Characterizing experiential elements of early-life stress to inform resilience: Buffering effects of controllability and predictability and the importance of their timing / Dylan G. GEE ; Taylor J. KEDING ; Jeffrey D. MANDELL ; Madeline E. NOTTI ; Lucinda M. SISK in Development and Psychopathology, 35-5 (December 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-5 (December 2023) . - p.2288-2301 Titre : Characterizing experiential elements of early-life stress to inform resilience: Buffering effects of controllability and predictability and the importance of their timing Type de document : texte imprimé Auteurs : Dylan G. GEE, Auteur ; Taylor J. KEDING, Auteur ; Jeffrey D. MANDELL, Auteur ; Madeline E. NOTTI, Auteur ; Lucinda M. SISK, Auteur Article en page(s) : p.2288-2301 Mots-clés : adversity  controllability  dimensional  predictability  stress  trauma-related symptomatology  traumatic stress Index. décimale : PER Périodiques Résumé : Key theoretical frameworks have proposed that examining the impact of exposure to specific dimensions of stress at specific developmental periods is likely to yield important insight into processes of risk and resilience. Utilizing a sample of N = 549 young adults who provided a detailed retrospective history of their lifetime exposure to numerous dimensions of traumatic stress and ratings of their current trauma-related symptomatology via completion of an online survey, here we test whether an individual?s perception of their lifetime stress as either controllable or predictable buffered the impact of exposure on trauma-related symptomatology assessed in adulthood. Further, we tested whether this moderation effect differed when evaluated in the context of early childhood, middle childhood, adolescence, and young adulthood stress. Consistent with hypotheses, results highlight both stressor controllability and stressor predictability as buffering the impact of traumatic stress exposure on trauma-related symptomatology and suggest that the potency of this buffering effect varies across unique developmental periods. Leveraging dimensional ratings of lifetime stress exposure to probe heterogeneity in outcomes following stress ? and, critically, considering interactions between dimensions of exposure and the developmental period when stress occurred ? is likely to yield increased understanding of risk and resilience following traumatic stress. En ligne : https://dx.doi.org/10.1017/S0954579423000822 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Characterizing experiential elements of early-life stress to inform resilience: Buffering effects of controllability and predictability and the importance of their timing [texte imprimé] / Dylan G. GEE, Auteur ; Taylor J. KEDING, Auteur ; Jeffrey D. MANDELL, Auteur ; Madeline E. NOTTI, Auteur ; Lucinda M. SISK, Auteur . - p.2288-2301. in Development and Psychopathology > 35-5 (December 2023) . - p.2288-2301 Mots-clés : adversity  controllability  dimensional  predictability  stress  trauma-related symptomatology  traumatic stress Index. décimale : PER Périodiques Résumé : Key theoretical frameworks have proposed that examining the impact of exposure to specific dimensions of stress at specific developmental periods is likely to yield important insight into processes of risk and resilience. Utilizing a sample of N = 549 young adults who provided a detailed retrospective history of their lifetime exposure to numerous dimensions of traumatic stress and ratings of their current trauma-related symptomatology via completion of an online survey, here we test whether an individual?s perception of their lifetime stress as either controllable or predictable buffered the impact of exposure on trauma-related symptomatology assessed in adulthood. Further, we tested whether this moderation effect differed when evaluated in the context of early childhood, middle childhood, adolescence, and young adulthood stress. Consistent with hypotheses, results highlight both stressor controllability and stressor predictability as buffering the impact of traumatic stress exposure on trauma-related symptomatology and suggest that the potency of this buffering effect varies across unique developmental periods. Leveraging dimensional ratings of lifetime stress exposure to probe heterogeneity in outcomes following stress ? and, critically, considering interactions between dimensions of exposure and the developmental period when stress occurred ? is likely to yield increased understanding of risk and resilience following traumatic stress. En ligne : https://dx.doi.org/10.1017/S0954579423000822 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

Neurobehavioral correlates of impaired emotion recognition in pediatric PTSD / Sara A. HEYN in Development and Psychopathology, 34-3 (August 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-3 (August 2022) . - p.946-956 Titre : Neurobehavioral correlates of impaired emotion recognition in pediatric PTSD Type de document : texte imprimé Auteurs : Sara A. HEYN, Auteur ; Collin SCHMIT, Auteur ; Taylor J. KEDING, Auteur ; Richard WOLF, Auteur ; Ryan J. HERRINGA, Auteur Article en page(s) : p.946-956 Langues : Anglais (eng) Mots-clés : adolescent  emotion  functional neuroimaging  posttraumatic stress disorders Index. décimale : PER Périodiques Résumé : Despite broad evidence suggesting that adversity-exposed youth experience an impaired ability to recognize emotion in others, the underlying biological mechanisms remains elusive. This study uses a multimethod approach to target the neurological substrates of this phenomenon in a well-phenotyped sample of youth meeting diagnostic criteria for posttraumatic stress disorder (PTSD). Twenty-one PTSD-afflicted youth and 23 typically developing (TD) controls completed clinical interview schedules, an emotion recognition task with eye-tracking, and an implicit emotion processing task during functional magnetic resonance imaging )fMRI). PTSD was associated with decreased accuracy in identification of angry, disgust, and neutral faces as compared to TD youth. Of note, these impairments occurred despite the normal deployment of visual attention in youth with PTSD relative to TD youth. Correlation with a related fMRI task revealed a group by accuracy interaction for amygdala “hippocampus functional connectivity (FC) for angry expressions, where TD youth showed a positive relationship between anger accuracy and amygdala “hippocampus FC; this relationship was reversed in youth with PTSD. These findings are a novel characterization of impaired threat recognition within a well-phenotyped population of severe pediatric PTSD. Further, the differential amygdala “hippocampus FC identified in youth with PTSD may imply aberrant efficiency of emotional contextualization circuits. En ligne : http://dx.doi.org/10.1017/S0954579420001704 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Neurobehavioral correlates of impaired emotion recognition in pediatric PTSD [texte imprimé] / Sara A. HEYN, Auteur ; Collin SCHMIT, Auteur ; Taylor J. KEDING, Auteur ; Richard WOLF, Auteur ; Ryan J. HERRINGA, Auteur . - p.946-956. Langues : Anglais (eng) in Development and Psychopathology > 34-3 (August 2022) . - p.946-956 Mots-clés : adolescent  emotion  functional neuroimaging  posttraumatic stress disorders Index. décimale : PER Périodiques Résumé : Despite broad evidence suggesting that adversity-exposed youth experience an impaired ability to recognize emotion in others, the underlying biological mechanisms remains elusive. This study uses a multimethod approach to target the neurological substrates of this phenomenon in a well-phenotyped sample of youth meeting diagnostic criteria for posttraumatic stress disorder (PTSD). Twenty-one PTSD-afflicted youth and 23 typically developing (TD) controls completed clinical interview schedules, an emotion recognition task with eye-tracking, and an implicit emotion processing task during functional magnetic resonance imaging )fMRI). PTSD was associated with decreased accuracy in identification of angry, disgust, and neutral faces as compared to TD youth. Of note, these impairments occurred despite the normal deployment of visual attention in youth with PTSD relative to TD youth. Correlation with a related fMRI task revealed a group by accuracy interaction for amygdala “hippocampus functional connectivity (FC) for angry expressions, where TD youth showed a positive relationship between anger accuracy and amygdala “hippocampus FC; this relationship was reversed in youth with PTSD. These findings are a novel characterization of impaired threat recognition within a well-phenotyped population of severe pediatric PTSD. Further, the differential amygdala “hippocampus FC identified in youth with PTSD may imply aberrant efficiency of emotional contextualization circuits. En ligne : http://dx.doi.org/10.1017/S0954579420001704 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort / Quanfa HE in Journal of Neurodevelopmental Disorders, 15 (2023)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 15 (2023) Titre : Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort Type de document : texte imprimé Auteurs : Quanfa HE, Auteur ; Taylor J. KEDING, Auteur ; Qi ZHANG, Auteur ; Jiacheng MIAO, Auteur ; Justin D. RUSSELL, Auteur ; Ryan J. HERRINGA, Auteur ; Qiongshi LU, Auteur ; Brittany G. TRAVERS, Auteur ; James J. LI, Auteur Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Attention Deficit Disorder with Hyperactivity/genetics  Neurosciences  Brain/diagnostic imaging  Cerebral Cortex  Gray Matter/diagnostic imaging  Adhd  Brain volume  Functional annotation  Multiple mediation  Polygenic scores Index. décimale : PER Périodiques Résumé : BACKGROUND: ADHD polygenic scores (PGSs) have been previously shown to predict ADHD outcomes in several studies. However, ADHD PGSs are typically correlated with ADHD but not necessarily reflective of causal mechanisms. More research is needed to elucidate the neurobiological mechanisms underlying ADHD. We leveraged functional annotation information into an ADHD PGS to (1) improve the prediction performance over a non-annotated ADHD PGS and (2) test whether volumetric variation in brain regions putatively associated with ADHD mediate the association between PGSs and ADHD outcomes. METHODS: Data were from the Philadelphia Neurodevelopmental Cohort (N = 555). Multiple mediation models were tested to examine the indirect effects of two ADHD PGSs-one using a traditional computation involving clumping and thresholding and another using a functionally annotated approach (i.e., AnnoPred)-on ADHD inattention (IA) and hyperactivity-impulsivity (HI) symptoms, via gray matter volumes in the cingulate gyrus, angular gyrus, caudate, dorsolateral prefrontal cortex (DLPFC), and inferior temporal lobe. RESULTS: A direct effect was detected between the AnnoPred ADHD PGS and IA symptoms in adolescents. No indirect effects via brain volumes were detected for either IA or HI symptoms. However, both ADHD PGSs were negatively associated with the DLPFC. CONCLUSIONS: The AnnoPred ADHD PGS was a more developmentally specific predictor of adolescent IA symptoms compared to the traditional ADHD PGS. However, brain volumes did not mediate the effects of either a traditional or AnnoPred ADHD PGS on ADHD symptoms, suggesting that we may still be underpowered in clarifying brain-based biomarkers for ADHD using genetic measures. En ligne : https://dx.doi.org/10.1186/s11689-023-09498-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort [texte imprimé] / Quanfa HE, Auteur ; Taylor J. KEDING, Auteur ; Qi ZHANG, Auteur ; Jiacheng MIAO, Auteur ; Justin D. RUSSELL, Auteur ; Ryan J. HERRINGA, Auteur ; Qiongshi LU, Auteur ; Brittany G. TRAVERS, Auteur ; James J. LI, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 15 (2023) Mots-clés : Adolescent  Humans  Attention Deficit Disorder with Hyperactivity/genetics  Neurosciences  Brain/diagnostic imaging  Cerebral Cortex  Gray Matter/diagnostic imaging  Adhd  Brain volume  Functional annotation  Multiple mediation  Polygenic scores Index. décimale : PER Périodiques Résumé : BACKGROUND: ADHD polygenic scores (PGSs) have been previously shown to predict ADHD outcomes in several studies. However, ADHD PGSs are typically correlated with ADHD but not necessarily reflective of causal mechanisms. More research is needed to elucidate the neurobiological mechanisms underlying ADHD. We leveraged functional annotation information into an ADHD PGS to (1) improve the prediction performance over a non-annotated ADHD PGS and (2) test whether volumetric variation in brain regions putatively associated with ADHD mediate the association between PGSs and ADHD outcomes. METHODS: Data were from the Philadelphia Neurodevelopmental Cohort (N = 555). Multiple mediation models were tested to examine the indirect effects of two ADHD PGSs-one using a traditional computation involving clumping and thresholding and another using a functionally annotated approach (i.e., AnnoPred)-on ADHD inattention (IA) and hyperactivity-impulsivity (HI) symptoms, via gray matter volumes in the cingulate gyrus, angular gyrus, caudate, dorsolateral prefrontal cortex (DLPFC), and inferior temporal lobe. RESULTS: A direct effect was detected between the AnnoPred ADHD PGS and IA symptoms in adolescents. No indirect effects via brain volumes were detected for either IA or HI symptoms. However, both ADHD PGSs were negatively associated with the DLPFC. CONCLUSIONS: The AnnoPred ADHD PGS was a more developmentally specific predictor of adolescent IA symptoms compared to the traditional ADHD PGS. However, brain volumes did not mediate the effects of either a traditional or AnnoPred ADHD PGS on ADHD symptoms, suggesting that we may still be underpowered in clarifying brain-based biomarkers for ADHD using genetic measures. En ligne : https://dx.doi.org/10.1186/s11689-023-09498-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

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