Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes / Sandra K. LOO in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.950-957 Titre : Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes Type de document : Texte imprimé et/ou numérique Auteurs : Sandra K. LOO, Auteur ; Erika CARPENTER RICH, Auteur ; Janeen ISHII, Auteur ; James MCGOUGH, Auteur ; Stanley NELSON, Auteur ; Susan L. SMALLEY, Auteur ; James T. MCCRACKEN, Auteur Année de publication : 2008 Article en page(s) : p.950-957 Langues : Anglais (eng) Mots-clés : Endophenotype working-memory DRD4 genetics executive-function neuropsychology parent-psychopathology Index. décimale : PER Périodiques Résumé : Background: This paper examines familiality and candidate gene associations of cognitive measures as potential endophenotypes in attention-deficit/hyperactivity disorder (ADHD). Methods: The sample consists of 540 participants, aged 6 to 18, who were diagnosed with ADHD from 251 families recruited for a larger genetic study of ADHD. All members of the family underwent psychiatric interviews and children were administered a large battery of cognitive tasks. Subjects were genotyped for several dopaminergic candidate genes (DAT1, DRD4, and DRD5). Results: Performance on measures of intelligence, working memory, and set-shifting had the highest sibling correlations and exhibited significant familial clustering. The 7-repeat allele of the dopamine receptor D4 (DRD4) gene was associated with poor performance on measures of intelligence, color naming, interference control, and working memory. There were no significant associations with DAT1 and DRD5. Conclusions: Sibling correlations, familial clustering and candidate gene associations provide strong support for verbal working memory as a candidate endophenotype for ADHD. More complex models of, and larger sample sizes for, genetic association with cognitive functions are encouraged for future study. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01928.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes [Texte imprimé et/ou numérique] / Sandra K. LOO, Auteur ; Erika CARPENTER RICH, Auteur ; Janeen ISHII, Auteur ; James MCGOUGH, Auteur ; Stanley NELSON, Auteur ; Susan L. SMALLEY, Auteur ; James T. MCCRACKEN, Auteur . - 2008 . - p.950-957. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.950-957 Mots-clés : Endophenotype working-memory DRD4 genetics executive-function neuropsychology parent-psychopathology Index. décimale : PER Périodiques Résumé : Background: This paper examines familiality and candidate gene associations of cognitive measures as potential endophenotypes in attention-deficit/hyperactivity disorder (ADHD). Methods: The sample consists of 540 participants, aged 6 to 18, who were diagnosed with ADHD from 251 families recruited for a larger genetic study of ADHD. All members of the family underwent psychiatric interviews and children were administered a large battery of cognitive tasks. Subjects were genotyped for several dopaminergic candidate genes (DAT1, DRD4, and DRD5). Results: Performance on measures of intelligence, working memory, and set-shifting had the highest sibling correlations and exhibited significant familial clustering. The 7-repeat allele of the dopamine receptor D4 (DRD4) gene was associated with poor performance on measures of intelligence, color naming, interference control, and working memory. There were no significant associations with DAT1 and DRD5. Conclusions: Sibling correlations, familial clustering and candidate gene associations provide strong support for verbal working memory as a candidate endophenotype for ADHD. More complex models of, and larger sample sizes for, genetic association with cognitive functions are encouraged for future study. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01928.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

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