuli (humans) or non-social stimuli (objects or animals). ASD were slower to recognize images during their emergence, but as fast as CON when indicating the dissipation of the image irrespective of its content. Social stimuli were recognized faster and remained discernable longer in both diagnostic groups. Thus, ASD participants show a largely intact preference for the processing of social images. An exploratory analysis of response subsets reveals subtle differences between groups that could be investigated in future studies. En ligne : http://dx.doi.org/10.1007/s10803-021-05195-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 Closing the species gap: Translational approaches to studying sensory processing differences relevant for autism spectrum disorder / Kaela E. SCOTT in Autism Research, 14-7 (July 2021)
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PermalinkCulture and psychopathology: An attempt at reconsidering the role of social learning / Peter FONAGY in Development and Psychopathology, 34-4 (October 2022)
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PermalinkEditorial: Environmental conditions for growing healthy children / Joan L. LUBY in Journal of Child Psychology and Psychiatry, 63-9 (September 2022)
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PermalinkEvolutionary constrained genes associated with autism spectrum disorder across 2,054 nonhuman primate genomes / Mohammed UDDIN ; Joris A VELTMAN ; Sara WELLS ; Christopher MORRIS ; Marc WOODBURY-SMITH in Molecular Autism, 16 (2025)
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PermalinkImpaired synaptic function and hyperexcitability of the pyramidal neurons in the prefrontal cortex of autism-associated Shank3 mutant dogs / Feipeng ZHU in Molecular Autism, 15 (2024)
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