Altered Metabolic Characteristics in Plasma of Young Boys with Autism Spectrum Disorder / Lei WANG in Journal of Autism and Developmental Disorders, 52-11 (November 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4897-4907 Titre : Altered Metabolic Characteristics in Plasma of Young Boys with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lei WANG, Auteur ; Ruixuan ZHENG, Auteur ; Ying XU, Auteur ; Ziyun ZHOU, Auteur ; Ping GUAN, Auteur ; Yanling WU, Auteur ; Jian ZHOU, Auteur ; Zaohuo CHENG, Auteur ; Lili ZHANG, Auteur Article en page(s) : p.4897-4907 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Biomarkers  Child  Choline  Chromatography, Liquid  Humans  Male  Ornithine  Tandem Mass Spectrometry  Autism Spectrum Disorder (ASD)  Liquid chromatography-tandem mass spectrometry (LC-MS/MS)  Metabolic profile  Plasma Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a serious neurodevelopmental disorder with no clinical biomarker. This study used untargeted metabolomic analysis to identify metabolic characteristics in plasma that can distinguish ASD children. 29 boys with ASD (3.02 Â+ 0.67 years) and 30 typically developing (TD) boys (3.13 Â+ 0.46 years) were recruited. Developmental and behavioral assessments were conducted in ASD group. Samples of plasma were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The association between metabolite concentration and scale score was assessed by Spearman rank correlation. Altered metabolic characteristics were found in boys with ASD. In Receiver Operating Characteristic (ROC) analysis, ornithine had the highest AUC (Area under ROC) value. Furthermore, the concentration of choline and ornithine was negatively correlated with ABC-language score in ASD group. En ligne : http://dx.doi.org/10.1007/s10803-021-05364-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Altered Metabolic Characteristics in Plasma of Young Boys with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Lei WANG, Auteur ; Ruixuan ZHENG, Auteur ; Ying XU, Auteur ; Ziyun ZHOU, Auteur ; Ping GUAN, Auteur ; Yanling WU, Auteur ; Jian ZHOU, Auteur ; Zaohuo CHENG, Auteur ; Lili ZHANG, Auteur . - p.4897-4907. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4897-4907 Mots-clés : Autism Spectrum Disorder/diagnosis  Biomarkers  Child  Choline  Chromatography, Liquid  Humans  Male  Ornithine  Tandem Mass Spectrometry  Autism Spectrum Disorder (ASD)  Liquid chromatography-tandem mass spectrometry (LC-MS/MS)  Metabolic profile  Plasma Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a serious neurodevelopmental disorder with no clinical biomarker. This study used untargeted metabolomic analysis to identify metabolic characteristics in plasma that can distinguish ASD children. 29 boys with ASD (3.02 Â+ 0.67 years) and 30 typically developing (TD) boys (3.13 Â+ 0.46 years) were recruited. Developmental and behavioral assessments were conducted in ASD group. Samples of plasma were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The association between metabolite concentration and scale score was assessed by Spearman rank correlation. Altered metabolic characteristics were found in boys with ASD. In Receiver Operating Characteristic (ROC) analysis, ornithine had the highest AUC (Area under ROC) value. Furthermore, the concentration of choline and ornithine was negatively correlated with ABC-language score in ASD group. En ligne : http://dx.doi.org/10.1007/s10803-021-05364-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

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