Carbamazepine serum levels in children with epilepsy: a micro immuno-assay technique / W. I. FORSYTHE in Developmental Medicine & Child Neurology, 21-4 (August 1979)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 21-4 (August 1979) . - p.441-447 Titre : Carbamazepine serum levels in children with epilepsy: a micro immuno-assay technique Type de document : Texte imprimé et/ou numérique Auteurs : W. I. FORSYTHE, Auteur ; M. P. PRENDERGAST, Auteur ; C. TOOTHILL, Auteur ; P. M. G. BROUGHTON, Auteur Année de publication : 1979 Article en page(s) : p.441-447 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In part 1 of this study, 26 children with seizures were given 20 mg/kg/day carbamazepine and five developed side-effects. With this initial dose, equilibrium was reached in the serum within four to six days in 25 of the 26 children. The sudden withdrawal of other anticonvulsants did not usually affect the rise of carbamazepine in serum, unless given in high doses. In Part 2 of the study it was shown that satisfactory levels were obtained in the serum of 38 children given carbamazepine either twice or three times daily, but higher levels were obtained with the latter. The lowest carbamazepine serum level associated with complete control of seizures was 6mg/1. Seizure control was comparable whether carbamazepine was given twice or three times daily. Complete control of temporal-lobe seizures was obtained in nine of 20 children, and of grand mal in 10 of 18 children. Serum levels of carbamazepine remained remarkable constant during the follow-up period of between 10 and 30 months. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 [article] Carbamazepine serum levels in children with epilepsy: a micro immuno-assay technique [Texte imprimé et/ou numérique] / W. I. FORSYTHE, Auteur ; M. P. PRENDERGAST, Auteur ; C. TOOTHILL, Auteur ; P. M. G. BROUGHTON, Auteur . - 1979 . - p.441-447. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 21-4 (August 1979) . - p.441-447 Index. décimale : PER Périodiques Résumé : In part 1 of this study, 26 children with seizures were given 20 mg/kg/day carbamazepine and five developed side-effects. With this initial dose, equilibrium was reached in the serum within four to six days in 25 of the 26 children. The sudden withdrawal of other anticonvulsants did not usually affect the rise of carbamazepine in serum, unless given in high doses. In Part 2 of the study it was shown that satisfactory levels were obtained in the serum of 38 children given carbamazepine either twice or three times daily, but higher levels were obtained with the latter. The lowest carbamazepine serum level associated with complete control of seizures was 6mg/1. Seizure control was comparable whether carbamazepine was given twice or three times daily. Complete control of temporal-lobe seizures was obtained in nine of 20 children, and of grand mal in 10 of 18 children. Serum levels of carbamazepine remained remarkable constant during the follow-up period of between 10 and 30 months. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498

Phenytoin serum levels in children with epilepsy: a micro immuno-assay technique / W. I. FORSYTHE in Developmental Medicine & Child Neurology, 21-4 (August 1979)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 21-4 (August 1979) . - p.448-454 Titre : Phenytoin serum levels in children with epilepsy: a micro immuno-assay technique Type de document : Texte imprimé et/ou numérique Auteurs : W. I. FORSYTHE, Auteur ; M. P. PRENDERGAST, Auteur ; C. TOOTHILL, Auteur ; P. M. G. BROUGHTON, Auteur Année de publication : 1979 Article en page(s) : p.448-454 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The enzyme multiple immuno-assay technique (EMIT) was used to study phenytoin serum levels in 50 children with seizures. It was found that: (1) a single dose of phenytoin suspension or capsules (5mg/kg/day) produced inadequate serum levels 16 and 24 hours after ingestion, and for this reason single dosage is not recommended; (2) twice-daily dosage of phenytoin suspension or capsules (5mg/kg/day) produced adequate serum levels in most children throughout the 24 hours, and this dosage is recommended; (3) 12 children continued to have seizures but when the dose was increased to 10mg/kg/day six of the 12 obtained control of seizures; (4) phenytoin reached equilibrium in the serum in five days provided the child had not previously been taking phenobarbitone; (5) of 13 children who had been taking phenobarbitone, 10 did not achieve equilibrium of phenytoin in serum for one to four weeks; (6) phenytoin suspension given twice-daily produced satisfactory serum levels provided the bottle was shaken well before dispensing; (7) apart from minor variations, phenytoin maintained its level in serum during the 14 to 30 months follow-up period, whether 5mg or 10mg/kg/day of phenytoin was given. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 [article] Phenytoin serum levels in children with epilepsy: a micro immuno-assay technique [Texte imprimé et/ou numérique] / W. I. FORSYTHE, Auteur ; M. P. PRENDERGAST, Auteur ; C. TOOTHILL, Auteur ; P. M. G. BROUGHTON, Auteur . - 1979 . - p.448-454. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 21-4 (August 1979) . - p.448-454 Index. décimale : PER Périodiques Résumé : The enzyme multiple immuno-assay technique (EMIT) was used to study phenytoin serum levels in 50 children with seizures. It was found that: (1) a single dose of phenytoin suspension or capsules (5mg/kg/day) produced inadequate serum levels 16 and 24 hours after ingestion, and for this reason single dosage is not recommended; (2) twice-daily dosage of phenytoin suspension or capsules (5mg/kg/day) produced adequate serum levels in most children throughout the 24 hours, and this dosage is recommended; (3) 12 children continued to have seizures but when the dose was increased to 10mg/kg/day six of the 12 obtained control of seizures; (4) phenytoin reached equilibrium in the serum in five days provided the child had not previously been taking phenobarbitone; (5) of 13 children who had been taking phenobarbitone, 10 did not achieve equilibrium of phenytoin in serum for one to four weeks; (6) phenytoin suspension given twice-daily produced satisfactory serum levels provided the bottle was shaken well before dispensing; (7) apart from minor variations, phenytoin maintained its level in serum during the 14 to 30 months follow-up period, whether 5mg or 10mg/kg/day of phenytoin was given. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498

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