Carbamazepine serum levels in children with epilepsy: a micro immuno-assay technique / W. I. FORSYTHE in Developmental Medicine & Child Neurology, 21-4 (August 1979)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 21-4 (August 1979) . - p.441-447 Titre : Carbamazepine serum levels in children with epilepsy: a micro immuno-assay technique Type de document : Texte imprimé et/ou numérique Auteurs : W. I. FORSYTHE, Auteur ; M. P. PRENDERGAST, Auteur ; C. TOOTHILL, Auteur ; P. M. G. BROUGHTON, Auteur Année de publication : 1979 Article en page(s) : p.441-447 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In part 1 of this study, 26 children with seizures were given 20 mg/kg/day carbamazepine and five developed side-effects. With this initial dose, equilibrium was reached in the serum within four to six days in 25 of the 26 children. The sudden withdrawal of other anticonvulsants did not usually affect the rise of carbamazepine in serum, unless given in high doses. In Part 2 of the study it was shown that satisfactory levels were obtained in the serum of 38 children given carbamazepine either twice or three times daily, but higher levels were obtained with the latter. The lowest carbamazepine serum level associated with complete control of seizures was 6mg/1. Seizure control was comparable whether carbamazepine was given twice or three times daily. Complete control of temporal-lobe seizures was obtained in nine of 20 children, and of grand mal in 10 of 18 children. Serum levels of carbamazepine remained remarkable constant during the follow-up period of between 10 and 30 months. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 [article] Carbamazepine serum levels in children with epilepsy: a micro immuno-assay technique [Texte imprimé et/ou numérique] / W. I. FORSYTHE, Auteur ; M. P. PRENDERGAST, Auteur ; C. TOOTHILL, Auteur ; P. M. G. BROUGHTON, Auteur . - 1979 . - p.441-447. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 21-4 (August 1979) . - p.441-447 Index. décimale : PER Périodiques Résumé : In part 1 of this study, 26 children with seizures were given 20 mg/kg/day carbamazepine and five developed side-effects. With this initial dose, equilibrium was reached in the serum within four to six days in 25 of the 26 children. The sudden withdrawal of other anticonvulsants did not usually affect the rise of carbamazepine in serum, unless given in high doses. In Part 2 of the study it was shown that satisfactory levels were obtained in the serum of 38 children given carbamazepine either twice or three times daily, but higher levels were obtained with the latter. The lowest carbamazepine serum level associated with complete control of seizures was 6mg/1. Seizure control was comparable whether carbamazepine was given twice or three times daily. Complete control of temporal-lobe seizures was obtained in nine of 20 children, and of grand mal in 10 of 18 children. Serum levels of carbamazepine remained remarkable constant during the follow-up period of between 10 and 30 months. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498

Eye-movement Tics in Children / Sharon BINYON in Developmental Medicine & Child Neurology, 33-4 (April 1991)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 33-4 (April 1991) . - p.352-355 Titre : Eye-movement Tics in Children Type de document : Texte imprimé et/ou numérique Auteurs : Sharon BINYON, Auteur ; M. P. PRENDERGAST, Auteur Année de publication : 1991 Article en page(s) : p.352-355 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Tics de mouvements oculaires chez l'enfant Les tics sont relativement communs durant l'enfance surtout entre six et 12 ans. Alors que les tics de clignement et de fermeture des yeux sont bien reconnus, les tics de mouvements oculaires ne le sont pas. Trois enfants avec des tics de mouvements oculaires conjugués survenant seuls ou en combinaison avec d'autres tics sont étudiés et le diagnostic differentiel discuté. Le traitement de première intention des tics consiste à rassurer et à expliquer. Une investigation ultérieure n'est pas indiquée mais le suivi est souhaitable si les tics persistent puisque certains enfants peuvent évoluer vers un syndrome de la Tourette ou une maladie chronique des tics. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=135 [article] Eye-movement Tics in Children [Texte imprimé et/ou numérique] / Sharon BINYON, Auteur ; M. P. PRENDERGAST, Auteur . - 1991 . - p.352-355. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 33-4 (April 1991) . - p.352-355 Index. décimale : PER Périodiques Résumé : Tics de mouvements oculaires chez l'enfant Les tics sont relativement communs durant l'enfance surtout entre six et 12 ans. Alors que les tics de clignement et de fermeture des yeux sont bien reconnus, les tics de mouvements oculaires ne le sont pas. Trois enfants avec des tics de mouvements oculaires conjugués survenant seuls ou en combinaison avec d'autres tics sont étudiés et le diagnostic differentiel discuté. Le traitement de première intention des tics consiste à rassurer et à expliquer. Une investigation ultérieure n'est pas indiquée mais le suivi est souhaitable si les tics persistent puisque certains enfants peuvent évoluer vers un syndrome de la Tourette ou une maladie chronique des tics. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=135

Phenytoin serum levels in children with epilepsy: a micro immuno-assay technique / W. I. FORSYTHE in Developmental Medicine & Child Neurology, 21-4 (August 1979)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 21-4 (August 1979) . - p.448-454 Titre : Phenytoin serum levels in children with epilepsy: a micro immuno-assay technique Type de document : Texte imprimé et/ou numérique Auteurs : W. I. FORSYTHE, Auteur ; M. P. PRENDERGAST, Auteur ; C. TOOTHILL, Auteur ; P. M. G. BROUGHTON, Auteur Année de publication : 1979 Article en page(s) : p.448-454 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The enzyme multiple immuno-assay technique (EMIT) was used to study phenytoin serum levels in 50 children with seizures. It was found that: (1) a single dose of phenytoin suspension or capsules (5mg/kg/day) produced inadequate serum levels 16 and 24 hours after ingestion, and for this reason single dosage is not recommended; (2) twice-daily dosage of phenytoin suspension or capsules (5mg/kg/day) produced adequate serum levels in most children throughout the 24 hours, and this dosage is recommended; (3) 12 children continued to have seizures but when the dose was increased to 10mg/kg/day six of the 12 obtained control of seizures; (4) phenytoin reached equilibrium in the serum in five days provided the child had not previously been taking phenobarbitone; (5) of 13 children who had been taking phenobarbitone, 10 did not achieve equilibrium of phenytoin in serum for one to four weeks; (6) phenytoin suspension given twice-daily produced satisfactory serum levels provided the bottle was shaken well before dispensing; (7) apart from minor variations, phenytoin maintained its level in serum during the 14 to 30 months follow-up period, whether 5mg or 10mg/kg/day of phenytoin was given. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 [article] Phenytoin serum levels in children with epilepsy: a micro immuno-assay technique [Texte imprimé et/ou numérique] / W. I. FORSYTHE, Auteur ; M. P. PRENDERGAST, Auteur ; C. TOOTHILL, Auteur ; P. M. G. BROUGHTON, Auteur . - 1979 . - p.448-454. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 21-4 (August 1979) . - p.448-454 Index. décimale : PER Périodiques Résumé : The enzyme multiple immuno-assay technique (EMIT) was used to study phenytoin serum levels in 50 children with seizures. It was found that: (1) a single dose of phenytoin suspension or capsules (5mg/kg/day) produced inadequate serum levels 16 and 24 hours after ingestion, and for this reason single dosage is not recommended; (2) twice-daily dosage of phenytoin suspension or capsules (5mg/kg/day) produced adequate serum levels in most children throughout the 24 hours, and this dosage is recommended; (3) 12 children continued to have seizures but when the dose was increased to 10mg/kg/day six of the 12 obtained control of seizures; (4) phenytoin reached equilibrium in the serum in five days provided the child had not previously been taking phenobarbitone; (5) of 13 children who had been taking phenobarbitone, 10 did not achieve equilibrium of phenytoin in serum for one to four weeks; (6) phenytoin suspension given twice-daily produced satisfactory serum levels provided the bottle was shaken well before dispensing; (7) apart from minor variations, phenytoin maintained its level in serum during the 14 to 30 months follow-up period, whether 5mg or 10mg/kg/day of phenytoin was given. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498

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