Mapping potential pathways from polygenic liability through brain structure to psychological problems across the transition to adolescence / E. Leighton DURHAM ; Sarah J. BRISLIN ; Peter B. BARR ; Danielle M. DICK ; Tyler M. MOORE ; Brandon L. PIERCE ; Lin TONG ; Gabrielle E. REIMANN ; Hee Jung JEONG ; Randolph M. DUPONT ; Antonia N. KACZKURKIN in Journal of Child Psychology and Psychiatry, 65-8 (August 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1047-1060 Titre : Mapping potential pathways from polygenic liability through brain structure to psychological problems across the transition to adolescence Type de document : Texte imprimé et/ou numérique Auteurs : E. Leighton DURHAM, Auteur ; Sarah J. BRISLIN, Auteur ; Peter B. BARR, Auteur ; Danielle M. DICK, Auteur ; Tyler M. MOORE, Auteur ; Brandon L. PIERCE, Auteur ; Lin TONG, Auteur ; Gabrielle E. REIMANN, Auteur ; Hee Jung JEONG, Auteur ; Randolph M. DUPONT, Auteur ; Antonia N. KACZKURKIN, Auteur Article en page(s) : p.1047-1060 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background We used a polygenic score for externalizing behavior (extPGS) and structural MRI to examine potential pathways from genetic liability to conduct problems via the brain across the adolescent transition. Methods Three annual assessments of child conduct problems, attention-deficit/hyperactivity problems, and internalizing problems were conducted across across 9-13?years of age among 4,475 children of European ancestry in the Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®). Results The extPGS predicted conduct problems in each wave (R2 = 2.0%-2.9%). Bifactor models revealed that the extPRS predicted variance specific to conduct problems (R2 = 1.7%-2.1%), but also variance that conduct problems shared with other measured problems (R2 = .8%-1.4%). Longitudinally, extPGS predicted levels of specific conduct problems (R2 = 2.0%), but not their slope of change across age. The extPGS was associated with total gray matter volume (TGMV; R2 = .4%) and lower TGMV predicted both specific conduct problems (R2 = 1.7%-2.1%) and the variance common to all problems in each wave (R2 = 1.6%-3.1%). A modest proportion of the polygenic liability specific to conduct problems in each wave was statistically mediated by TGMV. Conclusions Across the adolescent transition, the extPGS predicted both variance specific to conduct problems and variance shared by all measured problems. The extPGS also was associated with TGMV, which robustly predicted conduct problems. Statistical mediation analyses suggested the hypothesis that polygenic variation influences individual differences in brain development that are related to the likelihood of conduct problems during the adolescent transition, justifying new research to test this causal hypothesis. En ligne : https://doi.org/10.1111/jcpp.13944 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 [article] Mapping potential pathways from polygenic liability through brain structure to psychological problems across the transition to adolescence [Texte imprimé et/ou numérique] / E. Leighton DURHAM, Auteur ; Sarah J. BRISLIN, Auteur ; Peter B. BARR, Auteur ; Danielle M. DICK, Auteur ; Tyler M. MOORE, Auteur ; Brandon L. PIERCE, Auteur ; Lin TONG, Auteur ; Gabrielle E. REIMANN, Auteur ; Hee Jung JEONG, Auteur ; Randolph M. DUPONT, Auteur ; Antonia N. KACZKURKIN, Auteur . - p.1047-1060. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1047-1060 Index. décimale : PER Périodiques Résumé : Background We used a polygenic score for externalizing behavior (extPGS) and structural MRI to examine potential pathways from genetic liability to conduct problems via the brain across the adolescent transition. Methods Three annual assessments of child conduct problems, attention-deficit/hyperactivity problems, and internalizing problems were conducted across across 9-13?years of age among 4,475 children of European ancestry in the Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®). Results The extPGS predicted conduct problems in each wave (R2 = 2.0%-2.9%). Bifactor models revealed that the extPRS predicted variance specific to conduct problems (R2 = 1.7%-2.1%), but also variance that conduct problems shared with other measured problems (R2 = .8%-1.4%). Longitudinally, extPGS predicted levels of specific conduct problems (R2 = 2.0%), but not their slope of change across age. The extPGS was associated with total gray matter volume (TGMV; R2 = .4%) and lower TGMV predicted both specific conduct problems (R2 = 1.7%-2.1%) and the variance common to all problems in each wave (R2 = 1.6%-3.1%). A modest proportion of the polygenic liability specific to conduct problems in each wave was statistically mediated by TGMV. Conclusions Across the adolescent transition, the extPGS predicted both variance specific to conduct problems and variance shared by all measured problems. The extPGS also was associated with TGMV, which robustly predicted conduct problems. Statistical mediation analyses suggested the hypothesis that polygenic variation influences individual differences in brain development that are related to the likelihood of conduct problems during the adolescent transition, justifying new research to test this causal hypothesis. En ligne : https://doi.org/10.1111/jcpp.13944 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532

The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance / Sally I. Chun KUO in Development and Psychopathology, 34-5 (December 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-5 (December 2022) . - p.1865-1875 Titre : The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance Type de document : Texte imprimé et/ou numérique Auteurs : Sally I. Chun KUO, Auteur ; Holly E. POORE, Auteur ; Peter B. BARR, Auteur ; Isabella S. CHIRICO, Auteur ; Fazil ALIEV, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Grace CHAN, Auteur ; Chella KAMARAJAN, Auteur ; John R. KRAMER, Auteur ; Vivia V. MCCUTCHEON, Auteur ; Martin H. PLAWECKI, Auteur ; Danielle M. DICK, Auteur Article en page(s) : p.1865-1875 Langues : Anglais (eng) Mots-clés : adolescent externalizing  gene-environment correlation  genetic nurture  parenting  polygenic score Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine possible pathways by which genetic risk associated with externalizing is transmitted in families. We used molecular data to disentangle the genetic and environmental pathways contributing to adolescent externalizing behavior in a sample of 1,111 adolescents (50% female; 719 European and 392 African ancestry) and their parents from the Collaborative Study on the Genetics of Alcoholism. We found evidence for genetic nurture such that parental externalizing polygenic scores were associated with adolescent externalizing behavior, over and above the effect of adolescents’ own externalizing polygenic scores. Mediation analysis indicated that parental externalizing psychopathology partly explained the effect of parental genotype on children’s externalizing behavior. We also found evidence for evocative gene-environment correlation, whereby adolescent externalizing polygenic scores were associated with lower parent “child communication, less parent “child closeness, and lower parental knowledge, controlling for parental genotype. These effects were observed among participants of European ancestry but not African ancestry, likely due to the limited predictive power of polygenic scores across ancestral background. These results demonstrate that in addition to genetic transmission, genes influence offspring behavior through the influence of parental genotypes on their children’s environmental experiences, and the role of children’s genotypes in shaping parent “child relationships. En ligne : http://dx.doi.org/10.1017/S0954579422000700 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance [Texte imprimé et/ou numérique] / Sally I. Chun KUO, Auteur ; Holly E. POORE, Auteur ; Peter B. BARR, Auteur ; Isabella S. CHIRICO, Auteur ; Fazil ALIEV, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Grace CHAN, Auteur ; Chella KAMARAJAN, Auteur ; John R. KRAMER, Auteur ; Vivia V. MCCUTCHEON, Auteur ; Martin H. PLAWECKI, Auteur ; Danielle M. DICK, Auteur . - p.1865-1875. Langues : Anglais (eng) in Development and Psychopathology > 34-5 (December 2022) . - p.1865-1875 Mots-clés : adolescent externalizing  gene-environment correlation  genetic nurture  parenting  polygenic score Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine possible pathways by which genetic risk associated with externalizing is transmitted in families. We used molecular data to disentangle the genetic and environmental pathways contributing to adolescent externalizing behavior in a sample of 1,111 adolescents (50% female; 719 European and 392 African ancestry) and their parents from the Collaborative Study on the Genetics of Alcoholism. We found evidence for genetic nurture such that parental externalizing polygenic scores were associated with adolescent externalizing behavior, over and above the effect of adolescents’ own externalizing polygenic scores. Mediation analysis indicated that parental externalizing psychopathology partly explained the effect of parental genotype on children’s externalizing behavior. We also found evidence for evocative gene-environment correlation, whereby adolescent externalizing polygenic scores were associated with lower parent “child communication, less parent “child closeness, and lower parental knowledge, controlling for parental genotype. These effects were observed among participants of European ancestry but not African ancestry, likely due to the limited predictive power of polygenic scores across ancestral background. These results demonstrate that in addition to genetic transmission, genes influence offspring behavior through the influence of parental genotypes on their children’s environmental experiences, and the role of children’s genotypes in shaping parent “child relationships. En ligne : http://dx.doi.org/10.1017/S0954579422000700 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

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