Reduced Sensory Habituation in Autism and Its Correlation with Behavioral Measures / W. JAMAL in Journal of Autism and Developmental Disorders, 51-9 (September 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3153-3164 Titre : Reduced Sensory Habituation in Autism and Its Correlation with Behavioral Measures Type de document : Texte imprimé et/ou numérique Auteurs : W. JAMAL, Auteur ; A. CARDINAUX, Auteur ; A. J. HASKINS, Auteur ; M. KJELGAARD, Auteur ; P. SINHA, Auteur Article en page(s) : p.3153-3164 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Cognition  Electroencephalography  Habituation, Psychophysiologic  Humans  Audition  Autism  Hyper and hypo-sensitivity  Sensory habituation  Vision Index. décimale : PER Périodiques Résumé : Autism is strongly associated with sensory processing difficulties. We investigate sensory habituation, given its relevance for understanding important phenotypic traits like hyper- and hypo-sensitivities. We collected electroencephalography data from 22 neuro-typical(NT) and 13 autistic(ASD) children during the presentation of visual and auditory sequences of repeated stimuli. Our data show that the ASD children have significantly reduced habituation relative to the NT children for both auditory and visual stimuli. These results point to impaired habituation as a modality-general phenomenon in ASD. Additionally, the rates of habituation are correlated with several clinical scores associated with competence along diverse phenotypic dimensions. These data suggest that the sensory difficulties in autism are likely to be associated with reduced habituation and are related to clinical symptomology. En ligne : http://dx.doi.org/10.1007/s10803-020-04780-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Reduced Sensory Habituation in Autism and Its Correlation with Behavioral Measures [Texte imprimé et/ou numérique] / W. JAMAL, Auteur ; A. CARDINAUX, Auteur ; A. J. HASKINS, Auteur ; M. KJELGAARD, Auteur ; P. SINHA, Auteur . - p.3153-3164. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3153-3164 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Cognition  Electroencephalography  Habituation, Psychophysiologic  Humans  Audition  Autism  Hyper and hypo-sensitivity  Sensory habituation  Vision Index. décimale : PER Périodiques Résumé : Autism is strongly associated with sensory processing difficulties. We investigate sensory habituation, given its relevance for understanding important phenotypic traits like hyper- and hypo-sensitivities. We collected electroencephalography data from 22 neuro-typical(NT) and 13 autistic(ASD) children during the presentation of visual and auditory sequences of repeated stimuli. Our data show that the ASD children have significantly reduced habituation relative to the NT children for both auditory and visual stimuli. These results point to impaired habituation as a modality-general phenomenon in ASD. Additionally, the rates of habituation are correlated with several clinical scores associated with competence along diverse phenotypic dimensions. These data suggest that the sensory difficulties in autism are likely to be associated with reduced habituation and are related to clinical symptomology. En ligne : http://dx.doi.org/10.1007/s10803-020-04780-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Visual processing in genetic conditions linked to autism: A behavioral study of binocular rivalry in individuals with 16p11.2 deletions and age-matched controls / Yeo Bi CHOI in Autism Research, 16-4 (April 2023)  

Public ISBD [article]  inAutism Research > 16-4 (April 2023) . - p.831-840 Titre : Visual processing in genetic conditions linked to autism: A behavioral study of binocular rivalry in individuals with 16p11.2 deletions and age-matched controls Type de document : Texte imprimé et/ou numérique Auteurs : Yeo Bi CHOI, Auteur ; Jeff MENTCH, Auteur ; A. J. HASKINS, Auteur ; Caitlin VAN WICKLIN, Auteur ; Caroline E. ROBERTSON, Auteur Article en page(s) : p.831-840 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Close phenotypic characterization of individuals with genetic conditions linked to autism provides a promising approach to navigating the heterogeneity of autism spectrum conditions. The current study investigated sensory processing in individuals with a rare genetic event that is highly penetrant for autism, 16p11.2 deletions, using a well-characterized visual paradigm, binocular rivalry, which is thought to be a non-invasive index of excitatory/inhibitory balance in the visual cortex. We characterized rivalry dynamics in 45 adolescent and adult individuals (19 individuals with 16p11.2 deletions, 26 age-matched neurotypical controls). We found that binocular rivalry perceptual transition rates were significantly slower for individuals with 16p11.2 deletions, relative to controls. Importantly, these results could not be accounted for by differences in motor response latencies or perceptual decision criteria, which were matched between groups. Results should be interpreted with caution given the unmatched psychometric features between groups, such as IQ. Future studies should study visual processing in other genetic groups linked to autism beyond 16p to understand the specificity of these findings. These results highlight the importance of characterizing sensory functions in individuals with genetic alterations associated with autism. En ligne : https://doi.org/10.1002/aur.2901 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Visual processing in genetic conditions linked to autism: A behavioral study of binocular rivalry in individuals with 16p11.2 deletions and age-matched controls [Texte imprimé et/ou numérique] / Yeo Bi CHOI, Auteur ; Jeff MENTCH, Auteur ; A. J. HASKINS, Auteur ; Caitlin VAN WICKLIN, Auteur ; Caroline E. ROBERTSON, Auteur . - p.831-840. Langues : Anglais (eng) in Autism Research > 16-4 (April 2023) . - p.831-840 Index. décimale : PER Périodiques Résumé : Abstract Close phenotypic characterization of individuals with genetic conditions linked to autism provides a promising approach to navigating the heterogeneity of autism spectrum conditions. The current study investigated sensory processing in individuals with a rare genetic event that is highly penetrant for autism, 16p11.2 deletions, using a well-characterized visual paradigm, binocular rivalry, which is thought to be a non-invasive index of excitatory/inhibitory balance in the visual cortex. We characterized rivalry dynamics in 45 adolescent and adult individuals (19 individuals with 16p11.2 deletions, 26 age-matched neurotypical controls). We found that binocular rivalry perceptual transition rates were significantly slower for individuals with 16p11.2 deletions, relative to controls. Importantly, these results could not be accounted for by differences in motor response latencies or perceptual decision criteria, which were matched between groups. Results should be interpreted with caution given the unmatched psychometric features between groups, such as IQ. Future studies should study visual processing in other genetic groups linked to autism beyond 16p to understand the specificity of these findings. These results highlight the importance of characterizing sensory functions in individuals with genetic alterations associated with autism. En ligne : https://doi.org/10.1002/aur.2901 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

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