Intergenerational factors in the etiology of anencephalus and spina bifida / Lowell E. SEVER in Developmental Medicine & Child Neurology, 23-2 (April 1981)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 23-2 (April 1981) . - p.151-154 Titre : Intergenerational factors in the etiology of anencephalus and spina bifida Type de document : Texte imprimé et/ou numérique Auteurs : Lowell E. SEVER, Auteur ; Irvin EMANUEL, Auteur Année de publication : 1981 Article en page(s) : p.151-154 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : To test the hypothesis that events and conditions early in women's lives influence their future risk of producing babies with anencephalus and spina bifida, a case-control study compared mothers of affected infants with mothers whose infants were normal. Occupational class scores of husbands and fathers of the case mothers and control mothers were also compared. While there was no difference between the scores of case and control husbands, the mean score of fathers of case mothers was significantly less than that of the fathers of control mothers. This can be an indication that case mothers grew up under less favorable conditions. These findings, in conjunction with the pattern evident from previous epidemiological studies, support the hypothesis that intergenerational factors play a rôle in the etiology of these defects. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=516 [article] Intergenerational factors in the etiology of anencephalus and spina bifida [Texte imprimé et/ou numérique] / Lowell E. SEVER, Auteur ; Irvin EMANUEL, Auteur . - 1981 . - p.151-154. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 23-2 (April 1981) . - p.151-154 Index. décimale : PER Périodiques Résumé : To test the hypothesis that events and conditions early in women's lives influence their future risk of producing babies with anencephalus and spina bifida, a case-control study compared mothers of affected infants with mothers whose infants were normal. Occupational class scores of husbands and fathers of the case mothers and control mothers were also compared. While there was no difference between the scores of case and control husbands, the mean score of fathers of case mothers was significantly less than that of the fathers of control mothers. This can be an indication that case mothers grew up under less favorable conditions. These findings, in conjunction with the pattern evident from previous epidemiological studies, support the hypothesis that intergenerational factors play a rôle in the etiology of these defects. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=516

A population-based case-control study of anencephalus and spina bifida in a low-risk area / Marc A. STRASSBURG in Developmental Medicine & Child Neurology, 25-5 (October 1983)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 25-5 (October 1983) . - p.632-641 Titre : A population-based case-control study of anencephalus and spina bifida in a low-risk area Type de document : Texte imprimé et/ou numérique Auteurs : Marc A. STRASSBURG, Auteur ; Lowell E. SEVER, Auteur ; Sander GREENLAND, Auteur ; Lawrence D. PORTIGAL, Auteur Année de publication : 1983 Article en page(s) : p.632-641 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : For the period 1973 to 1977, a total of 536 cases of anencephalus and spina bifida were ascertained in Los Angeles County, California, a low-risk area, and compared with a 2 per cent random sample of all live births in the county. Women with Spanish surnames had an elevated risk for anencephalus and to a lesser extent for spina bifida; Blacks were at lowest risk, especially for spina bifida. The occurrence of a previous fetal death was a strong risk factor for anencephalus but there was no association between socio-economic status and either of the defects. Advanced maternal age was a stronger risk factor for spina bifida than for anencephalus but, as in other studies in low-risk areas, no increased risk was observed among teenage mothers. Paternal age did not show any independent association after controlling for mother's age. Finally, the association of high birth-order with the birth defects was weakened greatly after simultaneous adjustment for age and ethnicity. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] A population-based case-control study of anencephalus and spina bifida in a low-risk area [Texte imprimé et/ou numérique] / Marc A. STRASSBURG, Auteur ; Lowell E. SEVER, Auteur ; Sander GREENLAND, Auteur ; Lawrence D. PORTIGAL, Auteur . - 1983 . - p.632-641. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 25-5 (October 1983) . - p.632-641 Index. décimale : PER Périodiques Résumé : For the period 1973 to 1977, a total of 536 cases of anencephalus and spina bifida were ascertained in Los Angeles County, California, a low-risk area, and compared with a 2 per cent random sample of all live births in the county. Women with Spanish surnames had an elevated risk for anencephalus and to a lesser extent for spina bifida; Blacks were at lowest risk, especially for spina bifida. The occurrence of a previous fetal death was a strong risk factor for anencephalus but there was no association between socio-economic status and either of the defects. Advanced maternal age was a stronger risk factor for spina bifida than for anencephalus but, as in other studies in low-risk areas, no increased risk was observed among teenage mothers. Paternal age did not show any independent association after controlling for mother's age. Finally, the association of high birth-order with the birth defects was weakened greatly after simultaneous adjustment for age and ethnicity. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

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